StarFunc result for job id Q5H8C1

User Input

>input (2179 residues)
MNSLSWGAANAVLLLLLLAWASPTFISINRGVRVMKGHSAFLSGDDLKFAIPKEKDACKV
EVVMNEPITQRVGKLTPQVFDCHFLPNEVKYVHNGCPILDEDTVKLRLYRFTERDTFIET
FILWVYLLEPDCNIIHMSNNVLEVPEFNGLSQAIDKNLLRFDYDRMASLECTVSLDTART
RLPAHGQMVLGEPRPEEPRGDQPHSFFPESQLRAKLKCPGGSCTPGLKKIGSLKVSCEEF
LLMGLRYQHLDPPSPNIDYISIQLDLTDTRSKIVYKSESAWLPVYIRAGIPNQIPKAAFM
AVFILEVDQFILTSLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTW
KDLSDMQIAYQPPNSSHSERRHDEVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNT
GLSLLEGQSRAITWEQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFLFTVADLQAGV
VRYHHDDSDSTKDFVVFRIFDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILI
QGSMLRASDVDASDDYIFFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRH
FGGEIFEDSFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAY
ITKKQLHFIDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRS
FTQHAVNYMKVAYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEA
FTNPLKVTEGGQSIISTEHILISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSW
GDLHTLKVRYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMN
CSEGGEVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVT
YKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPV
DNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSV
GFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSII
INPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRG
FSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDGKHKI
LKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQ
NGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNNRSPA
LDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYG
QIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRTEHGVFEITLE
TVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGT
GLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQV
DQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGH
LENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQILELKW
SHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQF
DPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTKAAVKILDSKGGQCHPSYS
SNQSKHSTWEKGIWHLLPPGSSSSTTSGSFHLERRPLPSSMQLAVIRGDTLRGFDSTDLS
QRKLRTRGNGKTVRPSSVYRNGTDIIYNYHGIVSLKLEDDSFPTHKRKAKVSIISQPQKT
IKVAELPQADKVESTTDSHFPRQDQLPSFPKNCTLELKGLFHFEEGIQKLYQCNGIAWKA
WSPQTKDVEDKSCPAGWHQHSGYCHILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMR
WLWDIGGRKSFWIGLNDQVHAGHWEWIGGEPVAFTNGRRGPSQRSKLGKSCVLVQRQGKW
QTKDCRRAKPHNYVCSRKL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F1R4B2	0.448	0.450	0.000	2167	0.524	0.527	F1R4B2.pdb.gz
2	AFDB:Q5H8C1	1.000	1.000	0.000	2179	1.000	1.000	Q5H8C1.pdb.gz	FREM1_HUMAN FRAS1-related extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=FREM1 PE=1 SV=3
3	AFDB:Q4VA61	0.069	0.072	5.496E-33	2053	0.110	0.116	Q4VA61.pdb.gz	DSCL1_MOUSE Cell adhesion molecule DSCAML1 OS=Mus musculus OX=10090 GN=Dscaml1 PE=1 SV=2
4	AFDB:Q9VAF5	0.097	0.120	1.606E-31	1706	0.104	0.132	Q9VAF5.pdb.gz	CAD99_DROME Cadherin-99C OS=Drosophila melanogaster OX=7227 GN=Cad99C PE=1 SV=2
5	AFDB:Q9W213	0.078	0.107	1.250E-20	1395	0.066	0.103	Q9W213.pdb.gz	Q9W213_DROME Roundabout 1, isoform A OS=Drosophila melanogaster OX=7227 GN=robo1 PE=1 SV=3
6	AFDB:Q9VQW7	0.085	0.126	7.422E-20	1332	0.073	0.119	Q9VQW7.pdb.gz	Q9VQW7_DROME Echinoid, isoform A OS=Drosophila melanogaster OX=7227 GN=ed PE=1 SV=2
7	PDB:7sqcO0	0.081	0.127	2.139E-19	1140	0.055	0.104	7sqcO0.pdb.gz	Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
8	AFDB:A0A0A6YWY8	0.083	0.125	3.829E-19	1203	0.072	0.131	A0A0A6YWY8.pdb.gz	A0A0A6YWY8_MOUSE Protocadherin 9 OS=Mus musculus OX=10090 GN=Pcdh9 PE=1 SV=1
9	AFDB:Q9V7H4	0.067	0.082	1.295E-18	1567	0.065	0.091	Q9V7H4.pdb.gz	TM131_DROME Transmembrane protein 131 homolog OS=Drosophila melanogaster OX=7227 GN=CG8370 PE=1 SV=2
10	AFDB:B2RXR7	0.084	0.133	2.273E-18	1161	0.067	0.126	B2RXR7.pdb.gz	B2RXR7_MOUSE Pcdh9 protein OS=Mus musculus OX=10090 GN=Pcdh9 PE=2 SV=1
11	AFDB:F1R2D2	0.071	0.083	1.706E-17	1687	0.061	0.079	F1R2D2.pdb.gz
12	PDB:4aq1A	0.061	0.144	9.260E-13	721	0.038	0.115	4aq1A.pdb.gz	Sbsb Structure and Lattice Reconstruction Unveil Ca21 Triggered S-Layer Assembly
13	PDB:5oj2B	0.067	0.174	1.480E-12	692	0.048	0.152	5oj2B.pdb.gz
14	PDB:7q5zA	0.051	0.072	2.365E-12	1344	0.053	0.086	7q5zA.pdb.gz
15	PDB:1e07A	0.058	0.130	2.351E-11	642	0.041	0.140	1e07A.pdb.gz
16	PDB:5a42A	0.055	0.069	2.582E-11	1597	0.055	0.075	5a42A.pdb.gz
17	PDB:7q1yA	0.053	0.073	3.264E-11	1374	0.049	0.077	7q1yA.pdb.gz
18	PDB:6h03A	0.063	0.098	1.157E-10	1223	0.040	0.072	6h03A.pdb.gz
19	PDB:7vonA	0.053	0.069	1.206E-9	1399	0.042	0.066	7vonA.pdb.gz
20	PDB:4lnvA	0.080	0.109	1.524E-9	1276	0.037	0.063	4lnvA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B6IDE6	0.0	904	3113	0.280	0.196	B6IDE6_DANRE FRAS1-related extracellular matrix protein 2 precursor OS=Danio rerio OX=7955 GN=bla PE=1 SV=1
2	D7PS89	0.0	2338	2167	0.530	0.533	D7PS89_DANRE FRAS1-related extracellular matrix protein 1 precursor OS=Danio rerio OX=7955 GN=rfl PE=2 SV=1
3	D7PS91	0.0	905	3119	0.280	0.196	D7PS91_DANRE FRAS1-related extracellular matrix 2a OS=Danio rerio OX=7955 GN=bla PE=1 SV=1
4	P0C091	0.0	842	2139	0.281	0.287	FREM3_HUMAN FRAS1-related extracellular matrix protein 3 OS=Homo sapiens OX=9606 GN=FREM3 PE=3 SV=2
5	Q5H8B9	0.0	778	2123	0.268	0.275	FREM3_MOUSE FRAS1-related extracellular matrix protein 3 OS=Mus musculus OX=10090 GN=Frem3 PE=2 SV=2
6	Q5H8C1	0.0	4520	2179	1.000	1.000	FREM1_HUMAN FRAS1-related extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=FREM1 PE=1 SV=3
7	Q5SZK8	0.0	966	3169	0.298	0.205	FREM2_HUMAN FRAS1-related extracellular matrix protein 2 OS=Homo sapiens OX=9606 GN=FREM2 PE=1 SV=3
8	Q684R7	0.0	3480	2191	0.776	0.772	FREM1_MOUSE FRAS1-related extracellular matrix protein 1 OS=Mus musculus OX=10090 GN=Frem1 PE=1 SV=1
9	Q6NVD0	0.0	934	3160	0.288	0.199	FREM2_MOUSE FRAS1-related extracellular matrix protein 2 OS=Mus musculus OX=10090 GN=Frem2 PE=1 SV=2
10	Q80T14	3.10e-146	512	4010	0.212	0.115	FRAS1_MOUSE Extracellular matrix organizing protein FRAS1 OS=Mus musculus OX=10090 GN=Fras1 PE=1 SV=2
11	A0A0R4IQJ3	2.29e-131	465	4003	0.198	0.108	A0A0R4IQJ3_DANRE Extracellular matrix protein FRAS1 isoform X1 OS=Danio rerio OX=7955 GN=id:ibd5080 PE=1 SV=2
12	F1Q633	3.31e-131	464	3970	0.193	0.106	F1Q633_DANRE Extracellular matrix protein FRAS1 OS=Danio rerio OX=7955 GN=id:ibd5080 PE=1 SV=1
13	Q6UVK1	5.36e-49	196	2322	0.155	0.146	CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 OS=Homo sapiens OX=9606 GN=CSPG4 PE=1 SV=2
14	Q00657	2.03e-48	194	2326	0.156	0.146	CSPG4_RAT Chondroitin sulfate proteoglycan 4 OS=Rattus norvegicus OX=10116 GN=Cspg4 PE=1 SV=2
15	Q8VHY0	4.81e-48	192	2327	0.153	0.144	CSPG4_MOUSE Chondroitin sulfate proteoglycan 4 OS=Mus musculus OX=10090 GN=Cspg4 PE=1 SV=3
16	A3RLX3	1.02e-23	112	2381	0.149	0.136	A3RLX3_DROME Kon-tiki OS=Drosophila melanogaster OX=7227 GN=Kon PE=1 SV=1
17	Q9VJ82	1.23e-23	112	2381	0.149	0.136	Q9VJ82_DROME Kon-tiki, isoform B OS=Drosophila melanogaster OX=7227 GN=kon PE=4 SV=3
18	Q960X3	4.41e-14	79.7	514	0.055	0.232	Q960X3_DROME LD31354p OS=Drosophila melanogaster OX=7227 GN=kon PE=2 SV=1
19	L0N7P8	2.91e-11	67.4	216	0.018	0.181	L0N7P8_ONCMY CD209 antigen-like protein A OS=Oncorhynchus mykiss OX=8022 GN=cd209A PE=2 SV=1
20	Q75ZI3	1.78e-09	65.9	1570	0.017	0.024	Q75ZI3_DANRE Dermacan OS=Danio rerio OX=7955 GN=dcan PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF17963 Big_9	1.2e-13	62.9	Bacterial Ig domain
2	PF16184 Cadherin_3	1e-233	770.9	Cadherin-like
3	PF17803 Cadherin_4	1.3e-14	65.8	Bacterial cadherin-like domain
4	PF03160 Calx-beta	0.00069	31.1	Calx-beta domain
5	PF19309 Frem_N	2.2e-29	114.2	Frem protein N-terminal domain
6	PF00059 Lectin_C	1.6e-10	53.0	Lectin C-type domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000412940

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000389252	0.928	Nephronectin
2	9606.ENSP00000367316	0.927	Integrin alpha-8
3	9606.ENSP00000326330	0.908	Fraser extracellular matrix complex subunit 1
4	9606.ENSP00000280481	0.896	FRAS1-related extracellular matrix protein 2
5	9606.ENSP00000379350	0.828	Integrin beta-1
6	9606.ENSP00000271588	0.740	Hemicentin-1
7	9606.ENSP00000428544	0.724	Transmembrane protein 200B
8	9606.ENSP00000381098	0.710	Glutamate receptor-interacting protein 1
9	9606.ENSP00000376708	0.653	Von Willebrand factor A domain containing 2
10	9606.ENSP00000290536	0.642	Meiosis 1 arrest protein
11	9606.ENSP00000294964	0.640	Extracellular tyrosine-protein kinase PKDCC
12	9606.ENSP00000307911	0.640	Carbohydrate sulfotransferase 2
13	9606.ENSP00000469759	0.615	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
14	9606.ENSP00000417610	0.597	Ras-related protein Rab-23
15	9606.ENSP00000264864	0.556	Phosphatidylinositol 4-kinase type 2-beta
16	9606.ENSP00000370303	0.529	Palmitoyltransferase ZDHHC21
17	9606.ENSP00000417638	0.527	Testis anion transporter 1
18	9606.ENSP00000382356	0.517	Collagen alpha-1(XXVIII) chain
19	9606.ENSP00000370077	0.503	Coiled-coil domain containing 171

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0032501	0.977	multicellular organismal process
GO:0007275	0.974	multicellular organism development
GO:0048731	0.917	system development
GO:0009653	0.873	anatomical structure morphogenesis
GO:0009987	0.862	cellular process
GO:0048513	0.767	animal organ development
GO:0001501	0.622	skeletal system development
GO:1904888	0.612	cranial skeletal system development
GO:0048705	0.526	skeletal system morphogenesis
GO:0065007	0.449	biological regulation
GO:0050789	0.444	regulation of biological process
GO:0050794	0.416	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0062023	0.998	collagen-containing extracellular matrix
GO:0016020	0.773	membrane
GO:0043227	0.728	membrane-bounded organelle
GO:0043231	0.692	intracellular membrane-bounded organelle
GO:0005604	0.645	basement membrane
GO:0005737	0.563	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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