StarFunc result for job id Q14512

User Input

>input (234 residues)
MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKF
VTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNL
RSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETT
PSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q14512	1.000	1.000	1.259E-41	234	1.000	1.000	Q14512.pdb.gz	FGFP1_HUMAN Fibroblast growth factor-binding protein 1 OS=Homo sapiens OX=9606 GN=FGFBP1 PE=1 SV=1
2	AFDB:O70514	0.477	0.447	5.067E-25	251	0.620	0.578	O70514.pdb.gz	FGFP1_MOUSE Fibroblast growth factor-binding protein 1 OS=Mus musculus OX=10090 GN=Fgfbp1 PE=1 SV=1
3	AFDB:Q9QY10	0.484	0.476	1.485E-24	238	0.568	0.559	Q9QY10.pdb.gz	FGFP1_RAT Fibroblast growth factor-binding protein 1 OS=Rattus norvegicus OX=10116 GN=Fgfbp1 PE=1 SV=1
4	AFDB:A0A0B5JK58	0.397	0.470	6.992E-11	196	0.252	0.301	A0A0B5JK58.pdb.gz
5	AFDB:A3KP08	0.400	0.341	6.769E-10	279	0.205	0.172	A3KP08.pdb.gz	A3KP08_DANRE Fibroblast growth factor binding protein 2b OS=Danio rerio OX=7955 GN=fgfbp2b PE=2 SV=1
6	AFDB:Q8TAT2	0.375	0.342	7.384E-9	258	0.244	0.221	Q8TAT2.pdb.gz	FGFP3_HUMAN Fibroblast growth factor-binding protein 3 OS=Homo sapiens OX=9606 GN=FGFBP3 PE=1 SV=1
7	AFDB:Q1HCM0	0.366	0.351	1.809E-8	245	0.218	0.208	Q1HCM0.pdb.gz	FGFP3_MOUSE Fibroblast growth factor-binding protein 3 OS=Mus musculus OX=10090 GN=Fgfbp3 PE=1 SV=2
8	AFDB:Q9BYJ0	0.404	0.423	1.809E-8	223	0.201	0.211	Q9BYJ0.pdb.gz	FGFP2_HUMAN Fibroblast growth factor-binding protein 2 OS=Homo sapiens OX=9606 GN=FGFBP2 PE=1 SV=1
9	AFDB:O73791	0.138	0.041	6.630E-2	1116	0.085	0.018	O73791.pdb.gz	TIE2_DANRE Tyrosine-protein kinase receptor Tie-2 OS=Danio rerio OX=7955 GN=tie2 PE=2 SV=1
10	AFDB:Q9VV74	0.123	0.126	1.007E-1	226	0.145	0.150	Q9VV74.pdb.gz	SMN_DROME Survival motor neuron protein OS=Drosophila melanogaster OX=7227 GN=Smn PE=1 SV=1
11	PDB:4a60A	0.138	0.211	1.521E-1	141	0.030	0.050	4a60A.pdb.gz
12	PDB:4azqA	0.139	0.218	3.726E-1	136	0.047	0.081	4azqA.pdb.gz	Crystallographic Study of Fabp5 as an Intracellular Endocannabinoid Transporter.
13	PDB:7e25A	0.144	0.221	4.458E-1	139	0.034	0.058	7e25A.pdb.gz	Crystal structure of human brain-type fatty acid-binding protein FABP7 complexed with palmitic acid.
14	PDB:3nr3A	0.136	0.215	4.732E-1	135	0.034	0.059	3nr3A.pdb.gz
15	PDB:5hz9A	0.133	0.210	4.732E-1	135	0.026	0.044	5hz9A.pdb.gz	Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
16	PDB:7vbcI	0.115	0.215	5.023E-1	107	0.030	0.065	7vbcI.pdb.gz	Structure of the human RNA polymerase I elongation complex.
17	PDB:1e03L	0.098	0.060	6.009E-1	423	0.064	0.035	1e03L.pdb.gz	Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
18	PDB:5ur9F	0.145	0.232	6.009E-1	138	0.038	0.065	5ur9F.pdb.gz	The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.
19	PDB:7d59I	0.099	0.179	6.009E-1	108	0.064	0.139	7d59I.pdb.gz	Structural insights into transcriptional regulation of human RNA polymerase III.
20	PDB:7r7jB	0.152	0.074	6.009E-1	574	0.051	0.021	7r7jB.pdb.gz	X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q14512	6.33e-175	481	234	1.000	1.000	FGFP1_HUMAN Fibroblast growth factor-binding protein 1 OS=Homo sapiens OX=9606 GN=FGFBP1 PE=1 SV=1
2	O70514	2.04e-91	271	251	0.594	0.554	FGFP1_MOUSE Fibroblast growth factor-binding protein 1 OS=Mus musculus OX=10090 GN=Fgfbp1 PE=1 SV=1
3	Q9QY10	1.17e-79	240	238	0.585	0.576	FGFP1_RAT Fibroblast growth factor-binding protein 1 OS=Rattus norvegicus OX=10116 GN=Fgfbp1 PE=1 SV=1
4	Q9BYJ0	1.68e-10	61.2	223	0.209	0.220	FGFP2_HUMAN Fibroblast growth factor-binding protein 2 OS=Homo sapiens OX=9606 GN=FGFBP2 PE=1 SV=1
5	Q8TAT2	3.43e-06	48.9	258	0.231	0.209	FGFP3_HUMAN Fibroblast growth factor-binding protein 3 OS=Homo sapiens OX=9606 GN=FGFBP3 PE=1 SV=1
6	A3KP08	4.70e-05	45.8	279	0.209	0.176	A3KP08_DANRE Fibroblast growth factor binding protein 2b OS=Danio rerio OX=7955 GN=fgfbp2b PE=2 SV=1
7	Q1HCM0	4.72e-05	45.4	245	0.209	0.200	FGFP3_MOUSE Fibroblast growth factor-binding protein 3 OS=Mus musculus OX=10090 GN=Fgfbp3 PE=1 SV=2
8	F1QLT3	2.72e-04	43.5	279	0.209	0.176	F1QLT3_DANRE Fibroblast growth factor binding protein 2b isoform X1 OS=Danio rerio OX=7955 GN=zgc:162825 PE=3 SV=1
9	E2JF22	0.48	34.3	2547	0.094	0.009	PIEZ1_MOUSE Piezo-type mechanosensitive ion channel component 1 OS=Mus musculus OX=10090 GN=Piezo1 PE=1 SV=1
10	Q0VD83	3.3	31.6	1097	0.077	0.016	APOBR_HUMAN Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3
11	Q9NS13	3.4	31.2	1076	0.077	0.017	Q9NS13_HUMAN Placenta apolipoprotein B48 receptor type 2 OS=Homo sapiens OX=9606 GN=APOB48R PE=2 SV=1
12	A8MQH9	5.1	30.8	1014	0.068	0.016	A8MQH9_ARATH LONGIFOLIA protein OS=Arabidopsis thaliana OX=3702 GN=TRM3 PE=1 SV=1
13	Q9Y7T8	6.0	30.0	204	0.120	0.137	PSB3_SCHPO Probable proteasome subunit beta type-3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pup3 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF06473 FGF-BP1	1.7e-67	239.1	FGF binding protein 1 (FGF-BP1)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000371770

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000480791	0.998	Fibroblast growth factor 1
2	9606.ENSP00000264498	0.978	Fibroblast growth factor 2
3	9606.ENSP00000267843	0.944	Fibroblast growth factor 7
4	9606.ENSP00000410294	0.922	Fibroblast growth factor receptor 2
5	9606.ENSP00000334122	0.920	Fibroblast growth factor 3
6	9606.ENSP00000363827	0.851	Basement membrane-specific heparan sulfate proteoglycan core protein
7	9606.ENSP00000215530	0.789	Fibroblast growth factor 22
8	9606.ENSP00000264664	0.748	Fibroblast growth factor 10
9	9606.ENSP00000426809	0.684	Prominin-1
10	9606.ENSP00000240328	0.649	T-box transcription factor TBX2
11	9606.ENSP00000405574	0.646	F-box-like/WD repeat-containing protein TBL1XR1
12	9606.ENSP00000234590	0.629	Alpha-enolase
13	9606.ENSP00000385347	0.548	Transmembrane anterior posterior transformation protein 1 homolog
14	9606.ENSP00000366915	0.537	Krueppel-like factor 5
15	9606.ENSP00000342307	0.507	Forkhead box protein M1
16	9606.ENSP00000369317	0.506	Keratin, type II cytoskeletal 6A
17	9606.ENSP00000340989	0.501	14-3-3 protein sigma

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0008201	1.000	heparin binding
GO:0019838	0.351	growth factor binding
GO:0017134	0.339	fibroblast growth factor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

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[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0048522	0.987	positive regulation of cellular process
GO:0008284	0.984	positive regulation of cell population proliferation
GO:0023052	0.976	signaling
GO:0007154	0.976	cell communication
GO:0051239	0.942	regulation of multicellular organismal process
GO:2000145	0.902	regulation of cell motility
GO:0030334	0.893	regulation of cell migration
GO:0048523	0.861	negative regulation of cellular process
GO:0010632	0.840	regulation of epithelial cell migration
GO:0007267	0.795	cell-cell signaling
GO:0050678	0.787	regulation of epithelial cell proliferation
GO:0010594	0.754	regulation of endothelial cell migration
GO:0050896	0.733	response to stimulus
GO:0001936	0.730	regulation of endothelial cell proliferation
GO:0043535	0.697	regulation of blood vessel endothelial cell migration
GO:2000147	0.611	positive regulation of cell motility
GO:0030335	0.578	positive regulation of cell migration
GO:0090049	0.497	regulation of cell migration involved in sprouting angiogenesis
GO:0010634	0.457	positive regulation of epithelial cell migration
GO:0051716	0.423	cellular response to stimulus
GO:0050679	0.384	positive regulation of epithelial cell proliferation
GO:0007165	0.350	signal transduction
GO:0010595	0.350	positive regulation of endothelial cell migration
GO:0032502	0.315	developmental process
GO:0001938	0.313	positive regulation of endothelial cell proliferation
GO:0043536	0.302	positive regulation of blood vessel endothelial cell migration

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005576	0.999	extracellular region
GO:0005615	0.988	extracellular space
GO:0005622	0.580	intracellular anatomical structure
GO:0043227	0.368	membrane-bounded organelle
GO:0043231	0.345	intracellular membrane-bounded organelle
GO:0005737	0.338	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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