StarFunc result for job id Q6XPS3

User Input

>input (522 residues)
MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYD
SKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFL
MDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLR
LIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS
FYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVF
TKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTH
SNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME
KKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWF
NTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q6XPS3	1.000	1.000	2.467E-98	522	1.000	1.000	Q6XPS3.pdb.gz	TPTE2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Homo sapiens OX=9606 GN=TPTE2 PE=1 SV=2
2	AFDB:P56180	0.895	0.849	1.464E-81	551	0.874	0.828	P56180.pdb.gz	TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE OS=Homo sapiens OX=9606 GN=TPTE PE=1 SV=3
3	AFDB:B3IUN7	0.726	0.740	1.571E-60	511	0.498	0.509	B3IUN7.pdb.gz
4	AFDB:A0A2R8RK27	0.551	0.717	1.368E-33	398	0.238	0.312	A0A2R8RK27.pdb.gz
5	AFDB:F1NT98	0.547	0.671	2.337E-33	423	0.245	0.303	F1NT98.pdb.gz
6	AFDB:A0A2R8Q8H3	0.546	0.671	2.465E-33	421	0.238	0.295	A0A2R8Q8H3.pdb.gz
7	AFDB:Q7ZZ56	0.556	0.720	7.593E-33	399	0.228	0.298	Q7ZZ56.pdb.gz	Q7ZZ56_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=fa11a08 PE=2 SV=1
8	AFDB:F1Q5Y5	0.544	0.636	2.339E-32	444	0.236	0.277	F1Q5Y5.pdb.gz
9	AFDB:E7FC59	0.541	0.602	2.603E-32	467	0.234	0.261	E7FC59.pdb.gz
10	AFDB:Q8T9S7	0.562	0.550	9.933E-32	533	0.226	0.221	Q8T9S7.pdb.gz	PTEN_DICDI Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Dictyostelium discoideum OX=44689 GN=pteN PE=2 SV=1
11	PDB:7jvxA	0.530	0.862	3.504E-29	314	0.245	0.408	7jvxA.pdb.gz
12	PDB:4ercA	0.253	0.834	9.357E-7	150	0.069	0.240	4ercA.pdb.gz	New Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate Screening.
13	PDB:1fq1A	0.261	0.675	3.770E-5	183	0.050	0.142	1fq1A.pdb.gz	Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
14	PDB:3s4oA	0.227	0.674	1.043E-4	163	0.052	0.166	3s4oA.pdb.gz
15	PDB:3f81A	0.225	0.568	3.981E-4	179	0.061	0.179	3f81A.pdb.gz	Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
16	PDB:2wgpA	0.229	0.651	4.431E-4	168	0.038	0.119	2wgpA.pdb.gz
17	PDB:2gwoC	0.225	0.586	7.176E-4	174	0.050	0.149	2gwoC.pdb.gz
18	PDB:5bx1A	0.223	0.698	8.890E-4	153	0.052	0.176	5bx1A.pdb.gz	Crystal Structure of PRL-1 complex with compound analogy 3
19	PDB:2esbA	0.214	0.601	1.044E-3	162	0.040	0.130	2esbA.pdb.gz
20	PDB:1r6hA	0.205	0.549	1.294E-3	172	0.054	0.163	1r6hA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	F1QG29	0.0	531	511	0.490	0.501	F1QG29_DANRE Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 isoform X1 OS=Danio rerio OX=7955 GN=tpip PE=3 SV=1
2	P56180	0.0	913	551	0.875	0.829	TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE OS=Homo sapiens OX=9606 GN=TPTE PE=1 SV=3
3	Q4V9E4	0.0	530	511	0.490	0.501	Q4V9E4_DANRE Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Danio rerio OX=7955 GN=wu:fd20e11 PE=2 SV=1
4	Q6XPS3	0.0	1076	522	1.000	1.000	TPTE2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Homo sapiens OX=9606 GN=TPTE2 PE=1 SV=2
5	O54857	1.02e-65	220	403	0.255	0.330	PTEN_RAT Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Rattus norvegicus OX=10116 GN=Pten PE=1 SV=1
6	F6KD01	2.33e-65	219	403	0.255	0.330	F6KD01_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=2 SV=1
7	P60484	2.33e-65	219	403	0.255	0.330	PTEN_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1
8	O08586	2.35e-65	219	403	0.255	0.330	PTEN_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Mus musculus OX=10090 GN=Pten PE=1 SV=1
9	B8XSI6	3.19e-65	219	403	0.255	0.330	B8XSI6_PIG Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Sus scrofa OX=9823 GN=PTEN PE=2 SV=1
10	Q6TGR7	1.09e-60	207	431	0.224	0.271	Q6TGR7_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=wu:fc52g04 PE=2 SV=1
11	Q7ZZ56	2.10e-58	201	399	0.239	0.313	Q7ZZ56_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=fa11a08 PE=2 SV=1
12	Q6PC66	3.47e-57	199	452	0.230	0.265	Q6PC66_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=ptena PE=2 SV=1
13	Q9Y0B6	1.46e-56	196	418	0.222	0.278	Q9Y0B6_DROME PTEN1 OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
14	Q7KMQ6	2.07e-55	196	514	0.222	0.226	Q7KMQ6_DROME IP16020p OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
15	Q9Y0B5	2.11e-55	196	511	0.222	0.227	Q9Y0B5_DROME PTEN2 OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
16	Q9U470	2.27e-55	195	506	0.222	0.229	Q9U470_DROME Phosphatase and tensin homolog OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
17	Q9V3L4	2.34e-55	195	509	0.222	0.228	Q9V3L4_DROME PTEN3 OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
18	Q54MG8	5.30e-55	201	998	0.232	0.121	Q54MG8_DICDI LIM-domain containing phosphatase OS=Dictyostelium discoideum OX=44689 GN=DDB_G0285967 PE=2 SV=2
19	Q9LT75	1.27e-54	196	611	0.232	0.198	PTN2A_ARATH Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A OS=Arabidopsis thaliana OX=3702 GN=PTEN2A PE=1 SV=1
20	Q8T9S7	1.10e-52	189	533	0.163	0.159	PTEN_DICDI Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Dictyostelium discoideum OX=44689 GN=pteN PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF06018 CodY	23	15.9	CodY GAF-like domain
2	PF00782 DSPc	0.0039	28.5	Dual specificity phosphatase, catalytic domain
3	PF00520 Ion_trans	0.051	24.4	Ion transport protein
4	PF08016 PKD_channel	14	16.6	Polycystin cation channel
5	PF10409 PTEN_C2	5.6e-25	99.1	C2 domain of PTEN tumour-suppressor protein
6	PF14566 PTPlike_phytase	2.7	19.6	Inositol hexakisphosphate
7	PF00102 Y_phosphatase	1.8	19.7	Protein-tyrosine phosphatase
8	PF13350 Y_phosphatase3	18	16.8	Tyrosine phosphatase family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000383089

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360777	0.927	72 kDa inositol polyphosphate 5-phosphatase
2	9606.ENSP00000333262	0.924	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
3	9606.ENSP00000362115	0.924	Type II inositol 1,4,5-trisphosphate 5-phosphatase
4	9606.ENSP00000347792	0.917	Synaptojanin-2
5	9606.ENSP00000360154	0.917	Inositol polyphosphate 5-phosphatase OCRL-1
6	9606.ENSP00000373713	0.917	Phosphatidylinositide phosphatase SAC1
7	9606.ENSP00000298229	0.915	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
8	9606.ENSP00000413937	0.914	Inositol polyphosphate 5-phosphatase K
9	9606.ENSP00000405338	0.913	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
10	9606.ENSP00000354519	0.910	Phosphatidylinositide phosphatase SAC2
11	9606.ENSP00000285419	0.909	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
12	9606.ENSP00000409667	0.907	Synaptojanin-1
13	9606.ENSP00000381102	0.906	Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
14	9606.ENSP00000345752	0.740	Myotubularin-related protein 2
15	9606.ENSP00000384164	0.619	Kinesin-like protein KIF16B
16	9606.ENSP00000321987	0.614	Thrombospondin-type laminin G domain and EAR repeat-containing protein
17	9606.ENSP00000442400	0.603	Keratinocyte associated protein 3
18	9606.ENSP00000383295	0.565	Neurobeachin
19	9606.ENSP00000373594	0.561	Transmembrane protein 266
20	9606.ENSP00000373648	0.539	Potassium voltage-gated channel subfamily KQT member 3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0034593	0.997	phosphatidylinositol bisphosphate phosphatase activity
GO:0005488	0.989	binding
GO:0005515	0.963	protein binding
GO:0004725	0.706	protein tyrosine phosphatase activity
GO:0034594	0.497	phosphatidylinositol trisphosphate phosphatase activity
GO:0106017	0.433	phosphatidylinositol-3,4-bisphosphate phosphatase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.997	organic substance metabolic process
GO:0044238	0.997	primary metabolic process
GO:0044237	0.997	cellular metabolic process
GO:0046488	0.990	phosphatidylinositol metabolic process
GO:0046474	0.949	glycerophospholipid biosynthetic process
GO:0006661	0.935	phosphatidylinositol biosynthetic process
GO:0016311	0.816	dephosphorylation
GO:0050794	0.590	regulation of cellular process
GO:0050896	0.469	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	1.000	membrane
GO:0043226	0.995	organelle
GO:0043227	0.994	membrane-bounded organelle
GO:0012505	0.989	endomembrane system
GO:0005622	0.988	intracellular anatomical structure
GO:0005737	0.975	cytoplasm
GO:0043231	0.973	intracellular membrane-bounded organelle
GO:0031090	0.942	organelle membrane
GO:0005794	0.701	Golgi apparatus
GO:0005783	0.659	endoplasmic reticulum
GO:0031984	0.635	organelle subcompartment
GO:0098588	0.634	bounding membrane of organelle
GO:0042175	0.467	nuclear outer membrane-endoplasmic reticulum membrane network
GO:0098827	0.459	endoplasmic reticulum subcompartment
GO:0005789	0.452	endoplasmic reticulum membrane
GO:0000139	0.370	Golgi membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.1.3.-	0.998	Phosphoric monoester hydrolases.
RHEA:10684	0.706	H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
EC:3.1.3.48	0.706	protein-tyrosine-phosphatase.

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