StarFunc result for job id Q5D862

User Input

>input (2391 residues)
MTDLLRSVVTVIDVFYKYTKQDGECGTLSKGELKELLEKELHPVLKNPDDPDTVDVIMHM
LDRDHDRRLDFTEFLLMIFKLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEE
DTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKR
YHRSSCGHSWSGGKDRHGSSSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGL
SCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSNSSGCGRPQNASSSCQS
HRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGAREN
GQPQNCGGQWRTGSSQSSCCGQYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSKCDQYG
SGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFG
QHGSGSGQSSGFGQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQ
SSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGS
GQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGS
GSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFG
QHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQS
SGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRS
HQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQH
GTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSG
FGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSG
QTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHG
SGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSG
FAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSG
QSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQT
GSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGD
TTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGES
ESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRP
QSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSG
HSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQ
TTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHGTT
HGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQ
HGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGV
SHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRS
SGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQS
GHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQ
TTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAG
SHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHS
GVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGR
RGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQS
GHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQG
TTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAG
SQQRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGS
SQVWKHGSYGPAEYDYGHTGYGPSGGSRKSISNSHLSWSTDSTANKQLSRH

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q5D862	1.000	1.000	0.000	2391	1.000	1.000	Q5D862.pdb.gz	FILA2_HUMAN Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1
2	AFDB:Q2VIS4	0.052	0.053	6.801E-62	2362	0.418	0.423	Q2VIS4.pdb.gz	FILA2_MOUSE Filaggrin-2 OS=Mus musculus OX=10090 GN=Flg2 PE=1 SV=2
3	AFDB:Q8VHD8	0.057	0.056	2.856E-25	2496	0.358	0.343	Q8VHD8.pdb.gz	HORN_MOUSE Hornerin OS=Mus musculus OX=10090 GN=Hrnr PE=1 SV=1
4	PDB:2lucA	0.037	0.762	3.172E-6	105	0.015	0.352	2lucA.pdb.gz
5	PDB:6zdyA	0.036	0.751	3.838E-6	108	0.012	0.259	6zdyA.pdb.gz	Divalent cations influence the dimerization mode of murine S100A9 protein by modulating its disulfide bond pattern.
6	PDB:1k96A	0.036	0.883	4.644E-6	89	0.012	0.315	1k96A.pdb.gz	Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.
7	PDB:7psqG	0.038	0.762	4.644E-6	108	0.011	0.250	7psqG.pdb.gz	Crystal structure of S100A4 labeled with NU074381b.
8	PDB:5csnA	0.037	0.885	6.379E-6	94	0.014	0.351	5csnA.pdb.gz	Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
9	PDB:5hloC	0.037	0.848	1.130E-5	93	0.011	0.290	5hloC.pdb.gz	Crystal structure of human S100A8 in complex with zinc and calcium.
10	PDB:2kayA	0.037	0.867	1.283E-5	92	0.013	0.337	2kayA.pdb.gz	Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states
11	AFDB:Q05331	0.018	0.026	2.480E-5	1218	0.134	0.263	Q05331.pdb.gz	Q05331_HUMAN Profilaggrin (Fragment) OS=Homo sapiens OX=9606 PE=4 SV=1
12	PDB:2k2fA	0.037	0.781	2.579E-5	93	0.015	0.376	2k2fA.pdb.gz	S100A1 and Calmodulin Compete for the Same Binding Site on Ryanodine Receptor.
13	PDB:7ui5A	0.034	0.622	4.567E-5	114	0.014	0.289	7ui5A.pdb.gz	Evolution avoids a pathological stabilizing interaction in the immune protein S100A9.
14	AFDB:P97347	0.045	0.085	6.429E-5	1118	0.102	0.217	P97347.pdb.gz	RPTN_MOUSE Repetin OS=Mus musculus OX=10090 GN=Rptn PE=2 SV=2
15	PDB:2rgiA	0.032	0.615	1.626E-4	93	0.011	0.290	2rgiA.pdb.gz
16	AFDB:Q9UGU0	0.027	0.030	1.017E-1	1960	0.119	0.145	Q9UGU0.pdb.gz	TCF20_HUMAN Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3
17	AFDB:Q9VRM6	0.019	0.022	9.999E-1	1929	0.082	0.102	Q9VRM6.pdb.gz	Q9VRM6_DROME Lethal (3) persistent salivary gland 2 OS=Drosophila melanogaster OX=7227 GN=l(3)psg2 PE=4 SV=2
18	AFDB:Q9VWF2	0.022	0.025	1.464	2006	0.079	0.095	Q9VWF2.pdb.gz	SAYP_DROME Supporter of activation of yellow protein OS=Drosophila melanogaster OX=7227 GN=e(y)3 PE=1 SV=3
19	AFDB:A7KAX9	0.024	0.026	1.771	2087	0.082	0.094	A7KAX9.pdb.gz	RHG32_HUMAN Rho GTPase-activating protein 32 OS=Homo sapiens OX=9606 GN=ARHGAP32 PE=1 SV=1
20	AFDB:Q9EPQ8	0.023	0.026	1.887	1987	0.117	0.141	Q9EPQ8.pdb.gz	TCF20_MOUSE Transcription factor 20 OS=Mus musculus OX=10090 GN=Tcf20 PE=1 SV=3

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q5D862	0.0	4321	2391	1.000	1.000	FILA2_HUMAN Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1
2	Q2VIS4	1.97e-147	515	2362	0.147	0.149	FILA2_MOUSE Filaggrin-2 OS=Mus musculus OX=10090 GN=Flg2 PE=1 SV=2
3	Q383G9	1.36e-51	204	1464	0.097	0.159	Q383G9_TRYB2 Spt5 C-terminal domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.2885 PE=4 SV=1
4	Q86YZ3	2.30e-46	187	2850	0.027	0.022	HORN_HUMAN Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2
5	P20930	1.59e-32	142	4061	0.039	0.023	FILA_HUMAN Filaggrin OS=Homo sapiens OX=9606 GN=FLG PE=1 SV=3
6	Q05331	2.84e-30	134	1218	0.039	0.077	Q05331_HUMAN Profilaggrin (Fragment) OS=Homo sapiens OX=9606 PE=4 SV=1
7	Q6XPR3	1.56e-28	127	784	0.018	0.055	RPTN_HUMAN Repetin OS=Homo sapiens OX=9606 GN=RPTN PE=1 SV=1
8	Q9UBG3	2.36e-25	115	495	0.018	0.085	CRNN_HUMAN Cornulin OS=Homo sapiens OX=9606 GN=CRNN PE=1 SV=1
9	P97347	2.26e-23	111	1118	0.019	0.040	RPTN_MOUSE Repetin OS=Mus musculus OX=10090 GN=Rptn PE=2 SV=2
10	Q8CIU0	1.21e-20	100	501	0.020	0.096	Q8CIU0_RAT Profilaggrin (Fragment) OS=Rattus norvegicus OX=10116 GN=Flg PE=4 SV=1
11	A0A0B4J1F9	1.52e-17	92.8	1599	0.018	0.027	A0A0B4J1F9_MOUSE Trichohyalin OS=Mus musculus OX=10090 GN=Tchh PE=1 SV=1
12	O96124	2.04e-17	92.4	2441	0.088	0.086	O96124_PLAF7 Erythrocyte membrane protein 3 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0201900 PE=4 SV=1
13	Q5B4D5	2.19e-09	65.1	512	0.036	0.170	Q5B4D5_EMENI An-Nup2 Nuclear pore complex protein (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_04595 PE=4 SV=1
14	Q6FRG1	2.46e-09	65.1	658	0.075	0.272	Q6FRG1_CANGA Candida glabrata strain CBS138 chromosome H complete sequence OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=CAGL0H08844g PE=4 SV=1
15	Q07283	2.86e-09	65.5	1943	0.017	0.021	TRHY_HUMAN Trichohyalin OS=Homo sapiens OX=9606 GN=TCHH PE=1 SV=2
16	P25815	4.15e-09	58.2	95	0.015	0.368	S100P_HUMAN Protein S100-P OS=Homo sapiens OX=9606 GN=S100P PE=1 SV=2
17	Q9VCH5	1.82e-08	62.8	1960	0.050	0.061	NUP98_DROME Nuclear pore complex protein Nup98-Nup96 OS=Drosophila melanogaster OX=7227 GN=Nup98-96 PE=1 SV=3
18	P80511	2.19e-08	55.8	92	0.012	0.304	S10AC_HUMAN Protein S100-A12 OS=Homo sapiens OX=9606 GN=S100A12 PE=1 SV=2
19	Q387F2	3.88e-08	61.6	1553	0.038	0.059	Q387F2_TRYB2 Nucleoporin, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.03.0140 PE=4 SV=1
20	P31725	4.66e-08	55.5	113	0.012	0.248	S10A9_MOUSE Protein S100-A9 OS=Mus musculus OX=10090 GN=S100a9 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00036 EF-hand_1	95	14.0	EF hand
2	PF13499 EF-hand_7	1.5	20.6	EF-hand domain pair
3	PF01023 S_100	8.7e-13	59.0	S-100/ICaBP type calcium binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000373370

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000357736	0.793	Late cornified envelope like proline rich 1
2	9606.ENSP00000334644	0.779	Late cornified envelope protein 3C
3	9606.ENSP00000332163	0.773	Small proline-rich protein 4
4	9606.ENSP00000357702	0.727	Protein S100-A3
5	9606.ENSP00000357731	0.652	Loricrin
6	9606.ENSP00000306461	0.632	Cornifin-B
7	9606.ENSP00000357712	0.632	S100 calcium binding protein A7
8	9606.ENSP00000307297	0.624	Carbohydrate sulfotransferase 14
9	9606.ENSP00000480991	0.624	Carbohydrate sulfotransferase 9
10	9606.ENSP00000365465	0.620	Corneodesmosin
11	9606.ENSP00000357718	0.611	Protein S100-A7A
12	9606.ENSP00000475216	0.605	Keratinocyte proline rich protein
13	9606.ENSP00000357751	0.594	Cornifin-A
14	9606.ENSP00000357714	0.579	S100 calcium binding protein A7 like 2
15	9606.ENSP00000335358	0.562	Late cornified envelope protein 3B
16	9606.ENSP00000393417	0.558	Caspase-14
17	9606.ENSP00000481096	0.548	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
18	9606.ENSP00000352936	0.539	Serine protease inhibitor Kazal-type 5
19	9606.ENSP00000357753	0.538	Involucrin
20	9606.ENSP00000370867	0.538	Protein-glutamine gamma-glutamyltransferase E

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0046872	0.945	metal ion binding
GO:0005509	0.939	calcium ion binding
GO:0042802	0.335	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.997	cellular process
GO:0008544	0.979	epidermis development
GO:0060429	0.978	epithelium development
GO:0043588	0.975	skin development
GO:0098773	0.935	skin epidermis development
GO:0007155	0.880	cell adhesion
GO:0048729	0.797	tissue morphogenesis
GO:0002009	0.400	morphogenesis of an epithelium
GO:0048730	0.370	epidermis morphogenesis

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	0.998	endomembrane system
GO:0005634	0.998	nucleus
GO:0005576	0.997	extracellular region
GO:0070013	0.996	intracellular organelle lumen
GO:0099503	0.995	secretory vesicle
GO:0016020	0.992	membrane
GO:0030141	0.990	secretory granule
GO:0071944	0.986	cell periphery
GO:0005886	0.983	plasma membrane
GO:1904724	0.967	tertiary granule lumen
GO:0005829	0.949	cytosol
GO:0001533	0.879	cornified envelope
GO:0005615	0.830	extracellular space
GO:0070062	0.802	extracellular exosome
GO:0031981	0.317	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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