StarFunc result for job id Q5I0G3

User Input

>input (518 residues)
MAKFVIAGRADCPYYAKTELVADYLQKNLPDFRIHKITQRPEVWEDWLKDVCEKNKWSHK
NSPIIWRELLDRGGKGLLLGGYNEFLEHAQLYYDVTSSMTTELMMVIAQENLGAHIEKEQ
EEEALKTCINPLQVWITSASAPACYNLIPILTSGEVFGMHTEISITLFDNKQAEEHLKSL
VVETQDLASPVLRSVSICTKVEEAFRQAHVIVVLDDSTNKEVFTLEDCLRSRVPLCRLYG
YLIEKNAHESVRVIVGGRTFVNLKTVLLMRYAPRIAHNIIAVALGVEGEAKAILARKLKT
APSYIKDVIIWGNISGNNYVDLRKTRVYRYESAIWGPLHYSRPVLNLIFDSEWVKREFVA
ILKNLTTTGRQFGGILAAHSIATTLKYWYHGSPPGEIVSLGILSEGQFGIPKGIVFSMPV
KFENGTWVVLTDLKDVEISEQIMTRMTSDLIQEKLVALGDKIHFQPYQSGHKDLVPDEEK
NLAMSDAAEFPNQIPQTTFEKPQSLEFLNEFEGKTVES

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9FJU0	0.584	0.879	3.866E-29	339	0.178	0.271	Q9FJU0.pdb.gz	MDHC3_ARATH Malate dehydrogenase 3, cytoplasmic OS=Arabidopsis thaliana OX=3702 GN=MDH3 PE=2 SV=1
2	AFDB:F1C7I4	0.585	0.899	5.371E-29	332	0.191	0.298	F1C7I4.pdb.gz	MDHC_TAESO Malate dehydrogenase, cytoplasmic OS=Taenia solium OX=6204 GN=MDH PE=1 SV=1
3	AFDB:Q9UAV5	0.582	0.883	1.697E-28	336	0.170	0.262	Q9UAV5.pdb.gz	MDHC_CAEEL Malate dehydrogenase, cytoplasmic OS=Caenorhabditis elegans OX=6239 GN=mdh-1 PE=1 SV=1
4	AFDB:Q8MQS7	0.578	0.874	2.233E-28	337	0.174	0.267	Q8MQS7.pdb.gz	Q8MQS7_DROME Malate dehydrogenase OS=Drosophila melanogaster OX=7227 GN=Mdh1 PE=2 SV=1
5	AFDB:O88989	0.582	0.890	1.220E-27	334	0.181	0.281	O88989.pdb.gz	MDHC_RAT Malate dehydrogenase, cytoplasmic OS=Rattus norvegicus OX=10116 GN=Mdh1 PE=1 SV=3
6	AFDB:P57106	0.579	0.888	1.289E-27	332	0.168	0.262	P57106.pdb.gz	MDHC2_ARATH Malate dehydrogenase 2, cytoplasmic OS=Arabidopsis thaliana OX=3702 GN=MDH2 PE=1 SV=1
7	PDB:5nueB	0.578	0.886	4.258E-27	332	0.172	0.268	5nueB.pdb.gz	Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
8	AFDB:Q383F3	0.574	0.891	5.971E-26	328	0.147	0.232	Q383F3.pdb.gz	Q383F3_TRYB2 Malate dehydrogenase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.3040 PE=3 SV=1
9	AFDB:Q4Q7X6	0.571	0.895	1.601E-25	324	0.156	0.250	Q4Q7X6.pdb.gz	Q4Q7X6_LEIMA Malate dehydrogenase OS=Leishmania major OX=5664 GN=cMDH PE=1 SV=1
10	PDB:4mdhA	0.574	0.874	1.972E-25	334	0.178	0.275	4mdhA.pdb.gz	Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution.
11	AFDB:P9WK13	0.566	0.873	8.752E-25	329	0.160	0.252	P9WK13.pdb.gz	MDH_MYCTU Malate dehydrogenase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=mdh PE=1 SV=1
12	AFDB:Q54D04	0.574	0.841	2.222E-24	348	0.166	0.247	Q54D04.pdb.gz	MDHB_DICDI Probable malate dehydrogenase 2, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=mdhB PE=1 SV=1
13	PDB:4i1iA	0.556	0.882	2.322E-24	320	0.151	0.244	4i1iA.pdb.gz	Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin in complex with NAD
14	PDB:4tvoA	0.571	0.882	9.651E-24	328	0.160	0.253	4tvoA.pdb.gz
15	PDB:5nfrA	0.480	0.757	7.657E-14	313	0.083	0.137	5nfrA.pdb.gz
16	PDB:1oc4A	0.493	0.771	5.815E-13	315	0.089	0.146	1oc4A.pdb.gz	Crystal Structure of Plasmodium Berghei Lactate Dehydrogenase Indicates the Unique Structural Differences of These Enzymes are Shared Across the Plasmodium Genus
17	PDB:4qsmA	0.495	0.739	5.815E-13	332	0.081	0.127	4qsmA.pdb.gz	Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.
18	PDB:7dbjA	0.483	0.725	1.941E-12	333	0.100	0.156	7dbjA.pdb.gz	Identification of the first highly selective inhibitor of human lactate dehydrogenase B.
19	PDB:1ldbA	0.457	0.759	3.547E-12	294	0.069	0.122	1ldbA.pdb.gz	Structure determination and refinement of Bacillus stearothermophilus lactate dehydrogenase.
20	PDB:7epmA	0.480	0.712	4.416E-12	335	0.083	0.128	7epmA.pdb.gz	Identification of human LDHC4 as a potential target for anticancer drug discovery.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9FJU0	4.33e-35	136	339	0.180	0.274	MDHC3_ARATH Malate dehydrogenase 3, cytoplasmic OS=Arabidopsis thaliana OX=3702 GN=MDH3 PE=2 SV=1
2	P14152	1.52e-34	134	334	0.189	0.293	MDHC_MOUSE Malate dehydrogenase, cytoplasmic OS=Mus musculus OX=10090 GN=Mdh1 PE=1 SV=3
3	O88989	3.43e-34	134	334	0.187	0.290	MDHC_RAT Malate dehydrogenase, cytoplasmic OS=Rattus norvegicus OX=10116 GN=Mdh1 PE=1 SV=3
4	P11708	3.95e-34	133	334	0.181	0.281	MDHC_PIG Malate dehydrogenase, cytoplasmic OS=Sus scrofa OX=9823 GN=MDH1 PE=1 SV=4
5	P40925	1.13e-33	132	334	0.183	0.284	MDHC_HUMAN Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4
6	V9HWF2	1.13e-33	132	334	0.183	0.284	V9HWF2_HUMAN Malate dehydrogenase OS=Homo sapiens OX=9606 GN=HEL-S-32 PE=2 SV=1
7	A0A5K1VW95	1.25e-33	132	353	0.183	0.269	A0A5K1VW95_HUMAN Malate dehydrogenase OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=1
8	F1C7I4	2.29e-32	128	332	0.195	0.304	MDHC_TAESO Malate dehydrogenase, cytoplasmic OS=Taenia solium OX=6204 GN=MDH PE=1 SV=1
9	P93819	4.28e-32	127	332	0.170	0.265	MDHC1_ARATH Malate dehydrogenase 1, cytoplasmic OS=Arabidopsis thaliana OX=3702 GN=MDH1 PE=1 SV=2
10	Q9VKX2	6.67e-31	124	337	0.174	0.267	Q9VKX2_DROME Malate dehydrogenase OS=Drosophila melanogaster OX=7227 GN=Mdh1 PE=1 SV=2
11	P57106	1.01e-30	124	332	0.170	0.265	MDHC2_ARATH Malate dehydrogenase 2, cytoplasmic OS=Arabidopsis thaliana OX=3702 GN=MDH2 PE=1 SV=1
12	Q5ZME2	4.40e-30	122	334	0.176	0.272	MDHC_CHICK Malate dehydrogenase, cytoplasmic OS=Gallus gallus OX=9031 GN=MDH1 PE=2 SV=1
13	Q8MQS7	4.75e-30	122	337	0.172	0.264	Q8MQS7_DROME Malate dehydrogenase OS=Drosophila melanogaster OX=7227 GN=Mdh1 PE=2 SV=1
14	Q9UAV5	1.87e-27	115	336	0.178	0.274	MDHC_CAEEL Malate dehydrogenase, cytoplasmic OS=Caenorhabditis elegans OX=6239 GN=mdh-1 PE=1 SV=1
15	P9WK13	6.06e-25	107	329	0.160	0.252	MDH_MYCTU Malate dehydrogenase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=mdh PE=1 SV=1
16	Q4Q7X6	3.00e-23	102	324	0.168	0.269	Q4Q7X6_LEIMA Malate dehydrogenase OS=Leishmania major OX=5664 GN=cMDH PE=1 SV=1
17	Q54D04	8.42e-23	101	348	0.166	0.247	MDHB_DICDI Probable malate dehydrogenase 2, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=mdhB PE=1 SV=1
18	Q95WV4	1.40e-22	100	328	0.158	0.250	Q95WV4_9TRYP Malate dehydrogenase OS=Trypanosoma brucei OX=5691 PE=3 SV=1
19	Q383F3	1.64e-22	100	328	0.158	0.250	Q383F3_TRYB2 Malate dehydrogenase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.3040 PE=3 SV=1
20	Q8H1E2	8.78e-21	97.1	443	0.180	0.210	MDHNP_ARATH Malate dehydrogenase [NADP], chloroplastic OS=Arabidopsis thaliana OX=3702 GN=At5g58330 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00056 Ldh_1_N	4.3e+02	12.4	lactate/malate dehydrogenase, NAD binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000363533

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000356982	0.723	Ubiquitin-fold modifier-conjugating enzyme 1
2	9606.ENSP00000355518	0.703	Fumarate hydratase, mitochondrial
3	9606.ENSP00000253382	0.702	Acetyl-coenzyme A synthetase, cytoplasmic
4	9606.ENSP00000360124	0.671	Phosphoglucomutase-1
5	9606.ENSP00000379678	0.666	Phosphoglucomutase-like protein 5
6	9606.ENSP00000327070	0.654	Malate dehydrogenase, mitochondrial
7	9606.ENSP00000408025	0.651	Fructose-1,6-bisphosphatase 1
8	9606.ENSP00000363216	0.650	2-oxoglutarate dehydrogenase-like, mitochondrial
9	9606.ENSP00000264932	0.647	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
10	9606.ENSP00000217901	0.645	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
11	9606.ENSP00000452762	0.644	Electron transfer flavoprotein subunit alpha, mitochondrial
12	9606.ENSP00000342056	0.629	Citrate synthase, mitochondrial
13	9606.ENSP00000349142	0.623	ATP synthase subunit gamma, mitochondrial
14	9606.ENSP00000377446	0.619	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
15	9606.ENSP00000222673	0.612	2-oxoglutarate dehydrogenase, mitochondrial
16	9606.ENSP00000370223	0.612	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
17	9606.ENSP00000316898	0.600	Uncharacterized protein C12orf54
18	9606.ENSP00000446743	0.595	Uncharacterized protein
19	9606.ENSP00000316924	0.587	Acetyl-coenzyme A synthetase 2-like, mitochondrial
20	9606.ENSP00000321259	0.580	Transaldolase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0016616	0.998	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016615	0.959	malate dehydrogenase activity
GO:0030060	0.954	L-malate dehydrogenase activity
GO:0097159	0.606	organic cyclic compound binding
GO:1901363	0.592	heterocyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0044237	0.987	cellular metabolic process
GO:0071704	0.986	organic substance metabolic process
GO:0044238	0.972	primary metabolic process
GO:0044281	0.947	small molecule metabolic process
GO:0043436	0.330	oxoacid metabolic process
GO:0019752	0.316	carboxylic acid metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.999	cytoplasm
GO:0043227	0.998	membrane-bounded organelle
GO:0070013	0.975	intracellular organelle lumen
GO:0005576	0.969	extracellular region
GO:0005829	0.962	cytosol
GO:0070062	0.949	extracellular exosome
GO:0043231	0.945	intracellular membrane-bounded organelle
GO:0032991	0.482	protein-containing complex
GO:0005634	0.355	nucleus
GO:0016020	0.320	membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.1.1.-	0.998	With NAD(+) or NADP(+) as acceptor.
RHEA:21432	0.954	(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
EC:1.1.1.37	0.954	malate dehydrogenase.

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