StarFunc result for job id Q8IVT5

User Input

>input (923 residues)
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRT
KCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRP
EVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKED
SSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPT
PSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVC
HVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAE
PHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPG
QRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAA
DGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLA
PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMK
RVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
SSKVVPRFERFGLGVLESSNPKM

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R8Y5H9	0.454	0.451	0.000	928	0.974	0.969	A0A2R8Y5H9.pdb.gz	A0A2R8Y5H9_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=1
2	AFDB:Q61097	0.389	0.410	0.000	873	0.862	0.912	Q61097.pdb.gz	KSR1_MOUSE Kinase suppressor of Ras 1 OS=Mus musculus OX=10090 GN=Ksr1 PE=1 SV=1
3	AFDB:Q8IVT5	1.000	1.000	0.000	923	1.000	1.000	Q8IVT5.pdb.gz	KSR1_HUMAN Kinase suppressor of Ras 1 OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=3
4	AFDB:Q3UVC0	0.388	0.376	2.409E-66	959	0.498	0.480	Q3UVC0.pdb.gz	KSR2_MOUSE Kinase suppressor of Ras 2 OS=Mus musculus OX=10090 GN=Ksr2 PE=1 SV=3
5	PDB:7mfdA	0.268	0.579	7.321E-17	410	0.113	0.254	7mfdA.pdb.gz	Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
6	PDB:6uanB	0.227	0.758	2.234E-14	261	0.102	0.360	6uanB.pdb.gz
7	PDB:2h8hA	0.255	0.510	5.427E-14	445	0.079	0.164	2h8hA.pdb.gz	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
8	PDB:4fl2A	0.253	0.411	1.137E-13	555	0.057	0.095	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
9	PDB:1k9aB	0.240	0.483	2.159E-13	441	0.072	0.150	1k9aB.pdb.gz
10	PDB:4k2rA	0.236	0.387	9.481E-13	551	0.065	0.109	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
11	PDB:4rerA	0.235	0.456	1.800E-12	459	0.068	0.137	4rerA.pdb.gz	Structural basis of AMPK regulation by adenine nucleotides and glycogen.
12	PDB:4rgjA	0.230	0.441	1.987E-12	463	0.056	0.112	4rgjA.pdb.gz
13	PDB:3uc4A	0.227	0.644	2.303E-12	295	0.075	0.234	3uc4A.pdb.gz
14	PDB:4eomC	0.236	0.718	3.096E-12	276	0.065	0.217	4eomC.pdb.gz	An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
15	AFDB:Q24315	0.230	0.175	3.530E-12	1235	0.143	0.107	Q24315.pdb.gz	Q24315_DROME Tyrosine kinase (Fragment) OS=Drosophila melanogaster OX=7227 GN=Tie PE=2 SV=1
16	AFDB:Q5B953	0.248	0.275	1.153E-11	828	0.138	0.153	Q5B953.pdb.gz	Q5B953_EMENI Checkpoint protein kinase, putative (AFU_orthologue AFUA_3G08100) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_02927 PE=4 SV=1
17	AFDB:A0A024RDM3	0.245	0.212	2.943E-11	1088	0.163	0.138	A0A024RDM3.pdb.gz
18	AFDB:B2BJC0	0.253	0.218	1.574E-10	1078	0.147	0.126	B2BJC0.pdb.gz	B2BJC0_DANRE Lats2-2 OS=Danio rerio OX=7955 GN=si:ch211-173o4.2 PE=2 SV=1
19	AFDB:O95835	0.245	0.204	2.453E-10	1130	0.154	0.126	O95835.pdb.gz	LATS1_HUMAN Serine/threonine-protein kinase LATS1 OS=Homo sapiens OX=9606 GN=LATS1 PE=1 SV=1
20	AFDB:Q54I36	0.229	0.160	9.290E-10	1338	0.131	0.090	Q54I36.pdb.gz	PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dictyostelium discoideum OX=44689 GN=pyk3 PE=1 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0A0MQW1	0.0	1756	846	0.917	1.000	A0A0A0MQW1_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=1
2	A0A2R8Y4X0	0.0	1430	829	0.827	0.920	A0A2R8Y4X0_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=1
3	A0A2R8Y5H9	0.0	1832	928	0.975	0.970	A0A2R8Y5H9_HUMAN non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=1
4	A0A8I5ZQW6	0.0	1456	889	0.866	0.899	A0A8I5ZQW6_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ksr1 PE=4 SV=1
5	A0A8I6AAT0	0.0	1420	850	0.843	0.915	A0A8I6AAT0_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ksr1 PE=4 SV=1
6	A0A8I6ADF9	0.0	1253	817	0.745	0.842	A0A8I6ADF9_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ksr1 PE=4 SV=1
7	A0A8I6AR82	0.0	1222	795	0.720	0.836	A0A8I6AR82_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ksr1 PE=4 SV=1
8	A8MY87	0.0	1261	612	0.660	0.995	A8MY87_HUMAN non-specific serine/threonine protein kinase (Fragment) OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=2
9	D3ZHL1	0.0	1503	888	0.883	0.918	D3ZHL1_RAT non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ksr1 PE=1 SV=3
10	Q3UVC0	0.0	602	959	0.362	0.348	KSR2_MOUSE Kinase suppressor of Ras 2 OS=Mus musculus OX=10090 GN=Ksr2 PE=1 SV=3
11	Q61097	0.0	1469	873	0.855	0.904	KSR1_MOUSE Kinase suppressor of Ras 1 OS=Mus musculus OX=10090 GN=Ksr1 PE=1 SV=1
12	Q6VAB6	0.0	619	950	0.362	0.352	KSR2_HUMAN Kinase suppressor of Ras 2 OS=Homo sapiens OX=9606 GN=KSR2 PE=1 SV=2
13	Q8IVT5	0.0	1909	923	1.000	1.000	KSR1_HUMAN Kinase suppressor of Ras 1 OS=Homo sapiens OX=9606 GN=KSR1 PE=1 SV=3
14	Q24170	1.49e-94	322	966	0.163	0.155	Q24170_DROME KSR OS=Drosophila melanogaster OX=7227 GN=ksr PE=2 SV=1
15	Q8ISD7	1.51e-94	322	966	0.163	0.155	Q8ISD7_DROME Kinase suppressor of ras OS=Drosophila melanogaster OX=7227 GN=ksr PE=4 SV=1
16	Q8I0R4	1.57e-94	322	966	0.163	0.155	Q8I0R4_DROME Kinase suppressor of ras OS=Drosophila melanogaster OX=7227 GN=ksr PE=4 SV=1
17	Q8ISD8	1.57e-94	322	966	0.163	0.155	Q8ISD8_DROME Kinase suppressor of ras OS=Drosophila melanogaster OX=7227 GN=ksr PE=4 SV=1
18	Q24171	1.60e-94	322	966	0.163	0.155	Q24171_DROME AT08303p OS=Drosophila melanogaster OX=7227 GN=ksr PE=2 SV=1
19	Q8ISD9	1.65e-94	322	966	0.163	0.155	Q8ISD9_DROME Kinase suppressor of ras OS=Drosophila melanogaster OX=7227 GN=ksr PE=4 SV=1
20	Q2XY02	1.39e-93	318	953	0.160	0.155	Q2XY02_DROME CG2899 (Fragment) OS=Drosophila melanogaster OX=7227 GN=ksr PE=4 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01636 APH	2.7e+02	12.8	Phosphotransferase enzyme family
2	PF00130 C1_1	14	17.0	Phorbol esters/diacylglycerol binding domain (C1 domain)
3	PF13095 FTA2	3.9e+02	12.1	Kinetochore Sim4 complex subunit FTA2
4	PF06293 Kdo	3e+02	12.2	Lipopolysaccharide kinase (Kdo/WaaP) family
5	PF14531 Kinase-like	0.071	24.0	Kinase-like
6	PF00069 Pkinase	9.8e-34	128.5	Protein kinase domain
7	PF07714 PK_Tyr_Ser-Thr	2.6e-44	163.1	Protein tyrosine and serine/threonine kinase
8	PF01163 RIO1	9.9	17.2	RIO1 family
9	PF13543 SAM_KSR1	3.2e-09	48.1	SAM like domain present in kinase suppressor RAS 1
10	PF20406 SAM_KSR1_N	2.7e-18	76.5	Kinase suppressor RAS 1 N-terminal helical hairpin

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9544.ENSMMUP00000023517

Rank	PPI partner	STRING score	Description
1	9544.ENSMMUP00000032163	0.992	Uncharacterized protein
2	9544.ENSMMUP00000025705	0.962	Mitogen-activated protein kinase kinase 2
3	9544.ENSMMUP00000022508	0.937	BRCA1-associated protein
4	9544.ENSMMUP00000004442	0.935	Lymphocyte-specific protein 1
5	9544.ENSMMUP00000004857	0.867	Non-specific serine/threonine protein kinase
6	9544.ENSMMUP00000009848	0.865	Connector enhancer of kinase suppressor of Ras 2
7	9544.ENSMMUP00000040509	0.847	Connector enhancer of kinase suppressor of Ras 1
8	9544.ENSMMUP00000020173	0.839	KRAS proto-oncogene, GTPase
9	9544.ENSMMUP00000022140	0.834	Dual specificity mitogen-activated protein kinase kinase 1
10	9544.ENSMMUP00000016444	0.833	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily
11	9544.ENSMMUP00000012063	0.831	Uncharacterized protein
12	9544.ENSMMUP00000009777	0.823	RAF proto-oncogene serine/threonine-protein kinase
13	9544.ENSMMUP00000002635	0.812	GTPase NRas
14	9544.ENSMMUP00000028522	0.811	GTPase HRas isoform 2
15	9544.ENSMMUP00000023356	0.799	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily
16	9544.ENSMMUP00000022174	0.779	Mitogen-activated protein kinase organizer 1
17	9544.ENSMMUP00000002709	0.774	Vaccinia related kinase 2
18	9544.ENSMMUP00000008547	0.772	14-3-3 protein zeta/delta
19	9544.ENSMMUP00000036148	0.772	Uncharacterized protein
20	9544.ENSMMUP00000005516	0.749	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0031434	0.999	mitogen-activated protein kinase kinase binding
GO:0005524	0.991	ATP binding
GO:0071889	0.973	14-3-3 protein binding
GO:0003824	0.762	catalytic activity
GO:0016772	0.612	transferase activity, transferring phosphorus-containing groups
GO:0140096	0.582	catalytic activity, acting on a protein
GO:0016773	0.508	phosphotransferase activity, alcohol group as acceptor
GO:0016301	0.487	kinase activity
GO:0060090	0.454	molecular adaptor activity
GO:0004672	0.427	protein kinase activity
GO:0030674	0.398	protein-macromolecule adaptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.998	biological regulation
GO:0009966	0.991	regulation of signal transduction
GO:0023056	0.985	positive regulation of signaling
GO:0010647	0.985	positive regulation of cell communication
GO:0009967	0.984	positive regulation of signal transduction
GO:1902531	0.969	regulation of intracellular signal transduction
GO:1902533	0.946	positive regulation of intracellular signal transduction
GO:0043408	0.852	regulation of MAPK cascade
GO:0009987	0.839	cellular process
GO:0043410	0.806	positive regulation of MAPK cascade
GO:0008152	0.559	metabolic process
GO:0044237	0.541	cellular metabolic process
GO:0006796	0.499	phosphate-containing compound metabolic process
GO:0050896	0.466	response to stimulus
GO:0065009	0.463	regulation of molecular function
GO:0016310	0.407	phosphorylation
GO:0051716	0.348	cellular response to stimulus
GO:0007154	0.331	cell communication
GO:0023052	0.330	signaling
GO:0007165	0.321	signal transduction
GO:0019222	0.300	regulation of metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0016020	0.939	membrane
GO:0012505	0.459	endomembrane system
GO:0071944	0.406	cell periphery
GO:0005886	0.385	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.-.-	0.612	Transferring phosphorus-containing groups.
EC:2.7.1.-	0.508	Phosphotransferases with an alcohol group as acceptor.

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