StarFunc result for job id Q6P4R8

User Input

>input (1299 residues)
MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQE
VLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEV
VKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRT
PEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLS
TTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLA
ALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKE
EPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAA
PNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLE
TKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRM
HGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEI
CELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFE
RIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPV
TPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPAS
SQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPA
TATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTS
APSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSI
TTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAA
DSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASS
EAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSK
TVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSV
VTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVR
IQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q6P4R8	1.000	1.000	0.000	1299	1.000	1.000	Q6P4R8.pdb.gz	NFRKB_HUMAN Nuclear factor related to kappa-B-binding protein OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=2
2	AFDB:F2Z3U3	0.043	0.044	2.798E-4	1266	0.157	0.161	F2Z3U3.pdb.gz	F2Z3U3_MOUSE Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 OS=Mus musculus OX=10090 GN=Raph1 PE=1 SV=2
3	AFDB:Q6P1D7	0.036	0.033	2.308E-3	1565	0.137	0.114	Q6P1D7.pdb.gz	SLX4_MOUSE Structure-specific endonuclease subunit SLX4 OS=Mus musculus OX=10090 GN=Slx4 PE=1 SV=1
4	AFDB:P48681	0.039	0.034	2.882E-3	1621	0.146	0.117	P48681.pdb.gz	NEST_HUMAN Nestin OS=Homo sapiens OX=9606 GN=NES PE=1 SV=2
5	AFDB:E9Q6H8	0.038	0.039	3.221E-3	1269	0.118	0.121	E9Q6H8.pdb.gz	E9Q6H8_MOUSE Pleckstrin homology domain containing, family A member 5 OS=Mus musculus OX=10090 GN=Plekha5 PE=1 SV=1
6	AFDB:Q7Z591	0.051	0.047	7.831E-3	1439	0.118	0.106	Q7Z591.pdb.gz	AKNA_HUMAN Microtubule organization protein AKNA OS=Homo sapiens OX=9606 GN=AKNA PE=1 SV=2
7	AFDB:B7YZK8	0.048	0.042	9.250E-3	1517	0.137	0.117	B7YZK8.pdb.gz	B7YZK8_DROME Thin, isoform C OS=Drosophila melanogaster OX=7227 GN=tn PE=1 SV=1
8	AFDB:Q80U93	0.044	0.034	9.778E-3	2085	0.168	0.105	Q80U93.pdb.gz	NU214_MOUSE Nuclear pore complex protein Nup214 OS=Mus musculus OX=10090 GN=Nup214 PE=1 SV=2
9	AFDB:Q24079	0.043	0.043	1.034E-2	1221	0.112	0.120	Q24079.pdb.gz	Q24079_DROME E93 OS=Drosophila melanogaster OX=7227 GN=Eip93F PE=2 SV=1
10	AFDB:Q8BZ32	0.073	0.070	1.093E-2	1370	0.155	0.147	Q8BZ32.pdb.gz	ASXL2_MOUSE Putative Polycomb group protein ASXL2 OS=Mus musculus OX=10090 GN=Asxl2 PE=1 SV=1
11	PDB:7z1mO	0.074	0.136	2.586E-1	570	0.026	0.060	7z1mO.pdb.gz	Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals.
12	PDB:5xf8C	0.049	0.104	2.889E-1	469	0.027	0.075	5xf8C.pdb.gz
13	PDB:2ct9B	0.039	0.205	5.625E-1	198	0.011	0.071	2ct9B.pdb.gz	Structural characterization of calcineurin B homologous protein 1
14	PDB:7u0tA	0.038	0.202	5.625E-1	190	0.010	0.068	7u0tA.pdb.gz	Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
15	PDB:5f8cB	0.041	0.134	6.645E-1	363	0.014	0.050	5f8cB.pdb.gz
16	PDB:5mrc8	0.031	0.127	7.426E-1	199	0.025	0.166	5mrc8.pdb.gz	The structure of the yeast mitochondrial ribosome.
17	PDB:5l4kO	0.046	0.129	9.272E-1	376	0.015	0.051	5l4kO.pdb.gz
18	PDB:5l4kP	0.035	0.087	9.802E-1	456	0.008	0.024	5l4kP.pdb.gz
19	PDB:7s78M	0.050	0.110	1.036	359	0.022	0.081	7s78M.pdb.gz	Structure of a Cell Entry Defective Human Adenovirus Provides Insights into Precursor Proteins and Capsid Maturation.
20	PDB:6fvtR	0.050	0.127	1.528	405	0.006	0.020	6fvtR.pdb.gz	Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	E9PQ59	0.0	1953	987	0.741	0.976	E9PQ59_HUMAN Nuclear factor related to kappaB binding protein (Fragment) OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=1
2	Q6P4R8	0.0	2626	1299	1.000	1.000	NFRKB_HUMAN Nuclear factor related to kappa-B-binding protein OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=2
3	Q6PIJ4	0.0	2237	1296	0.939	0.941	NFRKB_MOUSE Nuclear factor related to kappa-B-binding protein OS=Mus musculus OX=10090 GN=Nfrkb PE=1 SV=1
4	Q9LZU7	8.10e-43	173	1298	0.063	0.063	Q9LZU7_ARATH DNA-binding protein-like OS=Arabidopsis thaliana OX=3702 GN=F16L2_40 PE=1 SV=1
5	M9PC48	0.003	44.7	18095	0.048	0.003	M9PC48_DROME Dumpy, isoform Y OS=Drosophila melanogaster OX=7227 GN=dpy PE=4 SV=1
6	M9PCJ6	0.003	44.7	18641	0.048	0.003	M9PCJ6_DROME Dumpy, isoform S OS=Drosophila melanogaster OX=7227 GN=dpy PE=4 SV=1
7	Q8BJM5	0.41	37.4	460	0.030	0.085	ZNT6_MOUSE Zinc transporter 6 OS=Mus musculus OX=10090 GN=Slc30a6 PE=1 SV=1
8	A6YIH7	0.45	37.4	970	0.022	0.029	A6YIH7_DANRE Mineralocorticoid receptor OS=Danio rerio OX=7955 GN=mr PE=2 SV=1
9	P87132	9.8	32.7	601	0.021	0.045	YFK5_SCHPO Uncharacterized protein C167.05 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC167.05 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF10351 Apt1	2.1e+02	12.2	Golgi-body localisation protein domain
2	PF14465 NFRKB_winged	3.2e-28	109.4	NFRKB Winged Helix-like
3	PF07636 PSRT	6.1e+02	11.5	PSRT

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000436926

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000356425	0.999	Ubiquitin carboxyl-terminal hydrolase isozyme L5
2	9606.ENSP00000243903	0.997	Actin-related protein 5
3	9606.ENSP00000355205	0.995	DNA helicase INO80
4	9606.ENSP00000457016	0.995	INO80 complex subunit E
5	9606.ENSP00000233331	0.979	INO80 complex subunit B
6	9606.ENSP00000318297	0.977	RuvB-like 1
7	9606.ENSP00000262238	0.969	Transcriptional repressor protein YY1
8	9606.ENSP00000349640	0.968	Microspherule protein 1
9	9606.ENSP00000336842	0.966	Actin-related protein 8
10	9606.ENSP00000375639	0.953	TCF3 fusion partner
11	9606.ENSP00000473172	0.950	RuvB-like 2
12	9606.ENSP00000391457	0.946	Chromosome 18 open reading frame 37, isoform CRA_a
13	9606.ENSP00000397552	0.946	Actin-like protein 6A
14	9606.ENSP00000384198	0.935	INO80 complex subunit D
15	9606.ENSP00000467041	0.929	Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
16	9606.ENSP00000350512	0.923	COP9 signalosome complex subunit 5
17	9606.ENSP00000216225	0.922	E3 ubiquitin-protein ligase RBX1
18	9606.ENSP00000254900	0.920	Bromodomain-containing protein 8
19	9606.ENSP00000350708	0.914	UV excision repair protein RAD23 homolog B
20	9606.ENSP00000467024	0.914	UV excision repair protein RAD23 homolog A

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0002020	1.000	protease binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.991	cellular process
GO:0050794	0.990	regulation of cellular process
GO:0071704	0.978	organic substance metabolic process
GO:0044238	0.977	primary metabolic process
GO:0080090	0.976	regulation of primary metabolic process
GO:0060255	0.976	regulation of macromolecule metabolic process
GO:0031323	0.976	regulation of cellular metabolic process
GO:0051171	0.975	regulation of nitrogen compound metabolic process
GO:0048522	0.975	positive regulation of cellular process
GO:0006807	0.968	nitrogen compound metabolic process
GO:0010604	0.959	positive regulation of macromolecule metabolic process
GO:0043170	0.953	macromolecule metabolic process
GO:0051173	0.952	positive regulation of nitrogen compound metabolic process
GO:0019219	0.943	regulation of nucleobase-containing compound metabolic process
GO:0031325	0.943	positive regulation of cellular metabolic process
GO:0009889	0.938	regulation of biosynthetic process
GO:0045739	0.932	positive regulation of DNA repair
GO:0044237	0.921	cellular metabolic process
GO:0031326	0.916	regulation of cellular biosynthetic process
GO:0051726	0.914	regulation of cell cycle
GO:0010556	0.907	regulation of macromolecule biosynthetic process
GO:0045893	0.902	positive regulation of DNA-templated transcription
GO:0071840	0.894	cellular component organization or biogenesis
GO:0016043	0.884	cellular component organization
GO:0006338	0.841	chromatin remodeling
GO:0034641	0.834	cellular nitrogen compound metabolic process
GO:1901360	0.825	organic cyclic compound metabolic process
GO:0006725	0.819	cellular aromatic compound metabolic process
GO:0090304	0.812	nucleic acid metabolic process
GO:0051128	0.802	regulation of cellular component organization
GO:0006275	0.800	regulation of DNA replication
GO:0033044	0.749	regulation of chromosome organization
GO:2001252	0.744	positive regulation of chromosome organization
GO:0032204	0.739	regulation of telomere maintenance
GO:0044260	0.705	cellular macromolecule metabolic process
GO:0006996	0.664	organelle organization
GO:0051276	0.651	chromosome organization
GO:0032200	0.644	telomere organization
GO:0006259	0.536	DNA metabolic process
GO:0032206	0.419	positive regulation of telomere maintenance

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0032991	0.984	protein-containing complex
GO:0043232	0.965	intracellular non-membrane-bounded organelle
GO:0140513	0.959	nuclear protein-containing complex
GO:1902494	0.889	catalytic complex
GO:0000785	0.847	chromatin
GO:0000228	0.838	nuclear chromosome
GO:0097346	0.836	INO80-type complex
GO:0031011	0.773	Ino80 complex
GO:0005829	0.503	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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