StarFunc result for job id Q58EX2

User Input

>input (2172 residues)
MWGLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW
LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEK
HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGR
YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVAN
ARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA
YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR
NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV
LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS
RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT
ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL
STVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARS
YQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQN
GILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS
KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEV
TMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGH
LSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTA
LTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGK
TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTS
PPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR
SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPS
SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRS
AQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI
WQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR
KGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTR
ELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA
PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNP
GATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE
AVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFL
AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSV
NVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFR
IRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE
ARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPA
QKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEM
MSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAE
SSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAY
SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPG
SRAPIAGFSSFV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q6V4S5	0.262	0.261	0.000	2176	0.942	0.940	Q6V4S5.pdb.gz	SDK2_MOUSE Protein sidekick-2 OS=Mus musculus OX=10090 GN=Sdk2 PE=1 SV=1
2	AFDB:Q8AV57	0.255	0.255	0.000	2177	0.868	0.866	Q8AV57.pdb.gz	SDK2_CHICK Protein sidekick-2 OS=Gallus gallus OX=9031 GN=SDK2 PE=1 SV=2
3	AFDB:Q8AV58	0.303	0.303	0.000	2169	0.589	0.590	Q8AV58.pdb.gz	SDK1_CHICK Protein sidekick-1 OS=Gallus gallus OX=9031 GN=SDK1 PE=1 SV=1
4	AFDB:Q92626	0.065	0.090	9.073E-26	1479	0.052	0.077	Q92626.pdb.gz	PXDN_HUMAN Peroxidasin homolog OS=Homo sapiens OX=9606 GN=PXDN PE=1 SV=2
5	PDB:5oj2B	0.070	0.205	1.276E-20	692	0.059	0.186	5oj2B.pdb.gz
6	AFDB:Q0KI85	0.071	0.130	1.417E-18	1087	0.054	0.109	Q0KI85.pdb.gz	Q0KI85_DROME Sidestep VI, isoform B OS=Drosophila melanogaster OX=7227 GN=side-VI PE=1 SV=1
7	PDB:1e07A	0.069	0.193	2.554E-15	642	0.044	0.148	1e07A.pdb.gz
8	PDB:5a42A	0.082	0.103	4.006E-13	1597	0.052	0.071	5a42A.pdb.gz
9	PDB:7q5zA	0.088	0.121	6.836E-13	1344	0.042	0.068	7q5zA.pdb.gz
10	PDB:7q1yA	0.079	0.104	1.375E-12	1374	0.046	0.073	7q1yA.pdb.gz
11	PDB:6pxvA	0.103	0.238	2.765E-12	823	0.031	0.081	6pxvA.pdb.gz
12	PDB:7sqcO0	0.056	0.092	9.106E-12	1140	0.051	0.096	7sqcO0.pdb.gz	Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
13	PDB:8dtlA	0.103	0.260	1.165E-11	741	0.029	0.084	8dtlA.pdb.gz
14	PDB:8eyyA	0.081	0.211	2.159E-11	775	0.027	0.076	8eyyA.pdb.gz
15	PDB:6h03A	0.082	0.113	2.544E-11	1223	0.029	0.051	6h03A.pdb.gz
16	AFDB:Q6NYV7	0.059	0.109	6.438E-11	1001	0.054	0.117	Q6NYV7.pdb.gz	Q6NYV7_DANRE Protocadherin 10a OS=Danio rerio OX=7955 GN=ZPCR1 PE=2 SV=1
17	AFDB:A0A0A6YY83	0.062	0.094	9.711E-11	1255	0.072	0.124	A0A0A6YY83.pdb.gz	A0A0A6YY83_MOUSE Protocadherin 7 OS=Mus musculus OX=10090 GN=Pcdh7 PE=1 SV=1
18	AFDB:Q8IU57	0.061	0.188	6.420E-8	520	0.033	0.138	Q8IU57.pdb.gz	INLR1_HUMAN Interferon lambda receptor 1 OS=Homo sapiens OX=9606 GN=IFNLR1 PE=1 SV=1
19	AFDB:Q9Y4C0	0.043	0.050	2.023E-4	1643	0.084	0.111	Q9Y4C0.pdb.gz	NRX3A_HUMAN Neurexin-3 OS=Homo sapiens OX=9606 GN=NRXN3 PE=1 SV=4
20	AFDB:F1R9D2	0.043	0.098	1.004E-2	825	0.028	0.073	F1R9D2.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O97394	0.0	1321	2224	0.389	0.379	SDK_DROME Protein sidekick OS=Drosophila melanogaster OX=7227 GN=sdk PE=1 SV=2
2	Q3UH53	0.0	2560	2193	0.581	0.576	SDK1_MOUSE Protein sidekick-1 OS=Mus musculus OX=10090 GN=Sdk1 PE=1 SV=1
3	Q58EX2	0.0	4459	2172	1.000	1.000	SDK2_HUMAN Protein sidekick-2 OS=Homo sapiens OX=9606 GN=SDK2 PE=1 SV=3
4	Q6V4S5	0.0	4150	2176	0.948	0.946	SDK2_MOUSE Protein sidekick-2 OS=Mus musculus OX=10090 GN=Sdk2 PE=1 SV=1
5	Q7Z5N4	0.0	2595	2213	0.582	0.572	SDK1_HUMAN Protein sidekick-1 OS=Homo sapiens OX=9606 GN=SDK1 PE=2 SV=3
6	Q8AV57	0.0	3877	2177	0.869	0.867	SDK2_CHICK Protein sidekick-2 OS=Gallus gallus OX=9031 GN=SDK2 PE=1 SV=2
7	Q8AV58	0.0	2637	2169	0.592	0.592	SDK1_CHICK Protein sidekick-1 OS=Gallus gallus OX=9031 GN=SDK1 PE=1 SV=1
8	P20241	4.36e-94	337	1302	0.134	0.223	NRG_DROME Neuroglian OS=Drosophila melanogaster OX=7227 GN=Nrg PE=1 SV=2
9	Q9P232	1.59e-87	313	1028	0.131	0.277	CNTN3_HUMAN Contactin-3 OS=Homo sapiens OX=9606 GN=CNTN3 PE=1 SV=3
10	F1NY98	1.50e-85	315	2034	0.164	0.175	DSCAM_CHICK Cell adhesion molecule DSCAM OS=Gallus gallus OX=9031 GN=DSCAM PE=1 SV=3
11	Q62682	7.54e-85	305	1028	0.131	0.276	CNTN3_RAT Contactin-3 OS=Rattus norvegicus OX=10116 GN=Cntn3 PE=1 SV=1
12	Q9UQ52	7.52e-84	301	1028	0.126	0.267	CNTN6_HUMAN Contactin-6 OS=Homo sapiens OX=9606 GN=CNTN6 PE=1 SV=1
13	O60469	3.62e-83	307	2012	0.163	0.175	DSCAM_HUMAN Cell adhesion molecule DSCAM OS=Homo sapiens OX=9606 GN=DSCAM PE=1 SV=2
14	Q8VHZ8	6.93e-83	306	2013	0.163	0.176	DSCAM_RAT Cell adhesion molecule DSCAM OS=Rattus norvegicus OX=10116 GN=Dscam PE=1 SV=1
15	Q9ERC8	8.87e-83	306	2013	0.163	0.176	DSCAM_MOUSE Cell adhesion molecule DSCAM OS=Mus musculus OX=10090 GN=Dscam PE=1 SV=1
16	P97528	1.06e-82	298	1028	0.128	0.269	CNTN6_RAT Contactin-6 OS=Rattus norvegicus OX=10116 GN=Cntn6 PE=1 SV=1
17	Q8IWV2	3.14e-82	296	1026	0.128	0.270	CNTN4_HUMAN Contactin-4 OS=Homo sapiens OX=9606 GN=CNTN4 PE=1 SV=1
18	E1C8P7	4.58e-82	304	2042	0.148	0.157	DSCL1_CHICK Cell adhesion molecule DSCAML1 OS=Gallus gallus OX=9031 GN=DSCAML1 PE=1 SV=2
19	Q9JMB8	2.01e-80	291	1028	0.126	0.266	CNTN6_MOUSE Contactin-6 OS=Mus musculus OX=10090 GN=Cntn6 PE=1 SV=2
20	Q8TD84	8.66e-80	296	2053	0.152	0.161	DSCL1_HUMAN Cell adhesion molecule DSCAML1 OS=Homo sapiens OX=9606 GN=DSCAML1 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF17425 Arylsulfotran_N	1.7e+02	13.6	Arylsulfotransferase Ig-like domain
2	PF05790 C2-set	2.2e+02	13.4	Immunoglobulin C2-set domain
3	PF08205 C2-set_2	1.6e-07	42.6	CD80-like C2-set immunoglobulin domain
4	PF00041 fn3	3.2e-173	573.9	Fibronectin type III domain
5	PF07679 I-set	2.9e-64	224.5	Immunoglobulin I-set domain
6	PF00047 ig	3.3e-33	125.0	Immunoglobulin domain
7	PF13895 Ig_2	6.6e-45	162.6	Immunoglobulin domain
8	PF13927 Ig_3	1.9e-65	228.7	Immunoglobulin domain
9	PF16681 Ig_5	4.1e-06	38.4	Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
10	PF18452 Ig_6	84	14.4	Immunoglobulin domain
11	PF17736 Ig_C17orf99	0.0029	29.0	C17orf99 Ig domain
12	PF09294 Interfer-bind	0.00031	32.4	Interferon-alpha/beta receptor, fibronectin type III
13	PF10179 NDNF	3.7e+02	12.6	Neuron-derived neurotrophic factor, first Fn(III) domain
14	PF16656 Pur_ac_phosph_N	6.1e-27	105.4	Purple acid Phosphatase, N-terminal domain
15	PF07686 V-set	1.9e-16	71.6	Immunoglobulin V-set domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000376421

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000270235	0.826	Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube
2	9606.ENSP00000173229	0.742	Netrin-1
3	9606.ENSP00000355613	0.649	Tripartite motif-containing protein 67
4	9606.ENSP00000359085	0.610	Netrin-G1
5	9606.ENSP00000376921	0.596	Netrin-G2
6	9606.ENSP00000252597	0.582	Usher syndrome type-1C protein-binding protein 1
7	9606.ENSP00000293973	0.582	Netrin-3
8	9606.ENSP00000332773	0.581	Immunoglobulin superfamily DCC subclass member 3
9	9606.ENSP00000246841	0.570	Leucine-rich repeat transmembrane protein FLRT1
10	9606.ENSP00000364526	0.540	Junctional protein associated with coronary artery disease
11	9606.ENSP00000353557	0.525	Solute carrier family 35 member F1
12	9606.ENSP00000242067	0.524	Protein PTHB1
13	9606.ENSP00000340297	0.524	Rho guanine nucleotide exchange factor 10
14	9606.ENSP00000383303	0.512	Down syndrome cell adhesion molecule

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0042802	0.976	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.990	cellular process
GO:0007275	0.979	multicellular organism development
GO:0048731	0.969	system development
GO:0007155	0.925	cell adhesion
GO:0016043	0.887	cellular component organization
GO:0007156	0.868	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007399	0.866	nervous system development
GO:0009653	0.854	anatomical structure morphogenesis
GO:0010842	0.842	retina layer formation
GO:0034330	0.787	cell junction organization
GO:0048869	0.762	cellular developmental process
GO:0050789	0.759	regulation of biological process
GO:0050794	0.754	regulation of cellular process
GO:0030154	0.750	cell differentiation
GO:0044085	0.664	cellular component biogenesis
GO:0048699	0.591	generation of neurons
GO:0030182	0.565	neuron differentiation
GO:0034329	0.479	cell junction assembly
GO:0050808	0.433	synapse organization
GO:0007416	0.420	synapse assembly
GO:0050896	0.331	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0110165	1.000	cellular anatomical entity
GO:0005575	1.000	cellular_component
GO:0071944	0.993	cell periphery
GO:0016020	0.993	membrane
GO:0030054	0.977	cell junction
GO:0005886	0.977	plasma membrane
GO:0045202	0.869	synapse
GO:0043226	0.689	organelle
GO:0005622	0.657	intracellular anatomical structure
GO:0005737	0.522	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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