StarFunc result for job id Q5FWF4

User Input

>input (1079 residues)
MPRVHNIKKSLTPHISCVTNESDNLLDFLPDRLRAKLLPFQKDGIIFALKRNGRCMVADE
MGLGKTIQAIGITYFYKEEWPLLIVVPSSLRYPWTEEIEKWIPELSPEEINVIQNKTDVR
RMSTSKVTVLGYGLLTADAKTLIDALNNQNFKVVIVDESHYMKSRNATRSRILLPIVQKA
RRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCNAHIRYFGKRPQWDCRGAS
NLNELHQLLSDIMIRRLKTEVLTQLPPKVRQRIPFDLPSAAAKELNTSFEEWEKIMRTPN
SGAMETVMGLITRMFKQTAIAKAGAVKDYIKMMLQNDSLKFLVFAHHLSMLQACTEAVIE
NKTRYIRIDGSVSSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYWD
PGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDTLMWGMLNRKAQVTGSTLNGRKEKIQAE
EGDKEKWDFLQFAEAWTPNDSSEELRKEALFTHFEKEKQHDIRSFFVPQPKKRQLMTSCD
ESKRFREENTVVSSDPTKTAARDIIDYESDVEPETKRLKLAASEDHCSPSEETPSQSKQI
RTPLVESVQEAKAQLTTPAFPVEGWQCSLCTYINNSELPYCEMCETPQGSAVMQIDSLNH
IQDKNEKDDSQKDTSKKVQTISDCEKQALAQSEPGQLADSKEETPKIEKEDGLTSQPGNE
QWKSSDTLPVYDTLMFCASRNTDRIHIYTKDGKQMSCNFIPLDIKLDLWEDLPASFQLKQ
YRSLILRFVREWSSLTAMKQRIIRKSGQLFCSPILALEEITKQQTKQNCTKRYITKEDVA
VASMDKVKNVGGHVRLITKESRPRDPFTKKLLEDGACVPFLNPYTVQADLTVKPSTSKGY
LQAVDNEGNPLCLRCQQPTCQTKQACKANSWDSRFCSLKCQEEFWIRSNNSYLRAKVFET
EHGVCQLCNVNAQELFLRLRDAPKSQRKNLLYATWTSKLPLEQLNEMIRNPGEGHFWQVD
HIKPVYGGGGQCSLDNLQTLCTVCHKERTARQAKERSQVRRQSLASKHGSDITRFLVKK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q5FWF4	1.000	1.000	0.000	1079	1.000	1.000	Q5FWF4.pdb.gz	ZRAB3_HUMAN DNA annealing helicase and endonuclease ZRANB3 OS=Homo sapiens OX=9606 GN=ZRANB3 PE=1 SV=2
2	AFDB:Q57UN8	0.348	0.335	1.668E-27	1126	0.127	0.122	Q57UN8.pdb.gz	Q57UN8_TRYB2 DNA excision repair protein, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.5F10.540 PE=4 SV=1
3	AFDB:Q9ZV43	0.360	0.328	3.413E-26	1187	0.117	0.106	Q9ZV43.pdb.gz	CHR8_ARATH Protein CHROMATIN REMODELING 8 OS=Arabidopsis thaliana OX=3702 GN=CHR8 PE=2 SV=1
4	PDB:7oo3b	0.361	0.706	1.794E-25	534	0.095	0.191	7oo3b.pdb.gz	Structural basis of human transcription-DNA repair coupling.
5	AFDB:Q9UR24	0.353	0.390	4.110E-25	973	0.112	0.124	Q9UR24.pdb.gz	RHP26_SCHPO DNA repair protein rhp26 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rhp26 PE=4 SV=1
6	PDB:6jylK	0.319	0.655	2.407E-22	504	0.104	0.222	6jylK.pdb.gz	Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.
7	AFDB:O13682	0.322	0.272	1.965E-21	1288	0.143	0.120	O13682.pdb.gz	SWR1_SCHPO Helicase swr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=swr1 PE=3 SV=1
8	PDB:6tdaS	0.312	0.421	2.001E-21	783	0.105	0.144	6tdaS.pdb.gz	Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome.
9	AFDB:P53115	0.377	0.277	2.303E-21	1489	0.117	0.085	P53115.pdb.gz	INO80_YEAST Chromatin-remodeling ATPase INO80 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=INO80 PE=1 SV=1
10	AFDB:Q383K6	0.347	0.310	3.336E-21	1211	0.115	0.102	Q383K6.pdb.gz	Q383K6_TRYB2 SNF2 DNA repair protein, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.2500 PE=4 SV=1
11	PDB:7epuB	0.217	0.282	8.589E-20	748	0.111	0.160	7epuB.pdb.gz	Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.
12	PDB:6g0lM	0.312	0.388	1.383E-19	855	0.097	0.123	6g0lM.pdb.gz	Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome.
13	PDB:5vvrM	0.326	0.655	2.611E-19	503	0.094	0.201	5vvrM.pdb.gz	Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.
14	PDB:6g0lW	0.316	0.384	3.783E-19	878	0.101	0.124	6g0lW.pdb.gz	Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome.
15	PDB:6gejM	0.296	0.453	1.091E-18	688	0.116	0.182	6gejM.pdb.gz	Structure and dynamics of the yeast SWR1-nucleosome complex.
16	PDB:6uxwA	0.325	0.441	7.339E-18	778	0.106	0.147	6uxwA.pdb.gz	Cryo-EM structure of SWI/SNF complex bound to a nucleosome.
17	PDB:6kw3Y	0.321	0.596	1.314E-17	548	0.117	0.230	6kw3Y.pdb.gz	Structure of the RSC complex bound to the nucleosome.
18	AFDB:Q03099	0.273	0.221	1.019E-14	1374	0.088	0.069	Q03099.pdb.gz	YMN3_YEAST Y' element ATP-dependent helicase YML133C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YML133C PE=2 SV=1
19	AFDB:Q9FNM7	0.250	0.311	1.140E-6	850	0.066	0.084	Q9FNM7.pdb.gz	RH26_ARATH DEAD-box ATP-dependent RNA helicase 26 OS=Arabidopsis thaliana OX=3702 GN=RH26 PE=1 SV=2
20	AFDB:Q22308	0.273	0.288	4.760E-6	1022	0.055	0.058	Q22308.pdb.gz	Q22308_CAEEL RNA helicase OS=Caenorhabditis elegans OX=6239 GN=ddx-19 PE=1 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	F5GYN7	0.0	1306	625	0.579	1.000	F5GYN7_HUMAN Zinc finger RANBP2-type containing 3 OS=Homo sapiens OX=9606 GN=ZRANB3 PE=1 SV=2
2	Q5FWF4	0.0	2258	1079	1.000	1.000	ZRAB3_HUMAN DNA annealing helicase and endonuclease ZRANB3 OS=Homo sapiens OX=9606 GN=ZRANB3 PE=1 SV=2
3	Q9NZC9	3.93e-106	357	954	0.187	0.212	SMAL1_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1
4	B2ZFP3	5.28e-102	342	807	0.181	0.242	SMAL1_DANRE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Danio rerio OX=7955 GN=smarcal1 PE=2 SV=1
5	Q8BJL0	3.75e-100	339	910	0.175	0.208	SMAL1_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Mus musculus OX=10090 GN=Smarcal1 PE=1 SV=1
6	H7BYI2	5.84e-95	322	796	0.180	0.244	H7BYI2_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (Fragment) OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1
7	Q9VMX6	2.86e-85	294	755	0.153	0.219	SMAL1_DROME SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Drosophila melanogaster OX=7227 GN=Marcal1 PE=1 SV=2
8	Q385P2	3.62e-76	273	968	0.180	0.200	Q385P2_TRYB2 SNF2 DNA repair protein, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.02.2930 PE=4 SV=1
9	Q384V0	2.69e-60	226	952	0.146	0.166	Q384V0_TRYB2 SNF2 DNA repair protein, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.02.5060 PE=4 SV=1
10	Q9H4L7	6.83e-37	153	1026	0.138	0.145	SMRCD_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2
11	A0A0R4IR86	1.72e-36	152	1799	0.120	0.072	A0A0R4IR86_DANRE DNA helicase OS=Danio rerio OX=7955 GN=si:ch211-196l7.5 PE=1 SV=1
12	O14647	1.05e-34	147	1828	0.114	0.067	CHD2_HUMAN Chromodomain-helicase-DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=CHD2 PE=1 SV=2
13	E9PZM4	1.21e-34	147	1827	0.112	0.066	CHD2_MOUSE Chromodomain-helicase-DNA-binding protein 2 OS=Mus musculus OX=10090 GN=Chd2 PE=1 SV=1
14	Q585S8	2.13e-34	145	1160	0.116	0.108	Q585S8_TRYB2 Transcription activator, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=27H14.35 PE=4 SV=1
15	Q9S775	5.41e-34	144	1384	0.121	0.095	PKL_ARATH CHD3-type chromatin-remodeling factor PICKLE OS=Arabidopsis thaliana OX=3702 GN=PKL PE=1 SV=1
16	Q54Q16	7.37e-34	144	1917	0.117	0.066	Q54Q16_DICDI Chromo domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0284171 PE=4 SV=1
17	Q8SVZ5	1.28e-33	143	1256	0.121	0.104	Q8SVZ5_ENCCU Similarity to HELICASE MOT1 OS=Encephalitozoon cuniculi (strain GB-M1) OX=284813 GN=ECU03_1530 PE=1 SV=1
18	G5EF53	5.47e-33	141	1474	0.121	0.089	SWSN4_CAEEL SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 OS=Caenorhabditis elegans OX=6239 GN=swsn-4 PE=1 SV=1
19	Q60EX7	5.52e-33	140	1128	0.121	0.116	CHR19_ORYSJ Probable ATP-dependent DNA helicase CHR719 OS=Oryza sativa subsp. japonica OX=39947 GN=CHR719 PE=1 SV=1
20	P32597	6.81e-33	140	1359	0.120	0.095	STH1_YEAST Nuclear protein STH1/NPS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=STH1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07652 Flavi_DEAD	31	16.0	Flavivirus DEAD domain
2	PF00271 Helicase_C	1e-10	53.3	Helicase conserved C-terminal domain
3	PF01844 HNH	1.4e-05	36.5	HNH endonuclease
4	PF14279 HNH_5	2.7e+02	12.9	HNH endonuclease
5	PF04851 ResIII	4.1e-05	35.1	Type III restriction enzyme, res subunit
6	PF00176 SNF2-rel_dom	7.7e-29	112.2	SNF2-related domain
7	PF00641 zf-RanBP	0.00074	30.1	Zn-finger in Ran binding protein and others

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000264159

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000368458	0.934	Proliferating cell nuclear antigen
2	9606.ENSP00000298139	0.883	Werner syndrome ATP-dependent helicase
3	9606.ENSP00000267430	0.821	Fanconi anemia group M protein
4	9606.ENSP00000369335	0.808	F-box DNA helicase 1
5	9606.ENSP00000370150	0.792	ATPase WRNIP1
6	9606.ENSP00000307208	0.747	Nucleosome-remodeling factor subunit BPTF
7	9606.ENSP00000386239	0.744	Tonsoku-like protein
8	9606.ENSP00000307853	0.709	Crossover junction endonuclease MUS81
9	9606.ENSP00000416739	0.694	ATP-dependent DNA helicase Q1
10	9606.ENSP00000343633	0.692	Forkhead box protein N2
11	9606.ENSP00000331487	0.671	Nuclear protein localization protein 4 homolog
12	9606.ENSP00000317636	0.670	ATP-dependent DNA helicase Q5
13	9606.ENSP00000361628	0.669	RPA-related protein RADX
14	9606.ENSP00000387010	0.669	R3H domain containing 1
15	9606.ENSP00000351185	0.654	DNA replication ATP-dependent helicase/nuclease DNA2
16	9606.ENSP00000332576	0.649	Oxysterol-binding protein 2
17	9606.ENSP00000275053	0.645	Protein MMS22-like
18	9606.ENSP00000385735	0.644	Galactosylceramide sulfotransferase
19	9606.ENSP00000369497	0.635	Breast cancer type 2 susceptibility protein
20	9606.ENSP00000372088	0.624	DNA repair protein RAD51 homolog 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0140657	1.000	ATP-dependent activity
GO:0004520	1.000	DNA endonuclease activity
GO:1990814	0.999	DNA/DNA annealing activity
GO:0070530	0.998	K63-linked polyubiquitin modification-dependent protein binding
GO:0036310	0.834	ATP-dependent DNA/DNA annealing activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0050896	0.995	response to stimulus
GO:0071704	0.995	organic substance metabolic process
GO:0090304	0.991	nucleic acid metabolic process
GO:0006950	0.987	response to stress
GO:0051716	0.987	cellular response to stimulus
GO:0050789	0.985	regulation of biological process
GO:0050794	0.984	regulation of cellular process
GO:0033554	0.984	cellular response to stress
GO:0006259	0.983	DNA metabolic process
GO:0006974	0.968	cellular response to DNA damage stimulus
GO:0006261	0.957	DNA-templated DNA replication
GO:0051052	0.953	regulation of DNA metabolic process
GO:0048523	0.952	negative regulation of cellular process
GO:0006281	0.950	DNA repair
GO:0045005	0.944	DNA-templated DNA replication maintenance of fidelity
GO:0071103	0.936	DNA conformation change
GO:0010605	0.917	negative regulation of macromolecule metabolic process
GO:0031297	0.894	replication fork processing
GO:0051053	0.858	negative regulation of DNA metabolic process
GO:0009314	0.832	response to radiation
GO:0000018	0.820	regulation of DNA recombination
GO:0032392	0.789	DNA geometric change
GO:0006275	0.767	regulation of DNA replication
GO:0090329	0.740	regulation of DNA-templated DNA replication
GO:0045910	0.660	negative regulation of DNA recombination
GO:0008156	0.608	negative regulation of DNA replication
GO:0009411	0.418	response to UV
GO:2000104	0.315	negative regulation of DNA-templated DNA replication

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0005694	0.998	chromosome
GO:0032991	0.955	protein-containing complex
GO:0000228	0.946	nuclear chromosome
GO:0005657	0.863	replication fork
GO:0043596	0.762	nuclear replication fork

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.1.-.-	1.000	Acting on ester bonds.

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