StarFunc result for job id Q8IZC6

User Input

>input (1860 residues)
MGAGSARGARGTAAAAAARGGGFLFSWILVSFACHLASTQGAPEDVDILQRLGLSWTKAG
SPAPPGVIPFQSGFIFTQRARLQAPTGTVIPAALGTELALVLSLCSHRVNHAFLFAVRSQ
KRKLQLGLQFLPGKTVVHLGSRRSVAFDLDMHDGRWHHLALELRGRTVTLVTACGQRRVP
VLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSIYPVTQVAHNYCTHLRKQCGQAD
TYQSPLGPLFSQDSGRPFTFQSDLALLGLENLTTATPALGSLPAGRGPRGTVAPATPTKP
QRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALDPMLPASVGGSTRTPRPAAAQPSQKIT
ATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTAPSSFTKSALPTQKQVPPTSRPVPARVSR
PAEKPIQRNPGMPRPPPPSTRPLPPTTSSSKKPIPTLARTEAKITSHASKPASARTSTHK
PPPFTALSSSPAPTPGSTRSTRPPATMVPPTSGTSTPRTAPAVPTPGSAPTGSKKPIGSE
ASKKAGPKSSPRKPVPLRPGKAARDVPLSDLTTRPSPRQPQPSQQTTPALVLAPAQFLSS
SPRPTSSGYSIFHLAGSTPFPLLMGPPGPKGDCGLPGPPGLPGLPGIPGARGPRGPPGPY
GNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSGNPGPPGRKGHKGYPGPAGHP
GEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVP
GKRGKMGMPGFPGVFGERGPPGLDGNPGELGLPGPPGVPGLIGDLGVLGPIGYPGPKGMK
GLMGSVGEPGLKGDKGEQGVPGVSGDPGFQGDKGSQGLPGFPGARGKPGPLGKVGDKGSI
GFPGPPGPEGFPGDIGPPGDNGPEGMKGKPGARGLPGPRGQLGPEGDEGPMGPPGAPGLE
GQPGRKGFPGRPGLDGVKGEPGDPGRPGPVGEQGFMGFIGLVGEPGIVGEKGDRGMMGPP
GVPGPKGSMGHPGMPGGMGTPGEPGPQGPPGSRGPPGMRGAKGRRGPRGPDGPAGEQGSR
GLKGPPGPQGRPGRPGQQGVAGERGHLGSRGFPGIPGPSGPPGTKGLPGEPGPQGPQGPI
GPPGEMGPKGPPGAVGEPGLPGEAGMKGDLGPLGTPGEQGLIGQRGEPGLEGDSGPMGPD
GLKGDRGDPGPDGEHGEKGQEGLMGEDGPPGPPGVTGVRGPEGKSGKQGEKGRTGAKGAK
GYQGQLGEMGVPGDPGPPGTPGPKGSRGSLGPTGAPGRMGAQGEPGLAGYDGHKGIVGPL
GPPGPKGEKGEQGEDGKAEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRGKPGQ
QGQPGHPGPRGWPGPKGSKGAEGPKGKQGKAGAPGRRGVQGLQGLPGPRGVVGRQGLEGI
AGPDGLPGRDGQAGQQGEQGDDGDPGPMGPAGKRGNPGVAGLPGAQGPPGFKGESGLPGQ
LGPPGKRGTEGRTGLPGNQGEPGSKGQPGDSGEMGFPGMAGLFGPKGPPGDIGFKGIQGP
RGPPGLMGKEGIVGPLGILGPSGLPGPKGDKGSRGDWGLQGPRGPPGPRGRPGPPGPPGG
PIQLQQDDLGAAFQTWMDTSGALRPESYSYPDRLVLDQGGEIFKTLHYLSNLIQSIKTPL
GTKENPARVCRDLMDCEQKMVDGTYWVDPNLGCSSDTIEVSCNFTHGGQTCLKPITASKV
EFAISRVQMNFLHLLSSEVTQHITIHCLNMTVWQEGTGQTPAKQAVRFRAWNGQIFEAGG
QFRPEVSMDGCKVQDGRWHQTLFTFRTQDPQQLPIISVDNLPPASSGKQYRLEVGPACFL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q5QNQ9	0.181	0.182	0.000	1845	0.807	0.814	Q5QNQ9.pdb.gz	CORA1_MOUSE Collagen alpha-1(XXVII) chain OS=Mus musculus OX=10090 GN=Col27a1 PE=2 SV=1
2	AFDB:Q8IZC6	1.000	1.000	0.000	1860	1.000	1.000	Q8IZC6.pdb.gz	CORA1_HUMAN Collagen alpha-1(XXVII) chain OS=Homo sapiens OX=9606 GN=COL27A1 PE=1 SV=1
3	AFDB:C7DZK3	0.123	0.128	8.592E-102	1783	0.526	0.549	C7DZK3.pdb.gz	CRA1A_DANRE Collagen alpha-1(XXVII) chain A OS=Danio rerio OX=7955 GN=col27a1a PE=2 SV=1
4	AFDB:Q17RW2	0.172	0.183	1.941E-82	1714	0.437	0.474	Q17RW2.pdb.gz	COOA1_HUMAN Collagen alpha-1(XXIV) chain OS=Homo sapiens OX=9606 GN=COL24A1 PE=1 SV=2
5	AFDB:Q30D77	0.178	0.189	1.055E-80	1733	0.432	0.464	Q30D77.pdb.gz	COOA1_MOUSE Collagen alpha-1(XXIV) chain OS=Mus musculus OX=10090 GN=Col24a1 PE=2 SV=2
6	AFDB:Q9JI03	0.120	0.121	5.075E-48	1840	0.369	0.373	Q9JI03.pdb.gz	CO5A1_RAT Collagen alpha-1(V) chain OS=Rattus norvegicus OX=10116 GN=Col5a1 PE=1 SV=1
7	AFDB:I3ISS1	0.107	0.110	3.642E-46	1803	0.361	0.372	I3ISS1.pdb.gz
8	AFDB:Q9JLI2	0.106	0.113	4.306E-44	1739	0.348	0.372	Q9JLI2.pdb.gz	Q9JLI2_MOUSE Collagen type V alpha 3 chain OS=Mus musculus OX=10090 GN=Col5a3 PE=1 SV=1
9	AFDB:P12107	0.114	0.116	2.406E-43	1806	0.347	0.358	P12107.pdb.gz	COBA1_HUMAN Collagen alpha-1(XI) chain OS=Homo sapiens OX=9606 GN=COL11A1 PE=1 SV=4
10	AFDB:P25940	0.107	0.114	5.846E-43	1745	0.349	0.372	P25940.pdb.gz	CO5A3_HUMAN Collagen alpha-3(V) chain OS=Homo sapiens OX=9606 GN=COL5A3 PE=1 SV=3
11	PDB:7zl1A	0.061	0.470	3.324E-6	215	0.011	0.093	7zl1A.pdb.gz
12	PDB:7qfqA	0.075	0.106	9.541E-6	1291	0.011	0.015	7qfqA.pdb.gz
13	PDB:4pbpB	0.063	0.501	1.009E-5	210	0.010	0.090	4pbpB.pdb.gz	Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces.
14	PDB:2a3wA	0.058	0.477	1.407E-5	204	0.008	0.074	2a3wA.pdb.gz	Ligand-assisted Aggregation of Proteins: DIMERIZATION OF SERUM AMYLOID P COMPONENT BY BIVALENT LIGANDS.
15	PDB:3v0aB	0.071	0.112	1.857E-5	1150	0.009	0.014	3v0aB.pdb.gz	Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
16	PDB:7ufgB	0.059	0.089	7.035E-5	1182	0.012	0.019	7ufgB.pdb.gz	Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
17	PDB:3vv1A	0.061	0.550	1.037E-4	141	0.012	0.156	3vv1A.pdb.gz	Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6
18	PDB:3o12A	0.065	0.449	1.097E-4	185	0.010	0.097	3o12A.pdb.gz
19	PDB:7ufgA	0.062	0.096	1.225E-4	1151	0.015	0.023	7ufgA.pdb.gz	Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
20	PDB:2d43A	0.071	0.245	1.530E-4	482	0.009	0.035	2d43A.pdb.gz	The family 42 carbohydrate-binding module of family 54 alpha-L-arabinofuranosidase specifically binds the arabinofuranose side chain of hemicellulose

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0MSJ1	0.0	1277	1658	0.411	0.461	CRA1B_DANRE Collagen alpha-1(XXVII) chain B OS=Danio rerio OX=7955 GN=col27a1b PE=2 SV=1
2	C7DZK3	0.0	1282	1783	0.526	0.549	CRA1A_DANRE Collagen alpha-1(XXVII) chain A OS=Danio rerio OX=7955 GN=col27a1a PE=2 SV=1
3	Q17RW2	0.0	929	1714	0.366	0.397	COOA1_HUMAN Collagen alpha-1(XXIV) chain OS=Homo sapiens OX=9606 GN=COL24A1 PE=1 SV=2
4	Q30D77	0.0	815	1733	0.360	0.386	COOA1_MOUSE Collagen alpha-1(XXIV) chain OS=Mus musculus OX=10090 GN=Col24a1 PE=2 SV=2
5	Q5QNQ9	0.0	2361	1845	0.809	0.815	CORA1_MOUSE Collagen alpha-1(XXVII) chain OS=Mus musculus OX=10090 GN=Col27a1 PE=2 SV=1
6	Q8IZC6	0.0	3509	1860	1.000	1.000	CORA1_HUMAN Collagen alpha-1(XXVII) chain OS=Homo sapiens OX=9606 GN=COL27A1 PE=1 SV=1
7	P02466	7.10e-139	470	1372	0.298	0.405	CO1A2_RAT Collagen alpha-2(I) chain OS=Rattus norvegicus OX=10116 GN=Col1a2 PE=1 SV=3
8	Q01149	1.33e-114	400	1372	0.265	0.359	CO1A2_MOUSE Collagen alpha-2(I) chain OS=Mus musculus OX=10090 GN=Col1a2 PE=1 SV=2
9	P08120	6.70e-112	397	1779	0.281	0.293	CO4A1_DROME Collagen alpha-1(IV) chain OS=Drosophila melanogaster OX=7227 GN=Col4a1 PE=1 SV=3
10	P02467	2.89e-110	387	1363	0.255	0.348	CO1A2_CHICK Collagen alpha-2(I) chain OS=Gallus gallus OX=9031 GN=COL1A2 PE=1 SV=3
11	Q6IQX2	4.31e-109	383	1352	0.284	0.391	Q6IQX2_DANRE Collagen alpha-2(I) chain precursor OS=Danio rerio OX=7955 GN=alpha2(I) PE=1 SV=1
12	F1LQ00	3.57e-105	374	1499	0.252	0.312	F1LQ00_RAT Collagen type V alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col5a2 PE=1 SV=4
13	Q9JLI2	5.88e-105	375	1739	0.287	0.307	Q9JLI2_MOUSE Collagen type V alpha 3 chain OS=Mus musculus OX=10090 GN=Col5a3 PE=1 SV=1
14	A0A8I6AII1	1.71e-104	371	1497	0.248	0.309	A0A8I6AII1_RAT Collagen type V alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col5a2 PE=1 SV=1
15	A0A8I6GEX8	1.73e-104	371	1498	0.252	0.312	A0A8I6GEX8_RAT Collagen type V alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col5a2 PE=4 SV=1
16	H0VHD0	1.68e-102	362	1287	0.259	0.374	H0VHD0_CAVPO Collagen type I alpha 2 chain OS=Cavia porcellus OX=10141 GN=COL1A2 PE=4 SV=2
17	Q9VMV5	2.53e-99	358	1940	0.262	0.252	Q9VMV5_DROME Viking, isoform A OS=Drosophila melanogaster OX=7227 GN=vkg PE=1 SV=1
18	O18407	5.55e-97	350	1761	0.260	0.275	O18407_DROME Collagen type IV alpha 2 OS=Drosophila melanogaster OX=7227 GN=vkg PE=1 SV=1
19	A0A0S2Z3H5	2.60e-96	345	1366	0.267	0.364	A0A0S2Z3H5_HUMAN Collagen type I alpha 2 isoform 1 (Fragment) OS=Homo sapiens OX=9606 GN=COL1A2 PE=2 SV=1
20	P08123	2.60e-96	345	1366	0.267	0.364	CO1A2_HUMAN Collagen alpha-2(I) chain OS=Homo sapiens OX=9606 GN=COL1A2 PE=1 SV=7

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01410 COLFI	2.7e-47	172.6	Fibrillar collagen C-terminal domain
2	PF01391 Collagen	1e-150	500.9	Collagen triple helix repeat (20 copies)
3	PF02210 Laminin_G_2	0.2	23.7	Laminin G domain
4	PF13385 Laminin_G_3	36	15.9	Concanavalin A-like lectin/glucanases superfamily

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000348385

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000362304	0.960	A disintegrin and metalloproteinase with thrombospondin motifs 14
2	9606.ENSP00000251582	0.949	A disintegrin and metalloproteinase with thrombospondin motifs 2
3	9606.ENSP00000061240	0.948	Tolloid-like protein 1
4	9606.ENSP00000305714	0.939	Bone morphogenetic protein 1
5	9606.ENSP00000223061	0.931	Procollagen C-endopeptidase enhancer 1
6	9606.ENSP00000295992	0.925	Procollagen C-endopeptidase enhancer 2
7	9606.ENSP00000350630	0.921	Tolloid-like protein 2
8	9606.ENSP00000263556	0.916	Prolyl 4-hydroxylase subunit alpha-1
9	9606.ENSP00000286657	0.915	A disintegrin and metalloproteinase with thrombospondin motifs 3
10	9606.ENSP00000384999	0.908	Prolyl 4-hydroxylase subunit alpha-2
11	9606.ENSP00000401749	0.907	Prolyl 4-hydroxylase subunit alpha-3
12	9606.ENSP00000236040	0.796	Prolyl 3-hydroxylase 1
13	9606.ENSP00000323696	0.794	Cartilage-associated protein
14	9606.ENSP00000282903	0.758	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
15	9606.ENSP00000258341	0.754	Laminin subunit gamma-1
16	9606.ENSP00000434412	0.753	Serpin H1
17	9606.ENSP00000354960	0.731	Procollagen galactosyltransferase 2
18	9606.ENSP00000223127	0.711	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
19	9606.ENSP00000196061	0.699	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
20	9606.ENSP00000316881	0.684	Prolyl 3-hydroxylase 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0030020	1.000	extracellular matrix structural constituent conferring tensile strength
GO:0005515	0.992	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.987	cellular process
GO:0048856	0.980	anatomical structure development
GO:0032501	0.970	multicellular organismal process
GO:0007275	0.927	multicellular organism development
GO:0043062	0.917	extracellular structure organization
GO:0045229	0.895	external encapsulating structure organization
GO:0001501	0.887	skeletal system development
GO:0048513	0.786	animal organ development
GO:0030198	0.740	extracellular matrix organization
GO:0009653	0.711	anatomical structure morphogenesis
GO:0009888	0.681	tissue development
GO:0061448	0.527	connective tissue development
GO:0060348	0.475	bone development
GO:0030154	0.461	cell differentiation
GO:0048705	0.452	skeletal system morphogenesis
GO:0065007	0.410	biological regulation
GO:0050789	0.397	regulation of biological process
GO:0035265	0.369	organ growth
GO:0060350	0.369	endochondral bone morphogenesis
GO:0050794	0.341	regulation of cellular process
GO:0051216	0.334	cartilage development

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0062023	1.000	collagen-containing extracellular matrix
GO:0005788	0.997	endoplasmic reticulum lumen
GO:0005576	0.996	extracellular region
GO:0032991	0.989	protein-containing complex
GO:0005581	0.866	collagen trimer
GO:0005615	0.614	extracellular space
GO:0099081	0.406	supramolecular polymer
GO:0098644	0.376	complex of collagen trimers
GO:0099512	0.345	supramolecular fiber

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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