StarFunc result for job id Q5TCS8

User Input

>input (1911 residues)
MTSQEKTEEYPFADIFDEDETERNFLLSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVE
ALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITEIPSL
SQDAMTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV
IENHRKKKKEAQKDGKGEEEEEEEEQEEEEAFIAEMQMVAEILHHLVQRPEDYLENVENI
VKLYKETILQTLEEVMAEHNPQYLIELNGNKPAEELFMIVMDRLKYLNLKRAAILTKLQG
AEEEINDTMENDELFRTLASYKLIAPRYRWQRSKWGRTCPVNLKDGNIYSGLPDYSVSFL
GKIYCLSSEEALKPFLLNPRPYLLPPMPGPPCKVFILGPQYSGKTTLCNMLAENYKGKVV
DYAQLVQPRFDKARETLVENTIAEATAAAIKVVKEKLLRELQARKQAETALREFQRQYEK
MEFGVFPMEATHSSIDEEGYIQGSQRDRGSSLVDTEEAKTKSENVLHDQAAKVDKDDGKE
TGETFTFKRHSQDASQDVKLYSDTAPTEDLIEEVTADHPEVVTMIEETIKMSQDINFEQP
YEKHAEILQEVLGEVMEENKDRFPGAPKYGGWIVDNCPIVKELWMALIKKGIIPDLVIYL
SDTENNGKCLFNRIYLQKKSEIDSKILERLLEELQKKKKEEEEARKATEEELRLEEENRR
LLELMKVKAKEAEETDNEDEEEIEGDELEVHEEPEASHDTRGSWLPEEFEASEVPETEPE
AVSEPIEETTVETEIPKGSKEGLEIEKLSETVVLPEFPEDSYPDVPEMEPFKEKIGSFII
LWKQLEATISEAYIKILNLEIADRTPQELLQKVVETMEKPFQYTAWELTGEDYEEETEDY
QTEAEVDEELEEEEEEEGEDKMKERKRHLGDTKHFCPVVLKENFILQPGNTEEAAKYREK
IYYFSSAEAKEKFLEHPEDYVAHEEPLKAPPLRICLVGPQGSGKTMCGRQLAEKLNIFHI
QFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKVEEENTKKQLPEVQ
LTEEEEVIKSSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRG
FFPDAAVFIQVDDQDIFDRLLPAQIEKWKLKQKKKLERKKLIKDMKAKIRVDTIAKRRAE
LILERDKKRRENVVRDDEEISEEELEEDNDDIENILEDEFPKDEEEMSGEEDEEQETDAI
ERLRGELGEKFEADTHNLQIIQDELERYLIPIISINGARRNHIVQYTLNMKLKPLVENRA
SIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQY
IYFLSSKETKEKFMKNPIKYIRQPKPKPTVPIRIIIVGPPKSGKTTVAKKITSEYGLKHL
SIGGALRYVLNNHPETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAGVVIDGY
PVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPYPLHNSAQIVAVNNV
KYRKNIGEIRQYYQEQHQNWYVIDGFHSKWWVWNEVIKNVQMVNKYMQTYLERIKAGKAA
CIDKLCITPQELLSRLGEFEQFCPVSLAESQELFDCSATDSLEFAAEFRGHYYKMSSQEK
LNKFLENPELYVPPLAPHPLPSADMIPKRLTLSELKSRFPKCAELQGYCPVTYKDGNQRY
EALVPGSINYALEYHNRIYICENKEKLQKFLRSPLKYWEQKLPHKLPPLREPILLTSLPL
PGYLEQGIATSLIKAMNAAGCLKPKFPFLSIRRSALLYIALHLKAFNPKGSEYTRKKYKK
KMEQFMESCELITYLGAKMTRKYKEPQFRAIDFDHKLKTFLSLRNIDPING

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R9YJL3	0.722	0.779	0.000	1762	0.401	0.435	A0A2R9YJL3.pdb.gz	A0A2R9YJL3_DANRE Cilia- and flagella-associated protein 206 OS=Danio rerio OX=7955 GN=si:ch211-199m3.4 PE=3 SV=1
2	AFDB:Q5TCS8	1.000	1.000	0.000	1911	1.000	1.000	Q5TCS8.pdb.gz	KAD9_HUMAN Adenylate kinase 9 OS=Homo sapiens OX=9606 GN=AK9 PE=1 SV=2
3	AFDB:Q32M07	0.095	0.360	5.294E-16	479	0.051	0.205	Q32M07.pdb.gz	KAD8_MOUSE Adenylate kinase 8 OS=Mus musculus OX=10090 GN=Ak8 PE=1 SV=1
4	AFDB:A5PMF1	0.093	0.299	1.740E-14	563	0.052	0.176	A5PMF1.pdb.gz	A5PMF1_DANRE Adenylate kinase 5 OS=Danio rerio OX=7955 GN=wu:fj63a06 PE=1 SV=1
5	AFDB:Q586D5	0.098	0.610	1.471E-10	260	0.024	0.177	Q586D5.pdb.gz	Q586D5_TRYB2 Adenylate kinase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=1F7.200 PE=3 SV=1
6	PDB:2c95A	0.089	0.745	1.091E-9	195	0.024	0.231	2c95A.pdb.gz	Structure of Adenylate Kinase 1 in Complex with P1, P4-Di(Adenosine)Tetraphosphate
7	PDB:3tlxB	0.093	0.599	1.600E-9	240	0.029	0.233	3tlxB.pdb.gz	Crystal Structure of PF10_0086, adenylate kinase from plasmodium falciparum
8	PDB:1ukyA	0.091	0.751	4.585E-9	196	0.019	0.184	1ukyA.pdb.gz	Substrate specificity and assembly of the catalytic center derived from two structures of ligated uridylate kinase.
9	PDB:2c9yA	0.091	0.721	9.398E-9	218	0.024	0.206	2c9yA.pdb.gz	Structure of Human Adenylate Kinase 2
10	PDB:2ar7A	0.097	0.686	1.138E-8	221	0.030	0.262	2ar7A.pdb.gz
11	PDB:2cdnA	0.083	0.708	1.378E-8	186	0.021	0.220	2cdnA.pdb.gz	The Crystal Structure of Mycobacterium Tuberculosis Adenylate Kinase in Complex with Two Molecules of Adp and Mg2+ Supports an Associative Mechanism for Phosphoryl Transfer.
12	PDB:1qf9A	0.089	0.733	3.260E-8	194	0.019	0.186	1qf9A.pdb.gz	pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog.
13	PDB:1tevA	0.092	0.803	3.260E-8	194	0.020	0.201	1tevA.pdb.gz
14	PDB:1akeA	0.094	0.684	3.763E-8	214	0.027	0.238	1akeA.pdb.gz	Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state.
15	PDB:1dvrA	0.091	0.707	6.682E-8	220	0.021	0.186	1dvrA.pdb.gz	Structure of a mutant adenylate kinase ligated with an ATP-analogue showing domain closure over ATP.
16	AFDB:O15381	0.057	0.109	4.389E-1	856	0.059	0.131	O15381.pdb.gz	NVL_HUMAN Nuclear valosin-containing protein-like OS=Homo sapiens OX=9606 GN=NVL PE=1 SV=1
17	AFDB:Q9USH9	0.044	0.087	5.848E-1	822	0.052	0.122	Q9USH9.pdb.gz	YJQ1_SCHPO Uncharacterized ABC transporter ATP-binding protein C825.01 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC825.01 PE=1 SV=1
18	AFDB:Q9VGI8	0.048	0.058	1.038	1487	0.080	0.103	Q9VGI8.pdb.gz	BLM_DROME RecQ-like DNA helicase Blm OS=Drosophila melanogaster OX=7227 GN=Blm PE=1 SV=1
19	AFDB:Q8I3J0	0.033	0.076	1.199	458	0.035	0.144	Q8I3J0.pdb.gz	Q8I3J0_PLAF7 Hsc70-interacting protein OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0527500 PE=4 SV=1
20	AFDB:Q8I2H7	0.048	0.074	1.523	1056	0.037	0.067	Q8I2H7.pdb.gz	Q8I2H7_PLAF7 DNA helicase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0934100 PE=3 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A2R9YJL3	0.0	707	1762	0.175	0.190	A0A2R9YJL3_DANRE Cilia- and flagella-associated protein 206 OS=Danio rerio OX=7955 GN=si:ch211-199m3.4 PE=3 SV=1
2	J3KP89	0.0	1495	736	0.382	0.992	J3KP89_HUMAN nucleoside-diphosphate kinase OS=Homo sapiens OX=9606 GN=AK9 PE=1 SV=1
3	Q5TCS8	0.0	3904	1911	1.000	1.000	KAD9_HUMAN Adenylate kinase 9 OS=Homo sapiens OX=9606 GN=AK9 PE=1 SV=2
4	Q38A96	3.19e-21	104	2169	0.071	0.062	Q38A96_TRYB2 Cilia- and flagella-associated protein 206 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.6k15.1760 PE=4 SV=1
5	Q8VYL1	2.47e-13	77.4	588	0.032	0.104	KAD5_ARATH Adenylate kinase 5, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=At5g35170 PE=1 SV=1
6	Q38CF7	1.89e-12	71.6	260	0.024	0.177	Q38CF7_TRYB2 Adenylate kinase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.7330 PE=3 SV=1
7	P69441	3.01e-12	70.1	214	0.025	0.224	KAD_ECOLI Adenylate kinase OS=Escherichia coli (strain K12) OX=83333 GN=adk PE=1 SV=1
8	Q9FIJ7	1.06e-11	70.1	283	0.021	0.141	KAD2_ARATH Adenylate kinase 2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=At5g47840 PE=1 SV=1
9	Q9Y6K8	3.62e-10	67.4	562	0.024	0.082	KAD5_HUMAN Adenylate kinase isoenzyme 5 OS=Homo sapiens OX=9606 GN=AK5 PE=1 SV=2
10	P00571	7.33e-10	62.8	194	0.021	0.211	KAD1_PIG Adenylate kinase isoenzyme 1 OS=Sus scrofa OX=9823 GN=AK1 PE=1 SV=1
11	F1R4S7	7.38e-10	63.5	225	0.024	0.200	F1R4S7_DANRE GTP:AMP phosphotransferase AK3, mitochondrial OS=Danio rerio OX=7955 GN=ak3l1 PE=1 SV=1
12	P39069	1.11e-09	62.0	194	0.021	0.206	KAD1_RAT Adenylate kinase isoenzyme 1 OS=Rattus norvegicus OX=10116 GN=Ak1 PE=1 SV=3
13	P54819	1.34e-09	62.8	239	0.021	0.167	KAD2_HUMAN Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2
14	Q38EC4	1.58e-09	62.0	200	0.030	0.285	Q38EC4_TRYB2 Adenylate kinase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.211.0350 PE=3 SV=1
15	Q9WUR9	1.59e-09	62.4	223	0.023	0.193	KAD4_MOUSE Adenylate kinase 4, mitochondrial OS=Mus musculus OX=10090 GN=Ak4 PE=1 SV=1
16	Q8IJV6	1.64e-09	62.8	242	0.026	0.202	KAD1_PLAF7 Adenylate kinase 1 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=AK1 PE=1 SV=1
17	Q9WUS0	1.82e-09	62.4	223	0.023	0.193	KAD4_RAT Adenylate kinase 4, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ak4 PE=2 SV=1
18	Q38BZ2	1.85e-09	62.0	222	0.020	0.171	Q38BZ2_TRYB2 Adenylate kinase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.5150 PE=3 SV=1
19	Q5T9B7	2.79e-09	61.2	210	0.021	0.190	Q5T9B7_HUMAN Adenylate kinase isoenzyme 1 OS=Homo sapiens OX=9606 GN=AK1 PE=1 SV=1
20	Q9R0Y5	3.04e-09	60.8	194	0.020	0.201	KAD1_MOUSE Adenylate kinase isoenzyme 1 OS=Mus musculus OX=10090 GN=Ak1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01591 6PF2K	53	14.6	6-phosphofructo-2-kinase
2	PF00004 AAA	2.4e-11	55.6	ATPase family associated with various cellular activities (AAA)
3	PF13173 AAA_14	1.8e-05	36.2	AAA domain
4	PF13191 AAA_16	4.8e-07	41.8	AAA ATPase domain
5	PF13207 AAA_17	5.6e-28	109.5	AAA domain
6	PF13238 AAA_18	1.1e-19	82.7	AAA domain
7	PF13245 AAA_19	3.6	19.3	AAA domain
8	PF13401 AAA_22	9.6e-10	50.3	AAA domain
9	PF13479 AAA_24	1.2e-08	46.5	AAA domain
10	PF13481 AAA_25	70	14.4	AAA domain
11	PF13521 AAA_28	1e-05	37.3	AAA domain
12	PF13604 AAA_30	2.4	19.4	AAA domain
13	PF13671 AAA_33	5.2e-08	44.6	AAA domain
14	PF07728 AAA_5	9.3e-06	37.1	AAA domain (dynein-related subfamily)
15	PF12775 AAA_7	23	15.9	P-loop containing dynein motor region
16	PF00005 ABC_tran	0.0049	28.8	ABC transporter
17	PF00406 ADK	1.4e-43	160.0	Adenylate kinase
18	PF03029 ATP_bind_1	1.9e+02	13.2	Conserved hypothetical ATP binding protein
19	PF02224 Cytidylate_kin	0.00056	31.2	Cytidylate kinase
20	PF19263 DUF5906	3.2	19.9	Family of unknown function (DUF5906)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000410186

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000286621	0.954	Adenosine kinase
2	9606.ENSP00000369456	0.950	Inosine triphosphate pyrophosphatase
3	9606.ENSP00000304802	0.947	Thymidylate kinase
4	9606.ENSP00000367615	0.942	Adenine phosphoribosyltransferase
5	9606.ENSP00000371230	0.939	GTP:AMP phosphotransferase AK3, mitochondrial
6	9606.ENSP00000256722	0.938	UMP-CMP kinase 2, mitochondrial
7	9606.ENSP00000355689	0.933	Guanylate kinase
8	9606.ENSP00000370376	0.927	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
9	9606.ENSP00000485525	0.919	Adenylosuccinate lyase
10	9606.ENSP00000322524	0.908	dCTP pyrophosphatase 1
11	9606.ENSP00000377814	0.908	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
12	9606.ENSP00000286648	0.906	Deoxycytidine kinase
13	9606.ENSP00000347213	0.902	Ectonucleoside triphosphate diphosphohydrolase 2
14	9606.ENSP00000368455	0.902	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
15	9606.ENSP00000422375	0.902	U8 snoRNA-decapping enzyme
16	9606.ENSP00000355587	0.900	Cancer-related nucleoside-triphosphatase
17	9606.ENSP00000416658	0.895	Nucleoside diphosphate kinase 6
18	9606.ENSP00000356785	0.888	Nucleoside diphosphate kinase 7
19	9606.ENSP00000219479	0.884	Nucleoside diphosphate kinase, mitochondrial
20	9606.ENSP00000376889	0.859	Nucleoside diphosphate kinase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0050145	0.998	nucleoside monophosphate kinase activity
GO:0004550	0.998	nucleoside diphosphate kinase activity
GO:0005515	0.877	protein binding
GO:0036094	0.385	small molecule binding
GO:0097159	0.331	organic cyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:1901293	0.997	nucleoside phosphate biosynthetic process
GO:0009150	0.996	purine ribonucleotide metabolic process
GO:1901137	0.995	carbohydrate derivative biosynthetic process
GO:0009394	0.993	2'-deoxyribonucleotide metabolic process
GO:0009152	0.993	purine ribonucleotide biosynthetic process
GO:0006165	0.992	nucleoside diphosphate phosphorylation
GO:0046033	0.992	AMP metabolic process
GO:0046034	0.990	ATP metabolic process
GO:0009201	0.986	ribonucleoside triphosphate biosynthetic process
GO:0046031	0.985	ADP metabolic process
GO:0009206	0.982	purine ribonucleoside triphosphate biosynthetic process
GO:0006091	0.966	generation of precursor metabolites and energy
GO:0006757	0.947	ATP generation from ADP
GO:0006754	0.947	ATP biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0005829	0.999	cytosol
GO:0031965	0.999	nuclear membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:24036	0.998	a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP
EC:2.7.4.6	0.998	nucleoside-diphosphate kinase.
EC:2.7.4.4	0.998	nucleoside-phosphate kinase.

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