StarFunc result for job id Q8IZJ3

User Input

>input (1885 residues)
MSGALLWPLLPLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREV
TVQAQLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTS
VTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRH
LKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQ
DLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICV
RDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGL
AYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEIPSIPTSAQHVW
LETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPC
NFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDV
CVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGE
VVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFW
WAGLTAQRRRRSSVFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAF
QPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVG
EAVALSTSQGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMK
LSVPKGIQFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCR
DGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYE
FQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEP
VASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTG
WGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRL
PFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAF
GERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKD
IQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYAL
TLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMT
AYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINL
TVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDP
VAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVC
TRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSR
CLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEV
ERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREA
ACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDP
EPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSP
VFVYSPAFQSGGEEGLWMSNTCTLR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q6YHK3	0.653	0.843	0.000	1445	0.239	0.311	Q6YHK3.pdb.gz	CD109_HUMAN CD109 antigen OS=Homo sapiens OX=9606 GN=CD109 PE=1 SV=2
2	AFDB:Q8IZJ3	0.999	0.999	0.000	1885	1.000	1.000	Q8IZJ3.pdb.gz	CPMD8_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CPAMD8 PE=1 SV=2
3	AFDB:Q6GQT1	0.644	0.813	4.214E-102	1474	0.209	0.267	Q6GQT1.pdb.gz	A2MG_MOUSE Alpha-2-macroglobulin-P OS=Mus musculus OX=10090 GN=A2m PE=2 SV=2
4	AFDB:A8K2U0	0.637	0.811	1.441E-101	1454	0.216	0.281	A8K2U0.pdb.gz	A2ML1_HUMAN Alpha-2-macroglobulin-like protein 1 OS=Homo sapiens OX=9606 GN=A2ML1 PE=1 SV=3
5	AFDB:A0A0R4IDD1	0.603	0.770	4.808E-99	1442	0.213	0.278	A0A0R4IDD1.pdb.gz
6	PDB:7q1yA	0.613	0.822	6.973E-95	1374	0.213	0.293	7q1yA.pdb.gz
7	AFDB:P01024	0.617	0.693	7.909E-88	1663	0.192	0.217	P01024.pdb.gz	CO3_HUMAN Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2
8	PDB:7q5zA	0.600	0.823	5.720E-86	1344	0.213	0.299	7q5zA.pdb.gz
9	AFDB:P01026	0.608	0.683	5.660E-85	1663	0.194	0.220	P01026.pdb.gz	CO3_RAT Complement C3 OS=Rattus norvegicus OX=10116 GN=C3 PE=1 SV=3
10	PDB:7vonA	0.618	0.817	5.820E-84	1399	0.216	0.292	7vonA.pdb.gz
11	PDB:4lnvA	0.470	0.668	1.193E-76	1276	0.177	0.261	4lnvA.pdb.gz
12	PDB:7nycA	0.360	0.431	1.065E-67	1542	0.172	0.211	7nycA.pdb.gz	Structural basis of soluble membrane attack complex packaging for clearance.
13	PDB:6h03A	0.355	0.532	4.124E-60	1223	0.153	0.236	6h03A.pdb.gz
14	PDB:4lnvB	0.445	0.754	6.524E-56	1063	0.151	0.267	4lnvB.pdb.gz
15	PDB:5a42A	0.396	0.457	3.031E-49	1597	0.109	0.129	5a42A.pdb.gz
16	PDB:4ziqA	0.260	0.316	7.022E-45	1450	0.117	0.152	4ziqA.pdb.gz
17	PDB:4rtdA	0.262	0.393	1.749E-39	1122	0.097	0.163	4rtdA.pdb.gz
18	AFDB:Q9W213	0.064	0.078	6.301E-16	1395	0.065	0.087	Q9W213.pdb.gz	Q9W213_DROME Roundabout 1, isoform A OS=Drosophila melanogaster OX=7227 GN=robo1 PE=1 SV=3
19	AFDB:Q9Z2I4	0.055	0.068	3.903E-15	1366	0.059	0.081	Q9Z2I4.pdb.gz	ROBO3_MOUSE Roundabout homolog 3 OS=Mus musculus OX=10090 GN=Robo3 PE=1 SV=2
20	AFDB:P13590	0.072	0.101	3.118E-14	1091	0.051	0.089	P13590.pdb.gz	NCAM1_CHICK Neural cell adhesion molecule 1 OS=Gallus gallus OX=9031 GN=NCAM1 PE=1 SV=3

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8IZJ3	0.0	3887	1885	1.000	1.000	CPMD8_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CPAMD8 PE=1 SV=2
2	Q6YHK3	6.36e-92	332	1445	0.110	0.144	CD109_HUMAN CD109 antigen OS=Homo sapiens OX=9606 GN=CD109 PE=1 SV=2
3	Q9NFV7	6.00e-89	323	1420	0.101	0.135	Q9NFV7_DROME GH01829p OS=Drosophila melanogaster OX=7227 GN=Tep2 PE=1 SV=1
4	P20742	2.04e-87	318	1482	0.103	0.131	PZP_HUMAN Pregnancy zone protein OS=Homo sapiens OX=9606 GN=PZP PE=1 SV=4
5	P01023	1.34e-85	312	1474	0.110	0.140	A2MG_HUMAN Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3
6	Q8R422	3.11e-83	305	1442	0.101	0.132	CD109_MOUSE CD109 antigen OS=Mus musculus OX=10090 GN=Cd109 PE=1 SV=1
7	A8K2U0	5.53e-83	304	1454	0.105	0.136	A2ML1_HUMAN Alpha-2-macroglobulin-like protein 1 OS=Homo sapiens OX=9606 GN=A2ML1 PE=1 SV=3
8	Q03626	1.75e-81	300	1487	0.099	0.126	MUG1_RAT Murinoglobulin-1 OS=Rattus norvegicus OX=10116 GN=Mug1 PE=2 SV=1
9	P28665	3.11e-81	299	1476	0.102	0.130	MUG1_MOUSE Murinoglobulin-1 OS=Mus musculus OX=10090 GN=Mug1 PE=1 SV=3
10	Q63041	5.23e-81	298	1500	0.101	0.127	A1M_RAT Alpha-1-macroglobulin OS=Rattus norvegicus OX=10116 GN=A1m PE=1 SV=1
11	Q61838	1.78e-80	296	1495	0.103	0.130	PZP_MOUSE Pregnancy zone protein OS=Mus musculus OX=10090 GN=Pzp PE=1 SV=3
12	Q7SIH1	2.14e-80	296	1510	0.102	0.128	A2MG_BOVIN Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2
13	P06238	5.88e-79	291	1472	0.098	0.125	A2MG_RAT Alpha-2-macroglobulin OS=Rattus norvegicus OX=10116 GN=A2m PE=2 SV=2
14	B8QSI4	6.22e-79	291	1442	0.095	0.125	B8QSI4_DANRE Alpha-2 macroglobulin-like protein OS=Danio rerio OX=7955 GN=A2ML PE=1 SV=1
15	Q6GQT1	7.98e-79	291	1474	0.100	0.128	A2MG_MOUSE Alpha-2-macroglobulin-P OS=Mus musculus OX=10090 GN=A2m PE=2 SV=2
16	Q9VLY7	1.20e-71	268	1469	0.103	0.133	Q9VLY7_DROME GH05679p OS=Drosophila melanogaster OX=7227 GN=Tep3 PE=1 SV=2
17	Q9NFV6	1.32e-71	268	1469	0.103	0.133	Q9NFV6_DROME TEP3 protein OS=Drosophila melanogaster OX=7227 GN=Tep3 PE=2 SV=1
18	M9PD73	2.48e-69	261	1476	0.097	0.124	M9PD73_DROME Thioester-containing protein 4, isoform B OS=Drosophila melanogaster OX=7227 GN=Tep4 PE=1 SV=1
19	M9PDF6	3.93e-69	260	1478	0.097	0.124	M9PDF6_DROME Thioester-containing protein 4, isoform D OS=Drosophila melanogaster OX=7227 GN=Tep4 PE=1 SV=1
20	Q9VIT9	4.34e-69	260	1496	0.097	0.122	Q9VIT9_DROME Thioester-containing protein 4, isoform A OS=Drosophila melanogaster OX=7227 GN=Tep4 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00207 A2M	2.6e-24	96.2	Alpha-2-macroglobulin family
2	PF07703 A2M_BRD	5.1e-40	148.5	Alpha-2-macroglobulin bait region domain
3	PF07677 A2M_recep	7.5e-21	85.9	A-macroglobulin receptor binding domain
4	PF00050 Kazal_1	0.75	21.2	Kazal-type serine protease inhibitor domain
5	PF07648 Kazal_2	0.00078	30.8	Kazal-type serine protease inhibitor domain
6	PF12248 Methyltransf_FA	2.3e-26	103.3	Farnesoic acid 0-methyl transferase
7	PF17790 MG1	4.8	18.9	Macroglobulin domain MG1
8	PF01835 MG2	2.8e-07	42.2	MG2 domain
9	PF17791 MG3	9.8e-06	37.1	Macroglobulin domain MG3
10	PF17789 MG4	1e-05	37.0	Macroglobulin domain MG4
11	PF07678 TED_complement	5.5e-104	359.1	A-macroglobulin TED domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000402505

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000345295	0.713	SH2 domain containing 4B
2	9606.ENSP00000355437	0.713	E3 ubiquitin-protein ligase TRIM58
3	9606.ENSP00000217173	0.700	RING finger protein 37
4	9606.ENSP00000285737	0.692	Lon protease homolog 2, peroxisomal
5	9606.ENSP00000263666	0.689	E3 ubiquitin-protein ligase PDZRN3
6	9606.ENSP00000315182	0.688	Protein SHQ1 homolog
7	9606.ENSP00000313759	0.678	CST complex subunit CTC1
8	9606.ENSP00000386722	0.678	FCH and double SH3 domains 2
9	9606.ENSP00000308976	0.668	Von Willebrand factor C domain-containing protein 2-like
10	9606.ENSP00000260983	0.578	E3 ubiquitin-protein ligase HECW2
11	9606.ENSP00000248076	0.554	Proteinase-activated receptor 4
12	9606.ENSP00000245105	0.547	SH3 domain and tetratricopeptide repeats 1
13	9606.ENSP00000248572	0.542	Guanine nucleotide-binding protein G(T) subunit gamma-T1
14	9606.ENSP00000483552	0.539	Furin
15	9606.ENSP00000269299	0.526	Asialoglycoprotein receptor 1
16	9606.ENSP00000401328	0.520	Serine protease 48
17	9606.ENSP00000226105	0.513	Ran guanine nucleotide release factor
18	9606.ENSP00000333982	0.510	Nuclear distribution protein nudE-like 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0098772	0.897	molecular function regulator activity
GO:0004857	0.718	enzyme inhibitor activity
GO:0019955	0.553	cytokine binding
GO:0030414	0.357	peptidase inhibitor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0032501	0.914	multicellular organismal process
GO:0048731	0.887	system development
GO:0048513	0.884	animal organ development
GO:0065007	0.776	biological regulation
GO:0050789	0.774	regulation of biological process
GO:0048880	0.648	sensory system development
GO:0007423	0.632	sensory organ development
GO:0050794	0.611	regulation of cellular process
GO:0050896	0.396	response to stimulus
GO:0150063	0.304	visual system development

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005576	1.000	extracellular region
GO:0005615	0.984	extracellular space
GO:0043226	0.931	organelle
GO:0016020	0.767	membrane
GO:0043227	0.758	membrane-bounded organelle
GO:0005622	0.754	intracellular anatomical structure
GO:0043229	0.675	intracellular organelle
GO:0005737	0.436	cytoplasm
GO:0071944	0.406	cell periphery

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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