StarFunc result for job id Q4U2R8

User Input

>input (563 residues)
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
RQQQEHQKYMVPLQASAQEKNGL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q4U2R8	1.000	1.000	7.247E-77	563	1.000	1.000	Q4U2R8.pdb.gz	S22A6_HUMAN Solute carrier family 22 member 6 OS=Homo sapiens OX=9606 GN=SLC22A6 PE=1 SV=1
2	AFDB:O35956	0.919	0.938	3.316E-65	551	0.845	0.864	O35956.pdb.gz	S22A6_RAT Solute carrier family 22 member 6 OS=Rattus norvegicus OX=10116 GN=Slc22a6 PE=1 SV=1
3	AFDB:Q6NYN7	0.895	0.900	1.353E-48	560	0.496	0.498	Q6NYN7.pdb.gz	S22A6_DANRE Solute carrier family 22 member 6 OS=Danio rerio OX=7955 GN=slc22a6 PE=2 SV=1
4	AFDB:Q8TCC7	0.875	0.909	1.239E-46	542	0.494	0.513	Q8TCC7.pdb.gz	S22A8_HUMAN Organic anion transporter 3 OS=Homo sapiens OX=9606 GN=SLC22A8 PE=1 SV=1
5	AFDB:Q9R1U7	0.889	0.933	1.770E-45	536	0.465	0.489	Q9R1U7.pdb.gz	S22A8_RAT Organic anion transporter 3 OS=Rattus norvegicus OX=10116 GN=Slc22a8 PE=1 SV=1
6	AFDB:F1QN13	0.821	0.829	7.908E-44	557	0.451	0.456	F1QN13.pdb.gz
7	AFDB:Q3ZAV1	0.848	0.863	1.621E-43	553	0.435	0.443	Q3ZAV1.pdb.gz	S22AC_RAT Solute carrier family 22 member 12 OS=Rattus norvegicus OX=10116 GN=Slc22a12 PE=1 SV=1
8	AFDB:Q96S37	0.910	0.926	1.691E-43	553	0.439	0.447	Q96S37.pdb.gz	S22AC_HUMAN Solute carrier family 22 member 12 OS=Homo sapiens OX=9606 GN=SLC22A12 PE=1 SV=1
9	AFDB:Q9NSA0	0.886	0.907	1.079E-40	550	0.405	0.415	Q9NSA0.pdb.gz	S22AB_HUMAN Solute carrier family 22 member 11 OS=Homo sapiens OX=9606 GN=SLC22A11 PE=1 SV=1
10	AFDB:Q8N4F4	0.902	0.919	5.369E-40	552	0.385	0.393	Q8N4F4.pdb.gz	S22AO_HUMAN Steroid transmembrane transporter SLC22A24 OS=Homo sapiens OX=9606 GN=SLC22A24 PE=1 SV=2
11	PDB:7zh0A	0.671	0.752	2.482E-25	495	0.298	0.339	7zh0A.pdb.gz
12	PDB:7wsmA	0.641	0.767	5.293E-12	464	0.162	0.196	7wsmA.pdb.gz	Cryo-EM structure of human glucose transporter GLUT4.
13	PDB:4gbyA	0.557	0.644	6.008E-12	475	0.162	0.192	4gbyA.pdb.gz	Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
14	PDB:7sptA	0.569	0.663	7.113E-12	470	0.153	0.183	7sptA.pdb.gz	Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.
15	PDB:4ja4A	0.532	0.666	2.988E-11	442	0.147	0.188	4ja4A.pdb.gz
16	PDB:6thaA	0.598	0.741	1.060E-10	448	0.123	0.154	6thaA.pdb.gz
17	PDB:7aaqA	0.544	0.615	1.154E-10	487	0.146	0.168	7aaqA.pdb.gz	Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H + symporter STP10.
18	PDB:4ybqB	0.509	0.600	1.176E-9	462	0.144	0.175	4ybqB.pdb.gz
19	PDB:6kkkA	0.491	0.706	3.822E-7	381	0.126	0.186	6kkkA.pdb.gz
20	PDB:6oopA	0.493	0.680	5.829E-7	392	0.123	0.176	6oopA.pdb.gz	Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O35956	0.0	983	551	0.860	0.878	S22A6_RAT Solute carrier family 22 member 6 OS=Rattus norvegicus OX=10116 GN=Slc22a6 PE=1 SV=1
2	Q4U2R8	0.0	1156	563	1.000	1.000	S22A6_HUMAN Solute carrier family 22 member 6 OS=Homo sapiens OX=9606 GN=SLC22A6 PE=1 SV=1
3	Q6NYN7	0.0	591	560	0.496	0.498	S22A6_DANRE Solute carrier family 22 member 6 OS=Danio rerio OX=7955 GN=slc22a6 PE=2 SV=1
4	Q8TCC7	0.0	530	542	0.485	0.504	S22A8_HUMAN Organic anion transporter 3 OS=Homo sapiens OX=9606 GN=SLC22A8 PE=1 SV=1
5	Q8VC69	0.0	950	545	0.833	0.861	S22A6_MOUSE Solute carrier family 22 member 6 OS=Mus musculus OX=10090 GN=Slc22a6 PE=1 SV=1
6	Q9R1U7	2.39e-179	518	536	0.471	0.494	S22A8_RAT Organic anion transporter 3 OS=Rattus norvegicus OX=10116 GN=Slc22a8 PE=1 SV=1
7	Q8CFZ5	2.72e-167	488	553	0.442	0.450	S22AC_MOUSE Solute carrier family 22 member 12 OS=Mus musculus OX=10090 GN=Slc22a12 PE=1 SV=1
8	Q3ZAV1	3.43e-158	465	553	0.437	0.445	S22AC_RAT Solute carrier family 22 member 12 OS=Rattus norvegicus OX=10116 GN=Slc22a12 PE=1 SV=1
9	Q96S37	8.19e-148	438	553	0.433	0.441	S22AC_HUMAN Solute carrier family 22 member 12 OS=Homo sapiens OX=9606 GN=SLC22A12 PE=1 SV=1
10	Q9NSA0	4.72e-143	426	550	0.405	0.415	S22AB_HUMAN Solute carrier family 22 member 11 OS=Homo sapiens OX=9606 GN=SLC22A11 PE=1 SV=1
11	Q8N4F4	1.07e-137	412	552	0.385	0.393	S22AO_HUMAN Steroid transmembrane transporter SLC22A24 OS=Homo sapiens OX=9606 GN=SLC22A24 PE=1 SV=2
12	Q7T3D2	8.38e-129	389	546	0.362	0.374	Q7T3D2_DANRE Solute carrier family 22 member 7b, tandem duplicate 1 OS=Danio rerio OX=7955 GN=zgc:63958 PE=2 SV=1
13	Q8VCA0	6.11e-128	387	551	0.362	0.370	S22AJ_MOUSE Solute carrier family 22 member 19 OS=Mus musculus OX=10090 GN=Slc22a19 PE=1 SV=1
14	F1Q880	1.42e-127	386	546	0.361	0.372	F1Q880_DANRE Solute carrier family 22 member 7b, tandem duplicate 1 OS=Danio rerio OX=7955 GN=slc22a7b PE=4 SV=1
15	A4IG77	3.56e-127	385	560	0.355	0.357	A4IG77_DANRE Solute carrier family 22 member 7 OS=Danio rerio OX=7955 GN=zgc:162334 PE=2 SV=1
16	Q91WU2	1.81e-123	375	540	0.361	0.376	S22A7_MOUSE Solute carrier family 22 member 7 OS=Mus musculus OX=10090 GN=Slc22a7 PE=1 SV=1
17	Q76M99	2.24e-121	370	551	0.361	0.368	S22AO_RAT Steroid transmembrane transporter SLC22A24 OS=Rattus norvegicus OX=10116 GN=Slc22a24 PE=1 SV=1
18	Q5RLM2	8.80e-121	368	535	0.368	0.387	S22A7_RAT Solute carrier family 22 member 7 OS=Rattus norvegicus OX=10116 GN=Slc22a7 PE=1 SV=1
19	Q8IVM8	3.54e-120	367	553	0.375	0.382	S22A9_HUMAN Organic anion transporter 7 OS=Homo sapiens OX=9606 GN=SLC22A9 PE=1 SV=1
20	Q9Y694	1.16e-119	366	548	0.382	0.392	S22A7_HUMAN Solute carrier family 22 member 7 OS=Homo sapiens OX=9606 GN=SLC22A7 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07690 MFS_1	4.1e-23	93.5	Major Facilitator Superfamily
2	PF00083 Sugar_tr	2.5e-29	114.1	Sugar (and other) transporter
3	PF01988 VIT1	4.3e+02	12.2	VIT family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000367102

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000365686	0.829	Solute carrier family 15 member 1
2	9606.ENSP00000380250	0.749	Sodium-dependent phosphate transport protein 4
3	9606.ENSP00000362135	0.739	YrdC domain-containing protein, mitochondrial
4	9606.ENSP00000264784	0.728	Solute carrier family 2, facilitated glucose transporter member 9
5	9606.ENSP00000244527	0.726	Sodium-dependent phosphate transport protein 1
6	9606.ENSP00000341963	0.721	Regulatory solute carrier protein family 1 member 1
7	9606.ENSP00000256958	0.706	Solute carrier organic anion transporter family member 1B1
8	9606.ENSP00000261196	0.706	Solute carrier organic anion transporter family member 1B3
9	9606.ENSP00000441269	0.706	Solute carrier organic anion transporter family member
10	9606.ENSP00000359478	0.703	Canalicular multispecific organic anion transporter 1
11	9606.ENSP00000270570	0.701	Multidrug and toxin extrusion protein 1
12	9606.ENSP00000366084	0.699	Multidrug resistance-associated protein 4
13	9606.ENSP00000305974	0.696	Solute carrier organic anion transporter family member 1A2
14	9606.ENSP00000237612	0.695	ATP-binding cassette sub-family G member 2
15	9606.ENSP00000326671	0.688	Multidrug and toxin extrusion protein 2
16	9606.ENSP00000417085	0.681	Solute carrier family 15 member 2
17	9606.ENSP00000279027	0.658	Solute carrier family 13 member 3
18	9606.ENSP00000219833	0.649	Sodium-dependent noradrenaline transporter
19	9606.ENSP00000480703	0.642	Proton-coupled folate transporter
20	9606.ENSP00000289575	0.636	Solute carrier organic anion transporter family member 2B1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0008514	1.000	organic anion transmembrane transporter activity
GO:0005515	0.997	protein binding
GO:0015318	0.982	inorganic molecular entity transmembrane transporter activity
GO:0022804	0.977	active transmembrane transporter activity
GO:0015291	0.968	secondary active transmembrane transporter activity
GO:1901702	0.596	salt transmembrane transporter activity
GO:0015075	0.561	monoatomic ion transmembrane transporter activity
GO:0022890	0.475	inorganic cation transmembrane transporter activity
GO:0008324	0.474	monoatomic cation transmembrane transporter activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071702	0.997	organic substance transport
GO:0015711	0.993	organic anion transport
GO:0046942	0.537	carboxylic acid transport
GO:0009987	0.534	cellular process
GO:0055085	0.381	transmembrane transport

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0098590	0.977	plasma membrane region
GO:0043227	0.804	membrane-bounded organelle
GO:0031982	0.752	vesicle
GO:0005576	0.615	extracellular region
GO:0043230	0.578	extracellular organelle
GO:1903561	0.572	extracellular vesicle
GO:0045178	0.568	basal part of cell
GO:0009925	0.552	basal plasma membrane
GO:0070062	0.551	extracellular exosome
GO:0016323	0.482	basolateral plasma membrane
GO:0045177	0.475	apical part of cell
GO:0016324	0.474	apical plasma membrane
GO:0005622	0.372	intracellular anatomical structure

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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