StarFunc result for job id Q5VVJ2

User Input

>input (828 residues)
MAAEEADVDIEGDVVAAAGAQPGSGENTASVLQKDHYLDSSWRTENGLIPWTLDNTISEE
NRAVIEKMLLEEEYYLSKKSQPEKVWLDQKEDDKKYMKSLQKTAKIMVHSPTKPASYSVK
WTIEEKELFEQGLAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLDKETPNQKT
GHNLQVKNEDKGTKAWTPSCLRGRADPNLNAVKIEKLSDDEEVDITDEVDELSSQTPQKN
SSSDLLLDFPNSKMHETNQGEFITSDSQEALFSKSSRGCLQNEKQDETLSSSEITLWTEK
QSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLNDNEMLFHSC
QMVEESHEEEELKPPEQEIEIDRNIIQEEEKQAIPEFFEGRQAKTPERYLKIRNYILDQW
EICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAVYNRPQTVDKVRIR
DRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSAEELAKRREEEKG
RPVKSLKVPRPTKSSFDPFQLIPCNFFSEEKQEPFQVKVASEALLIMDLHAHVSMAEVIG
LLGGRYSEVDKVVEVCAAEPCNSLSTGLQCEMDPVSQTQASETLAVRGFSVIGWYHSHPA
FDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRNNPLPYSQITCLVISEEISPDGS
YRLPYKFEVQQMLEEPQWGLVFEKTRWIIEKYRLSHSSVPMDKIFRRDSDLTCLQKLLEC
MRKTLSKVTNCFMAEEFLTEIENLFLSNYKSNQENGVTEENCTKELLM

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q5VVJ2	1.000	1.000	0.000	828	1.000	1.000	Q5VVJ2.pdb.gz	MYSM1_HUMAN Deubiquitinase MYSM1 OS=Homo sapiens OX=9606 GN=MYSM1 PE=1 SV=1
2	AFDB:Q69Z66	0.338	0.341	0.000	819	0.792	0.801	Q69Z66.pdb.gz	MYSM1_MOUSE Deubiquitinase MYSM1 OS=Mus musculus OX=10090 GN=Mysm1 PE=1 SV=2
3	PDB:6gvwB	0.199	0.572	2.004E-11	262	0.070	0.221	6gvwB.pdb.gz	Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
4	PDB:6r7fE	0.156	0.383	3.731E-9	311	0.058	0.154	6r7fE.pdb.gz
5	PDB:5l4kV	0.165	0.431	4.706E-9	293	0.060	0.171	5l4kV.pdb.gz
6	PDB:4wsnF	0.164	0.428	1.504E-8	288	0.042	0.122	4wsnF.pdb.gz	Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
7	PDB:3jckG	0.158	0.471	1.790E-8	257	0.065	0.210	3jckG.pdb.gz	Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.
8	PDB:5gjqV	0.161	0.473	1.897E-8	257	0.066	0.214	5gjqV.pdb.gz	An atomic structure of the human 26S proteasome.
9	PDB:5mpbV	0.162	0.432	7.212E-8	289	0.066	0.190	5mpbV.pdb.gz	Structural insights into the functional cycle of the ATPase module of the 26S proteasome.
10	PDB:6zonF	0.162	0.451	1.366E-7	269	0.046	0.141	6zonF.pdb.gz	Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
11	PDB:6j30U	0.160	0.458	3.886E-7	262	0.043	0.137	6j30U.pdb.gz	Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations.
12	PDB:5l4kU	0.152	0.379	5.505E-7	292	0.047	0.134	5l4kU.pdb.gz
13	AFDB:B3DKL9	0.056	0.098	3.053E-3	426	0.072	0.141	B3DKL9.pdb.gz
14	AFDB:Q2TBE0	0.070	0.067	3.634E-3	894	0.129	0.120	Q2TBE0.pdb.gz	C19L2_HUMAN CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4
15	AFDB:Q59E36	0.053	0.072	1.304E-2	590	0.054	0.076	Q59E36.pdb.gz	RCOR_DROME REST corepressor OS=Drosophila melanogaster OX=7227 GN=CoRest PE=1 SV=2
16	AFDB:A0A0G3VTN5	0.069	0.073	3.116E-2	770	0.109	0.117	A0A0G3VTN5.pdb.gz	LHY_PETHY Protein LATE ELONGATED HYPOCOTYL OS=Petunia hybrida OX=4102 GN=LHY PE=2 SV=1
17	AFDB:Q6DCQ1	0.054	0.084	4.679E-2	455	0.054	0.099	Q6DCQ1.pdb.gz	IRX2_XENLA Iroquois-class homeodomain protein irx-2 OS=Xenopus laevis OX=8355 GN=irx2 PE=2 SV=1
18	AFDB:P28166	0.053	0.044	5.902E-2	1054	0.068	0.053	P28166.pdb.gz	ZFH1_DROME Zinc finger protein 1 OS=Drosophila melanogaster OX=7227 GN=zfh1 PE=1 SV=2
19	AFDB:Q9V490	0.066	0.091	9.954E-2	543	0.060	0.092	Q9V490.pdb.gz	Q9V490_DROME GH14454p OS=Drosophila melanogaster OX=7227 GN=toy PE=2 SV=4
20	AFDB:O42261	0.055	0.095	1.331E-1	448	0.058	0.107	O42261.pdb.gz	IRX3_XENLA Iroquois-class homeodomain protein irx-3 OS=Xenopus laevis OX=8355 GN=irx3 PE=2 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A590UJD8	0.0	1621	806	0.940	0.965	A0A590UJD8_HUMAN Myb-like, SWIRM and MPN domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MYSM1 PE=1 SV=1
2	Q5RGA4	0.0	790	822	0.535	0.539	MYSM1_DANRE Histone H2A deubiquitinase MYSM1 OS=Danio rerio OX=7955 GN=mysm1 PE=2 SV=2
3	Q5VVJ2	0.0	1722	828	1.000	1.000	MYSM1_HUMAN Deubiquitinase MYSM1 OS=Homo sapiens OX=9606 GN=MYSM1 PE=1 SV=1
4	Q69Z66	0.0	1303	819	0.792	0.801	MYSM1_MOUSE Deubiquitinase MYSM1 OS=Mus musculus OX=10090 GN=Mysm1 PE=1 SV=2
5	Q8N594	4.04e-21	99.8	471	0.064	0.113	MPND_HUMAN MPN domain-containing protein OS=Homo sapiens OX=9606 GN=MPND PE=1 SV=1
6	F1Q9K1	7.20e-12	72.0	1089	0.042	0.032	F1Q9K1_DANRE SWI/SNF complex subunit SMARCC1 isoform X1 OS=Danio rerio OX=7955 GN=smarcc1a PE=1 SV=1
7	D4A510	2.88e-11	69.7	1108	0.046	0.034	D4A510_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 OS=Rattus norvegicus OX=10116 GN=Smarcc2 PE=1 SV=4
8	A0A8I6AGR8	2.97e-11	69.7	1216	0.046	0.031	A0A8I6AGR8_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 OS=Rattus norvegicus OX=10116 GN=Smarcc2 PE=1 SV=1
9	A0A8I6A5E1	3.07e-11	69.7	1247	0.046	0.030	A0A8I6A5E1_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 OS=Rattus norvegicus OX=10116 GN=Smarcc2 PE=1 SV=1
10	Q8TAQ2	4.18e-11	69.3	1214	0.046	0.031	SMRC2_HUMAN SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1
11	F8VXC8	4.43e-11	69.3	1245	0.046	0.031	F8VXC8_HUMAN SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1
12	Q6PDG5	4.95e-11	69.3	1213	0.041	0.028	SMRC2_MOUSE SWI/SNF complex subunit SMARCC2 OS=Mus musculus OX=10090 GN=Smarcc2 PE=1 SV=2
13	Q8MSY3	9.91e-11	68.2	1002	0.043	0.036	Q8MSY3_DROME LD06146p OS=Drosophila melanogaster OX=7227 GN=mor PE=2 SV=1
14	A0A8I6AMA8	1.14e-10	67.8	1102	0.040	0.030	A0A8I6AMA8_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 OS=Rattus norvegicus OX=10116 GN=Smarcc1 PE=4 SV=1
15	Q92922	1.22e-10	67.8	1105	0.040	0.030	SMRC1_HUMAN SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3
16	P97496	1.23e-10	67.8	1104	0.040	0.030	SMRC1_MOUSE SWI/SNF complex subunit SMARCC1 OS=Mus musculus OX=10090 GN=Smarcc1 PE=1 SV=2
17	A0A8I5ZP90	1.26e-10	67.8	1045	0.040	0.032	A0A8I5ZP90_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 OS=Rattus norvegicus OX=10116 GN=Smarcc1 PE=1 SV=1
18	D3ZJU5	1.26e-10	67.8	1078	0.040	0.031	D3ZJU5_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 OS=Rattus norvegicus OX=10116 GN=Smarcc1 PE=1 SV=1
19	A0A0G2K9D6	1.30e-10	67.8	1083	0.040	0.030	A0A0G2K9D6_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 OS=Rattus norvegicus OX=10116 GN=Smarcc1 PE=1 SV=1
20	Q9VF03	1.37e-10	67.8	1209	0.043	0.030	Q9VF03_DROME Brahma associated protein 155 kDa OS=Drosophila melanogaster OX=7227 GN=mor PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01398 JAB	1.2e-07	43.1	JAB1/Mov34/MPN/PAD-1 ubiquitin protease
2	PF00249 Myb_DNA-binding	9.1e-09	46.7	Myb-like DNA-binding domain
3	PF13921 Myb_DNA-bind_6	4.4	18.9	Myb-like DNA-binding domain
4	PF15963 Myb_DNA-bind_7	13	17.0	Myb DNA-binding like
5	PF14464 Prok-JAB	7.5e-05	34.0	Prokaryotic homologs of the JAB domain
6	PF04433 SWIRM	5.9e-17	73.1	SWIRM domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000418734

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000263754	0.989	Histone acetyltransferase KAT2B
2	9606.ENSP00000304697	0.960	Polyubiquitin-B
3	9606.ENSP00000441543	0.949	Polyubiquitin-C
4	9606.ENSP00000388107	0.940	Ubiquitin-60S ribosomal protein L40
5	9606.ENSP00000272317	0.926	Ubiquitin-40S ribosomal protein S27a
6	9606.ENSP00000261303	0.907	26S proteasome regulatory subunit 4
7	9606.ENSP00000396937	0.906	Proteasome 26S subunit, non-ATPase 13
8	9606.ENSP00000395654	0.901	Transcription activator BRG1
9	9606.ENSP00000418695	0.896	Proteasome 26S subunit, non-ATPase 6
10	9606.ENSP00000265773	0.895	Probable global transcription activator SNF2L2
11	9606.ENSP00000263121	0.891	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
12	9606.ENSP00000332194	0.887	Histone H2A type 2-C
13	9606.ENSP00000263253	0.886	Histone acetyltransferase p300
14	9606.ENSP00000307208	0.884	Nucleosome-remodeling factor subunit BPTF
15	9606.ENSP00000157812	0.870	26S proteasome regulatory subunit 6B
16	9606.ENSP00000362334	0.869	Proteasome subunit beta type-2
17	9606.ENSP00000328848	0.858	RNA-binding protein 10
18	9606.ENSP00000219313	0.854	26S proteasome non-ATPase regulatory subunit 7
19	9606.ENSP00000290541	0.852	Proteasome subunit beta type-4
20	9606.ENSP00000264639	0.847	26S proteasome non-ATPase regulatory subunit 3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042393	0.998	histone binding
GO:0003713	0.998	transcription coactivator activity
GO:0140492	0.997	metal-dependent deubiquitinase activity
GO:0003676	0.733	nucleic acid binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.995	regulation of biological process
GO:0044238	0.992	primary metabolic process
GO:0006807	0.989	nitrogen compound metabolic process
GO:0043170	0.986	macromolecule metabolic process
GO:0050794	0.985	regulation of cellular process
GO:0060255	0.979	regulation of macromolecule metabolic process
GO:0019538	0.979	protein metabolic process
GO:0051171	0.974	regulation of nitrogen compound metabolic process
GO:0009987	0.969	cellular process
GO:0036211	0.956	protein modification process
GO:0019219	0.941	regulation of nucleobase-containing compound metabolic process
GO:0006508	0.908	proteolysis
GO:0070647	0.900	protein modification by small protein conjugation or removal
GO:0010468	0.890	regulation of gene expression
GO:0009889	0.857	regulation of biosynthetic process
GO:0048518	0.852	positive regulation of biological process
GO:0031326	0.850	regulation of cellular biosynthetic process
GO:0010556	0.844	regulation of macromolecule biosynthetic process
GO:0048522	0.826	positive regulation of cellular process
GO:0010604	0.825	positive regulation of macromolecule metabolic process
GO:2000026	0.823	regulation of multicellular organismal development
GO:0071840	0.795	cellular component organization or biogenesis
GO:0016043	0.788	cellular component organization
GO:0016570	0.732	histone modification
GO:0070646	0.723	protein modification by small protein removal
GO:0051252	0.711	regulation of RNA metabolic process
GO:0051173	0.706	positive regulation of nitrogen compound metabolic process
GO:0006355	0.703	regulation of DNA-templated transcription
GO:0045935	0.609	positive regulation of nucleobase-containing compound metabolic process
GO:0016579	0.497	protein deubiquitination
GO:0006338	0.362	chromatin remodeling
GO:0009891	0.354	positive regulation of biosynthetic process
GO:0031328	0.340	positive regulation of cellular biosynthetic process
GO:0010557	0.335	positive regulation of macromolecule biosynthetic process
GO:0006357	0.324	regulation of transcription by RNA polymerase II
GO:1902680	0.306	positive regulation of RNA biosynthetic process
GO:0045893	0.304	positive regulation of DNA-templated transcription

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0005730	1.000	nucleolus
GO:0032991	0.993	protein-containing complex
GO:0005737	0.777	cytoplasm
GO:0005829	0.566	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.4.-.-	0.998	Acting on peptide bonds (peptidases).

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