StarFunc result for job id Q68D85

User Input

>input (454 residues)
MTWRAAASTCAALLILLWALTTEGDLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITS
MGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEY
RCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDKYMCESSGFYPEAINITWEKQ
TQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLR
SNFTLTAARHSLSETEKTDNFSIHWWPISFIGVGLVLLIVLIPWKKICNKSSSAYTPLKC
ILKHWNSFDTQTLKKEHLIFFCTRAWPSYQLQDGEAWPPEGSVNINTIQQLDVFCRQEGK
WSEVPYVQAFFALRDNPDLCQCCRIDPALLTVTSGKSIDDNSTKSEKQTPREHSDAVPDA
PILPVSPIWEPPPATTSTTPVLSSQPPTLLLPLQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q68D85	1.000	1.000	2.664E-89	454	1.000	1.000	Q68D85.pdb.gz	NR3L1_HUMAN Natural cytotoxicity triggering receptor 3 ligand 1 OS=Homo sapiens OX=9606 GN=NCR3LG1 PE=1 SV=1
2	AFDB:Q53FW8	0.399	0.387	1.994E-19	468	0.128	0.124	Q53FW8.pdb.gz	Q53FW8_HUMAN TAP binding protein-like variant (Fragment) OS=Homo sapiens OX=9606 PE=1 SV=1
3	AFDB:D4AE25	0.399	0.594	3.871E-18	290	0.112	0.176	D4AE25.pdb.gz	D4AE25_RAT CD274 molecule OS=Rattus norvegicus OX=10116 GN=Cd274 PE=4 SV=2
4	AFDB:Q8VE98	0.414	0.576	4.863E-18	316	0.119	0.171	Q8VE98.pdb.gz	CD276_MOUSE CD276 antigen OS=Mus musculus OX=10090 GN=Cd276 PE=1 SV=1
5	AFDB:Q9EP73	0.406	0.606	4.863E-18	290	0.110	0.172	Q9EP73.pdb.gz	PD1L1_MOUSE Programmed cell death 1 ligand 1 OS=Mus musculus OX=10090 GN=Cd274 PE=1 SV=1
6	AFDB:Q3SAU8	0.417	0.428	3.790E-17	442	0.132	0.136	Q3SAU8.pdb.gz	Q3SAU8_ONCMY Tapasin OS=Oncorhynchus mykiss OX=8022 PE=2 SV=1
7	AFDB:Q9NZQ7	0.380	0.558	4.012E-17	290	0.104	0.162	Q9NZQ7.pdb.gz	PD1L1_HUMAN Programmed cell death 1 ligand 1 OS=Homo sapiens OX=9606 GN=CD274 PE=1 SV=1
8	AFDB:Q4QTK1	0.372	0.546	9.439E-17	287	0.112	0.178	Q4QTK1.pdb.gz	Q4QTK1_PIG CD274 molecule OS=Sus scrofa OX=9823 GN=CD274 PE=2 SV=1
9	AFDB:A4JYS5	0.283	0.391	5.855E-16	298	0.128	0.195	A4JYS5.pdb.gz	A4JYS5_DANRE Uncharacterized protein LOC792578 OS=Danio rerio OX=7955 GN=zgc:165604 PE=1 SV=1
10	AFDB:Q62556	0.381	0.334	5.855E-16	524	0.110	0.095	Q62556.pdb.gz	BT1A1_MOUSE Butyrophilin subfamily 1 member A1 OS=Mus musculus OX=10090 GN=Btn1a1 PE=1 SV=2
11	PDB:5c7kF	0.204	0.411	3.053E-14	212	0.095	0.203	5c7kF.pdb.gz	Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.
12	PDB:3u0wL	0.209	0.417	7.181E-14	213	0.104	0.221	3u0wL.pdb.gz
13	PDB:1gafL	0.213	0.414	9.021E-14	214	0.093	0.196	1gafL.pdb.gz	The immunological evolution of catalysis.
14	PDB:3u7wL	0.206	0.416	1.200E-13	210	0.088	0.190	3u7wL.pdb.gz
15	PDB:1cicA	0.205	0.413	1.270E-13	214	0.095	0.201	1cicA.pdb.gz
16	PDB:1d6vL	0.214	0.420	1.507E-13	211	0.104	0.223	1d6vL.pdb.gz	Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
17	PDB:6b9yA	0.220	0.417	1.507E-13	214	0.106	0.224	6b9yA.pdb.gz	Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag.
18	PDB:1fdlL	0.215	0.413	1.596E-13	214	0.095	0.201	1fdlL.pdb.gz
19	PDB:1k4dB	0.215	0.425	1.689E-13	212	0.088	0.189	1k4dB.pdb.gz
20	PDB:4lluB	0.216	0.420	1.689E-13	210	0.097	0.210	4lluB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q68D85	0.0	939	454	1.000	1.000	NR3L1_HUMAN Natural cytotoxicity triggering receptor 3 ligand 1 OS=Homo sapiens OX=9606 GN=NCR3LG1 PE=1 SV=1
2	Q53FW8	3.95e-15	79.7	468	0.117	0.113	Q53FW8_HUMAN TAP binding protein-like variant (Fragment) OS=Homo sapiens OX=9606 PE=1 SV=1
3	Q9BX59	7.08e-15	79.0	468	0.117	0.113	TPSNR_HUMAN Tapasin-related protein OS=Homo sapiens OX=9606 GN=TAPBPL PE=1 SV=2
4	P97797	1.04e-07	56.6	513	0.123	0.109	SHPS1_MOUSE Tyrosine-protein phosphatase non-receptor type substrate 1 OS=Mus musculus OX=10090 GN=Sirpa PE=1 SV=2
5	F7AD18	2.56e-06	48.9	130	0.097	0.338	F7AD18_MOUSE Histocompatibility 2, class II, locus Mb2 OS=Mus musculus OX=10090 GN=H2-DMb2 PE=1 SV=3
6	Q9R066	3.18e-06	51.6	365	0.099	0.123	CXAR_RAT Coxsackievirus and adenovirus receptor homolog OS=Rattus norvegicus OX=10116 GN=Cxadr PE=1 SV=2
7	Q3SAV0	5.39e-06	50.8	442	0.117	0.120	Q3SAV0_ONCMY TAP binding protein (tapasin), tandem duplicate 1 OS=Oncorhynchus mykiss OX=8022 GN=tapbp.1 PE=2 SV=1
8	Q3SAU9	5.79e-06	50.8	442	0.117	0.120	Q3SAU9_ONCMY Tapasin OS=Oncorhynchus mykiss OX=8022 PE=2 SV=1
9	Q8N126	7.92e-06	50.4	398	0.088	0.101	CADM3_HUMAN Cell adhesion molecule 3 OS=Homo sapiens OX=9606 GN=CADM3 PE=1 SV=1
10	Q3SAU8	1.01e-05	50.1	442	0.117	0.120	Q3SAU8_ONCMY Tapasin OS=Oncorhynchus mykiss OX=8022 PE=2 SV=1
11	Q95602	1.68e-05	48.5	261	0.097	0.169	Q95602_MOUSE MB2q1 protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
12	D4AE25	1.69e-05	48.9	290	0.108	0.169	D4AE25_RAT CD274 molecule OS=Rattus norvegicus OX=10116 GN=Cd274 PE=4 SV=2
13	P70241	1.78e-05	48.5	261	0.097	0.169	P70241_MOUSE MB2w5 protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
14	P70238	1.79e-05	48.5	261	0.097	0.169	P70238_MOUSE MB2p protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
15	Q31113	1.79e-05	48.5	261	0.097	0.169	Q31113_MOUSE MHC class II H2-M beta 2 chain OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
16	B7ZNR4	1.88e-05	48.5	261	0.097	0.169	B7ZNR4_MOUSE Histocompatibility 2, class II, locus Mb2 OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
17	P35737	1.89e-05	48.5	261	0.097	0.169	DMB_MOUSE Class II histocompatibility antigen, M beta 1 chain OS=Mus musculus OX=10090 GN=H2-DMb1 PE=2 SV=1
18	P70679	1.95e-05	48.5	261	0.097	0.169	P70679_MOUSE MB2k1 protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
19	P70239	1.96e-05	48.5	261	0.097	0.169	P70239_MOUSE MB2r protein OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1
20	B7ZNR3	2.07e-05	48.1	261	0.097	0.169	B7ZNR3_MOUSE Histocompatibility 2, class II, locus Mb2 OS=Mus musculus OX=10090 GN=H2-DMb2 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF07654 C1-set	1.7e-07	42.8	Immunoglobulin C1-set domain
2	PF08205 C2-set_2	0.1	24.0	CD80-like C2-set immunoglobulin domain
3	PF07679 I-set	24	16.4	Immunoglobulin I-set domain
4	PF00047 ig	0.011	27.2	Immunoglobulin domain
5	PF13927 Ig_3	6.6e-05	34.7	Immunoglobulin domain
6	PF16706 Izumo-Ig	1.4e+02	13.8	Izumo-like Immunoglobulin domain
7	PF07686 V-set	0.0037	28.8	Immunoglobulin V-set domain
8	PF08204 V-set_CD47	8.2	17.9	CD47 immunoglobulin-like domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000341637

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000342156	0.999	Natural cytotoxicity triggering receptor 3
2	9606.ENSP00000356320	0.781	UL16-binding protein 2
3	9606.ENSP00000354782	0.774	T-cell surface glycoprotein CD3 zeta chain
4	9606.ENSP00000240618	0.756	Killer cell lectin-like receptor subfamily K, member 1
5	9606.ENSP00000362181	0.711	Natural cytotoxicity triggering receptor 2
6	9606.ENSP00000413079	0.710	MHC class I polypeptide-related sequence A
7	9606.ENSP00000291890	0.681	Natural cytotoxicity triggering receptor 1
8	9606.ENSP00000480609	0.681	annotation not available
9	9606.ENSP00000280200	0.653	CD226 antigen
10	9606.ENSP00000371333	0.651	Natural killer cells antigen CD94
11	9606.ENSP00000358470	0.637	V-set domain-containing T-cell activation inhibitor 1
12	9606.ENSP00000370989	0.619	Programmed cell death 1 ligand 1
13	9606.ENSP00000252229	0.618	MHC class I polypeptide-related sequence B
14	9606.ENSP00000350402	0.617	HERV-H LTR-associating protein 2
15	9606.ENSP00000252483	0.612	Nectin-2
16	9606.ENSP00000365131	0.603	Large proline-rich protein BAG6
17	9606.ENSP00000229708	0.602	UL16-binding protein 1
18	9606.ENSP00000402060	0.602	Poliovirus receptor
19	9606.ENSP00000358165	0.601	High affinity immunoglobulin gamma Fc receptor I
20	9606.ENSP00000320084	0.572	CD276 antigen

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0042802	0.432	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050789	0.985	regulation of biological process
GO:0009987	0.980	cellular process
GO:0002682	0.950	regulation of immune system process
GO:0050794	0.924	regulation of cellular process
GO:0050896	0.907	response to stimulus
GO:0048518	0.801	positive regulation of biological process
GO:0048583	0.781	regulation of response to stimulus
GO:0050776	0.644	regulation of immune response
GO:0051716	0.558	cellular response to stimulus
GO:0002376	0.463	immune system process
GO:0051239	0.439	regulation of multicellular organismal process
GO:0048522	0.429	positive regulation of cellular process
GO:0002694	0.426	regulation of leukocyte activation
GO:0048519	0.419	negative regulation of biological process
GO:0002684	0.413	positive regulation of immune system process
GO:0032101	0.399	regulation of response to external stimulus
GO:0002831	0.393	regulation of response to biotic stimulus
GO:0031347	0.393	regulation of defense response
GO:0023052	0.368	signaling
GO:0002697	0.362	regulation of immune effector process
GO:0007154	0.356	cell communication
GO:0002706	0.342	regulation of lymphocyte mediated immunity
GO:0007165	0.341	signal transduction
GO:0048523	0.335	negative regulation of cellular process
GO:0050778	0.325	positive regulation of immune response
GO:0051249	0.322	regulation of lymphocyte activation
GO:0002683	0.316	negative regulation of immune system process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0005622	0.637	intracellular anatomical structure
GO:0005737	0.632	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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