StarFunc result for job id Q16850

User Input

>input (503 residues)
MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKS
PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS
KNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK
EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL
LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE
VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDL
NLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD
FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFP
TVNYTTMIHTPENPVIRYKRRSK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q16850	1.000	1.000	2.195E-79	503	1.000	1.000	Q16850.pdb.gz	CP51A_HUMAN Lanosterol 14-alpha demethylase OS=Homo sapiens OX=9606 GN=CYP51A1 PE=1 SV=4
2	AFDB:Q1JPY5	0.912	0.919	4.214E-63	499	0.759	0.766	Q1JPY5.pdb.gz	CYP51_DANRE Lanosterol 14-alpha demethylase OS=Danio rerio OX=7955 GN=cyp51 PE=1 SV=1
3	AFDB:Q09736	0.865	0.878	2.470E-38	495	0.386	0.392	Q09736.pdb.gz	CP51_SCHPO Lanosterol 14-alpha demethylase erg11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=erg11 PE=1 SV=1
4	AFDB:B8N2C8	0.857	0.841	3.090E-37	513	0.372	0.365	B8N2C8.pdb.gz	CP51A_ASPFN Sterol 14-alpha demethylase OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=cyp51A PE=1 SV=1
5	AFDB:B8NUK6	0.846	0.831	3.233E-37	513	0.366	0.359	B8NUK6.pdb.gz	CP51C_ASPFN Sterol 14-alpha demethylase OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=cyp51c PE=1 SV=1
6	AFDB:Q9SAA9	0.856	0.882	9.987E-37	488	0.362	0.373	Q9SAA9.pdb.gz	CP511_ARATH Sterol 14-demethylase OS=Arabidopsis thaliana OX=3702 GN=CYP51G1 PE=1 SV=1
7	AFDB:P10613	0.855	0.817	6.940E-35	528	0.362	0.345	P10613.pdb.gz	CP51_CANAL Lanosterol 14-alpha demethylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ERG11 PE=1 SV=2
8	AFDB:P50859	0.855	0.808	7.260E-35	533	0.372	0.351	P50859.pdb.gz	CP51_CANGA Lanosterol 14-alpha demethylase OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=ERG11 PE=1 SV=1
9	PDB:5eqbA	0.851	0.807	2.241E-34	531	0.370	0.350	5eqbA.pdb.gz	Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
10	AFDB:P10614	0.849	0.808	2.243E-34	530	0.374	0.355	P10614.pdb.gz	CP51_YEAST Lanosterol 14-alpha demethylase CYP51 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ERG11 PE=1 SV=1
11	PDB:5jlcA	0.850	0.845	8.291E-34	506	0.356	0.354	5jlcA.pdb.gz	Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.
12	PDB:5v5zA	0.840	0.865	1.244E-33	488	0.364	0.375	5v5zA.pdb.gz	Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.
13	AFDB:B8NFL5	0.781	0.799	5.270E-32	491	0.358	0.367	B8NFL5.pdb.gz	CP51B_ASPFN Sterol 14-alpha demethylase OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=cyp51B PE=1 SV=2
14	PDB:1e9xA	0.760	0.845	3.497E-30	449	0.280	0.314	1e9xA.pdb.gz	Crystal Structure of Cytochrome P450 14Alpha -Sterol Demethylase (Cyp51) from Mycobacterium Tuberculosis in Complex with Azole Inhibitors
15	PDB:4bjkA	0.822	0.915	1.696E-29	450	0.298	0.333	4bjkA.pdb.gz	Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 as Anti-Chagas Agents.
16	PDB:2w0aA	0.743	0.871	2.542E-28	424	0.280	0.333	2w0aA.pdb.gz	Trypanosoma Cruzi Cyp51 Inhibitor Derived from a Mycobacterium Tuberculosis Screen Hit.
17	PDB:7mk8B	0.735	0.790	1.913E-19	465	0.193	0.209	7mk8B.pdb.gz	Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7.
18	PDB:5te8B	0.738	0.784	2.507E-19	471	0.187	0.200	5te8B.pdb.gz	Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.
19	PDB:7kvjA	0.678	0.812	3.439E-19	415	0.169	0.205	7kvjA.pdb.gz	Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength.
20	PDB:2j0dB	0.721	0.808	4.119E-19	445	0.183	0.207	2j0dB.pdb.gz	Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q16850	0.0	1048	509	1.000	0.988	CP51A_HUMAN Lanosterol 14-alpha demethylase OS=Homo sapiens OX=9606 GN=CYP51A1 PE=1 SV=4
2	Q1JPY5	0.0	813	499	0.757	0.764	CYP51_DANRE Lanosterol 14-alpha demethylase OS=Danio rerio OX=7955 GN=cyp51 PE=1 SV=1
3	Q64654	0.0	990	503	0.934	0.934	CP51A_RAT Lanosterol 14-alpha demethylase OS=Rattus norvegicus OX=10116 GN=Cyp51a1 PE=1 SV=1
4	Q8K0C4	0.0	974	503	0.913	0.913	CP51A_MOUSE Lanosterol 14-alpha demethylase OS=Mus musculus OX=10090 GN=Cyp51a1 PE=1 SV=1
5	Q09736	6.35e-115	350	495	0.396	0.402	CP51_SCHPO Lanosterol 14-alpha demethylase erg11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=erg11 PE=1 SV=1
6	Q9SAA9	6.33e-111	339	488	0.366	0.377	CP511_ARATH Sterol 14-demethylase OS=Arabidopsis thaliana OX=3702 GN=CYP51G1 PE=1 SV=1
7	B8NFL5	5.98e-107	329	491	0.366	0.375	CP51B_ASPFN Sterol 14-alpha demethylase OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=cyp51B PE=1 SV=2
8	B8N2C8	2.45e-103	320	513	0.366	0.359	CP51A_ASPFN Sterol 14-alpha demethylase OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=cyp51A PE=1 SV=1
9	B8NUK6	5.79e-103	320	513	0.360	0.353	CP51C_ASPFN Sterol 14-alpha demethylase OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=cyp51c PE=1 SV=1
10	P10614	4.54e-101	315	530	0.382	0.362	CP51_YEAST Lanosterol 14-alpha demethylase CYP51 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ERG11 PE=1 SV=1
11	P10613	4.24e-97	305	528	0.378	0.360	CP51_CANAL Lanosterol 14-alpha demethylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ERG11 PE=1 SV=2
12	P50859	1.69e-96	303	533	0.356	0.336	CP51_CANGA Lanosterol 14-alpha demethylase OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=ERG11 PE=1 SV=1
13	P9WPP9	1.84e-74	244	451	0.292	0.326	CP51_MYCTU Sterol 14alpha-demethylase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=cyp51 PE=1 SV=1
14	Q385E8	1.28e-70	234	481	0.304	0.318	Q385E8_TRYB2 Lanosterol 14-alpha-demethylase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.02.4080 PE=1 SV=1
15	Q9K498	1.01e-38	149	461	0.209	0.228	EIZFM_STRCO Bifunctional albaflavenone monooxygenase/terpene synthase OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) OX=100226 GN=SCO5223 PE=1 SV=1
16	Q82IY3	6.62e-36	140	449	0.197	0.220	PTLI_STRAW Pentalenene oxygenase OS=Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) OX=227882 GN=ptlI PE=1 SV=1
17	P9WPM5	9.75e-30	124	476	0.201	0.212	CP137_MYCTU Putative cytochrome P450 137 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=cyp137 PE=1 SV=1
18	Q8N118	1.16e-29	124	509	0.225	0.222	CP4X1_HUMAN Cytochrome P450 4X1 OS=Homo sapiens OX=9606 GN=CYP4X1 PE=1 SV=1
19	G3V861	3.03e-29	122	497	0.217	0.219	G3V861_RAT Cytochrome P450, family 26, subfamily a, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp26a1 PE=3 SV=1
20	Q9PUB4	3.88e-29	122	492	0.205	0.209	CP26A_CHICK Cytochrome P450 26A1 OS=Gallus gallus OX=9031 GN=CYP26A1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00067 p450	2.9e-71	252.3	Cytochrome P450

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000003100

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000261507	0.999	Methylsterol monooxygenase 1
2	9606.ENSP00000380837	0.999	Lanosterol synthase
3	9606.ENSP00000264027	0.998	Lathosterol oxidase
4	9606.ENSP00000359297	0.997	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
5	9606.ENSP00000279263	0.995	Delta(14)-sterol reductase
6	9606.ENSP00000480828	0.995	Squalene synthase
7	9606.ENSP00000254521	0.994	3-keto-steroid reductase
8	9606.ENSP00000265896	0.994	Squalene monooxygenase
9	9606.ENSP00000339883	0.989	Lamin-B receptor
10	9606.ENSP00000322706	0.988	Hydroxymethylglutaryl-CoA synthase, cytoplasmic
11	9606.ENSP00000360316	0.981	Delta(24)-sterol reductase
12	9606.ENSP00000287936	0.978	3-hydroxy-3-methylglutaryl-coenzyme A reductase
13	9606.ENSP00000370748	0.975	Isopentenyl-diphosphate Delta-isomerase 1
14	9606.ENSP00000354476	0.965	Sterol regulatory element-binding protein 2
15	9606.ENSP00000419970	0.958	NADPH--cytochrome P450 reductase
16	9606.ENSP00000348069	0.957	Sterol regulatory element-binding protein 1
17	9606.ENSP00000217971	0.956	Membrane-associated progesterone receptor component 1
18	9606.ENSP00000301012	0.956	Diphosphomevalonate decarboxylase
19	9606.ENSP00000349078	0.956	Farnesyl pyrophosphate synthase
20	9606.ENSP00000277010	0.931	Sigma non-opioid intracellular receptor 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0032451	1.000	demethylase activity
GO:0016709	1.000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0005488	0.959	binding
GO:0097159	0.575	organic cyclic compound binding
GO:0005515	0.565	protein binding
GO:1901363	0.483	heterocyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:1901615	0.997	organic hydroxy compound metabolic process
GO:0008202	0.997	steroid metabolic process
GO:0016125	0.988	sterol metabolic process
GO:0008610	0.986	lipid biosynthetic process
GO:0008203	0.978	cholesterol metabolic process
GO:1902653	0.976	secondary alcohol biosynthetic process
GO:0016126	0.976	sterol biosynthetic process
GO:0009987	0.613	cellular process
GO:0044237	0.448	cellular metabolic process
GO:0065007	0.386	biological regulation
GO:0050789	0.312	regulation of biological process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	0.999	endomembrane system
GO:0005737	0.999	cytoplasm
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0016020	0.980	membrane
GO:0031090	0.950	organelle membrane
GO:0005789	0.898	endoplasmic reticulum membrane
GO:0031410	0.310	cytoplasmic vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.14.13.-	1.000	With NADH or NADPH as one donor, and incorporation of one atom of oxygen.

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