StarFunc result for job id Q7L8J4

User Input

>input (393 residues)
MAELRQVPGGRETPQGELRPEVVEDEVPRSPVAEEPGGGGSSSSEAKLSPREEEELDPRI
QEELEHLNQASEEINQVELQLDEARTTYRRILQESARKLNTQGSHLGSCIEKARPYYEAR
RLAKEAQQETQKAALRYERAVSMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKV
NEAEEERLRGEREHQRVTRLCQQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHK
AKVTELEQQVAQAKTRYSVALRNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPED
MEDGDSGIEGAEGAGLEEGSSLGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDH
VSLDGQELGTRSGGRRGSDGGARGGRHQRSVSL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q7L8J4	1.000	1.000	4.205E-50	393	1.000	1.000	Q7L8J4.pdb.gz	3BP5L_HUMAN SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1
2	AFDB:Q9V785	0.562	0.465	3.510E-17	477	0.382	0.314	Q9V785.pdb.gz	3BP5H_DROME SH3 domain-binding protein 5 homolog OS=Drosophila melanogaster OX=7227 GN=pcs PE=1 SV=4
3	AFDB:Q9Z131	0.576	0.491	1.217E-16	463	0.318	0.270	Q9Z131.pdb.gz	3BP5_MOUSE SH3 domain-binding protein 5 OS=Mus musculus OX=10090 GN=Sh3bp5 PE=1 SV=3
4	AFDB:F4JHE9	0.266	0.093	5.907E-8	1185	0.155	0.051	F4JHE9.pdb.gz	F4JHE9_ARATH K+ efflux antiporter 2 OS=Arabidopsis thaliana OX=3702 GN=KEA2 PE=1 SV=1
5	AFDB:Q9ZTZ7	0.229	0.081	1.901E-6	1193	0.135	0.044	Q9ZTZ7.pdb.gz	KEA1_ARATH K(+) efflux antiporter 1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=KEA1 PE=1 SV=2
6	AFDB:Q8K1N2	0.224	0.081	4.832E-6	1249	0.160	0.050	Q8K1N2.pdb.gz	PHLB2_MOUSE Pleckstrin homology-like domain family B member 2 OS=Mus musculus OX=10090 GN=Phldb2 PE=1 SV=2
7	AFDB:Q6NSJ2	0.188	0.128	5.944E-6	640	0.173	0.106	Q6NSJ2.pdb.gz	PHLB3_HUMAN Pleckstrin homology-like domain family B member 3 OS=Homo sapiens OX=9606 GN=PHLDB3 PE=1 SV=3
8	AFDB:K7EM85	0.250	0.089	1.858E-5	1163	0.181	0.061	K7EM85.pdb.gz	K7EM85_HUMAN Rho GTPase activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=1
9	AFDB:Q54GD0	0.187	0.095	2.671E-5	920	0.137	0.059	Q54GD0.pdb.gz	MGP1_DICDI GTPase activating protein homolog 1 OS=Dictyostelium discoideum OX=44689 GN=mgp1 PE=3 SV=1
10	AFDB:A0QX22	0.247	0.198	3.461E-5	497	0.130	0.103	A0QX22.pdb.gz	RIPA_MYCS2 Peptidoglycan endopeptidase RipA OS=Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) OX=246196 GN=ripA PE=1 SV=1
11	PDB:3hajA	0.167	0.212	1.036E-2	286	0.104	0.143	3hajA.pdb.gz	Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
12	PDB:5ew5A	0.169	0.142	1.150E-2	490	0.064	0.051	5ew5A.pdb.gz
13	PDB:4o9yA	0.183	0.040	1.652E-2	2490	0.115	0.018	4o9yA.pdb.gz
14	PDB:2b5uA	0.146	0.125	1.833E-2	470	0.069	0.057	2b5uA.pdb.gz
15	PDB:6z6oC	0.198	0.148	3.786E-2	548	0.071	0.051	6z6oC.pdb.gz	Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies.
16	PDB:4ke2A	0.181	0.328	4.422E-2	196	0.071	0.143	4ke2A.pdb.gz
17	PDB:6ikoA	0.179	0.229	4.657E-2	303	0.074	0.096	6ikoA.pdb.gz
18	PDB:7nsuD	0.141	0.132	7.819E-2	420	0.059	0.055	7nsuD.pdb.gz
19	PDB:5lkiA	0.166	0.061	8.673E-2	1427	0.074	0.020	5lkiA.pdb.gz
20	PDB:7z8fe	0.143	0.018	1.246E-1	4579	0.087	0.007	7z8fe.pdb.gz	Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q7L8J4	0.0	787	393	1.000	1.000	3BP5L_HUMAN SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1
2	Q9V785	2.32e-73	238	477	0.333	0.275	3BP5H_DROME SH3 domain-binding protein 5 homolog OS=Drosophila melanogaster OX=7227 GN=pcs PE=1 SV=4
3	O60239	5.59e-60	202	455	0.295	0.255	3BP5_HUMAN SH3 domain-binding protein 5 OS=Homo sapiens OX=9606 GN=SH3BP5 PE=1 SV=2
4	Q91Y80	1.97e-59	201	457	0.277	0.239	3BP5_RAT SH3 domain-binding protein 5 OS=Rattus norvegicus OX=10116 GN=Sh3bp5 PE=1 SV=2
5	Q9Z131	6.24e-59	200	463	0.277	0.235	3BP5_MOUSE SH3 domain-binding protein 5 OS=Mus musculus OX=10090 GN=Sh3bp5 PE=1 SV=3
6	P42171	5.74e-15	76.3	244	0.183	0.295	REI1_CAEEL Guanine nucleotide exchange factor rei-1 OS=Caenorhabditis elegans OX=6239 GN=rei-1 PE=1 SV=1
7	Q8IDX6	0.018	40.0	3130	0.094	0.012	RH2A_PLAF7 Reticulocyte-binding protein homolog 2a OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=RH2a PE=1 SV=1
8	P25386	0.72	34.7	1790	0.150	0.033	USO1_YEAST Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=USO1 PE=1 SV=2
9	Q9W1B0	0.91	34.3	1637	0.127	0.031	GEK_DROME Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster OX=7227 GN=gek PE=1 SV=1
10	P22674	3.6	32.0	350	0.064	0.071	CCNO_HUMAN Cyclin-O OS=Homo sapiens OX=9606 GN=CCNO PE=1 SV=2
11	Q9Z2R9	3.6	32.3	619	0.092	0.058	E2AK1_MOUSE Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Mus musculus OX=10090 GN=Eif2ak1 PE=1 SV=2
12	Q09EF7	3.7	32.3	1955	0.071	0.014	CROCC_CAEEL Rootletin OS=Caenorhabditis elegans OX=6239 GN=che-10 PE=2 SV=2
13	Q6FHZ7	4.1	32.0	437	0.053	0.048	Q6FHZ7_HUMAN Perilipin OS=Homo sapiens OX=9606 GN=ADFP PE=2 SV=1
14	Q99541	4.1	32.0	437	0.053	0.048	PLIN2_HUMAN Perilipin-2 OS=Homo sapiens OX=9606 GN=PLIN2 PE=1 SV=2
15	Q09591	5.0	32.0	1244	0.137	0.043	MIX1_CAEEL Mitotic chromosome and X-chromosome-associated protein mix-1 OS=Caenorhabditis elegans OX=6239 GN=mix-1 PE=1 SV=2
16	P39880	7.8	31.2	1505	0.076	0.020	CUX1_HUMAN Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3
17	G5ECC0	8.2	31.2	587	0.056	0.037	G5ECC0_CAEEL Kinesin like protein OS=Caenorhabditis elegans OX=6239 GN=klp-16 PE=1 SV=1
18	A0A2R8Y852	8.8	31.2	1460	0.076	0.021	A0A2R8Y852_HUMAN Homeobox protein cut-like OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=1
19	A0A2R8YDI1	8.9	31.2	1358	0.076	0.022	A0A2R8YDI1_HUMAN Homeobox protein cut-like OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03036 Perilipin	74	13.8	Perilipin family
2	PF03836 RasGAP_C	56	15.3	RasGAP C-terminus
3	PF05276 SH3BP5	5.7e-93	322.5	SH3 domain-binding protein 5 (SH3BP5)
4	PF06485 Tab2-like_N	5.3e+02	11.7	RNA-binding protein Tab2/Atab2 N terminal

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000355428

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000262319	0.655	Telomere length regulation protein TEL2 homolog
2	9606.ENSP00000261368	0.617	Synphilin-1
3	9606.ENSP00000333547	0.595	Ras-related protein Rab-11B
4	9606.ENSP00000394316	0.592	Basic leucine zipper and W2 domain-containing protein 1
5	9606.ENSP00000480763	0.553	Ephrin type-A receptor 5
6	9606.ENSP00000425093	0.539	Cadherin-18
7	9606.ENSP00000261890	0.532	Ras-related protein Rab-11A
8	9606.ENSP00000379287	0.520	14-3-3 protein zeta/delta
9	9606.ENSP00000365807	0.509	Guanine nucleotide-binding protein subunit alpha-14
10	9606.ENSP00000310042	0.508	Zinc finger protein 622
11	9606.ENSP00000419160	0.504	Spermatogenesis-associated protein 45
12	9606.ENSP00000355459	0.502	Zinc finger protein 670
13	9606.ENSP00000362946	0.502	Ras-related protein Rab-14

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005085	1.000	guanyl-nucleotide exchange factor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.986	cellular process
GO:0050794	0.986	regulation of cellular process
GO:0019222	0.525	regulation of metabolic process
GO:0031323	0.508	regulation of cellular metabolic process
GO:0060255	0.477	regulation of macromolecule metabolic process
GO:0080090	0.345	regulation of primary metabolic process
GO:0051179	0.344	localization
GO:0051171	0.327	regulation of nitrogen compound metabolic process
GO:0042325	0.327	regulation of phosphorylation
GO:0051246	0.322	regulation of protein metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0005829	0.996	cytosol
GO:0070013	0.989	intracellular organelle lumen
GO:0031981	0.981	nuclear lumen
GO:0016020	0.953	membrane
GO:0005654	0.936	nucleoplasm
GO:0012505	0.846	endomembrane system
GO:0071944	0.647	cell periphery
GO:0005886	0.617	plasma membrane
GO:0031982	0.350	vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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