StarFunc result for job id Q14563

User Input

>input (771 residues)
MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTF
LLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV
LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASL
LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED
DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG
IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD
GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP
IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM
TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS
ACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPK
SQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTL
LKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDE
FCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R8Q5P4	0.817	0.833	0.000	756	0.553	0.563	A0A2R8Q5P4.pdb.gz
2	AFDB:M9MM94	0.830	0.826	0.000	775	0.562	0.559	M9MM94.pdb.gz
3	AFDB:O08665	0.936	0.935	0.000	772	0.955	0.953	O08665.pdb.gz	SEM3A_MOUSE Semaphorin-3A OS=Mus musculus OX=10090 GN=Sema3a PE=1 SV=2
4	AFDB:Q9W686	0.883	0.875	0.000	778	0.764	0.757	Q9W686.pdb.gz	SE3AB_DANRE Semaphorin-3ab OS=Danio rerio OX=7955 GN=sema3ab PE=2 SV=1
5	AFDB:Q9W7J1	0.869	0.780	0.000	860	0.685	0.614	Q9W7J1.pdb.gz	SE3AA_DANRE Semaphorin-3aa OS=Danio rerio OX=7955 GN=sema3aa PE=2 SV=1
6	AFDB:R4GJE6	0.894	0.847	0.000	815	0.856	0.810	R4GJE6.pdb.gz
7	AFDB:Q8BH34	0.844	0.837	3.195E-102	777	0.540	0.535	Q8BH34.pdb.gz	SEM3D_MOUSE Semaphorin-3D OS=Mus musculus OX=10090 GN=Sema3d PE=1 SV=1
8	AFDB:Q13214	0.844	0.868	4.368E-102	749	0.510	0.525	Q13214.pdb.gz	SEM3B_HUMAN Semaphorin-3B OS=Homo sapiens OX=9606 GN=SEMA3B PE=1 SV=1
9	AFDB:Q90663	0.833	0.843	1.693E-101	761	0.519	0.526	Q90663.pdb.gz	SEM3D_CHICK Semaphorin-3D OS=Gallus gallus OX=9031 GN=SEMA3D PE=2 SV=1
10	AFDB:A0A2R8QBF0	0.875	0.886	5.055E-101	761	0.482	0.489	A0A2R8QBF0.pdb.gz
11	PDB:6qp7A	0.684	0.842	5.831E-53	620	0.272	0.339	6qp7A.pdb.gz	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.
12	PDB:3nvqA	0.660	0.851	2.041E-42	588	0.220	0.289	3nvqA.pdb.gz
13	PDB:3nvnA	0.431	0.826	4.210E-21	383	0.088	0.178	3nvnA.pdb.gz	Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1.
14	PDB:6vxkB	0.374	0.384	4.088E-13	747	0.121	0.124	6vxkB.pdb.gz
15	PDB:4i79B	0.286	0.598	3.256E-6	316	0.056	0.136	4i79B.pdb.gz	Crystal structure of human nuclear pore complex component NUP43.
16	PDB:2vduD	0.270	0.500	3.613E-6	376	0.064	0.130	2vduD.pdb.gz
17	PDB:5y31B	0.276	0.386	6.409E-6	511	0.064	0.096	5y31B.pdb.gz	Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
18	PDB:6jp6A	0.140	0.114	6.752E-6	998	0.077	0.059	6jp6A.pdb.gz
19	PDB:7fikc	0.274	0.598	7.113E-6	309	0.052	0.129	7fikc.pdb.gz
20	PDB:7mq8LR	0.118	0.117	7.493E-6	773	0.064	0.063	7mq8LR.pdb.gz	Nucleolar maturation of the human small subunit processome.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A1D5PZ68	739	751	0.450	0.462	A0A1D5PZ68_CHICK Semaphorin-3C OS=Gallus gallus OX=9031 GN=SEMA3C PE=3 SV=1
2	A0A2R8Q5T8	741	791	0.481	0.469	A0A2R8Q5T8_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb OS=Danio rerio OX=7955 GN=sema3fb PE=3 SV=1
3	E7F6C0	748	787	0.481	0.471	E7F6C0_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb OS=Danio rerio OX=7955 GN=sema3fb PE=3 SV=1
4	F1NVZ5	1425	808	0.887	0.847	F1NVZ5_CHICK Semaphorin 3A OS=Gallus gallus OX=9031 GN=SEMA3A PE=3 SV=2
5	M9MM97	753	771	0.472	0.472	M9MM97_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl OS=Danio rerio OX=7955 GN=fc22d04 PE=3 SV=1
6	O08665	1538	772	0.955	0.953	SEM3A_MOUSE Semaphorin-3A OS=Mus musculus OX=10090 GN=Sema3a PE=1 SV=2
7	O15041	766	775	0.476	0.474	SEM3E_HUMAN Semaphorin-3E OS=Homo sapiens OX=9606 GN=SEMA3E PE=1 SV=1
8	O42236	736	751	0.449	0.461	SEM3C_CHICK Semaphorin-3C OS=Gallus gallus OX=9031 GN=SEMA3C PE=2 SV=1
9	O42237	765	785	0.466	0.457	SEM3E_CHICK Semaphorin-3E OS=Gallus gallus OX=9031 GN=SEMA3E PE=2 SV=1
10	O88632	726	785	0.475	0.466	SEM3F_MOUSE Semaphorin-3F OS=Mus musculus OX=10090 GN=Sema3f PE=2 SV=2
11	P70275	773	775	0.470	0.467	SEM3E_MOUSE Semaphorin-3E OS=Mus musculus OX=10090 GN=Sema3e PE=1 SV=3
12	Q13214	804	749	0.520	0.535	SEM3B_HUMAN Semaphorin-3B OS=Homo sapiens OX=9606 GN=SEMA3B PE=1 SV=1
13	Q13275	729	785	0.477	0.469	SEM3F_HUMAN Semaphorin-3F OS=Homo sapiens OX=9606 GN=SEMA3F PE=2 SV=2
14	Q14563	1625	771	1.000	1.000	SEM3A_HUMAN Semaphorin-3A OS=Homo sapiens OX=9606 GN=SEMA3A PE=1 SV=1
15	Q1LYS1	716	768	0.464	0.466	Q1LYS1_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E OS=Danio rerio OX=7955 GN=fj37c11 PE=3 SV=1
16	Q4LFA9	698	780	0.467	0.462	SEM3G_MOUSE Semaphorin-3G OS=Mus musculus OX=10090 GN=Sema3g PE=2 SV=1
17	Q62181	724	751	0.445	0.457	SEM3C_MOUSE Semaphorin-3C OS=Mus musculus OX=10090 GN=Sema3c PE=1 SV=2
18	Q63548	1548	772	0.960	0.959	SEM3A_RAT Semaphorin-3A OS=Rattus norvegicus OX=10116 GN=Sema3a PE=2 SV=1
19	Q8BH34	874	777	0.543	0.539	SEM3D_MOUSE Semaphorin-3D OS=Mus musculus OX=10090 GN=Sema3d PE=1 SV=1
20	Q90607	1425	772	0.886	0.885	SEM3A_CHICK Semaphorin-3A OS=Gallus gallus OX=9031 GN=SEMA3A PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07679 I-set	2.6e+02	13.1	Immunoglobulin I-set domain
2	PF00047 ig	0.23	23.0	Immunoglobulin domain
3	PF13895 Ig_2	42	15.9	Immunoglobulin domain
4	PF13927 Ig_3	19	17.2	Immunoglobulin domain
5	PF18452 Ig_6	0.0043	28.3	Immunoglobulin domain
6	PF01437 PSI	37	16.3	Plexin repeat
7	PF01403 Sema	4.2e-63	224.0	Sema domain
8	PF07686 V-set	0.29	22.7	Immunoglobulin V-set domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000265362

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000265371	0.999	Neuropilin-1
2	9606.ENSP00000352882	0.996	Plexin-A4
3	9606.ENSP00000377061	0.996	Plexin-A1
4	9606.ENSP00000356000	0.995	Plexin-A2
5	9606.ENSP00000358696	0.980	Plexin-A3
6	9606.ENSP00000258526	0.976	Plexin-C1
7	9606.ENSP00000246792	0.950	Ras-related protein R-Ras
8	9606.ENSP00000353582	0.945	Neuropilin-2
9	9606.ENSP00000336740	0.929	LIM domain kinase 1
10	9606.ENSP00000324806	0.927	Glycogen synthase kinase-3 beta
11	9606.ENSP00000317128	0.920	Plexin-D1
12	9606.ENSP00000309539	0.915	Dihydropyrimidinase-related protein 2
13	9606.ENSP00000442736	0.915	Plexin-B3
14	9606.ENSP00000351338	0.903	Plexin-B1
15	9606.ENSP00000416293	0.885	Solute carrier family 2, facilitated glucose transporter member 1
16	9606.ENSP00000409171	0.876	Plexin-B2
17	9606.ENSP00000264042	0.869	FERM, ARHGEF and pleckstrin domain-containing protein 2
18	9606.ENSP00000321606	0.842	Dihydropyrimidinase-related protein 1
19	9606.ENSP00000343690	0.815	Dihydropyrimidinase-related protein 3
20	9606.ENSP00000173229	0.811	Netrin-1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0038191	1.000	neuropilin binding
GO:0098772	0.402	molecular function regulator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050896	0.991	response to stimulus
GO:0040011	0.987	locomotion
GO:0061564	0.987	axon development
GO:0050794	0.985	regulation of cellular process
GO:0097485	0.978	neuron projection guidance
GO:0007409	0.976	axonogenesis
GO:0048519	0.972	negative regulation of biological process
GO:0007411	0.966	axon guidance
GO:0048523	0.956	negative regulation of cellular process
GO:0051128	0.863	regulation of cellular component organization
GO:0031344	0.806	regulation of cell projection organization
GO:0051716	0.747	cellular response to stimulus
GO:0007154	0.743	cell communication
GO:0023052	0.737	signaling
GO:0008361	0.694	regulation of cell size
GO:0007165	0.692	signal transduction
GO:0051239	0.690	regulation of multicellular organismal process
GO:0061387	0.669	regulation of extent of cell growth
GO:0050793	0.661	regulation of developmental process
GO:0048518	0.638	positive regulation of biological process
GO:0051129	0.618	negative regulation of cellular component organization
GO:0048522	0.608	positive regulation of cellular process
GO:0045595	0.593	regulation of cell differentiation
GO:0120035	0.581	regulation of plasma membrane bounded cell projection organization
GO:2000026	0.562	regulation of multicellular organismal development
GO:0048638	0.560	regulation of developmental growth
GO:0030516	0.516	regulation of axon extension
GO:0060284	0.512	regulation of cell development
GO:0022603	0.494	regulation of anatomical structure morphogenesis
GO:0048583	0.475	regulation of response to stimulus
GO:0008045	0.471	motor neuron axon guidance
GO:0007166	0.441	cell surface receptor signaling pathway
GO:0051093	0.428	negative regulation of developmental process
GO:0010975	0.408	regulation of neuron projection development
GO:0031345	0.361	negative regulation of cell projection organization
GO:0010977	0.353	negative regulation of neuron projection development
GO:0032879	0.348	regulation of localization
GO:0009966	0.345	regulation of signal transduction
GO:0040012	0.338	regulation of locomotion

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005576	0.998	extracellular region
GO:0005615	0.984	extracellular space
GO:0005886	0.329	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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