StarFunc result for job id Q14106

User Input

>input (344 residues)
MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHI
GEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVLYLDDSEGC
GAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQSPSPTFIPRSAQPITFTTAS
FAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPRMARSPTNSLLKHKSLSLSMHSL
NFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPFGGSGAGTCNSSSFD
MAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPSQQFQPVVLAN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q14106	1.000	1.000	1.120E-50	344	1.000	1.000	Q14106.pdb.gz	TOB2_HUMAN Protein Tob2 OS=Homo sapiens OX=9606 GN=TOB2 PE=1 SV=2
2	AFDB:Q9JM55	0.630	0.629	3.960E-45	345	0.898	0.896	Q9JM55.pdb.gz	TOB2_MOUSE Protein Tob2 OS=Mus musculus OX=10090 GN=Tob2 PE=2 SV=1
3	AFDB:Q61471	0.427	0.407	2.935E-32	362	0.584	0.555	Q61471.pdb.gz	TOB1_MOUSE Protein Tob1 OS=Mus musculus OX=10090 GN=Tob1 PE=1 SV=2
4	AFDB:Q7SZR1	0.414	0.439	1.149E-30	322	0.584	0.624	Q7SZR1.pdb.gz	Q7SZR1_DANRE Protein Tob1 OS=Danio rerio OX=7955 GN=tob1 PE=2 SV=1
5	AFDB:Q9VXJ9	0.373	0.232	1.069E-19	564	0.427	0.261	Q9VXJ9.pdb.gz	Q9VXJ9_DROME Transducer of ERBB2, isoform A OS=Drosophila melanogaster OX=7227 GN=Tob PE=3 SV=1
6	PDB:5ci8A	0.333	0.976	1.907E-19	117	0.276	0.812	5ci8A.pdb.gz	Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach
7	AFDB:O70552	0.328	0.447	2.838E-12	250	0.169	0.232	O70552.pdb.gz	BTG4_MOUSE Protein BTG4 OS=Mus musculus OX=10090 GN=Btg4 PE=1 SV=2
8	AFDB:Q54NU5	0.307	0.251	1.413E-9	423	0.192	0.156	Q54NU5.pdb.gz	BTG_DICDI BTG family protein OS=Dictyostelium discoideum OX=44689 GN=btg PE=3 SV=1
9	PDB:6fhsC	0.059	0.046	8.511E-1	459	0.038	0.028	6fhsC.pdb.gz	Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.
10	AFDB:Q84JQ8	0.073	0.071	1.305	352	0.122	0.119	Q84JQ8.pdb.gz	DOF18_ARATH Dof zinc finger protein DOF1.8 OS=Arabidopsis thaliana OX=3702 GN=DOF1.8 PE=2 SV=1
11	AFDB:Q8N3X1	0.118	0.053	1.558	1017	0.157	0.053	Q8N3X1.pdb.gz	FNBP4_HUMAN Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3
12	PDB:5lcwR	0.078	0.071	1.631	383	0.015	0.013	5lcwR.pdb.gz	Molecular basis of APC/C regulation by the spindle assembly checkpoint.
13	PDB:2w4mA	0.155	0.207	1.731	250	0.038	0.052	2w4mA.pdb.gz
14	PDB:6pedB	0.061	0.141	2.067	126	0.041	0.111	6pedB.pdb.gz	Crystal structure of HEMK2-TRMT112 complex
15	AFDB:Q7JQU5	0.095	0.081	2.094	417	0.108	0.089	Q7JQU5.pdb.gz	Q7JQU5_DROME AT09333p OS=Drosophila melanogaster OX=7227 GN=uno PE=2 SV=1
16	PDB:1jw9B	0.065	0.088	2.193	240	0.015	0.021	1jw9B.pdb.gz	Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.
17	PDB:6q3xA	0.072	0.065	2.326	393	0.015	0.013	6q3xA.pdb.gz	Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
18	PDB:1zfnA	0.058	0.075	2.618	244	0.032	0.045	1zfnA.pdb.gz	Structural Analysis of Escherichia Coli ThiF.
19	PDB:4zilA	0.131	0.204	2.618	210	0.023	0.038	4zilA.pdb.gz
20	PDB:3v0aB	0.070	0.024	2.778	1150	0.015	0.004	3v0aB.pdb.gz	Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q14106	0.0	699	344	1.000	1.000	TOB2_HUMAN Protein Tob2 OS=Homo sapiens OX=9606 GN=TOB2 PE=1 SV=2
2	Q9JM55	0.0	540	345	0.875	0.872	TOB2_MOUSE Protein Tob2 OS=Mus musculus OX=10090 GN=Tob2 PE=2 SV=1
3	P50616	3.24e-108	321	345	0.587	0.586	TOB1_HUMAN Protein Tob1 OS=Homo sapiens OX=9606 GN=TOB1 PE=1 SV=1
4	Q7SZR1	2.67e-106	316	322	0.581	0.621	Q7SZR1_DANRE Protein Tob1 OS=Danio rerio OX=7955 GN=tob1 PE=2 SV=1
5	Q61471	1.12e-105	315	362	0.584	0.555	TOB1_MOUSE Protein Tob1 OS=Mus musculus OX=10090 GN=Tob1 PE=1 SV=2
6	Q9VXJ9	1.01e-57	197	564	0.244	0.149	Q9VXJ9_DROME Transducer of ERBB2, isoform A OS=Drosophila melanogaster OX=7227 GN=Tob PE=3 SV=1
7	P62324	2.71e-30	115	171	0.145	0.292	BTG1_HUMAN Protein BTG1 OS=Homo sapiens OX=9606 GN=BTG1 PE=1 SV=1
8	P62325	2.71e-30	115	171	0.145	0.292	BTG1_MOUSE Protein BTG1 OS=Mus musculus OX=10090 GN=Btg1 PE=1 SV=1
9	Q6IBC8	2.71e-30	115	171	0.145	0.292	Q6IBC8_HUMAN B-cell translocation gene 1, anti-proliferative OS=Homo sapiens OX=9606 GN=BTG1 PE=1 SV=1
10	Q63073	2.74e-30	115	171	0.145	0.292	BTG1_RAT Protein BTG1 OS=Rattus norvegicus OX=10116 GN=Btg1 PE=2 SV=1
11	P27049	1.07e-26	105	158	0.134	0.291	BTG2_RAT Protein BTG2 OS=Rattus norvegicus OX=10116 GN=Btg2 PE=1 SV=1
12	P78543	2.13e-26	104	158	0.134	0.291	BTG2_HUMAN Protein BTG2 OS=Homo sapiens OX=9606 GN=BTG2 PE=1 SV=1
13	Q04211	3.10e-26	104	158	0.134	0.291	BTG2_MOUSE Protein BTG2 OS=Mus musculus OX=10090 GN=Btg2 PE=1 SV=1
14	P50615	6.32e-19	87.0	252	0.151	0.206	BTG3_MOUSE Protein BTG3 OS=Mus musculus OX=10090 GN=Btg3 PE=2 SV=1
15	O88677	2.64e-18	85.1	252	0.148	0.202	BTG3_RAT Protein BTG3 OS=Rattus norvegicus OX=10116 GN=Btg3 PE=2 SV=1
16	Q14201	4.47e-17	81.6	252	0.119	0.163	BTG3_HUMAN Protein BTG3 OS=Homo sapiens OX=9606 GN=BTG3 PE=1 SV=3
17	O70552	1.85e-16	80.1	250	0.119	0.164	BTG4_MOUSE Protein BTG4 OS=Mus musculus OX=10090 GN=Btg4 PE=1 SV=2
18	Q9NY30	1.97e-14	73.6	223	0.105	0.161	BTG4_HUMAN Protein BTG4 OS=Homo sapiens OX=9606 GN=BTG4 PE=1 SV=1
19	Q54NU5	5.15e-12	68.6	423	0.099	0.080	BTG_DICDI BTG family protein OS=Dictyostelium discoideum OX=44689 GN=btg PE=3 SV=1
20	G5EDX7	8.59e-06	48.9	263	0.084	0.110	G5EDX7_CAEEL Anti-proliferative protein domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=fog-3 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07742 BTG	7.7e-33	124.1	BTG family
2	PF07145 PAM2	3e-09	47.0	Ataxin-2 C-terminal region

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000331305

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000355279	0.971	CCR4-NOT transcription complex subunit 7
2	9606.ENSP00000482128	0.837	Cytoplasmic polyadenylation element-binding protein 3
3	9606.ENSP00000313007	0.818	Polyadenylate-binding protein 1
4	9606.ENSP00000400921	0.768	SLAIN motif-containing protein 1
5	9606.ENSP00000288840	0.753	Mothers against decapentaplegic homolog 6
6	9606.ENSP00000261211	0.716	Cyclin-dependent kinase 17
7	9606.ENSP00000430493	0.692	CCR4-NOT transcription complex subunit 8
8	9606.ENSP00000341170	0.672	Pleiotrophin
9	9606.ENSP00000354733	0.667	Protein strawberry notch homolog 2
10	9606.ENSP00000361107	0.667	Bone morphogenetic protein receptor type-1A
11	9606.ENSP00000341021	0.666	Nanos homolog 2
12	9606.ENSP00000338157	0.654	Zinc finger and BTB domain-containing protein 16
13	9606.ENSP00000340874	0.642	Myocyte-specific enhancer factor 2C
14	9606.ENSP00000360493	0.634	Runt-related transcription factor 2
15	9606.ENSP00000361636	0.631	Troponin C, skeletal muscle
16	9606.ENSP00000364476	0.608	RIB43A domain with coiled-coils 1
17	9606.ENSP00000448051	0.606	DAZ associated protein 2
18	9606.ENSP00000284523	0.599	Protein Wnt-3a
19	9606.ENSP00000443827	0.575	Transcription factor Sp7
20	9606.ENSP00000358045	0.550	Extracellular matrix protein 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.996	regulation of cellular process
GO:0032501	0.980	multicellular organismal process
GO:0048523	0.976	negative regulation of cellular process
GO:0042127	0.961	regulation of cell population proliferation
GO:0009987	0.927	cellular process
GO:0048518	0.843	positive regulation of biological process
GO:0019222	0.798	regulation of metabolic process
GO:0060255	0.763	regulation of macromolecule metabolic process
GO:0010468	0.727	regulation of gene expression
GO:0048522	0.674	positive regulation of cellular process
GO:0032502	0.607	developmental process
GO:0048856	0.546	anatomical structure development
GO:0019953	0.533	sexual reproduction
GO:0031323	0.519	regulation of cellular metabolic process
GO:0051171	0.518	regulation of nitrogen compound metabolic process
GO:0080090	0.517	regulation of primary metabolic process
GO:0050793	0.450	regulation of developmental process
GO:0008285	0.441	negative regulation of cell population proliferation
GO:0010556	0.438	regulation of macromolecule biosynthetic process
GO:0031326	0.435	regulation of cellular biosynthetic process
GO:0032504	0.433	multicellular organism reproduction
GO:0045595	0.433	regulation of cell differentiation
GO:0051239	0.432	regulation of multicellular organismal process
GO:0022414	0.427	reproductive process
GO:0048609	0.421	multicellular organismal reproductive process
GO:0050896	0.404	response to stimulus
GO:0007276	0.395	gamete generation
GO:0010605	0.392	negative regulation of macromolecule metabolic process
GO:0019219	0.374	regulation of nucleobase-containing compound metabolic process
GO:0051172	0.361	negative regulation of nitrogen compound metabolic process
GO:0051252	0.358	regulation of RNA metabolic process
GO:0010604	0.335	positive regulation of macromolecule metabolic process
GO:0031324	0.335	negative regulation of cellular metabolic process
GO:0051173	0.334	positive regulation of nitrogen compound metabolic process
GO:0031325	0.328	positive regulation of cellular metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0005634	1.000	nucleus
GO:0005829	0.993	cytosol
GO:0032991	0.930	protein-containing complex
GO:0070013	0.326	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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