StarFunc result for job id Q5VT79

User Input

>input (327 residues)
MAWWKAWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIA
KSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEIL
ASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALAL
QDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSL
EEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYG
KTLSSMIMEDTSGDYKNALLSLVGSDP

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P13928	0.985	0.985	4.023E-45	327	0.994	0.994	P13928.pdb.gz	ANXA8_HUMAN Annexin A8 OS=Homo sapiens OX=9606 GN=ANXA8 PE=1 SV=3
2	PDB:1w45A	0.939	0.960	6.190E-38	320	0.976	0.997	1w45A.pdb.gz
3	AFDB:P09525	0.951	0.974	2.657E-31	319	0.544	0.558	P09525.pdb.gz	ANXA4_HUMAN Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4
4	PDB:2zocA	0.955	0.978	9.522E-31	319	0.544	0.558	2zocA.pdb.gz	The comparison of the loop structure of membrane binding sites between human and bovine annexin IV
5	AFDB:P20072	0.943	0.668	3.269E-30	463	0.492	0.348	P20072.pdb.gz	ANXA7_BOVIN Annexin A7 OS=Bos taurus OX=9913 GN=ANXA7 PE=1 SV=2
6	AFDB:P81287	0.961	0.979	4.403E-30	321	0.550	0.561	P81287.pdb.gz	ANXA5_BOVIN Annexin A5 OS=Bos taurus OX=9913 GN=ANXA5 PE=1 SV=3
7	AFDB:B5XEI6	0.937	0.960	5.930E-30	319	0.483	0.495	B5XEI6.pdb.gz	B5XEI6_SALSA Annexin OS=Salmo salar OX=8030 GN=ANXA4 PE=2 SV=1
8	AFDB:P20073	0.951	0.641	7.654E-30	488	0.492	0.330	P20073.pdb.gz	ANXA7_HUMAN Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3
9	AFDB:B5XAE0	0.938	0.968	7.987E-30	317	0.502	0.517	B5XAE0.pdb.gz	B5XAE0_SALSA Annexin OS=Salmo salar OX=8030 GN=ANXA5 PE=2 SV=1
10	AFDB:P50995	0.941	0.613	9.469E-30	505	0.517	0.335	P50995.pdb.gz	ANX11_HUMAN Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1
11	PDB:2h0kA	0.929	0.955	1.871E-29	318	0.538	0.553	2h0kA.pdb.gz	Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair.
12	AFDB:A9JTC0	0.936	0.966	2.125E-29	317	0.526	0.543	A9JTC0.pdb.gz
13	AFDB:Q27512	0.927	0.615	3.694E-29	497	0.446	0.294	Q27512.pdb.gz	Q27512_CAEEL Annexin OS=Caenorhabditis elegans OX=6239 GN=nex-2 PE=1 SV=2
14	PDB:1axnA	0.912	0.923	4.547E-28	323	0.477	0.483	1axnA.pdb.gz	The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.
15	PDB:7p70A	0.951	0.767	2.015E-27	407	0.443	0.356	7p70A.pdb.gz	Quantitative fragmentomics allow affinity mapping of interactomes.
16	PDB:7p73A	0.943	0.738	1.059E-26	420	0.443	0.345	7p73A.pdb.gz	Quantitative fragmentomics allow affinity mapping of interactomes.
17	PDB:5n7dA	0.939	0.729	6.322E-26	423	0.443	0.343	5n7dA.pdb.gz	Dynamic control of RSK complexes by phosphoswitch-based regulation.
18	PDB:7pc3A	0.920	0.747	6.884E-26	405	0.440	0.356	7pc3A.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
19	PDB:7qqnC	0.926	0.735	1.010E-25	414	0.443	0.350	7qqnC.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
20	PDB:1avcA	0.923	0.477	1.682E-25	642	0.508	0.259	1avcA.pdb.gz	Crystal structure of bovine annexin VI in a calcium-bound state.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P13928	0.0	674	327	0.994	0.994	ANXA8_HUMAN Annexin A8 OS=Homo sapiens OX=9606 GN=ANXA8 PE=1 SV=3
2	P09525	8.15e-124	359	319	0.544	0.558	ANXA4_HUMAN Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4
3	P13214	1.64e-123	358	319	0.550	0.564	ANXA4_BOVIN Annexin A4 OS=Bos taurus OX=9913 GN=ANXA4 PE=1 SV=2
4	P97429	6.30e-120	349	319	0.541	0.555	ANXA4_MOUSE Annexin A4 OS=Mus musculus OX=10090 GN=Anxa4 PE=1 SV=4
5	P81287	1.27e-114	336	321	0.547	0.558	ANXA5_BOVIN Annexin A5 OS=Bos taurus OX=9913 GN=ANXA5 PE=1 SV=3
6	P14668	3.85e-114	335	319	0.547	0.561	ANXA5_RAT Annexin A5 OS=Rattus norvegicus OX=10116 GN=Anxa5 PE=1 SV=3
7	P08758	1.06e-113	333	320	0.541	0.553	ANXA5_HUMAN Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2
8	Q803A1	8.99e-113	331	317	0.526	0.543	Q803A1_DANRE Annexin OS=Danio rerio OX=7955 GN=ANX V PE=1 SV=1
9	P48036	5.74e-111	327	319	0.529	0.542	ANXA5_MOUSE Annexin A5 OS=Mus musculus OX=10090 GN=Anxa5 PE=1 SV=1
10	P33477	2.88e-110	331	503	0.520	0.338	ANX11_RABIT Annexin A11 OS=Oryctolagus cuniculus OX=9986 GN=ANXA11 PE=1 SV=1
11	B5XAE0	1.21e-109	323	317	0.502	0.517	B5XAE0_SALSA Annexin OS=Salmo salar OX=8030 GN=ANXA5 PE=2 SV=1
12	P50995	1.23e-109	330	505	0.517	0.335	ANX11_HUMAN Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1
13	Q5T0G8	1.23e-109	330	505	0.517	0.335	Q5T0G8_HUMAN Annexin OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1
14	C0H815	1.96e-109	323	317	0.502	0.517	C0H815_SALSA Annexin OS=Salmo salar OX=8030 GN=ANXA5 PE=2 SV=1
15	P97384	6.95e-109	328	503	0.511	0.332	ANX11_MOUSE Annexin A11 OS=Mus musculus OX=10090 GN=Anxa11 PE=1 SV=2
16	A8KBY8	1.18e-107	330	667	0.529	0.259	A8KBY8_DANRE Annexin OS=Danio rerio OX=7955 GN=anx6 PE=1 SV=1
17	P17153	2.71e-107	317	321	0.511	0.520	ANXA5_CHICK Annexin A5 OS=Gallus gallus OX=9031 GN=ANXA5 PE=1 SV=2
18	B5XEI6	1.09e-106	316	319	0.483	0.495	B5XEI6_SALSA Annexin OS=Salmo salar OX=8030 GN=ANXA4 PE=2 SV=1
19	Q6IRJ7	1.92e-105	318	463	0.489	0.346	Q6IRJ7_RAT Annexin OS=Rattus norvegicus OX=10116 GN=Anxa7 PE=3 SV=1
20	P20072	2.09e-105	318	463	0.492	0.348	ANXA7_BOVIN Annexin A7 OS=Bos taurus OX=9913 GN=ANXA7 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00191 Annexin	4.1e-94	320.0	Annexin
2	PF11582 DUF3240	2.3e+02	13.3	Protein of unknown function (DUF3240)
3	PF12006 DUF3500	55	14.8	Protein of unknown function (DUF3500)
4	PF19668 DUF6171	1.6e+02	14.0	Family of unknown function (DUF6171)
5	PF17910 FeoB_Cyto	96	15.0	FeoB cytosolic helical domain
6	PF11987 IF-2	4.3	18.7	Translation-initiation factor 2
7	PF15963 Myb_DNA-bind_7	1.1	20.4	Myb DNA-binding like
8	PF04546 Sigma70_ner	1.4e+02	13.8	Sigma-70, non-essential region
9	PF04820 Trp_halogenase	83	13.5	Tryptophan halogenase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000480221

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000386881	0.821	Dysferlin
2	9606.ENSP00000251968	0.710	Tumor susceptibility gene 101 protein
3	9606.ENSP00000447730	0.691	CD63 antigen
4	9606.ENSP00000371958	0.689	CD9 antigen
5	9606.ENSP00000263645	0.687	CD81 antigen
6	9606.ENSP00000227155	0.653	CD82 antigen
7	9606.ENSP00000271638	0.593	Protein S100-A11
8	9606.ENSP00000312675	0.564	Tripartite motif-containing protein 72
9	9606.ENSP00000302961	0.561	Heat shock protein family A member 4
10	9606.ENSP00000417050	0.556	Tetraspanin
11	9606.ENSP00000335153	0.538	Heat shock protein HSP 90-alpha
12	9606.ENSP00000367263	0.515	Neuroblast differentiation-associated protein AHNAK
13	9606.ENSP00000411825	0.504	Programmed cell death 6-interacting protein

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.996	protein binding
GO:0005543	0.996	phospholipid binding
GO:0005544	0.992	calcium-dependent phospholipid binding
GO:0043168	0.969	anion binding
GO:0035091	0.944	phosphatidylinositol binding
GO:0044877	0.913	protein-containing complex binding
GO:0005509	0.904	calcium ion binding
GO:0003676	0.749	nucleic acid binding
GO:0005546	0.735	phosphatidylinositol-4,5-bisphosphate binding
GO:0051015	0.612	actin filament binding
GO:0005547	0.376	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325	0.369	phosphatidylinositol-3,4-bisphosphate binding
GO:0042802	0.365	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.992	cellular process
GO:0050789	0.989	regulation of biological process
GO:0050794	0.860	regulation of cellular process
GO:0071840	0.858	cellular component organization or biogenesis
GO:0016043	0.849	cellular component organization
GO:0010256	0.812	endomembrane system organization
GO:0050790	0.776	regulation of catalytic activity
GO:0050896	0.770	response to stimulus
GO:0019222	0.760	regulation of metabolic process
GO:0060255	0.738	regulation of macromolecule metabolic process
GO:0048519	0.732	negative regulation of biological process
GO:0051179	0.680	localization
GO:0051336	0.673	regulation of hydrolase activity
GO:0051171	0.660	regulation of nitrogen compound metabolic process
GO:0080090	0.657	regulation of primary metabolic process
GO:0051346	0.650	negative regulation of hydrolase activity
GO:0051246	0.520	regulation of protein metabolic process
GO:0051641	0.467	cellular localization
GO:0006810	0.460	transport
GO:0006996	0.436	organelle organization
GO:0048518	0.379	positive regulation of biological process
GO:0031323	0.336	regulation of cellular metabolic process
GO:0048522	0.334	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071944	0.999	cell periphery
GO:0016020	0.999	membrane
GO:0005737	0.999	cytoplasm
GO:0031982	0.999	vesicle
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0012505	0.998	endomembrane system
GO:0005886	0.993	plasma membrane
GO:0031410	0.993	cytoplasmic vesicle
GO:0005829	0.985	cytosol
GO:0012506	0.974	vesicle membrane
GO:0005768	0.960	endosome
GO:0030659	0.955	cytoplasmic vesicle membrane
GO:0005615	0.923	extracellular space
GO:0031012	0.923	extracellular matrix
GO:0070062	0.892	extracellular exosome
GO:0098588	0.757	bounding membrane of organelle
GO:0062023	0.696	collagen-containing extracellular matrix
GO:0005770	0.609	late endosome
GO:0005634	0.540	nucleus
GO:0099503	0.523	secretory vesicle
GO:0030141	0.445	secretory granule
GO:0010008	0.383	endosome membrane
GO:0031902	0.356	late endosome membrane
GO:0030054	0.306	cell junction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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