StarFunc result for job id Q86XE5

User Input

>input (327 residues)
MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEEN
LHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVE
MTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPV
DAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVC
ALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGG
PCRAPLQELSPAEEEALRMDFTSNGWL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q0P5I5	0.909	0.909	5.766E-54	327	0.902	0.902	Q0P5I5.pdb.gz	HOGA1_BOVIN 4-hydroxy-2-oxoglutarate aldolase, mitochondrial OS=Bos taurus OX=9913 GN=HOGA1 PE=1 SV=1
2	AFDB:Q9DCU9	0.912	0.929	3.502E-53	321	0.878	0.894	Q9DCU9.pdb.gz	HOGA1_MOUSE 4-hydroxy-2-oxoglutarate aldolase, mitochondrial OS=Mus musculus OX=10090 GN=Hoga1 PE=1 SV=1
3	PDB:3s5oA	0.905	1.000	1.496E-52	296	0.905	1.000	3s5oA.pdb.gz
4	AFDB:A6Y9S5	0.837	0.867	8.339E-24	315	0.278	0.289	A6Y9S5.pdb.gz	LGA1_HYPJE L-threo-3-deoxy-hexylosonate aldolase OS=Hypocrea jecorina OX=51453 GN=lga1 PE=1 SV=1
5	AFDB:P0A6L2	0.837	0.934	2.916E-22	292	0.214	0.240	P0A6L2.pdb.gz	DAPA_ECOLI 4-hydroxy-tetrahydrodipicolinate synthase OS=Escherichia coli (strain K12) OX=83333 GN=dapA PE=1 SV=1
6	PDB:5t26B	0.848	0.940	2.009E-21	294	0.217	0.241	5t26B.pdb.gz
7	AFDB:Q8UGL3	0.834	0.924	6.327E-21	294	0.257	0.286	Q8UGL3.pdb.gz	DAPA_AGRFC 4-hydroxy-tetrahydrodipicolinate synthase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) OX=176299 GN=dapA PE=1 SV=1
8	PDB:5c54A	0.824	0.867	1.590E-20	310	0.232	0.245	5c54A.pdb.gz
9	PDB:5j5dA	0.836	0.917	3.717E-20	297	0.232	0.256	5j5dA.pdb.gz	Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues
10	AFDB:Q8NMD2	0.821	0.859	3.842E-20	312	0.232	0.244	Q8NMD2.pdb.gz	Q8NMD2_CORGL Dihydrodipicolinate synthase/N-acetylneuraminate lyase OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) OX=196627 GN=Cgl2646 PE=1 SV=1
11	AFDB:P9WP25	0.841	0.914	6.193E-20	300	0.235	0.257	P9WP25.pdb.gz	DAPA_MYCTU 4-hydroxy-tetrahydrodipicolinate synthase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=dapA PE=1 SV=1
12	AFDB:P0A6L4	0.793	0.870	1.234E-19	297	0.223	0.246	P0A6L4.pdb.gz	NANA_ECOLI N-acetylneuraminate lyase OS=Escherichia coli (strain K12) OX=83333 GN=nanA PE=1 SV=2
13	AFDB:P75682	0.817	0.881	1.373E-19	302	0.245	0.265	P75682.pdb.gz	YAGE_ECOLI Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE OS=Escherichia coli (strain K12) OX=83333 GN=yagE PE=1 SV=2
14	PDB:3nevA	0.819	0.895	2.646E-19	298	0.242	0.265	3nevA.pdb.gz	Identification of biochemical and putative biological role of a xenolog from Escherichia coli using structural analysis.
15	AFDB:Q97R25	0.830	0.871	2.885E-19	311	0.190	0.199	Q97R25.pdb.gz	DAPA_STRPN 4-hydroxy-tetrahydrodipicolinate synthase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=dapA PE=1 SV=1
16	PDB:2wpbA	0.803	0.866	2.943E-19	302	0.220	0.238	2wpbA.pdb.gz	Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
17	PDB:6arhB	0.832	0.895	3.037E-18	303	0.232	0.251	6arhB.pdb.gz
18	PDB:2r94A	0.778	0.882	3.306E-17	286	0.208	0.238	2r94A.pdb.gz	Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax.
19	PDB:6g3zA	0.770	0.854	8.592E-17	293	0.205	0.229	6g3zA.pdb.gz	Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases: The Structures of Picrophilus torridus 2-Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2-Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2-Keto-3-deoxy-6-phosphogluconate.
20	PDB:2nuyA	0.768	0.865	2.233E-16	288	0.183	0.208	2nuyA.pdb.gz	Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q0P5I5	0.0	618	327	0.902	0.902	HOGA1_BOVIN 4-hydroxy-2-oxoglutarate aldolase, mitochondrial OS=Bos taurus OX=9913 GN=HOGA1 PE=1 SV=1
2	Q86XE5	0.0	676	327	1.000	1.000	HOGA1_HUMAN 4-hydroxy-2-oxoglutarate aldolase, mitochondrial OS=Homo sapiens OX=9606 GN=HOGA1 PE=1 SV=1
3	Q9DCU9	0.0	603	321	0.878	0.894	HOGA1_MOUSE 4-hydroxy-2-oxoglutarate aldolase, mitochondrial OS=Mus musculus OX=10090 GN=Hoga1 PE=1 SV=1
4	E9PAM4	2.97e-41	151	449	0.220	0.160	E9PAM4_HUMAN Phosphatidylinositol 4-kinase type 2 OS=Homo sapiens OX=9606 PE=3 SV=1
5	A6Y9S5	3.47e-28	113	315	0.297	0.308	LGA1_HYPJE L-threo-3-deoxy-hexylosonate aldolase OS=Hypocrea jecorina OX=51453 GN=lga1 PE=1 SV=1
6	Q97R25	1.15e-27	111	311	0.220	0.232	DAPA_STRPN 4-hydroxy-tetrahydrodipicolinate synthase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=dapA PE=1 SV=1
7	Q8UGL3	1.72e-26	108	294	0.254	0.282	DAPA_AGRFC 4-hydroxy-tetrahydrodipicolinate synthase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) OX=176299 GN=dapA PE=1 SV=1
8	P75682	4.67e-24	101	302	0.220	0.238	YAGE_ECOLI Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE OS=Escherichia coli (strain K12) OX=83333 GN=yagE PE=1 SV=2
9	P9WP25	4.70e-24	101	300	0.232	0.253	DAPA_MYCTU 4-hydroxy-tetrahydrodipicolinate synthase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=dapA PE=1 SV=1
10	P0A6L2	3.49e-20	90.9	292	0.187	0.209	DAPA_ECOLI 4-hydroxy-tetrahydrodipicolinate synthase OS=Escherichia coli (strain K12) OX=83333 GN=dapA PE=1 SV=1
11	P0A6L4	5.12e-20	90.5	297	0.235	0.259	NANA_ECOLI N-acetylneuraminate lyase OS=Escherichia coli (strain K12) OX=83333 GN=nanA PE=1 SV=2
12	Q8NMD2	1.57e-19	89.4	312	0.202	0.212	Q8NMD2_CORGL Dihydrodipicolinate synthase/N-acetylneuraminate lyase OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) OX=196627 GN=Cgl2646 PE=1 SV=1
13	Q9BXD5	7.93e-19	87.4	320	0.257	0.263	NPL_HUMAN N-acetylneuraminate lyase OS=Homo sapiens OX=9606 GN=NPL PE=1 SV=1
14	P39359	2.92e-18	85.9	301	0.232	0.252	YJHH_ECOLI Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH OS=Escherichia coli (strain K12) OX=83333 GN=yjhH PE=1 SV=2
15	Q9I490	5.32e-18	85.1	305	0.208	0.223	Q9I490_PSEAE Probable dihydrodipicolinate synthetase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA1254 PE=3 SV=1
16	Q9DCJ9	2.49e-17	83.2	320	0.248	0.253	NPL_MOUSE N-acetylneuraminate lyase OS=Mus musculus OX=10090 GN=Npl PE=1 SV=1
17	Q6KZI8	4.99e-17	81.6	266	0.177	0.218	KDGA_PICTO 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase OS=Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828 / KAW 2/3) OX=1122961 GN=PTO1279 PE=1 SV=1
18	Q9BEC7	1.06e-15	78.6	319	0.235	0.241	NPL_PIG N-acetylneuraminate lyase OS=Sus scrofa OX=9823 GN=NPL PE=1 SV=1
19	Q97U28	1.48e-15	78.2	308	0.242	0.256	KDGA_SACS2 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase OS=Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) OX=273057 GN=eda PE=1 SV=1
20	O54288	1.57e-15	77.8	294	0.242	0.269	KDGA_SACSO 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase OS=Saccharolobus solfataricus OX=2287 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00701 DHDPS	5.8e-46	168.1	Dihydrodipicolinate synthetase family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000359680

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000313432	0.992	Glyoxylate reductase/hydroxypyruvate reductase
2	9606.ENSP00000302620	0.989	Alanine-glyoxylate aminotransferase
3	9606.ENSP00000368066	0.931	Hydroxyacid oxidase 1
4	9606.ENSP00000359539	0.929	Aspartate aminotransferase, cytoplasmic
5	9606.ENSP00000483507	0.929	Hydroxyacid oxidase 2
6	9606.ENSP00000245206	0.924	Aspartate aminotransferase, mitochondrial
7	9606.ENSP00000303077	0.917	Putative aspartate aminotransferase, cytoplasmic 2
8	9606.ENSP00000228476	0.837	D-amino-acid oxidase
9	9606.ENSP00000231420	0.823	Alanine--glyoxylate aminotransferase 2, mitochondrial
10	9606.ENSP00000253233	0.820	Probable peptide chain release factor C12orf65, mitochondrial
11	9606.ENSP00000322439	0.811	Elongation factor Tu, mitochondrial
12	9606.ENSP00000313877	0.786	Elongation factor Ts, mitochondrial
13	9606.ENSP00000362036	0.774	Mitochondrial ribosomal protein S16
14	9606.ENSP00000374353	0.769	Hydroxyacylglutathione hydrolase-like protein
15	9606.ENSP00000419038	0.766	Elongation factor G, mitochondrial
16	9606.ENSP00000418008	0.764	Mitochondrial ribosomal protein S22
17	9606.ENSP00000357838	0.740	Ornithine aminotransferase, mitochondrial
18	9606.ENSP00000331487	0.717	Nuclear protein localization protein 4 homolog
19	9606.ENSP00000222673	0.674	2-oxoglutarate dehydrogenase, mitochondrial
20	9606.ENSP00000420294	0.661	Polyhomeotic-like protein 3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016833	1.000	oxo-acid-lyase activity
GO:0016832	1.000	aldehyde-lyase activity
GO:0005515	0.995	protein binding
GO:0042802	0.977	identical protein binding
GO:0042803	0.716	protein homodimerization activity
GO:0008700	0.536	4-hydroxy-2-oxoglutarate aldolase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0046395	0.998	carboxylic acid catabolic process
GO:0044238	0.973	primary metabolic process
GO:0072329	0.958	monocarboxylic acid catabolic process
GO:0006807	0.900	nitrogen compound metabolic process
GO:1901564	0.874	organonitrogen compound metabolic process
GO:0006081	0.833	cellular aldehyde metabolic process
GO:0046185	0.739	aldehyde catabolic process
GO:1901576	0.618	organic substance biosynthetic process
GO:0006520	0.589	amino acid metabolic process
GO:0044249	0.530	cellular biosynthetic process
GO:1901605	0.510	alpha-amino acid metabolic process
GO:1901565	0.387	organonitrogen compound catabolic process
GO:0043648	0.380	dicarboxylic acid metabolic process
GO:1901360	0.365	organic cyclic compound metabolic process
GO:0044283	0.334	small molecule biosynthetic process
GO:0046483	0.331	heterocycle metabolic process
GO:1901606	0.311	alpha-amino acid catabolic process
GO:0016053	0.309	organic acid biosynthetic process
GO:0009063	0.303	amino acid catabolic process
GO:0046394	0.301	carboxylic acid biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0070013	0.996	intracellular organelle lumen
GO:0005759	0.825	mitochondrial matrix
GO:0031981	0.419	nuclear lumen
GO:0005654	0.331	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:4.1.3.-	1.000	Oxo-acid-lyases.
EC:4.1.2.-	1.000	Aldehyde-lyases.
RHEA:18169	0.536	4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
EC:4.1.3.16	0.536	4-hydroxy-2-oxoglutarate aldolase.

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