StarFunc result for job id Q13224

User Input

>input (1484 residues)
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A7XY94	0.664	0.680	0.000	1448	0.828	0.849	A7XY94.pdb.gz	NMDE2_XENLA Glutamate receptor ionotropic, NMDA 2B OS=Xenopus laevis OX=8355 GN=grin2b PE=1 SV=1
2	AFDB:B7ZSK1	0.593	0.606	0.000	1451	0.537	0.549	B7ZSK1.pdb.gz	NMDE1_XENLA Glutamate receptor ionotropic, NMDA 2A OS=Xenopus laevis OX=8355 GN=grin2a PE=1 SV=1
3	AFDB:O15399	0.539	0.596	0.000	1336	0.369	0.410	O15399.pdb.gz	NMDE4_HUMAN Glutamate receptor ionotropic, NMDA 2D OS=Homo sapiens OX=9606 GN=GRIN2D PE=1 SV=2
4	AFDB:P35436	0.604	0.612	0.000	1464	0.538	0.545	P35436.pdb.gz	NMDE1_MOUSE Glutamate receptor ionotropic, NMDA 2A OS=Mus musculus OX=10090 GN=Grin2a PE=1 SV=2
5	AFDB:Q01098	0.545	0.647	0.000	1239	0.369	0.441	Q01098.pdb.gz	NMDE3_MOUSE Glutamate receptor ionotropic, NMDA 2C OS=Mus musculus OX=10090 GN=Grin2c PE=1 SV=2
6	AFDB:Q13224	1.000	1.000	0.000	1484	1.000	1.000	Q13224.pdb.gz	NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B OS=Homo sapiens OX=9606 GN=GRIN2B PE=1 SV=3
7	PDB:4tllA	0.215	0.400	1.105E-53	767	0.136	0.263	4tllA.pdb.gz	NMDA receptor structures reveal subunit arrangement and pore architecture.
8	PDB:4pe5C	0.212	0.402	9.247E-53	754	0.137	0.269	4pe5C.pdb.gz	Crystal structure of a heterotetrameric NMDA receptor ion channel.
9	PDB:7rz4A	0.198	0.277	8.479E-50	993	0.119	0.177	7rz4A.pdb.gz	Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
10	PDB:7ocaA	0.181	0.312	4.291E-49	775	0.121	0.232	7ocaA.pdb.gz	Gating and modulation of a hetero-octameric AMPA glutamate receptor.
11	PDB:5iouA	0.207	0.365	9.386E-49	803	0.145	0.268	5iouA.pdb.gz	Mechanism of NMDA Receptor Inhibition and Activation.
12	PDB:4tlmC	0.211	0.399	1.642E-48	750	0.133	0.264	4tlmC.pdb.gz	NMDA receptor structures reveal subunit arrangement and pore architecture.
13	PDB:7rzaA	0.191	0.268	2.032E-47	981	0.117	0.176	7rzaA.pdb.gz	Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
14	PDB:5idfB	0.185	0.344	9.625E-46	734	0.114	0.230	5idfB.pdb.gz
15	PDB:5weoA	0.199	0.280	1.883E-45	988	0.119	0.179	5weoA.pdb.gz	Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
16	PDB:5kbtA	0.197	0.281	1.127E-44	973	0.119	0.181	5kbtA.pdb.gz	Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.
17	AFDB:Q17602	0.038	0.040	2.667E-3	1390	0.081	0.086	Q17602.pdb.gz	NU214_CAEEL Nuclear pore complex protein 14 OS=Caenorhabditis elegans OX=6239 GN=npp-14 PE=1 SV=1
18	AFDB:A0A0F7NGI8	0.032	0.052	1.427E-2	752	0.067	0.132	A0A0F7NGI8.pdb.gz	A0A0F7NGI8_HUMAN Leucine rich repeat (In FLII) interacting protein 1, isoform CRA_c OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=2 SV=1
19	AFDB:Q9NSY1	0.038	0.046	4.129E-2	1161	0.067	0.085	Q9NSY1.pdb.gz	BMP2K_HUMAN BMP-2-inducible protein kinase OS=Homo sapiens OX=9606 GN=BMP2K PE=1 SV=2
20	AFDB:O70361	0.032	0.039	6.458E-2	1113	0.064	0.085	O70361.pdb.gz	PER3_MOUSE Period circadian protein homolog 3 OS=Mus musculus OX=10090 GN=Per3 PE=1 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A7XY94	0.0	2500	1448	0.831	0.852	NMDE2_XENLA Glutamate receptor ionotropic, NMDA 2B OS=Xenopus laevis OX=8355 GN=grin2b PE=1 SV=1
2	B7ZSK1	0.0	1509	1451	0.550	0.562	NMDE1_XENLA Glutamate receptor ionotropic, NMDA 2A OS=Xenopus laevis OX=8355 GN=grin2a PE=1 SV=1
3	G1TPJ8	0.0	866	888	0.291	0.486	G1TPJ8_RABIT Glutamate receptor OS=Oryctolagus cuniculus OX=9986 GN=GRIN2D PE=3 SV=2
4	O15399	0.0	946	1336	0.312	0.347	NMDE4_HUMAN Glutamate receptor ionotropic, NMDA 2D OS=Homo sapiens OX=9606 GN=GRIN2D PE=1 SV=2
5	P35436	0.0	1505	1464	0.544	0.552	NMDE1_MOUSE Glutamate receptor ionotropic, NMDA 2A OS=Mus musculus OX=10090 GN=Grin2a PE=1 SV=2
6	Q00959	0.0	1503	1464	0.542	0.550	NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A OS=Rattus norvegicus OX=10116 GN=Grin2a PE=1 SV=2
7	Q00960	0.0	3062	1482	0.985	0.986	NMDE2_RAT Glutamate receptor ionotropic, NMDA 2B OS=Rattus norvegicus OX=10116 GN=Grin2b PE=1 SV=1
8	Q00961	0.0	1049	1237	0.338	0.405	NMDE3_RAT Glutamate receptor ionotropic, NMDA 2C OS=Rattus norvegicus OX=10116 GN=Grin2c PE=1 SV=1
9	Q01097	0.0	3059	1482	0.985	0.986	NMDE2_MOUSE Glutamate receptor ionotropic, NMDA 2B OS=Mus musculus OX=10090 GN=Grin2b PE=1 SV=3
10	Q01098	0.0	1044	1239	0.329	0.394	NMDE3_MOUSE Glutamate receptor ionotropic, NMDA 2C OS=Mus musculus OX=10090 GN=Grin2c PE=1 SV=2
11	Q03391	0.0	947	1323	0.311	0.349	NMDE4_MOUSE Glutamate receptor ionotropic, NMDA 2D OS=Mus musculus OX=10090 GN=Grin2d PE=1 SV=3
12	Q12879	0.0	1481	1464	0.540	0.548	NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A OS=Homo sapiens OX=9606 GN=GRIN2A PE=1 SV=1
13	Q13224	0.0	3112	1484	1.000	1.000	NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B OS=Homo sapiens OX=9606 GN=GRIN2B PE=1 SV=3
14	Q14957	0.0	1039	1233	0.330	0.397	NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C OS=Homo sapiens OX=9606 GN=GRIN2C PE=1 SV=3
15	Q61984	0.0	920	1203	0.286	0.353	Q61984_MOUSE Glutamate receptor OS=Mus musculus OX=10090 GN=NMDA2C PE=3 SV=1
16	Q62645	0.0	947	1323	0.313	0.351	NMDE4_RAT Glutamate receptor ionotropic, NMDA 2D OS=Rattus norvegicus OX=10116 GN=Grin2d PE=1 SV=2
17	Q6IWN7	1.02e-139	459	1070	0.183	0.254	Q6IWN7_DROME NMDA receptor 2, isoform F OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=2 SV=1
18	X2JDW0	1.27e-139	459	1082	0.183	0.251	X2JDW0_DROME NMDA receptor 2, isoform G OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=3 SV=1
19	Q9W581	1.32e-139	459	1083	0.183	0.251	Q9W581_DROME NMDA receptor 2, isoform C OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=2 SV=2
20	E1JJC6	9.14e-139	453	941	0.183	0.288	E1JJC6_DROME NMDA receptor 2, isoform E OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01094 ANF_receptor	1.9e-09	48.8	Receptor family ligand binding region
2	PF00060 Lig_chan	3.8e-30	116.2	Ligand-gated ion channel
3	PF10613 Lig_chan-Glu_bd	6e-27	105.4	Ligated ion channel L-glutamate- and glycine-binding site
4	PF10565 NMDAR2_C	3e-240	811.4	N-methyl D-aspartate receptor 2B3 C-terminus
5	PF00497 SBP_bac_3	1.6e-20	85.1	Bacterial extracellular solute-binding proteins, family 3

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000477455

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360608	0.999	Glutamate receptor ionotropic, NMDA 1
2	9606.ENSP00000381412	0.999	Calcium/calmodulin-dependent protein kinase type II subunit alpha
3	9606.ENSP00000382428	0.999	Disks large homolog 4
4	9606.ENSP00000346671	0.998	Tyrosine-protein kinase Fyn
5	9606.ENSP00000363480	0.998	Disks large homolog 3
6	9606.ENSP00000405963	0.995	Ras-specific guanine nucleotide-releasing factor 1
7	9606.ENSP00000477999	0.993	Nitric oxide synthase, brain
8	9606.ENSP00000426909	0.989	Receptor of activated protein C kinase 1
9	9606.ENSP00000354859	0.988	D(2) dopamine receptor
10	9606.ENSP00000365272	0.988	Disks large homolog 2
11	9606.ENSP00000386135	0.987	Death-associated protein kinase 1
12	9606.ENSP00000403636	0.982	Ras/Rap GTPase-activating protein SynGAP
13	9606.ENSP00000379818	0.975	Glutamate receptor ionotropic, NMDA 2A
14	9606.ENSP00000345731	0.970	Disks large homolog 1
15	9606.ENSP00000265381	0.968	Amyloid-beta A4 precursor protein-binding family A member 1
16	9606.ENSP00000342235	0.968	Receptor tyrosine-protein kinase erbB-4
17	9606.ENSP00000277120	0.963	BDNF/NT-3 growth factors receptor
18	9606.ENSP00000309539	0.963	Dihydropyrimidinase-related protein 2
19	9606.ENSP00000443495	0.962	Alpha-actinin-2
20	9606.ENSP00000319060	0.961	Calcium/calmodulin-dependent protein kinase type II subunit gamma

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0005261	0.999	monoatomic cation channel activity
GO:0004972	0.999	NMDA glutamate receptor activity
GO:0046873	0.993	metal ion transmembrane transporter activity
GO:1901702	0.992	salt transmembrane transporter activity
GO:0005262	0.980	calcium channel activity
GO:0016597	0.786	amino acid binding
GO:0099094	0.775	ligand-gated monoatomic cation channel activity
GO:0099604	0.735	ligand-gated calcium channel activity
GO:0043169	0.663	cation binding
GO:0099507	0.652	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO:0022849	0.363	glutamate-gated calcium ion channel activity
GO:0098960	0.300	postsynaptic neurotransmitter receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.990	cellular process
GO:0050794	0.990	regulation of cellular process
GO:0050896	0.989	response to stimulus
GO:0023052	0.988	signaling
GO:0007154	0.983	cell communication
GO:0042391	0.983	regulation of membrane potential
GO:0050806	0.983	positive regulation of synaptic transmission
GO:0032501	0.979	multicellular organismal process
GO:0051716	0.977	cellular response to stimulus
GO:0050890	0.973	cognition
GO:0007610	0.965	behavior
GO:0007165	0.958	signal transduction
GO:0048167	0.947	regulation of synaptic plasticity
GO:0099536	0.946	synaptic signaling
GO:0099537	0.943	trans-synaptic signaling
GO:0006811	0.938	monoatomic ion transport
GO:0045471	0.924	response to ethanol
GO:0007611	0.914	learning or memory
GO:0007268	0.907	chemical synaptic transmission
GO:0033555	0.886	multicellular organismal response to stress
GO:0006812	0.880	monoatomic cation transport
GO:0007166	0.879	cell surface receptor signaling pathway
GO:0002209	0.875	behavioral defense response
GO:0042596	0.867	fear response
GO:0007613	0.841	memory
GO:0048856	0.838	anatomical structure development
GO:0007612	0.829	learning
GO:0007215	0.818	glutamate receptor signaling pathway
GO:0007275	0.803	multicellular organism development
GO:0010941	0.794	regulation of cell death
GO:0048519	0.781	negative regulation of biological process
GO:0010243	0.779	response to organonitrogen compound
GO:0051966	0.779	regulation of synaptic transmission, glutamatergic
GO:0016043	0.778	cellular component organization
GO:0031644	0.778	regulation of nervous system process
GO:0019222	0.776	regulation of metabolic process
GO:0080090	0.764	regulation of primary metabolic process
GO:0014075	0.764	response to amine
GO:0048731	0.763	system development
GO:1905114	0.758	cell surface receptor signaling pathway involved in cell-cell signaling
GO:0060255	0.753	regulation of macromolecule metabolic process
GO:0050905	0.748	neuromuscular process
GO:0099565	0.741	chemical synaptic transmission, postsynaptic
GO:0051171	0.737	regulation of nitrogen compound metabolic process
GO:0051968	0.736	positive regulation of synaptic transmission, glutamatergic
GO:0001662	0.721	behavioral fear response
GO:0060078	0.720	regulation of postsynaptic membrane potential
GO:0032026	0.714	response to magnesium ion
GO:0051246	0.710	regulation of protein metabolic process
GO:0048583	0.705	regulation of response to stimulus
GO:1901701	0.704	cellular response to oxygen-containing compound
GO:0007399	0.692	nervous system development
GO:0009719	0.688	response to endogenous stimulus
GO:0009966	0.676	regulation of signal transduction
GO:0048168	0.672	regulation of neuronal synaptic plasticity
GO:0098815	0.672	modulation of excitatory postsynaptic potential
GO:0071310	0.663	cellular response to organic substance
GO:0006816	0.651	calcium ion transport
GO:0009605	0.578	response to external stimulus
GO:0007417	0.567	central nervous system development
GO:0048513	0.547	animal organ development
GO:0055085	0.546	transmembrane transport
GO:0009628	0.530	response to abiotic stimulus
GO:0034220	0.529	monoatomic ion transmembrane transport
GO:0070588	0.520	calcium ion transmembrane transport
GO:0097553	0.500	calcium ion transmembrane import into cytosol
GO:0010043	0.344	response to zinc ion
GO:0071704	0.317	organic substance metabolic process
GO:0048523	0.312	negative regulation of cellular process
GO:0065009	0.309	regulation of molecular function

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.998	cytoplasm
GO:0043231	0.998	intracellular membrane-bounded organelle
GO:0012505	0.997	endomembrane system
GO:0017146	0.997	NMDA selective glutamate receptor complex
GO:0030054	0.996	cell junction
GO:0031090	0.995	organelle membrane
GO:0045202	0.992	synapse
GO:0005789	0.976	endoplasmic reticulum membrane
GO:0098590	0.965	plasma membrane region
GO:0097060	0.960	synaptic membrane
GO:0045211	0.936	postsynaptic membrane
GO:0098978	0.793	glutamatergic synapse
GO:0043005	0.534	neuron projection
GO:0098984	0.448	neuron to neuron synapse
GO:0098793	0.416	presynapse
GO:0032279	0.383	asymmetric synapse
GO:0031981	0.336	nuclear lumen
GO:0005654	0.313	nucleoplasm
GO:0031982	0.301	vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:29671	0.981	Ca(2+)(in) = Ca(2+)(out)

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