StarFunc result for job id Q16775

User Input

>input (308 residues)
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDN
YMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESG
LKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFT
GDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAA
IREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK
DQFKMPRD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q16775	1.000	1.000	4.009E-65	308	1.000	1.000	Q16775.pdb.gz	GLO2_HUMAN Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2
2	AFDB:O35952	0.897	0.894	5.914E-57	309	0.851	0.848	O35952.pdb.gz	GLO2_RAT Hydroxyacylglutathione hydrolase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Hagh PE=1 SV=2
3	AFDB:Q5ZI23	0.897	0.891	1.962E-51	310	0.734	0.729	Q5ZI23.pdb.gz	GLO2_CHICK Hydroxyacylglutathione hydrolase, mitochondrial OS=Gallus gallus OX=9031 GN=HAGH PE=2 SV=1
4	AFDB:Q8IPU3	0.865	0.766	2.580E-43	348	0.523	0.463	Q8IPU3.pdb.gz	Q8IPU3_DROME Tenzing norgay, isoform C OS=Drosophila melanogaster OX=7227 GN=tzn PE=1 SV=1
5	AFDB:O24496	0.820	0.977	7.190E-37	258	0.448	0.535	O24496.pdb.gz	GLO2C_ARATH Hydroxyacylglutathione hydrolase cytoplasmic OS=Arabidopsis thaliana OX=3702 GN=GLX2-2 PE=1 SV=2
6	AFDB:C0H490	0.802	0.937	3.369E-31	263	0.338	0.395	C0H490.pdb.gz	C0H490_PLAF7 Cytosolic glyoxalase II OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0406400 PE=3 SV=1
7	AFDB:A0A024R415	0.841	0.675	5.039E-31	385	0.367	0.294	A0A024R415.pdb.gz
8	AFDB:Q8LDW8	0.784	0.731	4.233E-30	331	0.354	0.329	Q8LDW8.pdb.gz	GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=GLX2-4 PE=2 SV=1
9	AFDB:Q9SID3	0.763	0.726	3.989E-29	324	0.328	0.312	Q9SID3.pdb.gz	GLO2N_ARATH Hydroxyacylglutathione hydrolase 2, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At2g31350 PE=1 SV=1
10	AFDB:Q9UT36	0.737	0.881	1.123E-28	256	0.338	0.406	Q9UT36.pdb.gz	GLO21_SCHPO Probable hydroxyacylglutathione hydrolase C824.07 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC824.07 PE=3 SV=1
11	PDB:6rz0A	0.759	0.926	1.809E-23	251	0.282	0.347	6rz0A.pdb.gz	Crystal structure of Escherichia coli Glyoxalase II
12	PDB:4chlB	0.587	0.749	1.585E-13	237	0.182	0.236	4chlB.pdb.gz	Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.
13	PDB:4ad9A	0.469	0.498	3.951E-9	288	0.149	0.160	4ad9A.pdb.gz	Identification of Lactb2, a Metallo-Beta-Lactamase Protein, as a Human Mitochondrial Endoribonuclease
14	PDB:5evdA	0.475	0.539	1.483E-8	267	0.140	0.161	5evdA.pdb.gz	Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
15	PDB:2q0jA	0.463	0.460	6.618E-8	310	0.153	0.152	2q0jA.pdb.gz	Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
16	PDB:2m5cA	0.449	0.586	1.864E-7	227	0.107	0.145	2m5cA.pdb.gz	Solution structures of the Bacillus cereus metallo-beta-lactamase BcII and its complex with the broad spectrum inhibitor R-thiomandelic acid.
17	PDB:1m2xA	0.477	0.638	2.346E-7	219	0.120	0.169	1m2xA.pdb.gz	The 1.5 A structure of Chryseobacterium meningosepticum Zn-beta-lactamase in complex with the inhibitor, D-captopril
18	PDB:1hlkA	0.480	0.628	2.632E-7	227	0.120	0.163	1hlkA.pdb.gz	Identification of a series of tricyclic natural products as potent broad spectrum inhibitors of metallo-beta-lactamases
19	PDB:4uwpB	0.457	0.586	3.717E-7	230	0.094	0.126	4uwpB.pdb.gz	Structural and Biochemical Characterization of Vim-26 Show that Leu224 Has Implications for the Substrate Specificity of Vim Metallo-Beta-Lactamases.
20	PDB:6jkaC	0.471	0.609	3.937E-7	228	0.130	0.175	6jkaC.pdb.gz	Identification of the Inhibitory Compounds for Metallo-beta-lactamases and Structural Analysis of the Binding Modes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O35952	0.0	557	309	0.851	0.848	GLO2_RAT Hydroxyacylglutathione hydrolase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Hagh PE=1 SV=2
2	Q16775	0.0	638	308	1.000	1.000	GLO2_HUMAN Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2
3	Q99KB8	0.0	571	309	0.877	0.874	GLO2_MOUSE Hydroxyacylglutathione hydrolase, mitochondrial OS=Mus musculus OX=10090 GN=Hagh PE=1 SV=2
4	Q5ZI23	1.54e-173	484	310	0.740	0.735	GLO2_CHICK Hydroxyacylglutathione hydrolase, mitochondrial OS=Gallus gallus OX=9031 GN=HAGH PE=2 SV=1
5	Q9VPB3	2.32e-113	332	305	0.494	0.498	Q9VPB3_DROME LD26447p OS=Drosophila melanogaster OX=7227 GN=tzn PE=1 SV=2
6	Q9I7P8	2.40e-113	330	271	0.494	0.561	Q9I7P8_DROME Tenzing norgay, isoform B OS=Drosophila melanogaster OX=7227 GN=tzn PE=1 SV=1
7	Q8IPU3	1.80e-112	331	348	0.494	0.437	Q8IPU3_DROME Tenzing norgay, isoform C OS=Drosophila melanogaster OX=7227 GN=tzn PE=1 SV=1
8	O24496	2.00e-96	287	258	0.451	0.539	GLO2C_ARATH Hydroxyacylglutathione hydrolase cytoplasmic OS=Arabidopsis thaliana OX=3702 GN=GLX2-2 PE=1 SV=2
9	Q6PII5	2.97e-73	229	290	0.344	0.366	HAGHL_HUMAN Hydroxyacylglutathione hydrolase-like protein OS=Homo sapiens OX=9606 GN=HAGHL PE=1 SV=1
10	C0H490	1.47e-64	206	263	0.338	0.395	C0H490_PLAF7 Cytosolic glyoxalase II OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0406400 PE=3 SV=1
11	Q8N490	3.50e-59	196	385	0.331	0.265	PNKD_HUMAN Probable hydrolase PNKD OS=Homo sapiens OX=9606 GN=PNKD PE=1 SV=2
12	O94250	1.21e-57	187	256	0.351	0.422	GLO22_SCHPO Probable hydroxyacylglutathione hydrolase C13B11.03c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC13B11.03c PE=3 SV=1
13	Q69ZP3	1.95e-57	191	385	0.328	0.262	PNKD_MOUSE Probable hydrolase PNKD OS=Mus musculus OX=10090 GN=Pnkd PE=1 SV=2
14	Q8LDW8	3.74e-57	189	331	0.331	0.308	GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=GLX2-4 PE=2 SV=1
15	Q9UT36	6.79e-57	186	256	0.338	0.406	GLO21_SCHPO Probable hydroxyacylglutathione hydrolase C824.07 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC824.07 PE=3 SV=1
16	Q9SID3	2.05e-52	176	324	0.328	0.312	GLO2N_ARATH Hydroxyacylglutathione hydrolase 2, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At2g31350 PE=1 SV=1
17	Q05584	5.40e-49	166	274	0.312	0.350	GLO2_YEAST Hydroxyacylglutathione hydrolase, cytoplasmic isozyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GLO2 PE=1 SV=1
18	O24495	2.01e-48	166	331	0.302	0.281	GLO2M_ARATH Hydroxyacylglutathione hydrolase 1, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=GLX2-1 PE=2 SV=2
19	Q585D9	3.02e-41	146	296	0.308	0.321	Q585D9_TRYB2 Hydroxyacylglutathione hydrolase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb06.3A7.500 PE=3 SV=1
20	Q12320	1.44e-39	142	285	0.289	0.312	GLO4_YEAST Hydroxyacylglutathione hydrolase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GLO4 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16123 HAGH_C	5.9e-25	98.8	Hydroxyacylglutathione hydrolase C-terminus
2	PF00753 Lactamase_B	5.4e-08	44.6	Metallo-beta-lactamase superfamily
3	PF12706 Lactamase_B_2	3.5	18.6	Beta-lactamase superfamily domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000380514

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000362463	0.999	Lactoylglutathione lyase
2	9606.ENSP00000300051	0.912	Probable D-lactate dehydrogenase, mitochondrial
3	9606.ENSP00000428864	0.773	Carboxylesterase 5A
4	9606.ENSP00000317842	0.769	Cocaine esterase
5	9606.ENSP00000326627	0.767	Acid-sensing ion channel 4
6	9606.ENSP00000367992	0.729	S-formylglutathione hydrolase
7	9606.ENSP00000425809	0.713	Phosphoacetylglucosamine mutase
8	9606.ENSP00000307640	0.704	Tetratricopeptide repeat domain containing
9	9606.ENSP00000301281	0.665	UBX domain-containing protein 6
10	9606.ENSP00000304782	0.653	Carboxylesterase 3
11	9606.ENSP00000330918	0.646	Glycerol-3-phosphate phosphatase
12	9606.ENSP00000418770	0.640	Protein/nucleic acid deglycase DJ-1
13	9606.ENSP00000244137	0.622	Xaa-Pro dipeptidase
14	9606.ENSP00000416750	0.611	Serine/threonine-protein kinase 33
15	9606.ENSP00000308610	0.588	Glycerol-3-phosphate dehydrogenase, mitochondrial
16	9606.ENSP00000353720	0.587	Liver carboxylesterase 1
17	9606.ENSP00000276590	0.572	Endoribonuclease LACTB2
18	9606.ENSP00000355689	0.568	Guanylate kinase
19	9606.ENSP00000328570	0.560	Glutaredoxin-related protein 5, mitochondrial
20	9606.ENSP00000332013	0.551	Zinc finger CCCH-type with G patch domain-containing protein

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005488	1.000	binding
GO:0004416	1.000	hydroxyacylglutathione hydrolase activity
GO:0005515	0.991	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044237	0.995	cellular metabolic process
GO:0006807	0.920	nitrogen compound metabolic process
GO:1901576	0.848	organic substance biosynthetic process
GO:0044249	0.844	cellular biosynthetic process
GO:0006749	0.830	glutathione metabolic process
GO:1901564	0.750	organonitrogen compound metabolic process
GO:0034641	0.704	cellular nitrogen compound metabolic process
GO:0044238	0.687	primary metabolic process
GO:0044271	0.606	cellular nitrogen compound biosynthetic process
GO:1901566	0.605	organonitrogen compound biosynthetic process
GO:0043603	0.496	amide metabolic process
GO:0044281	0.458	small molecule metabolic process
GO:0019184	0.437	nonribosomal peptide biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0070013	0.990	intracellular organelle lumen
GO:0005829	0.971	cytosol
GO:0005634	0.770	nucleus
GO:0005759	0.577	mitochondrial matrix
GO:0005654	0.392	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:25245	1.000	(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
EC:3.1.2.6	1.000	hydroxyacylglutathione hydrolase.

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