StarFunc result for job id Q8IYQ7

User Input

>input (743 residues)
MLHFNRCHHLKKITQKCFSSIHVKTDKHAQRFLSRTFALAELRKSWYSTHSLVGDKNIIL
MGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVL
NFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLDLICRLKLMKTDRIVGQNSGT
SMKDLLKFRRQYYKKWYDARVFCESGASPEEVADKVLNAIKRYQDVDSETFISTRHVWPE
DCEQKVSAKFFSEAVIEGLASDGGLFVPAKEFPKLSCGEWKSLVGATYVERAQILLERCI
HPADIPAARLGEMIETAYGENFACSKIAPVRHLSGNQFILELFHGPTGSFKDLSLQLMPH
IFAHCIPPSCNYMILVATSGDTGSAVLNGFSRLNKNDKQRIAVVAFFPENGVSDFQKAQI
IGSQRENGWAVGVESDFDFCQTAIKRIFNDSDFTGFLTVEYGTILSSANSINWGRLLPQV
VYHASAYLDLVSQGFISFGSPVDVCIPTGNFGNILAAVYAKMMGIPIRKFICASNQNHVL
TDFIKTGHYDLRERKLAQTFSPSIDILKSSNLERHLHLMANKDGQLMTELFNRLESQHHF
QIEKALVEKLQQDFVADWCSEGECLAAINSTYNTSGYILDPHTAVAKVVADRVQDKTCPV
IISSTAHYSKFAPAIMQALKIKEINETSSSQLYLLGSYNALPPLHEALLERTKQQEKMEY
QVCAADMNVLKSHVEQLVQNQFI

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q57X55	0.673	0.738	6.344E-46	675	0.292	0.321	Q57X55.pdb.gz	Q57X55_TRYB2 threonine synthase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.26A24.1130 PE=3 SV=1
2	AFDB:Q42598	0.608	0.869	1.233E-38	514	0.223	0.323	Q42598.pdb.gz	THRC_SCHPO Threonine synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=thrc PE=1 SV=1
3	AFDB:A0A1D8PNG9	0.606	0.873	5.153E-38	510	0.217	0.316	A0A1D8PNG9.pdb.gz	A0A1D8PNG9_CANAL threonine synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=THR4 PE=3 SV=1
4	AFDB:P16120	0.607	0.867	5.946E-38	514	0.230	0.333	P16120.pdb.gz	THRC_YEAST Threonine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=THR4 PE=1 SV=1
5	PDB:1kl7A	0.595	0.857	3.192E-35	509	0.233	0.340	1kl7A.pdb.gz	Structure and function of threonine synthase from yeast.
6	AFDB:Q2YDP8	0.575	0.880	6.394E-33	476	0.176	0.275	Q2YDP8.pdb.gz	THNS2_DANRE Threonine synthase-like 2 OS=Danio rerio OX=7955 GN=thnsl2 PE=2 SV=1
7	AFDB:Q80W22	0.581	0.875	1.636E-31	483	0.175	0.269	Q80W22.pdb.gz	THNS2_MOUSE Threonine synthase-like 2 OS=Mus musculus OX=10090 GN=Thnsl2 PE=1 SV=1
8	AFDB:P00934	0.524	0.885	1.041E-26	428	0.182	0.315	P00934.pdb.gz	THRC_ECOLI Threonine synthase OS=Escherichia coli (strain K12) OX=83333 GN=thrC PE=1 SV=1
9	PDB:1vb3A	0.516	0.869	3.355E-25	428	0.180	0.313	1vb3A.pdb.gz	Crystal Structure of Threonine Synthase from Escherichia coli
10	PDB:1e5xA	0.345	0.532	9.203E-12	451	0.121	0.200	1e5xA.pdb.gz
11	PDB:2d1fA	0.325	0.637	9.843E-10	349	0.083	0.178	2d1fA.pdb.gz	Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis.
12	AFDB:Q9P7R0	0.235	0.136	1.091E-9	1573	0.166	0.078	Q9P7R0.pdb.gz	ARO1_SCHPO Pentafunctional AROM polypeptide OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=aro1 PE=1 SV=1
13	AFDB:P0A6D7	0.208	0.840	8.891E-9	173	0.057	0.243	P0A6D7.pdb.gz	AROK_ECOLI Shikimate kinase 1 OS=Escherichia coli (strain K12) OX=83333 GN=aroK PE=1 SV=2
14	AFDB:Q9QZX7	0.319	0.645	1.302E-8	339	0.074	0.162	Q9QZX7.pdb.gz	SRR_MOUSE Serine racemase OS=Mus musculus OX=10090 GN=Srr PE=1 SV=1
15	PDB:1kagA	0.187	0.812	3.306E-7	158	0.055	0.259	1kagA.pdb.gz
16	PDB:1p5jA	0.305	0.631	3.467E-7	319	0.063	0.147	1p5jA.pdb.gz	Crystallization and preliminary crystallographic analysis of human serine dehydratase.
17	PDB:1pwhA	0.298	0.617	4.000E-7	327	0.069	0.156	1pwhA.pdb.gz	Crystal structure of serine dehydratase from rat liver.
18	PDB:7nbcAAA	0.314	0.656	4.841E-7	323	0.075	0.173	7nbcAAA.pdb.gz	Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
19	PDB:5tciH	0.374	0.636	6.758E-7	406	0.078	0.143	5tciH.pdb.gz	A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
20	PDB:1tdjA	0.328	0.471	7.088E-7	494	0.078	0.117	1tdjA.pdb.gz	Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q57X55	2.61e-101	328	675	0.299	0.329	Q57X55_TRYB2 threonine synthase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.26A24.1130 PE=3 SV=1
2	P16120	4.92e-75	253	514	0.230	0.333	THRC_YEAST Threonine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=THR4 PE=1 SV=1
3	A0A1D8PNG9	8.98e-73	247	510	0.215	0.314	A0A1D8PNG9_CANAL threonine synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=THR4 PE=3 SV=1
4	Q42598	2.95e-67	233	514	0.203	0.294	THRC_SCHPO Threonine synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=thrc PE=1 SV=1
5	Q2YDP8	8.68e-46	172	476	0.174	0.271	THNS2_DANRE Threonine synthase-like 2 OS=Danio rerio OX=7955 GN=thnsl2 PE=2 SV=1
6	P00934	1.54e-38	150	428	0.171	0.297	THRC_ECOLI Threonine synthase OS=Escherichia coli (strain K12) OX=83333 GN=thrC PE=1 SV=1
7	Q80W22	2.08e-38	151	483	0.156	0.240	THNS2_MOUSE Threonine synthase-like 2 OS=Mus musculus OX=10090 GN=Thnsl2 PE=1 SV=1
8	P0A6E1	5.34e-09	58.5	174	0.058	0.247	AROL_ECOLI Shikimate kinase 2 OS=Escherichia coli (strain K12) OX=83333 GN=aroL PE=1 SV=3
9	Q8GY88	2.12e-08	58.5	300	0.066	0.163	SK2_ARATH Shikimate kinase 2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=SK2 PE=1 SV=1
10	F4IIJ2	7.31e-08	57.0	304	0.050	0.122	F4IIJ2_ARATH shikimate kinase OS=Arabidopsis thaliana OX=3702 GN=SK1 PE=1 SV=1
11	Q7X7H9	1.33e-07	56.2	287	0.051	0.132	SK3_ORYSJ Shikimate kinase 3, chloroplastic OS=Oryza sativa subsp. japonica OX=39947 GN=SK3 PE=1 SV=2
12	F4JW33	1.60e-07	56.2	308	0.050	0.120	F4JW33_ARATH shikimate kinase OS=Arabidopsis thaliana OX=3702 GN=SK2 PE=1 SV=1
13	Q9S7B5	1.88e-07	56.6	526	0.117	0.165	THRC1_ARATH Threonine synthase 1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=TS1 PE=1 SV=1
14	Q5NTH4	9.70e-07	53.5	308	0.048	0.117	SK1_ORYSJ Shikimate kinase 1, chloroplastic OS=Oryza sativa subsp. japonica OX=39947 GN=SK1 PE=1 SV=1
15	P0A6D7	1.57e-06	51.2	173	0.044	0.191	AROK_ECOLI Shikimate kinase 1 OS=Escherichia coli (strain K12) OX=83333 GN=aroK PE=1 SV=2
16	Q5NTH3	1.08e-05	50.4	307	0.043	0.104	SK2_ORYSJ Shikimate kinase 2, chloroplastic OS=Oryza sativa subsp. japonica OX=39947 GN=SK2 PE=1 SV=1
17	Q9P7R0	3.38e-05	50.1	1573	0.065	0.031	ARO1_SCHPO Pentafunctional AROM polypeptide OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=aro1 PE=1 SV=1
18	Q57W41	0.002	43.5	335	0.024	0.054	Q57W41_TRYB2 AAA+ ATPase domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb05.28F8.390 PE=3 SV=1
19	Q9LW20	0.004	42.4	280	0.034	0.089	SKL1_ARATH Probable inactive shikimate kinase like 1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=SKL1 PE=2 SV=1
20	P08566	0.012	41.6	1588	0.034	0.016	ARO1_YEAST Pentafunctional AROM polypeptide OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ARO1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00004 AAA	0.77	21.6	ATPase family associated with various cellular activities (AAA)
2	PF13207 AAA_17	1.7e+02	14.1	AAA domain
3	PF13238 AAA_18	0.0025	29.8	AAA domain
4	PF13401 AAA_22	2e+02	13.7	AAA domain
5	PF13671 AAA_33	0.67	21.6	AAA domain
6	PF12689 Acid_PPase	78	14.6	Acid Phosphatase
7	PF20030 bpMoxR	2.8e+02	12.0	MoxR domain in the MoxR-vWA-beta-propeller ternary systems
8	PF02224 Cytidylate_kin	1.6e+02	13.4	Cytidylate kinase
9	PF01712 dNK	1.1e+02	14.1	Deoxynucleoside kinase
10	PF01695 IstB_IS21	34	15.4	IstB-like ATP binding protein
11	PF01078 Mg_chelatase	8.2	17.3	Magnesium chelatase, subunit ChlI
12	PF00291 PALP	0.00083	30.5	Pyridoxal-phosphate dependent enzyme
13	PF03215 Rad17	78	14.6	Rad17 P-loop domain
14	PF05496 RuvB_N	3.2	19.0	Holliday junction DNA helicase RuvB P-loop domain
15	PF01202 SKI	9.5e-36	134.8	Shikimate kinase
16	PF14821 Thr_synth_N	8e-10	50.1	Threonine synthase N terminus
17	PF02367 TsaE	2.7e+02	12.9	Threonylcarbamoyl adenosine biosynthesis protein TsaE
18	PF06414 Zeta_toxin	2.4e+02	12.5	Zeta toxin

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000434887

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000436621	0.660	UPF0598 protein C8orf82
2	9606.ENSP00000360268	0.655	Delta-1-pyrroline-5-carboxylate synthase
3	9606.ENSP00000258955	0.572	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
4	9606.ENSP00000378854	0.556	Phosphoserine phosphatase
5	9606.ENSP00000450436	0.547	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
6	9606.ENSP00000291386	0.543	RNA polymerase II subunit A C-terminal domain phosphatase SSU72
7	9606.ENSP00000217456	0.535	Adipocyte plasma membrane-associated protein
8	9606.ENSP00000253270	0.535	UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
9	9606.ENSP00000234454	0.514	Sepiapterin reductase
10	9606.ENSP00000247970	0.507	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003824	0.999	catalytic activity
GO:0036094	0.998	small molecule binding
GO:0043167	0.997	ion binding
GO:0005515	0.965	protein binding
GO:0043168	0.918	anion binding
GO:0016740	0.839	transferase activity
GO:0016829	0.733	lyase activity
GO:0097159	0.717	organic cyclic compound binding
GO:1901363	0.716	heterocyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044238	0.998	primary metabolic process
GO:0044237	0.998	cellular metabolic process
GO:1901564	0.996	organonitrogen compound metabolic process
GO:0006520	0.989	amino acid metabolic process
GO:1901605	0.970	alpha-amino acid metabolic process
GO:0009058	0.954	biosynthetic process
GO:1901576	0.904	organic substance biosynthetic process
GO:0044249	0.890	cellular biosynthetic process
GO:0044283	0.871	small molecule biosynthetic process
GO:0009069	0.763	serine family amino acid metabolic process
GO:1901566	0.388	organonitrogen compound biosynthetic process
GO:1901360	0.372	organic cyclic compound metabolic process
GO:0006725	0.360	cellular aromatic compound metabolic process
GO:0034641	0.352	cellular nitrogen compound metabolic process
GO:0046394	0.335	carboxylic acid biosynthetic process
GO:0050789	0.322	regulation of biological process
GO:0046483	0.316	heterocycle metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.995	mitochondrion
GO:0005829	0.972	cytosol
GO:0070013	0.949	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	0.839	Transferases.
EC:4.-.-.-	0.733	Lyases.

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