StarFunc result for job id Q7Z4I7

User Input

>input (341 residues)
MTGSNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEG
RKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGR
HLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAREL
KGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKK
GLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFD
MKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q7Z4I7	1.000	1.000	1.224E-78	341	1.000	1.000	Q7Z4I7.pdb.gz	LIMS2_HUMAN LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens OX=9606 GN=LIMS2 PE=1 SV=1
2	AFDB:C0KUC6	0.856	0.761	2.637E-67	387	0.821	0.724	C0KUC6.pdb.gz	C0KUC6_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=1 SV=1
3	AFDB:F1R9E2	0.515	0.469	9.158E-62	377	0.733	0.663	F1R9E2.pdb.gz
4	AFDB:Q8INQ9	0.515	0.506	6.462E-56	348	0.633	0.621	Q8INQ9.pdb.gz	Q8INQ9_DROME LIM domain-containing protein OS=Drosophila melanogaster OX=7227 GN=stck PE=1 SV=1
5	AFDB:P50464	0.537	0.527	1.519E-54	348	0.589	0.578	P50464.pdb.gz	UNC97_CAEEL LIM domain-containing protein unc-97 OS=Caenorhabditis elegans OX=6239 GN=unc-97 PE=1 SV=1
6	AFDB:Q19157	0.354	0.363	1.293E-37	330	0.337	0.348	Q19157.pdb.gz	PIN2_CAEEL LIM domain-containing protein pin-2 OS=Caenorhabditis elegans OX=6239 GN=pin-2 PE=2 SV=2
7	AFDB:Q54NW4	0.404	0.269	2.309E-37	553	0.328	0.203	Q54NW4.pdb.gz	LIMB_DICDI LIM domain-containing protein B OS=Dictyostelium discoideum OX=44689 GN=limB PE=2 SV=1
8	AFDB:G5EDJ5	0.417	0.249	1.744E-27	619	0.238	0.131	G5EDJ5.pdb.gz	G5EDJ5_CAEEL LIM domain protein OS=Caenorhabditis elegans OX=6239 GN=lim-9 PE=1 SV=2
9	AFDB:A0A140VJQ8	0.421	0.265	1.663E-26	591	0.232	0.134	A0A140VJQ8.pdb.gz	A0A140VJQ8_HUMAN Paxillin OS=Homo sapiens OX=9606 GN=PXN PE=2 SV=1
10	AFDB:Q09476	0.456	0.393	3.168E-26	413	0.223	0.184	Q09476.pdb.gz	PXL1_CAEEL Paxillin homolog 1 OS=Caenorhabditis elegans OX=6239 GN=pxl-1 PE=1 SV=2
11	PDB:4kfzB	0.188	0.398	9.196E-8	148	0.076	0.176	4kfzB.pdb.gz	Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.
12	PDB:1b8tA	0.156	0.265	1.116E-7	192	0.111	0.198	1b8tA.pdb.gz	Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation.
13	PDB:1imlA	0.161	0.574	1.788E-2	76	0.062	0.276	1imlA.pdb.gz	Structure of the cysteine-rich intestinal protein, CRIP.
14	PDB:4kblA	0.132	0.118	4.701E-2	395	0.088	0.076	4kblA.pdb.gz	Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism.
15	PDB:7od1A	0.097	0.086	1.159E-1	430	0.088	0.070	7od1A.pdb.gz	CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
16	PDB:7c4cA	0.074	0.075	1.499E-1	332	0.044	0.045	7c4cA.pdb.gz	Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
17	PDB:4zynB	0.140	0.128	1.706E-1	385	0.097	0.086	4zynB.pdb.gz	A Ubl/ubiquitin switch in the activation of Parkin.
18	PDB:5dkaA	0.089	0.272	1.706E-1	96	0.044	0.156	5dkaA.pdb.gz	A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.
19	PDB:7uhyD	0.111	0.127	2.856E-1	288	0.023	0.028	7uhyD.pdb.gz	Structure of the nutrient-sensing hub GATOR2.
20	PDB:8d0kF	0.070	0.034	2.856E-1	915	0.065	0.024	8d0kF.pdb.gz	Structures of the human CST-Pol alpha-primase complex bound to telomere templates.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A8I5ZKY9	0.0	584	396	0.827	0.712	A0A8I5ZKY9_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=1 SV=1
2	A0A8I5ZPU7	0.0	584	337	0.833	0.843	A0A8I5ZPU7_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=4 SV=1
3	A0A8I5ZR99	0.0	521	315	0.762	0.825	A0A8I5ZR99_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=1 SV=1
4	A0A8I6A6W3	0.0	571	398	0.777	0.666	A0A8I6A6W3_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=1 SV=1
5	A0A8I6GA69	0.0	580	347	0.827	0.813	A0A8I6GA69_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=1 SV=1
6	C0KUC5	0.0	581	362	0.827	0.779	C0KUC5_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=1 SV=1
7	C0KUC6	0.0	580	387	0.824	0.726	C0KUC6_RAT LIM and senescent cell antigen-like-containing domain protein OS=Rattus norvegicus OX=10116 GN=Lims1 PE=1 SV=1
8	P48059	0.0	573	325	0.815	0.855	LIMS1_HUMAN LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4
9	Q501W5	0.0	583	336	0.830	0.842	Q501W5_DANRE LIM domain-containing protein OS=Danio rerio OX=7955 GN=zgc:112533 PE=1 SV=1
10	Q502G3	0.0	539	377	0.736	0.666	Q502G3_DANRE LIM domain-containing protein OS=Danio rerio OX=7955 GN=zgc:112257 PE=2 SV=1
11	Q7Z4I7	0.0	704	341	1.000	1.000	LIMS2_HUMAN LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens OX=9606 GN=LIMS2 PE=1 SV=1
12	Q91XD2	0.0	638	341	0.912	0.912	LIMS2_MOUSE LIM and senescent cell antigen-like-containing domain protein 2 OS=Mus musculus OX=10090 GN=Lims2 PE=1 SV=1
13	Q99JW4	0.0	575	325	0.821	0.862	LIMS1_MOUSE LIM and senescent cell antigen-like-containing domain protein 1 OS=Mus musculus OX=10090 GN=Lims1 PE=1 SV=3
14	Q8INQ9	8.00e-164	462	348	0.642	0.629	Q8INQ9_DROME LIM domain-containing protein OS=Drosophila melanogaster OX=7227 GN=stck PE=1 SV=1
15	Q8INR0	1.48e-163	462	345	0.642	0.635	Q8INR0_DROME LIM domain-containing protein OS=Drosophila melanogaster OX=7227 GN=stck PE=1 SV=1
16	Q9XYA7	5.30e-163	460	335	0.633	0.645	Q9XYA7_DROME LIM domain-containing protein OS=Drosophila melanogaster OX=7227 GN=stck PE=1 SV=1
17	P50464	2.99e-154	438	348	0.587	0.575	UNC97_CAEEL LIM domain-containing protein unc-97 OS=Caenorhabditis elegans OX=6239 GN=unc-97 PE=1 SV=1
18	Q8IGP6	6.26e-117	340	253	0.481	0.648	Q8IGP6_DROME RE52752p OS=Drosophila melanogaster OX=7227 GN=stck PE=2 SV=1
19	H0Y592	5.49e-100	294	169	0.434	0.876	H0Y592_HUMAN LIM zinc finger domain containing 2 (Fragment) OS=Homo sapiens OX=9606 GN=LIMS2 PE=1 SV=1
20	Q19157	3.87e-70	223	330	0.340	0.352	PIN2_CAEEL LIM domain-containing protein pin-2 OS=Caenorhabditis elegans OX=6239 GN=pin-2 PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00412 LIM	2.9e-58	205.3	LIM domain
2	PF11781 zf-RRN7	1.1e+02	13.9	Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
3	PF18439 zf_UBZ	62	14.7	Ubiquitin-Binding Zinc Finger

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9555.ENSPANP00000007416

Rank	PPI partner	STRING score	Description
1	9555.ENSPANP00000011162	0.983	Integrin-linked kinase
2	9555.ENSPANP00000019941	0.963	Ras suppressor protein 1
3	9555.ENSPANP00000009759	0.939	Parvin, alpha
4	9555.ENSPANP00000013511	0.920	Parvin, beta
5	9555.ENSPANP00000012046	0.900	NCK adaptor protein 2
6	9555.ENSPANP00000013516	0.816	Parvin, gamma
7	9555.ENSPANP00000005025	0.778	Transmembrane protein 203
8	9555.ENSPANP00000007955	0.778	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences
9	9555.ENSPANP00000003576	0.772	NCK adaptor protein 1
10	9555.ENSPANP00000016909	0.708	Fermitin family member 2
11	9555.ENSPANP00000017043	0.708	Fermitin family member 1
12	9555.ENSPANP00000004396	0.706	Replication factor C (activator 1) 3, 38kDa
13	9555.ENSPANP00000003344	0.704	Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
14	9555.ENSPANP00000015454	0.704	LPS-responsive vesicle trafficking, beach and anchor containing
15	9555.ENSPANP00000012909	0.693	Uncharacterized protein
16	9555.ENSPANP00000010474	0.679	Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
17	9555.ENSPANP00000015781	0.664	Tensin 1
18	9555.ENSPANP00000007622	0.656	Tensin 3
19	9555.ENSPANP00000009647	0.656	Tensin like C1 domain containing phosphatase (tensin 2)
20	9555.ENSPANP00000011830	0.655	Fermitin family member 3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009966	0.995	regulation of signal transduction
GO:0009987	0.891	cellular process
GO:0032501	0.841	multicellular organismal process
GO:1902531	0.652	regulation of intracellular signal transduction
GO:0051896	0.644	regulation of protein kinase B signaling
GO:0060047	0.588	heart contraction
GO:0050896	0.497	response to stimulus
GO:0048518	0.405	positive regulation of biological process
GO:0048522	0.371	positive regulation of cellular process
GO:0071840	0.346	cellular component organization or biogenesis
GO:0016043	0.315	cellular component organization
GO:0019222	0.304	regulation of metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0070161	0.998	anchoring junction
GO:0005925	0.982	focal adhesion
GO:0005622	0.968	intracellular anatomical structure
GO:0005737	0.948	cytoplasm
GO:0043226	0.797	organelle
GO:0043227	0.709	membrane-bounded organelle
GO:0032991	0.604	protein-containing complex
GO:0043229	0.560	intracellular organelle
GO:0005829	0.412	cytosol
GO:0043232	0.317	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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