StarFunc result for job id Q13751

User Input

>input (1172 residues)
MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
MLRSADLTGLEKRVEQIRDHINGRVLYYATCK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F1LPI5	0.425	0.425	0.000	1172	0.826	0.826	F1LPI5.pdb.gz	F1LPI5_RAT Laminin subunit beta 3 OS=Rattus norvegicus OX=10116 GN=Lamb3 PE=4 SV=2
2	AFDB:Q13751	1.000	1.000	0.000	1172	1.000	1.000	Q13751.pdb.gz	LAMB3_HUMAN Laminin subunit beta-3 OS=Homo sapiens OX=9606 GN=LAMB3 PE=1 SV=1
3	AFDB:Q61292	0.317	0.211	4.715E-73	1799	0.358	0.233	Q61292.pdb.gz	LAMB2_MOUSE Laminin subunit beta-2 OS=Mus musculus OX=10090 GN=Lamb2 PE=1 SV=2
4	AFDB:B7ZDA6	0.331	0.220	3.111E-72	1782	0.348	0.229	B7ZDA6.pdb.gz	B7ZDA6_DANRE Laminin subunit beta-2 precursor OS=Danio rerio OX=7955 GN=si:dkey-32e6.2 PE=1 SV=1
5	AFDB:D3ZQN7	0.338	0.226	3.476E-72	1786	0.342	0.225	D3ZQN7.pdb.gz	D3ZQN7_RAT Laminin subunit beta 1 OS=Rattus norvegicus OX=10116 GN=Lamb1 PE=1 SV=3
6	AFDB:P55268	0.319	0.213	4.105E-72	1798	0.358	0.234	P55268.pdb.gz	LAMB2_HUMAN Laminin subunit beta-2 OS=Homo sapiens OX=9606 GN=LAMB2 PE=1 SV=2
7	AFDB:A0A0R4IDN1	0.334	0.225	1.026E-70	1785	0.334	0.220	A0A0R4IDN1.pdb.gz
8	AFDB:P11046	0.298	0.197	5.898E-65	1788	0.286	0.187	P11046.pdb.gz	LAMB1_DROME Laminin subunit beta-1 OS=Drosophila melanogaster OX=7227 GN=LanB1 PE=1 SV=4
9	AFDB:O44565	0.335	0.226	2.868E-63	1790	0.284	0.186	O44565.pdb.gz	O44565_CAEEL Laminin subunit beta-1 OS=Caenorhabditis elegans OX=6239 GN=lam-1 PE=1 SV=3
10	AFDB:P11047	0.282	0.212	5.603E-47	1609	0.259	0.189	P11047.pdb.gz	LAMC1_HUMAN Laminin subunit gamma-1 OS=Homo sapiens OX=9606 GN=LAMC1 PE=1 SV=3
11	PDB:8a3tA	0.098	0.443	2.081E-5	219	0.021	0.114	8a3tA.pdb.gz	Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex
12	PDB:1xpwA	0.088	0.620	2.140E-4	143	0.019	0.154	1xpwA.pdb.gz
13	PDB:7kveB	0.105	0.091	2.392E-4	1374	0.025	0.021	7kveB.pdb.gz
14	PDB:4bxsV	0.090	0.084	2.825E-4	1262	0.021	0.020	4bxsV.pdb.gz	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
15	PDB:1k12A	0.077	0.459	3.941E-4	158	0.015	0.114	1k12A.pdb.gz	A novel fucose recognition fold involved in innate immunity.
16	PDB:7qe7L	0.093	0.496	5.811E-4	183	0.020	0.131	7qe7L.pdb.gz	High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1
17	PDB:7ungXA	0.100	0.432	9.575E-4	186	0.020	0.124	7ungXA.pdb.gz	SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
18	PDB:7z8bC	0.092	0.088	1.668E-3	1224	0.016	0.016	7z8bC.pdb.gz	Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.
19	PDB:2vmeA	0.090	0.355	3.246E-3	256	0.020	0.090	2vmeA.pdb.gz	Structure Determination of Discoidin II from Dictyostelium Discoideum and Carbohydrate Binding Properties of the Lectin Domain.
20	PDB:5fl1A	0.056	0.087	8.337E-3	703	0.012	0.020	5fl1A.pdb.gz	Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by humanO-GlcNAcase.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	F1LPI5	0.0	1930	1172	0.818	0.818	F1LPI5_RAT Laminin subunit beta 3 OS=Rattus norvegicus OX=10116 GN=Lamb3 PE=4 SV=2
2	Q13751	0.0	2409	1172	1.000	1.000	LAMB3_HUMAN Laminin subunit beta-3 OS=Homo sapiens OX=9606 GN=LAMB3 PE=1 SV=1
3	Q61087	0.0	1936	1168	0.823	0.826	LAMB3_MOUSE Laminin subunit beta-3 OS=Mus musculus OX=10090 GN=Lamb3 PE=1 SV=2
4	B7ZDA6	1.55e-126	429	1782	0.198	0.130	B7ZDA6_DANRE Laminin subunit beta-2 precursor OS=Danio rerio OX=7955 GN=si:dkey-32e6.2 PE=1 SV=1
5	Q61292	9.64e-126	427	1799	0.197	0.128	LAMB2_MOUSE Laminin subunit beta-2 OS=Mus musculus OX=10090 GN=Lamb2 PE=1 SV=2
6	P55268	1.50e-125	426	1798	0.197	0.128	LAMB2_HUMAN Laminin subunit beta-2 OS=Homo sapiens OX=9606 GN=LAMB2 PE=1 SV=2
7	D3ZQN7	6.65e-125	424	1786	0.192	0.126	D3ZQN7_RAT Laminin subunit beta 1 OS=Rattus norvegicus OX=10116 GN=Lamb1 PE=1 SV=3
8	P02469	6.85e-125	424	1786	0.191	0.125	LAMB1_MOUSE Laminin subunit beta-1 OS=Mus musculus OX=10090 GN=Lamb1 PE=1 SV=3
9	A0A8I5ZQ25	8.20e-125	425	1834	0.192	0.123	A0A8I5ZQ25_RAT Laminin subunit beta 1 OS=Rattus norvegicus OX=10116 GN=Lamb1 PE=1 SV=1
10	A0A8I6A3T2	9.31e-125	424	1792	0.192	0.126	A0A8I6A3T2_RAT Laminin subunit beta 1 OS=Rattus norvegicus OX=10116 GN=Lamb1 PE=1 SV=1
11	A0A8I5ZVQ5	1.93e-124	423	1741	0.192	0.129	A0A8I5ZVQ5_RAT Laminin subunit beta 1 OS=Rattus norvegicus OX=10116 GN=Lamb1 PE=1 SV=1
12	F1MNT4	3.95e-123	419	1786	0.189	0.124	F1MNT4_BOVIN Laminin subunit beta 1 OS=Bos taurus OX=9913 GN=LAMB1 PE=4 SV=3
13	P07942	4.44e-119	408	1786	0.189	0.124	LAMB1_HUMAN Laminin subunit beta-1 OS=Homo sapiens OX=9606 GN=LAMB1 PE=1 SV=2
14	Q8JHV7	2.49e-116	400	1785	0.193	0.127	Q8JHV7_DANRE Laminin beta 1 OS=Danio rerio OX=7955 GN=lamb1 PE=1 SV=1
15	O44565	3.15e-113	391	1790	0.186	0.122	O44565_CAEEL Laminin subunit beta-1 OS=Caenorhabditis elegans OX=6239 GN=lam-1 PE=1 SV=3
16	P11046	6.37e-103	360	1788	0.166	0.109	LAMB1_DROME Laminin subunit beta-1 OS=Drosophila melanogaster OX=7227 GN=LanB1 PE=1 SV=4
17	Q9HB63	1.76e-81	281	628	0.154	0.288	NET4_HUMAN Netrin-4 OS=Homo sapiens OX=9606 GN=NTN4 PE=1 SV=2
18	Q9JI33	5.18e-81	280	628	0.154	0.287	NET4_MOUSE Netrin-4 OS=Mus musculus OX=10090 GN=Ntn4 PE=1 SV=2
19	O15230	3.75e-76	280	3695	0.163	0.052	LAMA5_HUMAN Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8
20	Q01635	4.32e-75	253	303	0.112	0.432	LAMB1_CHICK Laminin subunit beta-1 (Fragment) OS=Gallus gallus OX=9031 GN=LAMB1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF15899 BNR_6	6.6e+02	11.9	BNR-Asp box repeat
2	PF00754 F5_F8_type_C	3.5e+02	12.7	F5/8 type C domain
3	PF00053 Laminin_EGF	1.7e-43	157.8	Laminin EGF domain
4	PF06009 Laminin_II	3.1	19.2	Laminin Domain II
5	PF00055 Laminin_N	3.1e-49	179.2	Laminin N-terminal (Domain VI)
6	PF03908 Sec20	14	17.0	Sec20

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000375778

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000200181	0.982	Integrin beta-4
2	9606.ENSP00000264144	0.978	Laminin subunit gamma-2
3	9606.ENSP00000324532	0.971	Laminin subunit alpha-3
4	9606.ENSP00000007722	0.961	Integrin alpha-3
5	9606.ENSP00000230538	0.955	Laminin subunit alpha-4
6	9606.ENSP00000305714	0.953	Bone morphogenetic protein 1
7	9606.ENSP00000379350	0.953	Integrin beta-1
8	9606.ENSP00000386896	0.953	Integrin alpha-6
9	9606.ENSP00000374309	0.947	Laminin subunit alpha-1
10	9606.ENSP00000258341	0.946	Laminin subunit gamma-1
11	9606.ENSP00000252999	0.945	Laminin subunit alpha-5
12	9606.ENSP00000400365	0.945	Laminin subunit alpha-2
13	9606.ENSP00000260228	0.943	Matrix metalloproteinase-20
14	9606.ENSP00000296585	0.943	Integrin alpha-2
15	9606.ENSP00000354360	0.941	Laminin subunit gamma-3
16	9606.ENSP00000308208	0.929	Matrix metalloproteinase-14
17	9606.ENSP00000282588	0.923	Integrin alpha-1
18	9606.ENSP00000219070	0.921	72 kDa type IV collagenase
19	9606.ENSP00000222399	0.920	Laminin subunit beta-1
20	9606.ENSP00000260302	0.920	Collagenase 3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.998	cellular process
GO:0048856	0.988	anatomical structure development
GO:0032501	0.984	multicellular organismal process
GO:0007275	0.972	multicellular organism development
GO:0009888	0.951	tissue development
GO:0048869	0.945	cellular developmental process
GO:0030154	0.943	cell differentiation
GO:0009653	0.940	anatomical structure morphogenesis
GO:0007369	0.779	gastrulation
GO:0001704	0.761	formation of primary germ layer
GO:0007492	0.754	endoderm development
GO:0065007	0.662	biological regulation
GO:0050789	0.654	regulation of biological process
GO:0050794	0.626	regulation of cellular process
GO:0035987	0.370	endodermal cell differentiation
GO:0048518	0.343	positive regulation of biological process
GO:0016043	0.338	cellular component organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005576	1.000	extracellular region
GO:0062023	1.000	collagen-containing extracellular matrix
GO:0032991	0.965	protein-containing complex
GO:0016020	0.839	membrane
GO:0005886	0.824	plasma membrane
GO:0043226	0.692	organelle
GO:0043227	0.663	membrane-bounded organelle
GO:0005604	0.591	basement membrane
GO:0043231	0.387	intracellular membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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