StarFunc result for job id Q14667

User Input

>input (2235 residues)
MPLFFSALLVLLLVALSALFLGRWLVVRLATKWCQRKLQAELKIGSFRFFWIQNVSLKFQ
QHQQTVEIDNLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSDLSAPFSQSAGVDQKEL
SFSPSLLKIFCQLFSIHVDAINIMVLKVDTSESLWHIQISRSRFLLDSDGKRLICEVSLC
KINSKVLKSGQLEDTCLVELSLALDLCLKVGISSRHLTAITVDVWTLHAELHEGLFQSQL
LCQGPSLASKPVPCSEVTENLVEPTLPGLFLLQQLPDQVKVKMENTSVVLSMNSQKRHLT
WTLKLLQFLYHRDEDQLPLRSFTANSDMAQMSTELLLEDGLLLSQSRQRIVCLNSLKASV
QVTTIDLSASLVLNTCIIHYRHQEFSHWLHLLALETQGSSSPVLKQRKKRTFPQILAPII
FSTSISNVNISIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHI
QRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQ
CLSRILSLMGPQSGKSAVSRHSSFGESVSLLWKVDLKVEDMNLFTLSALVGASEVRLDTL
TILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEV
QCGAGLTLLWSPPDHMYLYQHVLATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAP
EPLPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGN
SIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDE
AVGVQKWLKGLHQGTRAWASPSPVPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDE
SKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPMR
RALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVK
SFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPL
KFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDW
HMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCC
FLHLPDLCMTLDLQWLCHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIK
MDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYK
QLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVT
QMVSDLSQVTVHLMASPTEENADHCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSARDG
DPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPQMPAK
KPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQL
CGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLK
QKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELMESGQAVGG
MVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKE
DLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQ
LEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNQKLQL
QLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRL
TEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQ
SGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGRSVEDDEV
GDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPGKGVAQGLTRSSGVRRSFRKSPEHPVD
DIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDF
AMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSV
GDKNPGKKSIFGRRK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:K7VLR4	0.598	0.525	0.000	2605	0.169	0.145	K7VLR4.pdb.gz	APT1_MAIZE Protein ABERRANT POLLEN TRANSMISSION 1 OS=Zea mays OX=4577 GN=APT1 PE=2 SV=1
2	AFDB:Q06179	0.596	0.519	0.000	2628	0.151	0.128	Q06179.pdb.gz	FMP27_YEAST Protein FMP27, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=FMP27 PE=1 SV=1
3	AFDB:Q6IMT0	0.601	0.531	0.000	2587	0.172	0.148	Q6IMT0.pdb.gz	KIP_ARATH Protein KINKY POLLEN OS=Arabidopsis thaliana OX=3702 GN=KIP PE=2 SV=1
4	AFDB:Q6IMT1	0.576	0.508	0.000	2603	0.175	0.150	Q6IMT1.pdb.gz	SAB_ARATH Protein SABRE OS=Arabidopsis thaliana OX=3702 GN=SAB PE=1 SV=1
5	AFDB:Q6LA55	0.604	0.513	0.000	2699	0.170	0.141	Q6LA55.pdb.gz	YF49_SCHPO UPF0648 protein C3H5.09c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC3H5.09c PE=3 SV=2
6	AFDB:Q9VZS7	0.825	0.802	0.000	2300	0.312	0.303	Q9VZS7.pdb.gz	HOBIT_DROME Protein hobbit OS=Drosophila melanogaster OX=7227 GN=hob PE=3 SV=2
7	AFDB:P53855	0.193	0.252	1.254E-38	1592	0.064	0.090	P53855.pdb.gz	ATG2_YEAST Autophagy-related protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ATG2 PE=1 SV=1
8	AFDB:Q9VZX7	0.176	0.198	2.603E-34	1906	0.092	0.108	Q9VZX7.pdb.gz	Q9VZX7_DROME Autophagy-related 2, isoform A OS=Drosophila melanogaster OX=7227 GN=Atg2 PE=2 SV=1
9	AFDB:Q96BY7	0.110	0.116	1.725E-33	2078	0.106	0.115	Q96BY7.pdb.gz	ATG2B_HUMAN Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5
10	AFDB:Q21480	0.186	0.182	1.089E-32	2290	0.084	0.082	Q21480.pdb.gz	ATG2_CAEEL Autophagy-related protein 2 OS=Caenorhabditis elegans OX=6239 GN=atg-2 PE=1 SV=3
11	PDB:6oq5A	0.035	0.034	5.696E-3	2346	0.013	0.013	6oq5A.pdb.gz	Structure of the full-length Clostridium difficile toxin B.
12	PDB:7n9qA	0.036	0.035	6.916E-3	2315	0.014	0.013	7n9qA.pdb.gz
13	PDB:8d0bA	0.039	0.060	9.251E-3	1116	0.035	0.071	8d0bA.pdb.gz	Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
14	PDB:5cslB	0.031	0.032	1.179E-2	2072	0.018	0.019	5cslB.pdb.gz	Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
15	PDB:7d4iBE	0.041	0.060	1.179E-2	890	0.029	0.072	7d4iBE.pdb.gz	Cryo-EM structure of 90S small ribosomal precursors complex with Dhr1
16	PDB:6a9eA	0.038	0.181	1.738E-2	339	0.010	0.068	6a9eA.pdb.gz
17	PDB:5lqwX	0.040	0.059	2.440E-2	1095	0.039	0.079	5lqwX.pdb.gz	Molecular architecture of the Saccharomyces cerevisiae activated spliceosome
18	PDB:6r8yK	0.037	0.064	3.775E-2	825	0.029	0.078	6r8yK.pdb.gz	DNA damage detection in nucleosomes involves DNA register shifting.
19	PDB:4xd9A	0.030	0.136	7.444E-2	236	0.012	0.110	4xd9A.pdb.gz
20	PDB:2gufA	0.040	0.124	8.610E-2	551	0.021	0.087	2gufA.pdb.gz	In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 A Resolution.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q08E86	0.0	4331	2092	0.936	1.000	Q08E86_HUMAN Bridge-like lipid transfer protein family member 2 OS=Homo sapiens OX=9606 GN=BLTP2 PE=1 SV=1
2	Q9VZS7	0.0	1031	2300	0.277	0.269	HOBIT_DROME Protein hobbit OS=Drosophila melanogaster OX=7227 GN=hob PE=3 SV=2
3	Q6LA55	3.27e-18	94.7	2699	0.053	0.044	YF49_SCHPO UPF0648 protein C3H5.09c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC3H5.09c PE=3 SV=2
4	Q6IMT0	5.31e-10	67.8	2587	0.043	0.037	KIP_ARATH Protein KINKY POLLEN OS=Arabidopsis thaliana OX=3702 GN=KIP PE=2 SV=1
5	F4I9T6	5.99e-10	67.8	2655	0.060	0.050	F4I9T6_ARATH HYPERSENSITIVE TO PI STARVATION 4 OS=Arabidopsis thaliana OX=3702 GN=SAB PE=1 SV=1
6	Q6IMT1	9.32e-10	67.0	2603	0.060	0.051	SAB_ARATH Protein SABRE OS=Arabidopsis thaliana OX=3702 GN=SAB PE=1 SV=1
7	K7VLR4	5.40e-09	64.3	2605	0.048	0.041	APT1_MAIZE Protein ABERRANT POLLEN TRANSMISSION 1 OS=Zea mays OX=4577 GN=APT1 PE=2 SV=1
8	Q06179	4.51e-07	58.2	2628	0.016	0.014	FMP27_YEAST Protein FMP27, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=FMP27 PE=1 SV=1
9	Q9T0F3	0.16	39.3	394	0.020	0.114	IAN12_ARATH Immune-associated nucleotide-binding protein 12 OS=Arabidopsis thaliana OX=3702 GN=IAN12 PE=2 SV=1
10	Q9Y2P7	0.89	37.0	627	0.013	0.046	ZN256_HUMAN Zinc finger protein 256 OS=Homo sapiens OX=9606 GN=ZNF256 PE=1 SV=2
11	M9ND00	2.8	35.8	1190	0.013	0.025	M9ND00_DROME Dynamin associated protein 160, isoform D OS=Drosophila melanogaster OX=7227 GN=Dap160 PE=1 SV=1
12	M9PDC7	2.8	35.4	1005	0.014	0.032	M9PDC7_DROME Dynamin associated protein 160, isoform H OS=Drosophila melanogaster OX=7227 GN=Dap160 PE=1 SV=1
13	Q8INU2	2.8	35.8	1014	0.014	0.032	Q8INU2_DROME Dynamin associated protein 160, isoform B OS=Drosophila melanogaster OX=7227 GN=Dap160 PE=1 SV=1
14	O61639	2.9	35.4	1011	0.014	0.032	O61639_DROME Dynamin associated protein isoform Dap160-2 OS=Drosophila melanogaster OX=7227 GN=Dap160 PE=2 SV=1
15	O61618	3.2	35.4	1094	0.014	0.029	O61618_DROME Dynamin associated protein isoform Dap160-1 OS=Drosophila melanogaster OX=7227 GN=Dap160 PE=2 SV=1
16	P84138	3.2	34.7	274	0.009	0.073	PURNU_GEOS3 Purine nucleoside phosphorylase YlmD OS=Geobacillus stearothermophilus (strain DSM 13240 / CIP 106956 / 10) OX=272567 GN=ylmD PE=1 SV=2
17	P0C2I6	3.3	35.4	1755	0.013	0.017	YL13B_YEAST Transposon Ty1-LR3 Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY1B-LR3 PE=3 SV=1
18	Q9VIF7	3.3	35.4	1097	0.014	0.029	Q9VIF7_DROME Dynamin associated protein 160, isoform A OS=Drosophila melanogaster OX=7227 GN=Dap160 PE=1 SV=1
19	M9PBF6	3.4	35.4	1088	0.014	0.029	M9PBF6_DROME Dynamin associated protein 160, isoform G OS=Drosophila melanogaster OX=7227 GN=Dap160 PE=1 SV=1
20	P0C2J1	3.4	35.4	1755	0.013	0.017	YP14B_YEAST Transposon Ty1-PR3 Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY1B-PR3 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF10351 Apt1	1.9e-106	368.5	Golgi-body localisation protein domain
2	PF10293 DUF2405	1.8	20.0	Domain of unknown function (DUF2405)
3	PF10344 Fmp27	1.7e-61	220.2	Mitochondrial protein from FMP27
4	PF10347 Fmp27_GFWDK	4.1e-32	122.9	RNA pol II promoter Fmp27 protein domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000436773

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000291386	0.624	RNA polymerase II subunit A C-terminal domain phosphatase SSU72
2	9606.ENSP00000224140	0.609	Probable helicase senataxin
3	9606.ENSP00000354499	0.592	Cytochrome c oxidase subunit 1
4	9606.ENSP00000335371	0.591	Trafficking protein particle complex subunit 11
5	9606.ENSP00000262293	0.553	Proline-rich protein 11
6	9606.ENSP00000483965	0.550	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)
7	9606.ENSP00000359871	0.547	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
8	9606.ENSP00000281828	0.544	phenylalanyl-tRNA synthetase beta subunit
9	9606.ENSP00000386385	0.544	Peroxisomal membrane protein 4
10	9606.ENSP00000256544	0.534	KATNB1-like protein 1
11	9606.ENSP00000280871	0.530	Proton myo-inositol cotransporter
12	9606.ENSP00000219252	0.529	DNA-directed RNA polymerase II subunit RPB3
13	9606.ENSP00000452007	0.523	Iron-sulfur cluster assembly 2 homolog, mitochondrial
14	9606.ENSP00000244289	0.519	Hormone-sensitive lipase
15	9606.ENSP00000454407	0.504	Golgin subfamily A member 6-like protein 2
16	9606.ENSP00000442699	0.502	HIV Tat-specific factor 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0035091	0.509	phosphatidylinositol binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0065007	0.984	biological regulation
GO:0009987	0.972	cellular process
GO:0048518	0.959	positive regulation of biological process
GO:0050794	0.942	regulation of cellular process
GO:0008152	0.818	metabolic process
GO:0044237	0.801	cellular metabolic process
GO:0071840	0.731	cellular component organization or biogenesis
GO:0016043	0.724	cellular component organization
GO:0006996	0.697	organelle organization
GO:0048522	0.640	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0016020	0.993	membrane
GO:0005783	0.990	endoplasmic reticulum
GO:0031090	0.982	organelle membrane
GO:0031984	0.981	organelle subcompartment
GO:0005789	0.931	endoplasmic reticulum membrane
GO:0044232	0.867	organelle membrane contact site
GO:0140268	0.535	endoplasmic reticulum-plasma membrane contact site
GO:0070013	0.498	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]