StarFunc result for job id Q15323

User Input

>input (416 residues)
MPYNFCLPSLSCRTSCSSRPCVPPSCHSCTLPGACNIPANVSNCNWFCEGSFNGSEKETM
QFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKILCT
KSENARLVVQIDNAKLAADDFRTKYQTELSLRQLVESDINGLRRILDELTLCKSDLEAQV
ESLKEELLCLKSNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEALVETNR
REVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLRDSLENTL
TESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLL
ESEDCNLPSNPCATTNACSKPIGPCLSNPCTSCVPPAPCTPCAPRPRCGPCNSFVR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q15323	1.000	1.000	6.240E-53	416	1.000	1.000	Q15323.pdb.gz	K1H1_HUMAN Keratin, type I cuticular Ha1 OS=Homo sapiens OX=9606 GN=KRT31 PE=1 SV=3
2	AFDB:O76011	0.669	0.641	6.080E-42	436	0.839	0.800	O76011.pdb.gz	KRT34_HUMAN Keratin, type I cuticular Ha4 OS=Homo sapiens OX=9606 GN=KRT34 PE=1 SV=3
3	AFDB:O76013	0.697	0.625	1.250E-33	467	0.697	0.621	O76013.pdb.gz	KRT36_HUMAN Keratin, type I cuticular Ha6 OS=Homo sapiens OX=9606 GN=KRT36 PE=1 SV=1
4	AFDB:Q92764	0.654	0.607	2.802E-33	455	0.707	0.646	Q92764.pdb.gz	KRT35_HUMAN Keratin, type I cuticular Ha5 OS=Homo sapiens OX=9606 GN=KRT35 PE=1 SV=5
5	AFDB:Q14532	0.694	0.650	2.184E-32	448	0.673	0.625	Q14532.pdb.gz	K1H2_HUMAN Keratin, type I cuticular Ha2 OS=Homo sapiens OX=9606 GN=KRT32 PE=1 SV=3
6	AFDB:B1AQ75	0.457	0.413	4.894E-32	473	0.661	0.581	B1AQ75.pdb.gz	KRT36_MOUSE Keratin, type I cuticular Ha6 OS=Mus musculus OX=10090 GN=Krt36 PE=1 SV=1
7	AFDB:Q6IFW3	0.676	0.592	1.309E-27	481	0.567	0.491	Q6IFW3.pdb.gz	K1C39_RAT Keratin, type I cytoskeletal 39 OS=Rattus norvegicus OX=10116 GN=Krt39 PE=3 SV=1
8	AFDB:Q6A162	0.568	0.551	1.889E-27	431	0.594	0.573	Q6A162.pdb.gz	K1C40_HUMAN Keratin, type I cytoskeletal 40 OS=Homo sapiens OX=9606 GN=KRT40 PE=1 SV=2
9	AFDB:Q6A163	0.461	0.397	1.020E-26	491	0.579	0.491	Q6A163.pdb.gz	K1C39_HUMAN Keratin, type I cytoskeletal 39 OS=Homo sapiens OX=9606 GN=KRT39 PE=1 SV=2
10	AFDB:P02533	0.602	0.540	5.438E-23	472	0.488	0.430	P02533.pdb.gz	K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4
11	PDB:7qooU	0.175	0.311	9.111	186	0.082	0.183	7qooU.pdb.gz	Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B1AQ75	0.0	536	473	0.668	0.588	KRT36_MOUSE Keratin, type I cuticular Ha6 OS=Mus musculus OX=10090 GN=Krt36 PE=1 SV=1
2	O76009	0.0	749	404	0.909	0.936	KT33A_HUMAN Keratin, type I cuticular Ha3-I OS=Homo sapiens OX=9606 GN=KRT33A PE=2 SV=2
3	O76011	0.0	687	436	0.837	0.798	KRT34_HUMAN Keratin, type I cuticular Ha4 OS=Homo sapiens OX=9606 GN=KRT34 PE=1 SV=3
4	O76013	0.0	544	467	0.678	0.604	KRT36_HUMAN Keratin, type I cuticular Ha6 OS=Homo sapiens OX=9606 GN=KRT36 PE=1 SV=1
5	Q14525	0.0	753	404	0.913	0.941	KT33B_HUMAN Keratin, type I cuticular Ha3-II OS=Homo sapiens OX=9606 GN=KRT33B PE=1 SV=3
6	Q14532	0.0	546	448	0.668	0.621	K1H2_HUMAN Keratin, type I cuticular Ha2 OS=Homo sapiens OX=9606 GN=KRT32 PE=1 SV=3
7	Q15323	0.0	833	416	1.000	1.000	K1H1_HUMAN Keratin, type I cuticular Ha1 OS=Homo sapiens OX=9606 GN=KRT31 PE=1 SV=3
8	Q92764	0.0	547	455	0.675	0.618	KRT35_HUMAN Keratin, type I cuticular Ha5 OS=Homo sapiens OX=9606 GN=KRT35 PE=1 SV=5
9	O76015	1.37e-172	492	456	0.601	0.548	KRT38_HUMAN Keratin, type I cuticular Ha8 OS=Homo sapiens OX=9606 GN=KRT38 PE=1 SV=3
10	O76014	1.75e-166	476	449	0.582	0.539	KRT37_HUMAN Keratin, type I cuticular Ha7 OS=Homo sapiens OX=9606 GN=KRT37 PE=1 SV=3
11	Q6A162	9.13e-163	466	431	0.596	0.575	K1C40_HUMAN Keratin, type I cytoskeletal 40 OS=Homo sapiens OX=9606 GN=KRT40 PE=1 SV=2
12	Q6A163	7.14e-151	438	491	0.572	0.485	K1C39_HUMAN Keratin, type I cytoskeletal 39 OS=Homo sapiens OX=9606 GN=KRT39 PE=1 SV=2
13	Q6IFW3	2.96e-150	436	481	0.555	0.480	K1C39_RAT Keratin, type I cytoskeletal 39 OS=Rattus norvegicus OX=10116 GN=Krt39 PE=3 SV=1
14	P02533	1.20e-130	386	472	0.462	0.407	K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4
15	Q6IFU8	5.53e-130	383	433	0.474	0.455	K1C17_RAT Keratin, type I cytoskeletal 17 OS=Rattus norvegicus OX=10116 GN=Krt17 PE=1 SV=1
16	Q9QWL7	9.53e-130	382	433	0.474	0.455	K1C17_MOUSE Keratin, type I cytoskeletal 17 OS=Mus musculus OX=10090 GN=Krt17 PE=1 SV=3
17	Q6PVZ1	1.14e-129	383	467	0.457	0.407	K1C14_CHICK Keratin, type I cytoskeletal 14 OS=Gallus gallus OX=9031 GN=KRT14 PE=2 SV=1
18	P08779	1.70e-129	383	473	0.462	0.406	K1C16_HUMAN Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4
19	Q04695	2.40e-129	381	432	0.459	0.442	K1C17_HUMAN Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2
20	P08727	7.20e-129	379	400	0.430	0.448	K1C19_HUMAN Keratin, type I cytoskeletal 19 OS=Homo sapiens OX=9606 GN=KRT19 PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16888 DUF5082	35	16.1	Domain of unknown function (DUF5082)
2	PF00038 Filament	1.7e-103	358.1	Intermediate filament protein
3	PF07926 TPR_MLP1_2	3.2e+02	12.7	TPR/MLP1/MLP2-like protein

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000251645

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000301656	0.656	Keratin, type I cytoskeletal 27
2	9606.ENSP00000368447	0.620	GPALPP motifs containing 1
3	9606.ENSP00000278520	0.585	Coiled-coil domain containing 82
4	9606.ENSP00000305263	0.576	Keratin, type I cytoskeletal 28
5	9606.ENSP00000310573	0.568	Keratin, type I cytoskeletal 25
6	9606.ENSP00000246662	0.559	Keratin, type I cytoskeletal 9
7	9606.ENSP00000243056	0.556	Homeobox protein Hox-C13
8	9606.ENSP00000167588	0.555	Keratin, type I cytoskeletal 20
9	9606.ENSP00000269576	0.548	Keratin, type I cytoskeletal 10
10	9606.ENSP00000254043	0.545	Keratin, type I cytoskeletal 15
11	9606.ENSP00000301653	0.545	Keratin, type I cytoskeletal 16
12	9606.ENSP00000308452	0.545	Keratin, type I cytoskeletal 17
13	9606.ENSP00000167586	0.543	Keratin, type I cytoskeletal 14
14	9606.ENSP00000251643	0.535	Keratin, type I cytoskeletal 12
15	9606.ENSP00000264651	0.535	Keratin, type I cytoskeletal 24
16	9606.ENSP00000355124	0.535	Keratin, type I cytoskeletal 19
17	9606.ENSP00000246635	0.533	Keratin, type I cytoskeletal 13
18	9606.ENSP00000209718	0.520	Keratin, type I cytoskeletal 23
19	9606.ENSP00000334798	0.519	Keratin, type I cytoskeletal 26
20	9606.ENSP00000375428	0.516	Keratin-associated protein 3-3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005198	0.986	structural molecule activity
GO:0005200	0.549	structural constituent of cytoskeleton

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0032502	0.971	developmental process
GO:0048856	0.960	anatomical structure development
GO:0008544	0.772	epidermis development
GO:0009987	0.625	cellular process
GO:0032501	0.395	multicellular organismal process
GO:0065007	0.340	biological regulation
GO:0050789	0.331	regulation of biological process
GO:0050794	0.324	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0043227	0.997	membrane-bounded organelle
GO:0005615	0.997	extracellular space
GO:0031982	0.988	vesicle
GO:0070062	0.978	extracellular exosome
GO:0043232	0.895	intracellular non-membrane-bounded organelle
GO:0005856	0.748	cytoskeleton
GO:0045111	0.604	intermediate filament cytoskeleton
GO:0005882	0.578	intermediate filament

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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