StarFunc result for job id Q13829

User Input

>input (316 residues)
MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGR
MEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMC
QSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLL
KNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVE
FPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEETFELRDRVRRIHVKRY
STYDDRQLGHQSTHRD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q13829	1.000	1.000	6.033E-65	316	1.000	1.000	Q13829.pdb.gz	BACD2_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP1 PE=1 SV=1
2	AFDB:Q922M3	0.684	0.686	8.121E-47	315	0.712	0.714	Q922M3.pdb.gz	BACD3_MOUSE BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Mus musculus OX=10090 GN=Kctd10 PE=1 SV=1
3	AFDB:Q7TQ24	0.705	0.680	4.860E-44	329	0.639	0.614	Q7TQ24.pdb.gz
4	AFDB:A9ULR9	0.503	0.488	1.887E-40	330	0.579	0.555	A9ULR9.pdb.gz	BACD1_DANRE BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 OS=Danio rerio OX=7955 GN=kctd13 PE=2 SV=1
5	AFDB:Q7JZ62	0.646	0.674	3.812E-38	301	0.554	0.581	Q7JZ62.pdb.gz	Q7JZ62_DROME RE57120p OS=Drosophila melanogaster OX=7227 GN=Dmel\CG10465 PE=1 SV=1
6	AFDB:F5GWA4	0.504	0.547	8.015E-34	287	0.636	0.700	F5GWA4.pdb.gz	F5GWA4_HUMAN Potassium channel tetramerization domain containing 10 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1
7	AFDB:Q18986	0.324	0.427	8.231E-19	238	0.234	0.311	Q18986.pdb.gz	Q18986_CAEEL BTB domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=CELE_D2045.8 PE=1 SV=2
8	AFDB:O16612	0.288	0.437	5.125E-14	207	0.158	0.242	O16612.pdb.gz	O16612_CAEEL BTB domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=B0281.5 PE=1 SV=1
9	AFDB:Q9TZA6	0.293	0.419	1.713E-13	220	0.190	0.273	Q9TZA6.pdb.gz	Q9TZA6_CAEEL BTB domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=C40A11.7 PE=1 SV=1
10	AFDB:Q4G0X4	0.312	0.377	5.171E-9	260	0.136	0.165	Q4G0X4.pdb.gz	KCD21_HUMAN BTB/POZ domain-containing protein KCTD21 OS=Homo sapiens OX=9606 GN=KCTD21 PE=1 SV=1
11	PDB:3lutB	0.233	0.192	1.660E-4	390	0.085	0.069	3lutB.pdb.gz	Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement.
12	PDB:7phhA	0.278	0.225	3.862E-4	396	0.101	0.081	7phhA.pdb.gz
13	PDB:6sgaFS	0.232	0.262	4.357E-4	277	0.101	0.116	6sgaFS.pdb.gz	Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
14	PDB:7w6sB	0.262	0.190	4.357E-4	448	0.108	0.076	7w6sB.pdb.gz
15	PDB:2fa4A	0.211	0.559	5.891E-4	104	0.041	0.125	2fa4A.pdb.gz
16	PDB:7sizB	0.238	0.226	7.060E-4	334	0.066	0.063	7sizB.pdb.gz	Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel.
17	PDB:5xocB	0.267	0.572	7.965E-4	133	0.057	0.135	5xocB.pdb.gz
18	PDB:4in0A	0.225	0.467	8.986E-4	141	0.060	0.135	4in0A.pdb.gz
19	PDB:3qouA	0.235	0.260	9.545E-4	282	0.054	0.060	3qouA.pdb.gz	Escherichia coli Thioredoxin-like Protein YbbN Contains an Atypical Tetratricopeptide Repeat Motif and Is a Negative Regulator of GroEL.
20	PDB:4cdoA	0.260	0.515	9.545E-4	150	0.044	0.093	4cdoA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q13829	0.0	658	316	1.000	1.000	BACD2_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP1 PE=1 SV=1
2	Q7TNY1	0.0	642	316	0.962	0.962	BACD2_RAT BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 OS=Rattus norvegicus OX=10116 GN=Tnfaip1 PE=1 SV=1
3	Q6P7X5	1.20e-162	457	313	0.699	0.706	Q6P7X5_DANRE BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Danio rerio OX=7955 GN=wu:fb30g12 PE=2 SV=1
4	Q922M3	5.39e-155	438	315	0.712	0.714	BACD3_MOUSE BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Mus musculus OX=10090 GN=Kctd10 PE=1 SV=1
5	Q9H3F6	5.92e-155	437	313	0.703	0.709	BACD3_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1
6	Q8WZ19	3.51e-138	395	329	0.636	0.611	BACD1_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 OS=Homo sapiens OX=9606 GN=KCTD13 PE=1 SV=1
7	Q8BGV7	1.08e-134	387	329	0.617	0.593	BACD1_MOUSE BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 OS=Mus musculus OX=10090 GN=Kctd13 PE=2 SV=1
8	F5GWA4	6.56e-133	381	287	0.636	0.700	F5GWA4_HUMAN Potassium channel tetramerization domain containing 10 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1
9	Q7JZ62	1.31e-121	353	301	0.544	0.571	Q7JZ62_DROME RE57120p OS=Drosophila melanogaster OX=7227 GN=Dmel\CG10465 PE=1 SV=1
10	A9ULR9	1.05e-116	341	330	0.494	0.473	BACD1_DANRE BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 OS=Danio rerio OX=7955 GN=kctd13 PE=2 SV=1
11	B3KVY5	2.60e-56	180	132	0.316	0.758	B3KVY5_HUMAN Potassium channel tetramerisation domain containing 10, isoform CRA_a OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1
12	F5H268	1.65e-55	178	121	0.269	0.702	F5H268_HUMAN Potassium channel tetramerization domain containing 10 (Fragment) OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1
13	F5GWK6	1.76e-55	177	120	0.269	0.708	F5GWK6_HUMAN Potassium channel tetramerization domain containing 10 (Fragment) OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1
14	Q18986	4.99e-30	115	238	0.203	0.269	Q18986_CAEEL BTB domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=CELE_D2045.8 PE=1 SV=2
15	Q9TZA6	9.22e-19	85.5	220	0.161	0.232	Q9TZA6_CAEEL BTB domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=C40A11.7 PE=1 SV=1
16	O16612	2.16e-18	84.0	207	0.161	0.246	O16612_CAEEL BTB domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=B0281.5 PE=1 SV=1
17	Q4G0X4	1.02e-16	80.5	260	0.146	0.177	KCD21_HUMAN BTB/POZ domain-containing protein KCTD21 OS=Homo sapiens OX=9606 GN=KCTD21 PE=1 SV=1
18	Q8BJK1	5.94e-15	75.9	289	0.127	0.138	KCTD7_MOUSE BTB/POZ domain-containing protein KCTD7 OS=Mus musculus OX=10090 GN=Kctd7 PE=1 SV=1
19	Q9SE95	2.81e-14	74.3	298	0.146	0.154	FIP2_ARATH FH protein interacting protein FIP2 OS=Arabidopsis thaliana OX=3702 GN=FIP2 PE=1 SV=1
20	Q96MP8	1.26e-13	72.0	289	0.123	0.135	KCTD7_HUMAN BTB/POZ domain-containing protein KCTD7 OS=Homo sapiens OX=9606 GN=KCTD7 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00651 BTB	0.029	26.0	BTB/POZ domain
2	PF02214 BTB_2	4.6e-17	73.5	BTB/POZ domain
3	PF16017 BTB_3	11	17.3	BTB/POZ domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61853.ENSNLEP00000002341

Rank	PPI partner	STRING score	Description
1	61853.ENSNLEP00000011891	0.984	Cullin 3
2	61853.ENSNLEP00000023468	0.970	Potassium channel tetramerization domain containing 13
3	61853.ENSNLEP00000018569	0.947	Kelch-like family member 20
4	61853.ENSNLEP00000009181	0.932	Kelch repeat and BTB (POZ) domain containing 8
5	61853.ENSNLEP00000002030	0.930	Potassium channel tetramerization domain containing 10
6	61853.ENSNLEP00000021992	0.904	Kelch-like family member 12
7	61853.ENSNLEP00000004896	0.879	UBX domain protein 1
8	61853.ENSNLEP00000018730	0.873	Ring-box 1, E3 ubiquitin protein ligase
9	61853.ENSNLEP00000017915	0.864	Potassium channel tetramerization domain containing 17
10	61853.ENSNLEP00000000091	0.861	Leucine-zipper-like transcription regulator 1
11	61853.ENSNLEP00000005839	0.861	Ectodermal-neural cortex 1 (with BTB domain)
12	61853.ENSNLEP00000012947	0.861	Gigaxonin
13	61853.ENSNLEP00000011479	0.761	Potassium channel tetramerization domain containing 5
14	61853.ENSNLEP00000007348	0.692	Kelch-like family member 24
15	61853.ENSNLEP00000012696	0.667	Glomulin, FKBP associated protein
16	61853.ENSNLEP00000014507	0.635	Rho family GTPase 2
17	61853.ENSNLEP00000020190	0.594	Belongs to the cullin family.
18	61853.ENSNLEP00000023253	0.594	Cullin 1
19	61853.ENSNLEP00000001789	0.587	UBX domain protein 7
20	61853.ENSNLEP00000004416	0.587	Polymerase (DNA directed), delta 2, accessory subunit

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0042802	0.982	identical protein binding
GO:0003824	0.570	catalytic activity
GO:0019899	0.498	enzyme binding
GO:0019787	0.336	ubiquitin-like protein transferase activity
GO:0004842	0.315	ubiquitin-protein transferase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.989	regulation of cellular process
GO:0071704	0.984	organic substance metabolic process
GO:0044238	0.982	primary metabolic process
GO:0006807	0.972	nitrogen compound metabolic process
GO:0043170	0.959	macromolecule metabolic process
GO:0019538	0.941	protein metabolic process
GO:0009987	0.933	cellular process
GO:0044237	0.874	cellular metabolic process
GO:0048523	0.863	negative regulation of cellular process
GO:0019222	0.858	regulation of metabolic process
GO:0080090	0.838	regulation of primary metabolic process
GO:0060255	0.834	regulation of macromolecule metabolic process
GO:0048518	0.812	positive regulation of biological process
GO:0051171	0.812	regulation of nitrogen compound metabolic process
GO:0006508	0.802	proteolysis
GO:0009056	0.762	catabolic process
GO:0048583	0.762	regulation of response to stimulus
GO:0031323	0.760	regulation of cellular metabolic process
GO:0006511	0.753	ubiquitin-dependent protein catabolic process
GO:0048522	0.720	positive regulation of cellular process
GO:0071840	0.640	cellular component organization or biogenesis
GO:0070647	0.633	protein modification by small protein conjugation or removal
GO:0016043	0.610	cellular component organization
GO:0016567	0.571	protein ubiquitination
GO:0019219	0.562	regulation of nucleobase-containing compound metabolic process
GO:0050896	0.524	response to stimulus
GO:0048585	0.498	negative regulation of response to stimulus
GO:0010498	0.496	proteasomal protein catabolic process
GO:0009966	0.481	regulation of signal transduction
GO:0006996	0.475	organelle organization
GO:0051052	0.425	regulation of DNA metabolic process
GO:0010604	0.410	positive regulation of macromolecule metabolic process
GO:0009968	0.398	negative regulation of signal transduction
GO:0043161	0.382	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051054	0.375	positive regulation of DNA metabolic process
GO:0045740	0.346	positive regulation of DNA replication

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0032991	0.998	protein-containing complex
GO:0012505	0.986	endomembrane system
GO:1902494	0.963	catalytic complex
GO:0005634	0.951	nucleus
GO:0070013	0.948	intracellular organelle lumen
GO:0005654	0.940	nucleoplasm
GO:1990234	0.937	transferase complex
GO:0140535	0.916	intracellular protein-containing complex
GO:0031461	0.909	cullin-RING ubiquitin ligase complex
GO:0031463	0.887	Cul3-RING ubiquitin ligase complex
GO:0031982	0.798	vesicle
GO:0031410	0.567	cytoplasmic vesicle
GO:0005768	0.446	endosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	0.336	Transferases.

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