StarFunc result for job id Q16658

User Input

>input (493 residues)
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAV
CLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLS
CFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLA
FQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTL
KAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDR
DTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKN
GQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFND
GAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKA
SAETVDPASLWEY

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A384MEG1	0.994	0.994	5.383E-90	493	1.000	1.000	A0A384MEG1.pdb.gz	A0A384MEG1_HUMAN Fascin OS=Homo sapiens OX=9606 PE=2 SV=1
2	PDB:6b0tA	0.924	0.935	9.588E-82	487	0.988	1.000	6b0tA.pdb.gz	Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.
3	AFDB:F1QET7	0.983	0.987	6.162E-78	491	0.757	0.760	F1QET7.pdb.gz
4	AFDB:D3ZX02	0.967	0.969	2.276E-67	492	0.574	0.575	D3ZX02.pdb.gz	D3ZX02_RAT Fascin OS=Rattus norvegicus OX=10116 GN=Fscn2 PE=3 SV=1
5	AFDB:Q24524	0.901	0.870	6.379E-51	512	0.398	0.383	Q24524.pdb.gz	SING_DROME Protein singed OS=Drosophila melanogaster OX=7227 GN=sn PE=1 SV=1
6	AFDB:Q6AXQ1	0.871	0.863	6.539E-43	498	0.276	0.273	Q6AXQ1.pdb.gz	Q6AXQ1_RAT Fascin OS=Rattus norvegicus OX=10116 GN=Fscn3 PE=1 SV=1
7	AFDB:Q9NQT6	0.861	0.853	2.122E-42	498	0.270	0.267	Q9NQT6.pdb.gz	FSCN3_HUMAN Fascin-3 OS=Homo sapiens OX=9606 GN=FSCN3 PE=2 SV=1
8	AFDB:Q9GV36	0.244	0.151	3.364E-20	850	0.132	0.076	Q9GV36.pdb.gz	PRSN_PIEBR Pierisin OS=Pieris brassicae OX=7116 PE=1 SV=1
9	AFDB:Q0WQH3	0.227	0.216	6.525E-12	519	0.122	0.116	Q0WQH3.pdb.gz	Q0WQH3_ARATH Actin cross-linking protein OS=Arabidopsis thaliana OX=3702 GN=At1g27100 PE=1 SV=1
10	AFDB:A5HZZ6	0.312	0.465	5.429E-8	293	0.057	0.096	A5HZZ6.pdb.gz	A5HZZ6_CLOBH Hemagglutinin component of the neurotoxin complex OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=ha33 PE=1 SV=1
11	PDB:4qd2C	0.315	0.477	1.266E-7	286	0.061	0.105	4qd2C.pdb.gz	Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.
12	AFDB:Q9P7X3	0.224	0.432	1.762E-7	245	0.057	0.114	Q9P7X3.pdb.gz	FRG1_SCHPO Protein frg1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=frg1 PE=3 SV=1
13	PDB:7t3qA	0.218	0.064	3.914E-7	2103	0.077	0.018	7t3qA.pdb.gz	Structural basis for activation and gating of IP 3 receptors.
14	PDB:7t3pA	0.214	0.064	1.044E-6	2066	0.061	0.015	7t3pA.pdb.gz	Structural basis for activation and gating of IP 3 receptors.
15	PDB:3j8hA	0.225	0.046	1.209E-6	3660	0.095	0.013	3j8hA.pdb.gz	Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.
16	PDB:7t3rA	0.214	0.063	1.881E-6	2130	0.079	0.018	7t3rA.pdb.gz	Structural basis for activation and gating of IP 3 receptors.
17	PDB:7m6aA	0.229	0.038	2.525E-6	4306	0.095	0.011	7m6aA.pdb.gz	High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor.
18	PDB:7vmlA	0.209	0.034	3.559E-6	4044	0.122	0.015	7vmlA.pdb.gz	Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.
19	PDB:7tzcA	0.218	0.036	3.738E-6	4404	0.089	0.010	7tzcA.pdb.gz	A drug and ATP binding site in type 1 ryanodine receptor.
20	PDB:7ua3A	0.222	0.037	3.926E-6	4443	0.091	0.010	7ua3A.pdb.gz	Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A384MEG1	0.0	1028	493	1.000	1.000	A0A384MEG1_HUMAN Fascin OS=Homo sapiens OX=9606 PE=2 SV=1
2	D3ZX02	0.0	594	492	0.570	0.571	D3ZX02_RAT Fascin OS=Rattus norvegicus OX=10116 GN=Fscn2 PE=3 SV=1
3	O14926	0.0	576	492	0.564	0.565	FSCN2_HUMAN Fascin-2 OS=Homo sapiens OX=9606 GN=FSCN2 PE=1 SV=1
4	P85845	0.0	972	493	0.957	0.957	FSCN1_RAT Fascin OS=Rattus norvegicus OX=10116 GN=Fscn1 PE=1 SV=2
5	Q08C47	0.0	801	491	0.755	0.758	Q08C47_DANRE Fascin OS=Danio rerio OX=7955 GN=zgc:153632 PE=1 SV=1
6	Q16658	0.0	1028	493	1.000	1.000	FSCN1_HUMAN Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3
7	Q32M02	0.0	587	492	0.564	0.565	FSCN2_MOUSE Fascin-2 OS=Mus musculus OX=10090 GN=Fscn2 PE=2 SV=1
8	Q61553	0.0	999	493	0.966	0.966	FSCN1_MOUSE Fascin OS=Mus musculus OX=10090 GN=Fscn1 PE=1 SV=4
9	Q24524	3.70e-121	366	512	0.406	0.391	SING_DROME Protein singed OS=Drosophila melanogaster OX=7227 GN=sn PE=1 SV=1
10	Q9QXW4	2.67e-60	207	498	0.284	0.281	FSCN3_MOUSE Fascin-3 OS=Mus musculus OX=10090 GN=Fscn3 PE=2 SV=2
11	Q6AXQ1	2.78e-60	207	498	0.286	0.283	Q6AXQ1_RAT Fascin OS=Rattus norvegicus OX=10116 GN=Fscn3 PE=1 SV=1
12	Q9NQT6	1.83e-54	192	498	0.276	0.273	FSCN3_HUMAN Fascin-3 OS=Homo sapiens OX=9606 GN=FSCN3 PE=2 SV=1
13	F7FMC7	2.00e-50	181	475	0.254	0.263	F7FMC7_RAT Fascin OS=Rattus norvegicus OX=10116 GN=Fscn3 PE=1 SV=1
14	Q9P7X3	9.19e-05	46.2	245	0.041	0.082	FRG1_SCHPO Protein frg1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=frg1 PE=3 SV=1
15	F1LQY6	1.4	33.9	389	0.061	0.077	NECA2_RAT N-terminal EF-hand calcium-binding protein 2 OS=Rattus norvegicus OX=10116 GN=Necab2 PE=1 SV=3
16	Q55EE1	1.4	34.3	1214	0.059	0.024	Q55EE1_DICDI Myotubularin phosphatase domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0269272 PE=4 SV=1
17	Q6M0L9	1.8	33.1	259	0.047	0.089	PSA_METMP Proteasome subunit alpha OS=Methanococcus maripaludis (strain S2 / LL) OX=267377 GN=psmA PE=1 SV=1
18	Q4WU06	5.3	32.3	1592	0.057	0.018	Q4WU06_ASPFU non-specific serine/threonine protein kinase OS=Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) OX=330879 GN=AFUA_5G06750 PE=4 SV=1
19	Q14331	6.6	31.6	258	0.034	0.066	FRG1_HUMAN Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1
20	Q9LYZ5	7.4	31.6	480	0.041	0.042	Q9LYZ5_ARATH Cytochrome P450, family 96, subfamily A, polypeptide 13 OS=Arabidopsis thaliana OX=3702 GN=CYP96A13 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF04601 DUF569	9.1	17.4	Domain of unknown function (DUF569)
2	PF19116 DUF5801	4.4e+02	12.8	Domain of unknown function (DUF5801)
3	PF06268 Fascin	9.8e-125	420.3	Fascin domain
4	PF00167 FGF	23	16.4	Fibroblast growth factor
5	PF06229 FRG1	3.2e-16	71.1	FRG1-like domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000371798

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000344456	0.951	Catenin beta-1
2	9606.ENSP00000451828	0.946	RAC-alpha serine/threonine-protein kinase
3	9606.ENSP00000264657	0.938	Signal transducer and activator of transcription 3
4	9606.ENSP00000355652	0.927	Rho-related GTP-binding protein RhoU
5	9606.ENSP00000446007	0.926	Vimentin
6	9606.ENSP00000367059	0.916	Espin
7	9606.ENSP00000354394	0.912	Signal transducer and activator of transcription 1-alpha/beta
8	9606.ENSP00000335153	0.910	Heat shock protein HSP 90-alpha
9	9606.ENSP00000358022	0.909	Induced myeloid leukemia cell differentiation protein Mcl-1
10	9606.ENSP00000370343	0.908	Interferon regulatory factor 4
11	9606.ENSP00000384849	0.908	Cyclin-dependent kinase inhibitor 1
12	9606.ENSP00000229340	0.905	Ras-related protein Rab-35
13	9606.ENSP00000428056	0.905	Phosphatidylinositol 3-kinase regulatory subunit alpha
14	9606.ENSP00000330341	0.904	Suppressor of cytokine signaling 3
15	9606.ENSP00000327251	0.900	Nitric oxide synthase, inducible
16	9606.ENSP00000301455	0.817	Angiopoietin-related protein 4
17	9606.ENSP00000427866	0.811	Dematin
18	9606.ENSP00000381581	0.785	Plastin-2
19	9606.ENSP00000172229	0.778	Tumor necrosis factor receptor superfamily member 16
20	9606.ENSP00000348163	0.748	Plastin-3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0051015	1.000	actin filament binding
GO:0005102	0.850	signaling receptor binding
GO:0097159	0.754	organic cyclic compound binding
GO:1901363	0.748	heterocyclic compound binding
GO:0003676	0.441	nucleic acid binding
GO:0050839	0.380	cell adhesion molecule binding
GO:0045296	0.327	cadherin binding
GO:0003723	0.310	RNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071840	0.995	cellular component organization or biogenesis
GO:0050794	0.995	regulation of cellular process
GO:0044087	0.989	regulation of cellular component biogenesis
GO:0051017	0.985	actin filament bundle assembly
GO:0048522	0.980	positive regulation of cellular process
GO:0051130	0.956	positive regulation of cellular component organization
GO:0044089	0.956	positive regulation of cellular component biogenesis
GO:0120032	0.955	regulation of plasma membrane bounded cell projection assembly
GO:0031346	0.941	positive regulation of cell projection organization
GO:0051489	0.938	regulation of filopodium assembly
GO:0032501	0.936	multicellular organismal process
GO:0048856	0.920	anatomical structure development
GO:0050896	0.910	response to stimulus
GO:0120034	0.877	positive regulation of plasma membrane bounded cell projection assembly
GO:0051491	0.835	positive regulation of filopodium assembly
GO:0007275	0.831	multicellular organism development
GO:0051716	0.674	cellular response to stimulus
GO:0033043	0.662	regulation of organelle organization
GO:0048870	0.584	cell motility
GO:0016477	0.559	cell migration
GO:0007154	0.549	cell communication
GO:0010638	0.499	positive regulation of organelle organization
GO:0048731	0.496	system development

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.998	cytoplasm
GO:0043229	0.998	intracellular organelle
GO:0016020	0.994	membrane
GO:0043232	0.989	intracellular non-membrane-bounded organelle
GO:0042995	0.986	cell projection
GO:0015629	0.984	actin cytoskeleton
GO:0043227	0.982	membrane-bounded organelle
GO:0005829	0.980	cytosol
GO:0071944	0.975	cell periphery
GO:0120025	0.971	plasma membrane bounded cell projection
GO:0005576	0.968	extracellular region
GO:0005886	0.967	plasma membrane
GO:0031982	0.946	vesicle
GO:0043230	0.936	extracellular organelle
GO:0065010	0.928	extracellular membrane-bounded organelle
GO:1903561	0.922	extracellular vesicle
GO:0031252	0.895	cell leading edge
GO:0005615	0.886	extracellular space
GO:0030054	0.852	cell junction
GO:0043231	0.847	intracellular membrane-bounded organelle
GO:0070062	0.846	extracellular exosome
GO:0098858	0.841	actin-based cell projection
GO:0030175	0.811	filopodium
GO:0070161	0.725	anchoring junction
GO:0030027	0.714	lamellipodium
GO:0032432	0.708	actin filament bundle
GO:0042641	0.688	actomyosin
GO:0097517	0.685	contractile actin filament bundle
GO:0030427	0.679	site of polarized growth
GO:0150034	0.671	distal axon
GO:0030426	0.662	growth cone
GO:0001726	0.650	ruffle
GO:0001725	0.614	stress fiber
GO:0030055	0.584	cell-substrate junction
GO:0005925	0.564	focal adhesion
GO:0005902	0.429	microvillus
GO:0031981	0.413	nuclear lumen
GO:0032991	0.363	protein-containing complex
GO:0012505	0.335	endomembrane system
GO:0032587	0.322	ruffle membrane
GO:0005654	0.314	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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