StarFunc result for job id Q86VW0

User Input

>input (696 residues)
MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKA
RGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRL
GFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALI
NNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDE
LLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQW
GIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLS
DVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLL
EEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQ
RCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEK
HRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHR
LEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYFG
SPSDMASTAENIRDRMKLVNLKRQQLRHPEMVTTES

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q86VW0	1.000	1.000	8.478E-93	696	1.000	1.000	Q86VW0.pdb.gz	SESD1_HUMAN SEC14 domain and spectrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=SESTD1 PE=1 SV=2
2	AFDB:Q7SX85	0.953	0.929	9.332E-77	714	0.841	0.819	Q7SX85.pdb.gz	SESD1_DANRE SEC14 domain and spectrin repeat-containing protein 1 OS=Danio rerio OX=7955 GN=sestd1 PE=2 SV=3
3	AFDB:A0A0R4I9W4	0.451	0.243	2.122E-26	1632	0.247	0.105	A0A0R4I9W4.pdb.gz
4	AFDB:A0A2R8RHL8	0.565	0.211	2.960E-25	2306	0.244	0.074	A0A2R8RHL8.pdb.gz	A0A2R8RHL8_DANRE Kalirin RhoGEF kinase b OS=Danio rerio OX=7955 GN=wu:fc60a10 PE=4 SV=1
5	AFDB:Q7KVD1	0.366	0.154	7.684E-22	2263	0.218	0.067	Q7KVD1.pdb.gz	Q7KVD1_DROME Trio, isoform A OS=Drosophila melanogaster OX=7227 GN=trio PE=1 SV=1
6	AFDB:O15068	0.447	0.293	2.033E-19	1137	0.195	0.120	O15068.pdb.gz	MCF2L_HUMAN Guanine nucleotide exchange factor DBS OS=Homo sapiens OX=9606 GN=MCF2L PE=1 SV=2
7	AFDB:Q63406	0.465	0.302	3.295E-19	1149	0.197	0.119	Q63406.pdb.gz	MCF2L_RAT Guanine nucleotide exchange factor DBS OS=Rattus norvegicus OX=10116 GN=Mcf2l PE=1 SV=3
8	AFDB:O61528	0.398	0.138	1.909E-18	2488	0.198	0.055	O61528.pdb.gz	O61528_CAEEL CRAL-TRIO domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=unc-73 PE=1 SV=1
9	AFDB:Q6PDM6	0.495	0.315	5.478E-18	1166	0.198	0.118	Q6PDM6.pdb.gz	Q6PDM6_MOUSE Mcf.2 transforming sequence-like OS=Mus musculus OX=10090 GN=Mcf2l PE=1 SV=1
10	AFDB:Q8BLE2	0.431	0.317	1.020E-15	1031	0.165	0.112	Q8BLE2.pdb.gz	Q8BLE2_MOUSE Mcf.2 transforming sequence OS=Mus musculus OX=10090 GN=Mcf2 PE=2 SV=1
11	PDB:7wvtA	0.173	0.294	1.294E-3	364	0.045	0.085	7wvtA.pdb.gz	Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
12	PDB:4cizA	0.191	0.422	1.477E-3	284	0.049	0.120	4cizA.pdb.gz	Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9-Cis-Retinal Isomerase Activity.
13	PDB:3w68C	0.186	0.455	3.256E-3	252	0.040	0.111	3w68C.pdb.gz	Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
14	PDB:4d1eA	0.166	0.143	4.055E-3	859	0.096	0.078	4d1eA.pdb.gz
15	PDB:7r04A	0.148	0.049	5.762E-3	2326	0.145	0.043	7r04A.pdb.gz	Structural basis of activation of the tumor suppressor protein neurofibromin.
16	PDB:1oizA	0.188	0.443	6.869E-3	265	0.042	0.109	1oizA.pdb.gz	The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein
17	PDB:7wrbA	0.118	0.093	2.350E-2	930	0.134	0.100	7wrbA.pdb.gz	Structures of a mammalian TRPM8 in closed state.
18	PDB:1sjjA	0.195	0.166	2.565E-2	863	0.118	0.095	1sjjA.pdb.gz
19	PDB:4tlgA	0.155	0.251	4.744E-2	396	0.040	0.071	4tlgA.pdb.gz	Crystal structure of SEC14-like protein 4 (SEC14L4)
20	PDB:3b7nA	0.158	0.317	5.180E-2	307	0.033	0.075	3b7nA.pdb.gz	Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q7SX85	0.0	1201	714	0.833	0.812	SESD1_DANRE SEC14 domain and spectrin repeat-containing protein 1 OS=Danio rerio OX=7955 GN=sestd1 PE=2 SV=3
2	Q86VW0	0.0	1427	696	1.000	1.000	SESD1_HUMAN SEC14 domain and spectrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=SESTD1 PE=1 SV=2
3	C9JHW6	6.93e-100	304	146	0.210	1.000	C9JHW6_HUMAN SEC14 and spectrin domain containing 1 (Fragment) OS=Homo sapiens OX=9606 GN=SESTD1 PE=1 SV=1
4	C9J4X8	4.31e-97	297	143	0.205	1.000	C9J4X8_HUMAN SEC14 and spectrin domain containing 1 (Fragment) OS=Homo sapiens OX=9606 GN=SESTD1 PE=1 SV=1
5	A2CG49	3.42e-58	216	2964	0.250	0.059	KALRN_MOUSE Kalirin OS=Mus musculus OX=10090 GN=Kalrn PE=1 SV=1
6	H7BXZ5	4.55e-58	216	2955	0.250	0.059	H7BXZ5_HUMAN non-specific serine/threonine protein kinase (Fragment) OS=Homo sapiens OX=9606 GN=KALRN PE=1 SV=1
7	O60229	6.08e-58	215	2986	0.250	0.058	KALRN_HUMAN Kalirin OS=Homo sapiens OX=9606 GN=KALRN PE=1 SV=3
8	P97924	2.76e-57	213	2959	0.250	0.059	KALRN_RAT Kalirin OS=Rattus norvegicus OX=10116 GN=Kalrn PE=1 SV=3
9	F1M0Z1	7.82e-55	206	3100	0.246	0.055	TRIO_RAT Triple functional domain protein OS=Rattus norvegicus OX=10116 GN=Trio PE=1 SV=4
10	Q0KL02	1.01e-54	206	3102	0.247	0.055	TRIO_MOUSE Triple functional domain protein OS=Mus musculus OX=10090 GN=Trio PE=1 SV=3
11	O75962	1.89e-54	205	3097	0.244	0.055	TRIO_HUMAN Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2
12	A0A2R8RHL8	1.51e-53	202	2306	0.241	0.073	A0A2R8RHL8_DANRE Kalirin RhoGEF kinase b OS=Danio rerio OX=7955 GN=wu:fc60a10 PE=4 SV=1
13	O15068	1.99e-25	115	1137	0.151	0.092	MCF2L_HUMAN Guanine nucleotide exchange factor DBS OS=Homo sapiens OX=9606 GN=MCF2L PE=1 SV=2
14	Q7KY09	2.04e-25	115	2263	0.093	0.029	Q7KY09_DROME Trio OS=Drosophila melanogaster OX=7227 GN=trio PE=2 SV=1
15	Q7KVD1	2.33e-25	115	2263	0.092	0.028	Q7KVD1_DROME Trio, isoform A OS=Drosophila melanogaster OX=7227 GN=trio PE=1 SV=1
16	Q9W0L0	7.00e-25	113	2263	0.092	0.028	Q9W0L0_DROME Guanine-nucleotide-exchange-factor TRIO OS=Drosophila melanogaster OX=7227 GN=trio PE=2 SV=3
17	Q6PDM6	2.53e-23	108	1166	0.184	0.110	Q6PDM6_MOUSE Mcf.2 transforming sequence-like OS=Mus musculus OX=10090 GN=Mcf2l PE=1 SV=1
18	Q64096	3.01e-23	108	1149	0.184	0.111	MCF2L_MOUSE Guanine nucleotide exchange factor DBS OS=Mus musculus OX=10090 GN=Mcf2l PE=1 SV=2
19	Q63406	5.97e-23	107	1149	0.184	0.111	MCF2L_RAT Guanine nucleotide exchange factor DBS OS=Rattus norvegicus OX=10116 GN=Mcf2l PE=1 SV=3
20	Q7KPP4	6.43e-22	103	1638	0.213	0.090	Q7KPP4_CAEEL CRAL-TRIO domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=unc-73 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13716 CRAL_TRIO_2	2.3e-05	36.1	Divergent CRAL/TRIO domain
2	PF03883 H2O2_YaaD	6.9e+02	11.1	Peroxide stress protein YaaA
3	PF06303 MatP	4e+02	12.9	MatP N-terminal domain
4	PF14223 Retrotran_gag_2	46	15.2	gag-polypeptide of LTR copia-type
5	PF00435 Spectrin	0.088	24.7	Spectrin repeat

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000415332

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000262839	0.802	Short transient receptor potential channel 5
2	9606.ENSP00000369027	0.744	Short transient receptor potential channel 4
3	9606.ENSP00000376268	0.714	SEC14-like protein 1
4	9606.ENSP00000368215	0.699	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
5	9606.ENSP00000285243	0.689	Ankyrin repeat domain-containing protein 40
6	9606.ENSP00000370104	0.684	G protein pathway suppressor 2
7	9606.ENSP00000417510	0.663	SPT20 homolog, SAGA complex component
8	9606.ENSP00000344242	0.648	Leucine-rich repeat-containing protein 17
9	9606.ENSP00000251170	0.642	SEC14-like protein 5
10	9606.ENSP00000337439	0.639	Dapper homolog 1
11	9606.ENSP00000361769	0.625	Regulating synaptic membrane exocytosis protein 3
12	9606.ENSP00000418668	0.623	Caveolae-associated protein 4
13	9606.ENSP00000395995	0.596	Coiled-coil domain-containing protein 141
14	9606.ENSP00000295131	0.592	E3 ubiquitin-protein ligase ZSWIM2
15	9606.ENSP00000481103	0.557	Transcription factor E2F8
16	9606.ENSP00000331044	0.541	Enkurin
17	9606.ENSP00000361636	0.539	Troponin C, skeletal muscle
18	9606.ENSP00000264167	0.505	Alkyldihydroxyacetonephosphate synthase, peroxisomal

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0043325	1.000	phosphatidylinositol-3,4-bisphosphate binding
GO:0070300	1.000	phosphatidic acid binding
GO:0070273	1.000	phosphatidylinositol-4-phosphate binding
GO:0032266	1.000	phosphatidylinositol-3-phosphate binding
GO:0010314	1.000	phosphatidylinositol-5-phosphate binding
GO:0080025	1.000	phosphatidylinositol-3,5-bisphosphate binding
GO:0005546	0.995	phosphatidylinositol-4,5-bisphosphate binding
GO:0098772	0.344	molecular function regulator activity
GO:0030695	0.311	GTPase regulator activity
GO:0140678	0.301	molecular function inhibitor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.985	regulation of cellular process
GO:0048523	0.983	negative regulation of cellular process
GO:0043269	0.826	regulation of monoatomic ion transport
GO:0051051	0.686	negative regulation of transport
GO:0010959	0.675	regulation of metal ion transport
GO:0043271	0.657	negative regulation of monoatomic ion transport
GO:0034762	0.645	regulation of transmembrane transport
GO:0051924	0.642	regulation of calcium ion transport
GO:0034763	0.620	negative regulation of transmembrane transport
GO:0051926	0.618	negative regulation of calcium ion transport
GO:1904063	0.612	negative regulation of cation transmembrane transport
GO:1903169	0.547	regulation of calcium ion transmembrane transport
GO:0009987	0.500	cellular process
GO:1903170	0.412	negative regulation of calcium ion transmembrane transport
GO:0048856	0.355	anatomical structure development
GO:0032501	0.346	multicellular organismal process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	0.999	membrane
GO:0005856	0.998	cytoskeleton
GO:0032991	0.995	protein-containing complex
GO:0045111	0.990	intermediate filament cytoskeleton
GO:0005737	0.962	cytoplasm
GO:0098796	0.927	membrane protein complex
GO:0034704	0.921	calcium channel complex
GO:0005829	0.900	cytosol
GO:0043231	0.790	intracellular membrane-bounded organelle
GO:0005886	0.716	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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