StarFunc result for job id Q86YC2

User Input

>input (1186 residues)
MDEPPGKPLSCEEKEKLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQ
QDLSPQLKHSEPKNKICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDGPGGLPIQR
TDDTQEHFPHRVSDPSGEQKQKLPSRRKKQQKRTFISQERDCVFGTDSLRLSGKRLKEQE
EISSKNPARSPVTEIRTHLLSLKSELPDSPEPVTEINEDSVLIPPTAQPEKGVDTFLRRP
NFTRATTVPLQTLSDSGSSQHLEHIPPKGSSELTTHDLKNIRFTSPVSLEAQGKKMTVST
DNLLVNKAISKSGQLPTSSNLEANISCSLNELTYNNLPANENQNLKEQNQTEKSLKSPSD
TLDGRNENLQESEILSQPKSLSLEATSPLSAEKHSCTVPEGLLFPAEYYVRTTRSMSNCQ
RKVAVEAVIQSHLDVKKKGFKNKNKDASKNLNLSNEETDQSEIRMSGTCTGQPSSRTSQK
LLSLTKVSSPAGPTEDNDLSRKAVAQAPGRRYTGKRKSACTPASDHCEPLLPTSSLSIVN
RSKEEVTSHKYQHEKLFIQVKGKKSRHQKEDSLSWSNSAYLSLDDDAFTAPFHRDGMLSL
KQLLSFLSITDFQLPDEDFGPLKLEKVKSCSEKPVEPFESKMFGERHLKEGSCIFPEELS
PKRMDTEMEDLEEDLIVLPGKSHPKRPNSQSQHTKTGLSSSILLYTPLNTVAPDDNDRPT
TDMCSPAFPILGTTPAFGPQGSYEKASTEVAGRTCCTPQLAHLKDSVCLASDTKQFDSSG
SPAKPHTTLQVSGRQGQPTCDCDSVPPGTPPPIESFTFKENQLCRNTCQELHKHSVEQTE
TAELPASDSINPGNLQLVSELKNPSGSCSVDVSAMFWERAGCKEPCIITACEDVVSLWKA
LDAWQWEKLYTWHFAEVPVLQIVPVPDVYNLVCVALGNLEIREIRALFCSSDDESEKQVL
LKSGNIKAVLGLTKRRLVSSSGTLSDQQVEVMTFAEDGGGKENQFLMPPEETILTFAEVQ
GMQEALLGTTIMNNIVIWNLKTGQLLKKMHIDDSYQASVCHKAYSEMGLLFIVLSHPCAK
ESESLRSPVFQLIVINPKTTLSVGVMLYCLPPGQAGRFLEGDVKDHCAAAILTSGTIAIW
DLLLGQCTALLPPVSDQHWSFVKWSGTDSHLLAGQKDGNIFVYHYS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q86YC2	1.000	1.000	0.000	1186	1.000	1.000	Q86YC2.pdb.gz	PALB2_HUMAN Partner and localizer of BRCA2 OS=Homo sapiens OX=9606 GN=PALB2 PE=1 SV=1
2	AFDB:Q3U0P1	0.366	0.390	3.476E-100	1104	0.590	0.634	Q3U0P1.pdb.gz	PALB2_MOUSE Partner and localizer of BRCA2 OS=Mus musculus OX=10090 GN=Palb2 PE=1 SV=2
3	AFDB:Q9W002	0.202	0.163	2.318E-13	1504	0.116	0.092	Q9W002.pdb.gz	Q9W002_DROME Misshapen, isoform A OS=Drosophila melanogaster OX=7227 GN=msn PE=1 SV=3
4	PDB:7mq8LR	0.200	0.294	3.569E-13	773	0.035	0.054	7mq8LR.pdb.gz	Nucleolar maturation of the human small subunit processome.
5	PDB:7jvrB	0.216	0.650	4.177E-13	342	0.030	0.105	7jvrB.pdb.gz	Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
6	PDB:7qdrC	0.218	0.733	5.723E-13	305	0.041	0.161	7qdrC.pdb.gz
7	PDB:5nnzA	0.195	0.577	7.440E-13	335	0.036	0.128	5nnzA.pdb.gz
8	PDB:5mzhB	0.199	0.479	7.840E-13	415	0.028	0.080	5mzhB.pdb.gz
9	PDB:7vggA	0.204	0.668	1.074E-12	304	0.034	0.132	7vggA.pdb.gz
10	PDB:4v6wAg	0.199	0.612	2.125E-12	318	0.040	0.151	4v6wAg.pdb.gz	Structures of the human and Drosophila 80S ribosome.
11	PDB:7bt6x	0.194	0.408	2.125E-12	488	0.041	0.100	7bt6x.pdb.gz	Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel.
12	PDB:6nd4U	0.202	0.519	2.487E-12	407	0.033	0.096	6nd4U.pdb.gz	Conformational switches control early maturation of the eukaryotic small ribosomal subunit.
13	PDB:7mq8LU	0.209	0.505	5.185E-12	445	0.034	0.090	7mq8LU.pdb.gz	Nucleolar maturation of the human small subunit processome.
14	AFDB:Q9H2Y7	0.199	0.130	1.903E-11	1883	0.129	0.081	Q9H2Y7.pdb.gz	ZN106_HUMAN Zinc finger protein 106 OS=Homo sapiens OX=9606 GN=ZNF106 PE=1 SV=1
15	AFDB:B7YZK8	0.154	0.125	2.362E-10	1517	0.132	0.103	B7YZK8.pdb.gz	B7YZK8_DROME Thin, isoform C OS=Drosophila melanogaster OX=7227 GN=tn PE=1 SV=1
16	AFDB:Q9VZF4	0.196	0.177	1.201E-9	1326	0.147	0.131	Q9VZF4.pdb.gz	FBXW7_DROME F-box/WD repeat-containing protein 7 OS=Drosophila melanogaster OX=7227 GN=ago PE=1 SV=1
17	AFDB:Q9R0G8	0.150	0.126	1.601E-5	1455	0.120	0.098	Q9R0G8.pdb.gz	NRK_MOUSE Nik-related protein kinase OS=Mus musculus OX=10090 GN=Nrk PE=1 SV=2
18	AFDB:A1Z9W4	0.056	0.037	5.385E-4	1953	0.131	0.079	A1Z9W4.pdb.gz	A1Z9W4_DROME LD11480p OS=Drosophila melanogaster OX=7227 GN=Pcf11 PE=1 SV=2
19	AFDB:P47136	0.053	0.045	2.107E-3	1447	0.137	0.113	P47136.pdb.gz	BUD4_YEAST Bud site selection protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=BUD4 PE=1 SV=2
20	AFDB:Q924C5	0.049	0.039	3.042E-3	1678	0.129	0.091	Q924C5.pdb.gz	ALPK3_MOUSE Alpha-protein kinase 3 OS=Mus musculus OX=10090 GN=Alpk3 PE=1 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q3U0P1	0.0	1206	1104	0.584	0.628	PALB2_MOUSE Partner and localizer of BRCA2 OS=Mus musculus OX=10090 GN=Palb2 PE=1 SV=2
2	Q86YC2	0.0	2442	1186	1.000	1.000	PALB2_HUMAN Partner and localizer of BRCA2 OS=Homo sapiens OX=9606 GN=PALB2 PE=1 SV=1
3	Q72PB3	0.22	36.6	173	0.015	0.104	Q72PB3_LEPIC DUF1564 family protein OS=Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) OX=267671 GN=LIC_12559 PE=4 SV=1
4	P98204	1.1	36.2	1158	0.019	0.020	ALA1_ARATH Phospholipid-transporting ATPase 1 OS=Arabidopsis thaliana OX=3702 GN=ALA1 PE=2 SV=1
5	F4HXL0	1.9	35.0	713	0.023	0.038	PLIP2_ARATH Phospholipase A1 PLIP2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=PLIP2 PE=1 SV=1
6	Q4V8C4	2.6	34.3	328	0.020	0.073	WDR5B_RAT WD repeat-containing protein 5B OS=Rattus norvegicus OX=10116 GN=Wdr5b PE=2 SV=1
7	P41318	3.8	33.9	303	0.015	0.059	LST8_YEAST Target of rapamycin complex subunit LST8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=LST8 PE=1 SV=1
8	Q54KL5	5.1	33.5	335	0.014	0.051	WDR5_DICDI WD repeat-containing protein 5 homolog OS=Dictyostelium discoideum OX=44689 GN=wdr5 PE=3 SV=1
9	O75427	8.6	33.1	683	0.017	0.029	LRCH4_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2
10	K7GSE8	9.7	32.7	1103	0.019	0.020	K7GSE8_PIG Tyrosine-protein kinase OS=Sus scrofa OX=9823 GN=JAK3 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16756 PALB2_WD40	8e-184	621.9	Partner and localizer of BRCA2 WD40 domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000261584

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000369497	0.999	Breast cancer type 2 susceptibility protein
2	9606.ENSP00000372088	0.999	DNA repair protein RAD51 homolog 1
3	9606.ENSP00000418960	0.999	Breast cancer type 1 susceptibility protein
4	9606.ENSP00000171111	0.998	Kelch-like ECH-associated protein 1
5	9606.ENSP00000331310	0.998	Mortality factor 4-like protein 1
6	9606.ENSP00000336701	0.993	DNA repair protein RAD51 homolog 3
7	9606.ENSP00000287647	0.990	Fanconi anemia group D2 protein
8	9606.ENSP00000310842	0.990	Fanconi anemia group I protein
9	9606.ENSP00000294008	0.982	Structure-specific endonuclease subunit SLX4
10	9606.ENSP00000394417	0.976	Mortality factor 4-like protein 2
11	9606.ENSP00000259008	0.975	Fanconi anemia group J protein
12	9606.ENSP00000228843	0.958	RAD51-associated protein 1
13	9606.ENSP00000322570	0.955	DNA polymerase epsilon catalytic subunit A
14	9606.ENSP00000406046	0.951	DNA polymerase delta catalytic subunit
15	9606.ENSP00000307853	0.950	Crossover junction endonuclease MUS81
16	9606.ENSP00000361310	0.949	DNA polymerase eta
17	9606.ENSP00000363017	0.947	Replication protein A 32 kDa subunit
18	9606.ENSP00000376952	0.946	Crossover junction endonuclease EME1
19	9606.ENSP00000278616	0.945	Serine-protein kinase ATM
20	9606.ENSP00000318977	0.945	Flap endonuclease GEN homolog 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003677	1.000	DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044238	0.996	primary metabolic process
GO:0006974	0.995	cellular response to DNA damage stimulus
GO:0006302	0.989	double-strand break repair
GO:0006310	0.985	DNA recombination
GO:0000725	0.920	recombinational repair
GO:0000724	0.809	double-strand break repair via homologous recombination
GO:0065007	0.750	biological regulation
GO:0050789	0.709	regulation of biological process
GO:0050794	0.682	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:1990391	0.997	DNA repair complex
GO:0043232	0.973	intracellular non-membrane-bounded organelle
GO:0005694	0.850	chromosome
GO:0005737	0.769	cytoplasm
GO:0140513	0.457	nuclear protein-containing complex
GO:1990234	0.383	transferase complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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