StarFunc result for job id Q16825

User Input

>input (1174 residues)
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE
VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY
YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG
IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR
HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD
NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS
ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS
YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP
ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH
HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS
AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE
EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT
AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK
KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY
ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV
SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT
VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY
LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL
DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A286YBL8	0.273	0.266	0.000	1204	0.737	0.718	A0A286YBL8.pdb.gz	A0A286YBL8_DANRE protein-tyrosine-phosphatase OS=Danio rerio OX=7955 GN=ptpn21 PE=3 SV=1
2	AFDB:F1Q6T9	0.265	0.266	0.000	1168	0.737	0.741	F1Q6T9.pdb.gz	F1Q6T9_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=ptpn21 PE=3 SV=2
3	AFDB:Q16825	1.000	1.000	0.000	1174	1.000	1.000	Q16825.pdb.gz	PTN21_HUMAN Tyrosine-protein phosphatase non-receptor type 21 OS=Homo sapiens OX=9606 GN=PTPN21 PE=1 SV=2
4	AFDB:Q62728	0.275	0.275	0.000	1175	0.882	0.881	Q62728.pdb.gz	PTN21_RAT Tyrosine-protein phosphatase non-receptor type 21 OS=Rattus norvegicus OX=10116 GN=Ptpn21 PE=1 SV=1
5	AFDB:Q62130	0.284	0.281	1.955E-96	1189	0.549	0.542	Q62130.pdb.gz	PTN14_MOUSE Tyrosine-protein phosphatase non-receptor type 14 OS=Mus musculus OX=10090 GN=Ptpn14 PE=1 SV=2
6	PDB:3ps5A	0.225	0.485	1.356E-22	529	0.087	0.193	3ps5A.pdb.gz	Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.
7	AFDB:O17905	0.229	0.245	2.301E-21	1091	0.153	0.165	O17905.pdb.gz	O17905_CAEEL Moesin/ezrin/radixin homolog 1 OS=Caenorhabditis elegans OX=6239 GN=frm-3 PE=1 SV=2
8	AFDB:P23471	0.205	0.107	7.109E-21	2315	0.161	0.082	P23471.pdb.gz	PTPRZ_HUMAN Receptor-type tyrosine-protein phosphatase zeta OS=Homo sapiens OX=9606 GN=PTPRZ1 PE=1 SV=4
9	PDB:5xzrA	0.218	0.476	1.362E-20	519	0.083	0.189	5xzrA.pdb.gz	Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
10	PDB:4gwfA	0.221	0.505	2.453E-20	497	0.082	0.193	4gwfA.pdb.gz
11	PDB:6krwA	0.227	0.825	4.207E-20	306	0.077	0.294	6krwA.pdb.gz
12	AFDB:Q62656	0.203	0.106	7.125E-20	2316	0.145	0.073	Q62656.pdb.gz	PTPRZ_RAT Receptor-type tyrosine-protein phosphatase zeta OS=Rattus norvegicus OX=10116 GN=Ptprz1 PE=1 SV=1
13	PDB:4rm8A	0.229	0.693	1.237E-19	368	0.066	0.209	4rm8A.pdb.gz
14	PDB:3m4uA	0.205	0.782	8.875E-15	285	0.058	0.239	3m4uA.pdb.gz
15	AFDB:Q9VUH6	0.204	0.134	1.363E-14	1833	0.147	0.094	Q9VUH6.pdb.gz	Q9VUH6_DROME Myopic OS=Drosophila melanogaster OX=7227 GN=mop PE=1 SV=2
16	AFDB:D3ZW88	0.217	0.187	1.592E-10	1371	0.121	0.104	D3ZW88.pdb.gz	D3ZW88_RAT FERM and PDZ domain containing 1 OS=Rattus norvegicus OX=10116 GN=Frmpd1 PE=4 SV=3
17	PDB:7c3mA	0.189	0.368	3.394E-6	577	0.043	0.088	7c3mA.pdb.gz
18	PDB:6r9tA	0.124	0.071	3.239E-5	2185	0.028	0.015	6r9tA.pdb.gz
19	PDB:7lq1A	0.064	0.078	3.958E-3	950	0.012	0.015	7lq1A.pdb.gz	Discovery of a new series of PI3K-delta inhibitors from Virtual Screening.
20	PDB:3s4oA	0.115	0.684	5.579E-3	163	0.024	0.172	3s4oA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A286YBL8	0.0	1715	1204	0.741	0.723	A0A286YBL8_DANRE protein-tyrosine-phosphatase OS=Danio rerio OX=7955 GN=ptpn21 PE=3 SV=1
2	F1Q6T9	0.0	1735	1168	0.741	0.745	F1Q6T9_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=ptpn21 PE=3 SV=2
3	Q15678	0.0	1198	1187	0.561	0.555	PTN14_HUMAN Tyrosine-protein phosphatase non-receptor type 14 OS=Homo sapiens OX=9606 GN=PTPN14 PE=1 SV=2
4	Q16825	0.0	2438	1174	1.000	1.000	PTN21_HUMAN Tyrosine-protein phosphatase non-receptor type 21 OS=Homo sapiens OX=9606 GN=PTPN21 PE=1 SV=2
5	Q62130	0.0	1192	1189	0.555	0.548	PTN14_MOUSE Tyrosine-protein phosphatase non-receptor type 14 OS=Mus musculus OX=10090 GN=Ptpn14 PE=1 SV=2
6	Q62728	0.0	2087	1175	0.880	0.879	PTN21_RAT Tyrosine-protein phosphatase non-receptor type 21 OS=Rattus norvegicus OX=10116 GN=Ptpn21 PE=1 SV=1
7	Q9V3V3	8.72e-61	230	1252	0.118	0.110	Q9V3V3_DROME Pez, isoform A OS=Drosophila melanogaster OX=7227 GN=Pez PE=2 SV=1
8	Q562B7	5.37e-54	193	306	0.089	0.343	Q562B7_RAT Ptpn3 protein (Fragment) OS=Rattus norvegicus OX=10116 GN=Ptpn3 PE=2 SV=1
9	P26045	2.06e-50	196	913	0.090	0.116	PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 OS=Homo sapiens OX=9606 GN=PTPN3 PE=1 SV=2
10	A0A096MJA1	2.23e-50	196	967	0.089	0.109	A0A096MJA1_RAT Tyrosine-protein phosphatase non-receptor type OS=Rattus norvegicus OX=10116 GN=Ptpn3 PE=1 SV=2
11	F1LQQ5	2.94e-50	196	1018	0.089	0.103	F1LQQ5_RAT Tyrosine-protein phosphatase non-receptor type OS=Rattus norvegicus OX=10116 GN=Ptpn3 PE=3 SV=2
12	A0A8I5ZUL2	3.32e-50	195	935	0.089	0.112	A0A8I5ZUL2_RAT Tyrosine-protein phosphatase non-receptor type OS=Rattus norvegicus OX=10116 GN=Ptpn3 PE=1 SV=1
13	A0A8I5YBL2	4.33e-50	195	932	0.089	0.113	A0A8I5YBL2_RAT Tyrosine-protein phosphatase non-receptor type OS=Rattus norvegicus OX=10116 GN=Ptpn3 PE=1 SV=1
14	P28191	1.03e-48	191	1026	0.092	0.105	PTP1_CAEEL Tyrosine-protein phosphatase 1 OS=Caenorhabditis elegans OX=6239 GN=ptp-1 PE=2 SV=3
15	Q4JDL3	7.07e-48	179	420	0.089	0.248	PTN20_HUMAN Tyrosine-protein phosphatase non-receptor type 20 OS=Homo sapiens OX=9606 GN=PTPN20 PE=1 SV=1
16	P29351	1.31e-47	182	595	0.081	0.160	PTN6_MOUSE Tyrosine-protein phosphatase non-receptor type 6 OS=Mus musculus OX=10090 GN=Ptpn6 PE=1 SV=2
17	G3V9S3	1.96e-47	189	2460	0.100	0.048	G3V9S3_RAT Tyrosine-protein phosphatase non-receptor type 13 OS=Rattus norvegicus OX=10116 GN=Ptpn13 PE=1 SV=2
18	A0A8I6A6L8	2.49e-47	188	2266	0.100	0.052	A0A8I6A6L8_RAT Tyrosine-protein phosphatase non-receptor type 13 OS=Rattus norvegicus OX=10116 GN=Ptpn13 PE=3 SV=1
19	A0A8I5ZZK7	2.58e-47	188	2273	0.100	0.051	A0A8I5ZZK7_RAT Tyrosine-protein phosphatase non-receptor type 13 OS=Rattus norvegicus OX=10116 GN=Ptpn13 PE=3 SV=1
20	A0A0G2K1K1	2.78e-47	188	2445	0.100	0.048	A0A0G2K1K1_RAT Tyrosine-protein phosphatase non-receptor type 13 OS=Rattus norvegicus OX=10116 GN=Ptpn13 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00782 DSPc	4.4	18.6	Dual specificity phosphatase, catalytic domain
2	PF09380 FERM_C	6.3e-14	63.5	FERM C-terminal PH-like domain
3	PF00373 FERM_M	5.6e-17	73.6	FERM central domain
4	PF09379 FERM_N	1.8e-14	64.7	FERM N-terminal domain
5	PF14566 PTPlike_phytase	2.9e+02	13.0	Inositol hexakisphosphate
6	PF00102 Y_phosphatase	3e-68	241.4	Protein-tyrosine phosphatase
7	PF13350 Y_phosphatase3	5.4	18.5	Tyrosine phosphatase family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000452414

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000362680	0.996	Proto-oncogene tyrosine-protein kinase Src
2	9606.ENSP00000478212	0.984	A-kinase anchor protein 1, mitochondrial
3	9606.ENSP00000341189	0.919	Focal adhesion kinase 1
4	9606.ENSP00000346671	0.918	Tyrosine-protein kinase Fyn
5	9606.ENSP00000320821	0.911	Kinesin-like protein KIF1C
6	9606.ENSP00000337825	0.911	Tyrosine-protein kinase Lck
7	9606.ENSP00000462468	0.910	Tyrosine-protein kinase Yes
8	9606.ENSP00000427772	0.903	Protein KIBRA
9	9606.ENSP00000350224	0.834	Cytoplasmic tyrosine-protein kinase BMX
10	9606.ENSP00000280362	0.765	6-pyruvoyl tetrahydrobiopterin synthase
11	9606.ENSP00000240100	0.734	Dual specificity protein phosphatase 4
12	9606.ENSP00000360672	0.733	Partitioning defective 6 homolog beta
13	9606.ENSP00000451998	0.676	Echinoderm microtubule-associated protein-like 5
14	9606.ENSP00000438388	0.645	Kinesin-like protein KIF1A
15	9606.ENSP00000251038	0.643	Zinc finger CCCH domain-containing protein 14
16	9606.ENSP00000482306	0.575	Tetratricopeptide repeat protein 8
17	9606.ENSP00000384222	0.567	Protein WWC2
18	9606.ENSP00000377176	0.564	Spermatogenesis-associated protein 7
19	9606.ENSP00000265085	0.538	Cytoplasmic polyadenylation element-binding protein 4
20	9606.ENSP00000373244	0.538	Chondroitin sulfate proteoglycan 5

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0004725	1.000	protein tyrosine phosphatase activity
GO:0019899	0.558	enzyme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.987	cellular process
GO:0008152	0.933	metabolic process
GO:0071704	0.914	organic substance metabolic process
GO:0044238	0.914	primary metabolic process
GO:0044237	0.889	cellular metabolic process
GO:0006470	0.861	protein dephosphorylation
GO:0050789	0.775	regulation of biological process
GO:0050794	0.751	regulation of cellular process
GO:0032502	0.683	developmental process
GO:0048856	0.667	anatomical structure development
GO:0032501	0.628	multicellular organismal process
GO:0048731	0.484	system development
GO:0050896	0.340	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043229	1.000	intracellular organelle
GO:0005737	0.995	cytoplasm
GO:0043232	0.988	intracellular non-membrane-bounded organelle
GO:0043231	0.985	intracellular membrane-bounded organelle
GO:0031981	0.956	nuclear lumen
GO:0005654	0.953	nucleoplasm
GO:0005829	0.945	cytosol
GO:0016020	0.893	membrane
GO:0005856	0.872	cytoskeleton
GO:0071944	0.509	cell periphery
GO:0005886	0.455	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:10684	1.000	H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
EC:3.1.3.48	1.000	protein-tyrosine-phosphatase.

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