StarFunc result for job id Q16774

User Input

>input (197 residues)
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
LKEALSEEIKKAQRTGA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q16774	1.000	1.000	1.466E-41	197	1.000	1.000	Q16774.pdb.gz	KGUA_HUMAN Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2
2	AFDB:E9PTV0	0.990	0.891	8.634E-38	219	0.863	0.776	E9PTV0.pdb.gz	E9PTV0_RAT guanylate kinase OS=Rattus norvegicus OX=10116 GN=Guk1 PE=3 SV=3
3	AFDB:P31006	0.764	0.760	3.440E-36	198	0.898	0.894	P31006.pdb.gz	KGUA_PIG Guanylate kinase OS=Sus scrofa OX=9823 GN=GUK1 PE=1 SV=2
4	PDB:1lvgA	0.941	0.975	3.854E-33	190	0.853	0.884	1lvgA.pdb.gz	Structural characterization of the closed conformation of mouse guanylate kinase.
5	PDB:6nuiA	0.747	0.744	9.834E-33	198	1.000	0.995	6nuiA.pdb.gz
6	AFDB:A0A1D8PNS0	0.905	0.938	3.269E-27	190	0.508	0.526	A0A1D8PNS0.pdb.gz	A0A1D8PNS0_CANAL guanylate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=GUK1 PE=3 SV=1
7	AFDB:Q9P6I5	0.893	0.872	1.558E-26	202	0.472	0.460	Q9P6I5.pdb.gz	KGUA_SCHPO Guanylate kinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC1198.05 PE=3 SV=1
8	AFDB:P15454	0.695	0.729	1.475E-25	187	0.477	0.503	P15454.pdb.gz	KGUA_YEAST Guanylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GUK1 PE=1 SV=2
9	AFDB:P93757	0.909	0.466	7.484E-25	387	0.437	0.222	P93757.pdb.gz	GMK1_ARATH Guanylate kinase 1 OS=Arabidopsis thaliana OX=3702 GN=GK-1 PE=1 SV=3
10	AFDB:F4J3E9	0.872	0.450	1.584E-24	390	0.447	0.226	F4J3E9.pdb.gz	F4J3E9_ARATH guanylate kinase OS=Arabidopsis thaliana OX=3702 GN=AGK2 PE=1 SV=1
11	PDB:4f4jA	0.663	0.688	3.259E-23	189	0.477	0.497	4f4jA.pdb.gz
12	AFDB:Q8I2M1	0.911	0.902	2.361E-21	199	0.360	0.357	Q8I2M1.pdb.gz	Q8I2M1_PLAF7 guanylate kinase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0928900 PE=1 SV=1
13	AFDB:A0A3Q1LY00	0.659	0.225	1.275E-20	675	0.355	0.104	A0A3Q1LY00.pdb.gz	A0A3Q1LY00_BOVIN Protein PALS1 OS=Bos taurus OX=9913 GN=PALS1 PE=1 SV=1
14	PDB:1z6gA	0.818	0.842	4.859E-20	191	0.350	0.361	1z6gA.pdb.gz
15	PDB:2anbA	0.887	0.850	1.028E-19	206	0.391	0.374	2anbA.pdb.gz	Calorimetric and crystallographic analysis of the oligomeric structure of Escherichia coli GMP kinase
16	PDB:1z8fA	0.669	0.708	1.605E-18	184	0.365	0.391	1z8fA.pdb.gz
17	PDB:2xkxA	0.588	0.195	3.976E-14	721	0.325	0.089	2xkxA.pdb.gz
18	PDB:2ancF	0.580	0.729	4.177E-8	153	0.254	0.327	2ancF.pdb.gz
19	PDB:7mixC	0.603	0.388	1.551E-7	324	0.213	0.130	7mixC.pdb.gz	Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
20	PDB:2c95A	0.491	0.495	2.007E-6	195	0.147	0.149	2c95A.pdb.gz	Structure of Adenylate Kinase 1 in Complex with P1, P4-Di(Adenosine)Tetraphosphate

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q16774	2.77e-146	406	197	1.000	1.000	KGUA_HUMAN Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2
2	Q71RR7	1.51e-127	358	198	0.863	0.859	Q71RR7_RAT guanylate kinase OS=Rattus norvegicus OX=10116 GN=Guk1 PE=2 SV=1
3	E9PTV0	1.56e-127	359	207	0.863	0.821	E9PTV0_RAT guanylate kinase OS=Rattus norvegicus OX=10116 GN=Guk1 PE=3 SV=3
4	Q64520	5.70e-127	357	198	0.878	0.874	KGUA_MOUSE Guanylate kinase OS=Mus musculus OX=10090 GN=Guk1 PE=1 SV=2
5	A0A8I6A2B3	5.07e-126	357	266	0.863	0.639	A0A8I6A2B3_RAT guanylate kinase OS=Rattus norvegicus OX=10116 GN=Guk1 PE=1 SV=1
6	P46195	4.95e-125	352	198	0.904	0.899	KGUA_BOVIN Guanylate kinase OS=Bos taurus OX=9913 GN=GUK1 PE=1 SV=2
7	P31006	6.66e-124	349	198	0.898	0.894	KGUA_PIG Guanylate kinase OS=Sus scrofa OX=9823 GN=GUK1 PE=1 SV=2
8	A0A8I6GLP0	1.90e-122	347	234	0.863	0.726	A0A8I6GLP0_RAT guanylate kinase OS=Rattus norvegicus OX=10116 GN=Guk1 PE=1 SV=1
9	A0A8I5ZT32	1.95e-113	324	218	0.807	0.729	A0A8I5ZT32_RAT guanylate kinase OS=Rattus norvegicus OX=10116 GN=Guk1 PE=1 SV=1
10	A0A1D8PNS0	6.53e-67	205	190	0.513	0.532	A0A1D8PNS0_CANAL guanylate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=GUK1 PE=3 SV=1
11	Q9P6I5	1.73e-65	202	202	0.472	0.460	KGUA_SCHPO Guanylate kinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC1198.05 PE=3 SV=1
12	P15454	7.35e-62	192	187	0.482	0.508	KGUA_YEAST Guanylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GUK1 PE=1 SV=2
13	Q9M682	5.18e-57	186	389	0.447	0.226	GMK2_ARATH Guanylate kinase 2 OS=Arabidopsis thaliana OX=3702 GN=GK-2 PE=2 SV=1
14	F4J3E9	5.55e-57	186	390	0.447	0.226	F4J3E9_ARATH guanylate kinase OS=Arabidopsis thaliana OX=3702 GN=AGK2 PE=1 SV=1
15	P93757	6.96e-57	186	387	0.437	0.222	GMK1_ARATH Guanylate kinase 1 OS=Arabidopsis thaliana OX=3702 GN=GK-1 PE=1 SV=3
16	Q8I2M1	8.16e-43	144	199	0.360	0.357	Q8I2M1_PLAF7 guanylate kinase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0928900 PE=1 SV=1
17	P60546	3.22e-38	132	207	0.381	0.362	KGUA_ECOLI Guanylate kinase OS=Escherichia coli (strain K12) OX=83333 GN=gmk PE=1 SV=1
18	Q389H1	1.83e-37	129	178	0.350	0.388	Q389H1_TRYB2 Guanylate kinase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.26.0200 PE=4 SV=1
19	A0A3Q1LY00	1.75e-35	133	675	0.345	0.101	A0A3Q1LY00_BOVIN Protein PALS1 OS=Bos taurus OX=9913 GN=PALS1 PE=1 SV=1
20	Q9JLB2	1.90e-35	133	675	0.345	0.101	PALS1_MOUSE Protein PALS1 OS=Mus musculus OX=10090 GN=Pals1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00004 AAA	1.3e+02	14.4	ATPase family associated with various cellular activities (AAA)
2	PF13173 AAA_14	57	15.2	AAA domain
3	PF13191 AAA_16	0.057	25.3	AAA ATPase domain
4	PF13207 AAA_17	1.4e+02	14.3	AAA domain
5	PF13238 AAA_18	0.0071	28.3	AAA domain
6	PF13401 AAA_22	1.1	20.9	AAA domain
7	PF13476 AAA_23	7.8e+02	12.0	AAA domain
8	PF13479 AAA_24	19	16.4	AAA domain
9	PF13481 AAA_25	4.7e+02	11.7	AAA domain
10	PF13521 AAA_28	14	17.3	AAA domain
11	PF13555 AAA_29	25	16.0	P-loop containing region of AAA domain
12	PF13604 AAA_30	23	16.2	AAA domain
13	PF13671 AAA_33	0.0033	29.0	AAA domain
14	PF07728 AAA_5	80	14.7	AAA domain (dynein-related subfamily)
15	PF12775 AAA_7	3.2e+02	12.3	P-loop containing dynein motor region
16	PF00005 ABC_tran	1	21.3	ABC transporter
17	PF01637 ATPase_2	1.6e+02	13.6	ATPase domain predominantly from Archaea
18	PF02492 cobW	11	17.0	CobW/HypB/UreG, nucleotide-binding domain
19	PF01712 dNK	34	15.7	Deoxynucleoside kinase
20	PF09848 DUF2075	59	14.4	Schlafen group 3, DNA/RNA helicase domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 60711.ENSCSAP00000012547

Rank	PPI partner	STRING score	Description
1	60711.ENSCSAP00000004017	0.995	Hypoxanthine phosphoribosyltransferase 1
2	60711.ENSCSAP00000008209	0.993	Guanine monphosphate synthase
3	60711.ENSCSAP00000000608	0.990	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
4	60711.ENSCSAP00000001821	0.990	NME/NM23 nucleoside diphosphate kinase 1
5	60711.ENSCSAP00000007659	0.989	NME/NM23 nucleoside diphosphate kinase 3
6	60711.ENSCSAP00000001822	0.988	Nucleoside diphosphate kinase
7	60711.ENSCSAP00000003453	0.988	Ribonucleotide reductase M2
8	60711.ENSCSAP00000007286	0.988	NME/NM23 family member 7
9	60711.ENSCSAP00000008160	0.988	Ribonucleotide reductase M2 B (TP53 inducible)
10	60711.ENSCSAP00000008974	0.988	NME/NM23 nucleoside diphosphate kinase 4
11	60711.ENSCSAP00000011981	0.988	NME/NM23 nucleoside diphosphate kinase 6
12	60711.ENSCSAP00000011601	0.987	Deoxyguanosine kinase
13	60711.ENSCSAP00000011452	0.950	Adenylate kinase 9
14	60711.ENSCSAP00000015145	0.941	Adenine phosphoribosyltransferase
15	60711.ENSCSAP00000003851	0.920	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
16	60711.ENSCSAP00000018170	0.910	Belongs to the pyruvate kinase family.
17	60711.ENSCSAP00000001176	0.905	Deoxycytidine kinase
18	60711.ENSCSAP00000001027	0.902	5', 3'-nucleotidase, cytosolic
19	60711.ENSCSAP00000002443	0.902	Ectonucleoside triphosphate diphosphohydrolase 1
20	60711.ENSCSAP00000004705	0.902	5',3'-nucleotidase, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0004385	0.999	guanylate kinase activity
GO:1901363	0.470	heterocyclic compound binding
GO:0097159	0.470	organic cyclic compound binding
GO:0043167	0.467	ion binding
GO:0000166	0.426	nucleotide binding
GO:0043168	0.406	anion binding
GO:0017076	0.389	purine nucleotide binding
GO:0032555	0.336	purine ribonucleotide binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:1901564	0.997	organonitrogen compound metabolic process
GO:0006796	0.995	phosphate-containing compound metabolic process
GO:0019637	0.995	organophosphate metabolic process
GO:0055086	0.995	nucleobase-containing small molecule metabolic process
GO:1901576	0.994	organic substance biosynthetic process
GO:0006163	0.991	purine nucleotide metabolic process
GO:0044249	0.987	cellular biosynthetic process
GO:0009394	0.986	2'-deoxyribonucleotide metabolic process
GO:0009263	0.984	deoxyribonucleotide biosynthetic process
GO:0046385	0.981	deoxyribose phosphate biosynthetic process
GO:0009265	0.971	2'-deoxyribonucleotide biosynthetic process
GO:0072522	0.948	purine-containing compound biosynthetic process
GO:0009132	0.945	nucleoside diphosphate metabolic process
GO:0006164	0.941	purine nucleotide biosynthetic process
GO:0009135	0.822	purine nucleoside diphosphate metabolic process
GO:0019693	0.637	ribose phosphate metabolic process
GO:0009150	0.629	purine ribonucleotide metabolic process
GO:0050896	0.487	response to stimulus
GO:0009260	0.466	ribonucleotide biosynthetic process
GO:0009152	0.457	purine ribonucleotide biosynthetic process
GO:0016310	0.349	phosphorylation
GO:0009141	0.348	nucleoside triphosphate metabolic process
GO:0009123	0.348	nucleoside monophosphate metabolic process
GO:0009144	0.342	purine nucleoside triphosphate metabolic process
GO:0009126	0.308	purine nucleoside monophosphate metabolic process
GO:0009161	0.301	ribonucleoside monophosphate metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:20780	0.999	ATP + GMP = ADP + GDP
EC:2.7.4.8	0.999	guanylate kinase.

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