StarFunc result for job id Q68DK2

User Input

>input (2539 residues)
MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPP
ATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENP
ARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENE
LVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMK
QLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRN
QLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLN
HGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYY
QECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTL
ENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAK
SYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEV
TRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQL
DAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELE
GLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDIC
AQWLLTSHPRGAHGPGSRK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F6NK88	0.348	0.347	0.000	2552	0.457	0.455	F6NK88.pdb.gz	F6NK88_DANRE Zinc finger FYVE domain-containing protein 26 OS=Danio rerio OX=7955 GN=wu:fc33a03 PE=1 SV=1
2	AFDB:Q68DK2	1.000	1.000	0.000	2539	1.000	1.000	Q68DK2.pdb.gz	ZFY26_HUMAN Zinc finger FYVE domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZFYVE26 PE=1 SV=4
3	PDB:4bujB	0.070	0.103	2.690E-8	1367	0.071	0.132	4bujB.pdb.gz
4	PDB:7otmA	0.100	0.077	9.702E-8	3656	0.127	0.088	7otmA.pdb.gz	Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs.
5	PDB:7nfeA	0.085	0.069	1.593E-6	3585	0.114	0.081	7nfeA.pdb.gz	Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
6	PDB:7tyrA	0.086	0.068	3.207E-6	3905	0.143	0.093	7tyrA.pdb.gz
7	PDB:7k1nA	0.085	0.071	6.209E-6	3634	0.129	0.090	7k1nA.pdb.gz	Structure of an activated DNA-PK and its implications for NHEJ.
8	PDB:7mqaLM	0.082	0.095	6.977E-6	2041	0.115	0.143	7mqaLM.pdb.gz	Nucleolar maturation of the human small subunit processome.
9	PDB:7qpgR	0.080	0.086	9.899E-6	2208	0.081	0.093	7qpgR.pdb.gz
10	PDB:7ajuUT	0.089	0.095	1.250E-5	2313	0.113	0.124	7ajuUT.pdb.gz	Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
11	PDB:8escZ	0.080	0.069	1.404E-5	3543	0.130	0.093	8escZ.pdb.gz	Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
12	PDB:7tzcA	0.055	0.041	1.460E-5	4404	0.123	0.071	7tzcA.pdb.gz	A drug and ATP binding site in type 1 ryanodine receptor.
13	AFDB:F5HSE3	0.066	0.069	1.869E-4	2381	0.092	0.098	F5HSE3.pdb.gz	NIPLA_DANRE Nipped-B-like protein A OS=Danio rerio OX=7955 GN=nipbla PE=2 SV=1
14	AFDB:F1LQJ2	0.046	0.064	1.256E-3	1578	0.085	0.137	F1LQJ2.pdb.gz	F1LQJ2_RAT Formin homology 2 domain containing 3 OS=Rattus norvegicus OX=10116 GN=Fhod3 PE=4 SV=4
15	AFDB:Q8GYU3	0.043	0.061	3.728E-3	1465	0.083	0.144	Q8GYU3.pdb.gz	IYO_ARATH Transcriptional elongation regulator MINIYO OS=Arabidopsis thaliana OX=3702 GN=IYO PE=1 SV=1
16	AFDB:J7SA49	0.035	0.044	1.570E-2	1768	0.079	0.113	J7SA49.pdb.gz	J7SA49_CAEEL ARID domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=let-526 PE=1 SV=1
17	AFDB:M9MSM5	0.037	0.050	1.633E-2	1463	0.089	0.154	M9MSM5.pdb.gz	M9MSM5_DROME Dishevelled associated activator of morphogenesis, isoform D OS=Drosophila melanogaster OX=7227 GN=DAAM PE=4 SV=1
18	AFDB:Q8C0V1	0.062	0.143	1.983E-2	768	0.041	0.137	Q8C0V1.pdb.gz	TERB1_MOUSE Telomere repeats-binding bouquet formation protein 1 OS=Mus musculus OX=10090 GN=Terb1 PE=1 SV=2
19	AFDB:Q0WLC6	0.055	0.099	2.813E-2	1089	0.043	0.099	Q0WLC6.pdb.gz	PP349_ARATH Pentatricopeptide repeat-containing protein MRL1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=MRL1 PE=1 SV=2
20	AFDB:Q0KHX7	0.028	0.046	3.161E-2	1094	0.080	0.186	Q0KHX7.pdb.gz	Q0KHX7_DROME FI18193p1 OS=Drosophila melanogaster OX=7227 GN=spdi PE=1 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A067YRV0	0.0	1541	2269	0.401	0.449	A0A067YRV0_DANRE Zinc finger FYVE domain-containing protein 26 OS=Danio rerio OX=7955 GN=Suf PE=2 SV=1
2	F1Q533	0.0	1858	2551	0.462	0.460	F1Q533_DANRE Zinc finger FYVE domain-containing protein 26 OS=Danio rerio OX=7955 GN=wu:fc33a03 PE=1 SV=2
3	F6NK88	0.0	1861	2552	0.463	0.460	F6NK88_DANRE Zinc finger FYVE domain-containing protein 26 OS=Danio rerio OX=7955 GN=wu:fc33a03 PE=1 SV=1
4	Q68DK2	0.0	5207	2539	1.000	1.000	ZFY26_HUMAN Zinc finger FYVE domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZFYVE26 PE=1 SV=4
5	P34657	1.79e-16	84.3	266	0.012	0.113	YOTB_CAEEL Uncharacterized protein ZK632.12 OS=Caenorhabditis elegans OX=6239 GN=ZK632.12 PE=1 SV=2
6	Q9H8W4	9.67e-14	75.9	249	0.013	0.129	PKHF2_HUMAN Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1
7	O76902	7.14e-13	74.3	316	0.012	0.095	PKHF1_DROME Pleckstrin homology domain-containing family F member 1 homolog OS=Drosophila melanogaster OX=7227 GN=rush PE=1 SV=1
8	Q96S99	6.29e-12	70.9	279	0.012	0.108	PKHF1_HUMAN Pleckstrin homology domain-containing family F member 1 OS=Homo sapiens OX=9606 GN=PLEKHF1 PE=1 SV=3
9	Q960V6	3.21e-11	72.0	1343	0.011	0.022	Q960V6_DROME Zinc finger FYVE domain-containing protein OS=Drosophila melanogaster OX=7227 GN=Sara PE=2 SV=1
10	Q7K9H6	3.49e-11	71.6	1343	0.011	0.022	Q7K9H6_DROME Zinc finger FYVE domain-containing protein OS=Drosophila melanogaster OX=7227 GN=Sara PE=1 SV=1
11	Q54CH1	6.53e-11	70.1	580	0.013	0.059	ADCA_DICDI Arrestin domain-containing protein A OS=Dictyostelium discoideum OX=44689 GN=adcA PE=1 SV=1
12	O13821	1.26e-09	66.2	610	0.014	0.059	VPS27_SCHPO Vacuolar protein sorting-associated protein 27 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sst4 PE=3 SV=1
13	Q7Z6J4	1.44e-09	65.9	655	0.012	0.047	FGD2_HUMAN FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FGD2 PE=1 SV=1
14	B0G126	2.06e-09	66.2	2656	0.012	0.011	FYV1_DICDI 1-phosphatidylinositol 3-phosphate 5-kinase OS=Dictyostelium discoideum OX=44689 GN=pip5k3 PE=3 SV=1
15	Q6NPS1	2.25e-09	65.9	1171	0.011	0.023	Q6NPS1_ARATH At1g61690 OS=Arabidopsis thaliana OX=3702 GN=At1g61690 PE=1 SV=1
16	Q8BY35	5.32e-09	64.3	655	0.013	0.050	FGD2_MOUSE FYVE, RhoGEF and PH domain-containing protein 2 OS=Mus musculus OX=10090 GN=Fgd2 PE=1 SV=1
17	Q8BL66	9.41e-09	63.9	1411	0.010	0.018	EEA1_MOUSE Early endosome antigen 1 OS=Mus musculus OX=10090 GN=Eea1 PE=1 SV=2
18	Q15075	9.57e-09	63.5	1411	0.010	0.018	EEA1_HUMAN Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2
19	Q7Z3T8	1.33e-08	63.2	1539	0.016	0.027	ZFY16_HUMAN Zinc finger FYVE domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZFYVE16 PE=1 SV=3
20	Q86P45	1.83e-08	62.0	441	0.010	0.059	Q86P45_DROME SD23787p (Fragment) OS=Drosophila melanogaster OX=7227 GN=CG6001 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01363 FYVE	1.9e-10	52.0	FYVE zinc finger
2	PF09278 MerR-DNA-bind	81	15.2	MerR, DNA binding
3	PF13428 TPR_14	5e+02	13.0	Tetratricopeptide repeat
4	PF07719 TPR_2	26	16.3	Tetratricopeptide repeat

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000251119

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000261866	0.964	Spatacsin
2	9606.ENSP00000261647	0.948	Tetratricopeptide repeat protein 19, mitochondrial
3	9606.ENSP00000297562	0.941	AP-5 complex subunit zeta-1
4	9606.ENSP00000355231	0.912	Beclin-1
5	9606.ENSP00000481750	0.870	AP-5 complex subunit sigma-1
6	9606.ENSP00000454303	0.837	AP-5 complex subunit beta-1
7	9606.ENSP00000204566	0.725	Maspardin
8	9606.ENSP00000217402	0.700	Charged multivesicular body protein 4b
9	9606.ENSP00000261517	0.698	Vacuolar protein sorting-associated protein 13C
10	9606.ENSP00000259711	0.695	Kinesin-like protein KIF13A
11	9606.ENSP00000237536	0.692	Protein SOGA1
12	9606.ENSP00000407509	0.690	Neuropathy target esterase
13	9606.ENSP00000480893	0.679	Spastin
14	9606.ENSP00000352510	0.675	Tectonin beta-propeller repeat-containing protein 2
15	9606.ENSP00000216446	0.674	Pleckstrin-2
16	9606.ENSP00000337452	0.674	Magnesium transporter NIPA1
17	9606.ENSP00000414147	0.672	Spartin
18	9606.ENSP00000376335	0.669	Integral membrane protein GPR155
19	9606.ENSP00000268704	0.663	Paraplegin
20	9606.ENSP00000380352	0.649	Phospholipase DDHD2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0019901	1.000	protein kinase binding
GO:0032266	1.000	phosphatidylinositol-3-phosphate binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.993	cellular process
GO:0071704	0.960	organic substance metabolic process
GO:0044238	0.952	primary metabolic process
GO:0065007	0.948	biological regulation
GO:0044237	0.941	cellular metabolic process
GO:0006807	0.934	nitrogen compound metabolic process
GO:0061919	0.933	process utilizing autophagic mechanism
GO:0043170	0.917	macromolecule metabolic process
GO:0050789	0.915	regulation of biological process
GO:0071840	0.912	cellular component organization or biogenesis
GO:0050896	0.910	response to stimulus
GO:0050794	0.900	regulation of cellular process
GO:0007033	0.900	vacuole organization
GO:0006302	0.894	double-strand break repair
GO:0000725	0.876	recombinational repair
GO:0006914	0.845	autophagy
GO:0016236	0.785	macroautophagy
GO:0051302	0.772	regulation of cell division
GO:0000724	0.739	double-strand break repair via homologous recombination
GO:0010564	0.663	regulation of cell cycle process
GO:0032465	0.559	regulation of cytokinesis
GO:1905037	0.325	autophagosome organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005765	0.999	lysosomal membrane
GO:0030496	0.998	midbody
GO:0005770	0.998	late endosome
GO:0005769	0.998	early endosome
GO:0005813	0.996	centrosome
GO:0005829	0.500	cytosol
GO:0032991	0.432	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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