StarFunc result for job id Q13698

User Input

>input (1873 residues)
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE
EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLD
EDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRI
FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEML
MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF
PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKL
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFT
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLR
VLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDL
SKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL
YKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHY
NQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLR
TIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP
VMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHV
FSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAP
CQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTL
AADANFIMATGQALADACQMEPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQ
HQGSQETLIPPRL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:5gjwA	0.670	0.966	0.000	1291	0.663	0.961	5gjwA.pdb.gz	Structure of the voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution
2	PDB:7jpxA	0.591	0.989	0.000	1116	0.572	0.960	7jpxA.pdb.gz	Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*.
3	PDB:7uhfA	0.641	0.971	0.000	1230	0.513	0.781	7uhfA.pdb.gz	Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine.
4	AFDB:F1R736	0.736	0.742	0.000	1859	0.557	0.561	F1R736.pdb.gz
5	AFDB:P07293	0.856	0.856	0.000	1873	0.925	0.925	P07293.pdb.gz	CAC1S_RABIT Voltage-dependent L-type calcium channel subunit alpha-1S OS=Oryctolagus cuniculus OX=9986 GN=CACNA1S PE=1 SV=1
6	AFDB:P15381	0.793	0.686	0.000	2171	0.651	0.561	P15381.pdb.gz	CAC1C_RABIT Voltage-dependent L-type calcium channel subunit alpha-1C OS=Oryctolagus cuniculus OX=9986 GN=CACNA1C PE=1 SV=1
7	AFDB:P27732	0.762	0.650	0.000	2203	0.642	0.546	P27732.pdb.gz	CAC1D_RAT Voltage-dependent L-type calcium channel subunit alpha-1D OS=Rattus norvegicus OX=10116 GN=Cacna1d PE=1 SV=2
8	AFDB:Q01668	0.785	0.683	0.000	2161	0.645	0.559	Q01668.pdb.gz	CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D OS=Homo sapiens OX=9606 GN=CACNA1D PE=1 SV=2
9	AFDB:Q13936	0.778	0.658	0.000	2221	0.661	0.557	Q13936.pdb.gz	CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C OS=Homo sapiens OX=9606 GN=CACNA1C PE=1 SV=4
10	AFDB:Q5TZF1	0.771	0.660	0.000	2196	0.653	0.557	Q5TZF1.pdb.gz
11	AFDB:Q6RKB0	0.813	0.825	0.000	1847	0.661	0.670	Q6RKB0.pdb.gz	Q6RKB0_DANRE Voltage-dependent L-type calcium channel subunit alpha OS=Danio rerio OX=7955 GN=cacna1s PE=2 SV=1
12	AFDB:Q8MQA1	0.756	0.755	0.000	1877	0.534	0.533	Q8MQA1.pdb.gz	Q8MQA1_CAEEL Voltage-dependent L-type calcium channel subunit alpha OS=Caenorhabditis elegans OX=6239 GN=egl-19 PE=1 SV=1
13	AFDB:Q99246	0.782	0.677	0.000	2179	0.645	0.555	Q99246.pdb.gz	CAC1D_MOUSE Voltage-dependent L-type calcium channel subunit alpha-1D OS=Mus musculus OX=10090 GN=Cacna1d PE=1 SV=3
14	PDB:7mixA	0.646	0.901	4.186E-97	1326	0.357	0.504	7mixA.pdb.gz	Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
15	PDB:7vfsA	0.623	0.909	4.458E-95	1266	0.345	0.511	7vfsA.pdb.gz	Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2.
16	PDB:3jbrA	0.542	0.801	7.099E-92	1224	0.568	0.869	3jbrA.pdb.gz
17	PDB:7w9lA	0.557	0.723	1.244E-60	1420	0.215	0.283	7w9lA.pdb.gz	High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.
18	PDB:7we4A	0.518	0.844	1.510E-58	1122	0.192	0.321	7we4A.pdb.gz	Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.
19	PDB:7wliA	0.527	0.851	3.614E-58	1135	0.203	0.335	7wliA.pdb.gz	Structure, gating, and pharmacology of human Ca V 3.3 channel.
20	PDB:7xveA	0.527	0.756	5.001E-56	1276	0.200	0.293	7xveA.pdb.gz	Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A8I5ZMH8	1186	1960	0.311	0.297	A0A8I5ZMH8_RAT Voltage-dependent L-type calcium channel subunit alpha OS=Rattus norvegicus OX=10116 GN=Cacna1f PE=3 SV=1
2	A0A8I5ZS49	2036	1973	0.556	0.528	A0A8I5ZS49_RAT Voltage-dependent L-type calcium channel subunit alpha OS=Rattus norvegicus OX=10116 GN=Cacna1f PE=3 SV=1
3	A1XIQ4	2040	1980	0.558	0.528	A1XIQ4_RAT Voltage-dependent L-type calcium channel subunit alpha OS=Rattus norvegicus OX=10116 GN=Cacna1f PE=2 SV=1
4	F8W3Z0	712	2280	0.202	0.166	F8W3Z0_DANRE Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b OS=Danio rerio OX=7955 GN=CACNA1Ab PE=2 SV=2
5	G3V9W8	2040	1980	0.558	0.528	G3V9W8_RAT Voltage-dependent L-type calcium channel subunit alpha OS=Rattus norvegicus OX=10116 GN=Cacna1f PE=3 SV=1
6	G5EFB0	1189	1523	0.375	0.461	G5EFB0_CAEEL EF-hand domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=unc-2 PE=3 SV=2
7	G5EG02	1783	1783	0.508	0.534	G5EG02_CAEEL Voltage-dependent L-type calcium channel subunit alpha OS=Caenorhabditis elegans OX=6239 GN=egl-19 PE=1 SV=1
8	O00555	616	2506	0.177	0.132	CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A OS=Homo sapiens OX=9606 GN=CACNA1A PE=1 SV=3
9	O35505	2240	2169	0.616	0.532	CAC1C_CAVPO Voltage-dependent L-type calcium channel subunit alpha-1C OS=Cavia porcellus OX=10141 GN=CACNA1C PE=1 SV=2
10	O55017	608	2327	0.179	0.144	CAC1B_MOUSE Voltage-dependent N-type calcium channel subunit alpha-1B OS=Mus musculus OX=10090 GN=Cacna1b PE=1 SV=1
11	O60840	2048	1977	0.594	0.562	CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F OS=Homo sapiens OX=9606 GN=CACNA1F PE=1 SV=2
12	O89089	608	2333	0.179	0.144	O89089_RAT Voltage-dependent N-type calcium channel subunit alpha OS=Rattus norvegicus OX=10116 GN=Cacna1b PE=1 SV=1
13	P07293	3450	1873	0.926	0.926	CAC1S_RABIT Voltage-dependent L-type calcium channel subunit alpha-1S OS=Oryctolagus cuniculus OX=9986 GN=CACNA1S PE=1 SV=1
14	P15381	2258	2171	0.619	0.534	CAC1C_RABIT Voltage-dependent L-type calcium channel subunit alpha-1C OS=Oryctolagus cuniculus OX=9986 GN=CACNA1C PE=1 SV=1
15	P22002	2213	2169	0.611	0.527	CAC1C_RAT Voltage-dependent L-type calcium channel subunit alpha-1C OS=Rattus norvegicus OX=10116 GN=Cacna1c PE=1 SV=1
16	P27732	1639	2203	0.469	0.399	CAC1D_RAT Voltage-dependent L-type calcium channel subunit alpha-1D OS=Rattus norvegicus OX=10116 GN=Cacna1d PE=1 SV=2
17	P27884	617	2424	0.177	0.137	CAC1A_RABIT Voltage-dependent P/Q-type calcium channel subunit alpha-1A OS=Oryctolagus cuniculus OX=9986 GN=CACNA1A PE=1 SV=1
18	P54282	609	2212	0.176	0.149	CAC1A_RAT Voltage-dependent P/Q-type calcium channel subunit alpha-1A OS=Rattus norvegicus OX=10116 GN=Cacna1a PE=1 SV=1
19	P91645	1296	1851	0.415	0.420	CAC1A_DROME Voltage-dependent calcium channel type A subunit alpha-1 OS=Drosophila melanogaster OX=7227 GN=cac PE=1 SV=3
20	P97445	613	2368	0.176	0.139	CAC1A_MOUSE Voltage-dependent P/Q-type calcium channel subunit alpha-1A OS=Mus musculus OX=10090 GN=Cacna1a PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16885 CAC1F_C	7.5	17.4	Voltage-gated calcium channel subunit alpha, C-term
2	PF08763 Ca_chan_IQ	4.7e-25	98.9	Voltage gated calcium channel IQ domain
3	PF16905 GPHH	4.6e-25	98.6	Voltage-dependent L-type calcium channel, IQ-associated
4	PF00520 Ion_trans	4e-249	833.6	Ion transport protein
5	PF08016 PKD_channel	1.6e-10	52.4	Polycystin cation channel

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000355192

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000352608	0.998	Ryanodine receptor 1
2	9606.ENSP00000320025	0.991	Voltage-dependent L-type calcium channel subunit beta-2
3	9606.ENSP00000349320	0.989	Voltage-dependent calcium channel subunit alpha-2/delta-1
4	9606.ENSP00000329200	0.981	SH3 and cysteine-rich domain-containing protein 3
5	9606.ENSP00000438949	0.968	Voltage-dependent L-type calcium channel subunit beta-4
6	9606.ENSP00000301050	0.965	Voltage-dependent L-type calcium channel subunit beta-3
7	9606.ENSP00000372169	0.963	Voltage-dependent calcium channel subunit alpha-2/delta-4
8	9606.ENSP00000226021	0.958	Voltage-dependent calcium channel gamma-1 subunit
9	9606.ENSP00000288139	0.952	Voltage-dependent L-type calcium channel subunit alpha-1D
10	9606.ENSP00000365441	0.952	Voltage-dependent L-type calcium channel subunit alpha-1F
11	9606.ENSP00000377840	0.946	Voltage-dependent L-type calcium channel subunit beta-1
12	9606.ENSP00000327509	0.929	SH3 and cysteine rich domain 2
13	9606.ENSP00000375647	0.924	Voltage-dependent calcium channel gamma-7 subunit
14	9606.ENSP00000270458	0.921	Voltage-dependent calcium channel gamma-8 subunit
15	9606.ENSP00000262138	0.912	Voltage-dependent calcium channel gamma-4 subunit
16	9606.ENSP00000252729	0.907	Voltage-dependent calcium channel gamma-6 subunit
17	9606.ENSP00000266376	0.903	Voltage-dependent L-type calcium channel subunit alpha-1C
18	9606.ENSP00000005284	0.901	Voltage-dependent calcium channel gamma-3 subunit
19	9606.ENSP00000349467	0.901	Calmodulin-1
20	9606.ENSP00000291295	0.899	Calmodulin 3 (phosphorylase kinase, delta)

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005245	1.000	voltage-gated calcium channel activity
GO:0005515	0.999	protein binding
GO:0008331	0.868	high voltage-gated calcium channel activity
GO:0044325	0.359	transmembrane transporter binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.965	cellular process
GO:0006811	0.937	monoatomic ion transport
GO:0030001	0.902	metal ion transport
GO:0065007	0.885	biological regulation
GO:0006816	0.866	calcium ion transport
GO:0050789	0.849	regulation of biological process
GO:0032501	0.734	multicellular organismal process
GO:0050896	0.676	response to stimulus
GO:0003008	0.641	system process
GO:0050794	0.581	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0034703	0.998	cation channel complex
GO:0098797	0.996	plasma membrane protein complex
GO:0034704	0.986	calcium channel complex
GO:0005891	0.966	voltage-gated calcium channel complex
GO:0042383	0.950	sarcolemma
GO:0030315	0.783	T-tubule
GO:0005622	0.685	intracellular anatomical structure
GO:0043226	0.674	organelle
GO:0005737	0.664	cytoplasm
GO:0043227	0.663	membrane-bounded organelle
GO:0043229	0.529	intracellular organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:29671	1.000	Ca(2+)(in) = Ca(2+)(out)

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