StarFunc result for job id Q8N4E7

User Input

>input (242 residues)
MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTG
PAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSR
EETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHAL
ASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLGNENK
QN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8N4E7	1.000	1.000	2.653E-33	242	1.000	1.000	Q8N4E7.pdb.gz	FTMT_HUMAN Ferritin, mitochondrial OS=Homo sapiens OX=9606 GN=FTMT PE=1 SV=1
2	AFDB:Q9D5H4	0.730	0.746	7.293E-27	237	0.760	0.776	Q9D5H4.pdb.gz	FTMT_MOUSE Ferritin, mitochondrial OS=Mus musculus OX=10090 GN=Ftmt PE=1 SV=2
3	AFDB:P02794	0.748	0.988	1.260E-22	183	0.599	0.792	P02794.pdb.gz	FRIH_HUMAN Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2
4	PDB:7k26D	0.716	0.983	8.902E-22	176	0.587	0.807	7k26D.pdb.gz	Anisotropic Dynamics and Mechanics of Macromolecular Crystals Containing Lattice-Patterned Polymer Networks.
5	AFDB:C1BEL9	0.718	0.987	2.802E-20	176	0.517	0.710	C1BEL9.pdb.gz	C1BEL9_ONCMY Ferritin OS=Oncorhynchus mykiss OX=8022 GN=FRIH PE=2 SV=1
6	PDB:7tbhA	0.705	0.702	1.056E-18	243	0.574	0.572	7tbhA.pdb.gz	Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia.
7	AFDB:Q9BXU8	0.714	0.942	2.282E-18	183	0.479	0.634	Q9BXU8.pdb.gz	FHL17_HUMAN Ferritin heavy polypeptide-like 17 OS=Homo sapiens OX=9606 GN=FTHL17 PE=1 SV=1
8	AFDB:P02792	0.698	0.963	1.099E-16	175	0.388	0.537	P02792.pdb.gz	FRIL_HUMAN Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2
9	AFDB:P02793	0.706	0.932	1.209E-16	183	0.376	0.497	P02793.pdb.gz	FRIL1_RAT Ferritin light chain 1 OS=Rattus norvegicus OX=10116 GN=Ftl1 PE=1 SV=3
10	AFDB:Q9TYS3	0.687	0.976	1.536E-16	170	0.401	0.571	Q9TYS3.pdb.gz	Q9TYS3_CAEEL Ferritin OS=Caenorhabditis elegans OX=6239 GN=ftn-2 PE=1 SV=1
11	PDB:2fg8A	0.692	0.960	4.813E-16	174	0.388	0.540	2fg8A.pdb.gz
12	PDB:6zh5A	0.700	0.950	5.296E-16	178	0.364	0.494	6zh5A.pdb.gz
13	AFDB:O16453	0.685	0.973	7.443E-16	170	0.355	0.506	O16453.pdb.gz	O16453_CAEEL Ferritin OS=Caenorhabditis elegans OX=6239 GN=ftn-1 PE=1 SV=2
14	AFDB:Q39101	0.669	0.635	8.134E-15	255	0.368	0.349	Q39101.pdb.gz	FRI1_ARATH Ferritin-1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=FER1 PE=1 SV=1
15	PDB:5ls9F	0.614	0.891	2.464E-9	165	0.260	0.382	5ls9F.pdb.gz	Humanized archaeal ferritin as a tool for cell targeted delivery.
16	PDB:3bviF	0.643	0.889	2.567E-8	173	0.157	0.220	3bviF.pdb.gz	Structural basis for the iron uptake mechanism of Helicobacter pylori ferritin
17	PDB:4xgsB	0.615	0.897	6.071E-8	164	0.157	0.232	4xgsB.pdb.gz	Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria
18	PDB:7o6eA	0.587	0.792	3.921E-7	177	0.165	0.226	7o6eA.pdb.gz
19	PDB:4e6kA	0.565	0.848	1.170E-5	157	0.140	0.217	4e6kA.pdb.gz	The Structure of the BfrB-Bfd Complex Reveals Protein-Protein Interactions Enabling Iron Release from Bacterioferritin.
20	PDB:1bcfA	0.551	0.822	3.045E-5	158	0.136	0.209	1bcfA.pdb.gz	Structure of a unique twofold symmetric haem-binding site.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8N4E7	0.0	502	242	1.000	1.000	FTMT_HUMAN Ferritin, mitochondrial OS=Homo sapiens OX=9606 GN=FTMT PE=1 SV=1
2	Q9D5H4	9.58e-127	360	237	0.760	0.776	FTMT_MOUSE Ferritin, mitochondrial OS=Mus musculus OX=10090 GN=Ftmt PE=1 SV=2
3	P02794	1.08e-106	307	183	0.599	0.792	FRIH_HUMAN Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2
4	P09528	1.35e-105	305	182	0.595	0.791	FRIH_MOUSE Ferritin heavy chain OS=Mus musculus OX=10090 GN=Fth1 PE=1 SV=2
5	Q6NZ44	4.61e-105	303	183	0.591	0.781	Q6NZ44_HUMAN Ferritin OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=1
6	P19132	1.23e-104	302	182	0.591	0.786	FRIH_RAT Ferritin heavy chain OS=Rattus norvegicus OX=10116 GN=Fth1 PE=1 SV=3
7	C1BEL9	3.04e-90	265	176	0.517	0.710	C1BEL9_ONCMY Ferritin OS=Oncorhynchus mykiss OX=8022 GN=FRIH PE=2 SV=1
8	Q9BXU8	1.45e-77	233	183	0.483	0.639	FHL17_HUMAN Ferritin heavy polypeptide-like 17 OS=Homo sapiens OX=9606 GN=FTHL17 PE=1 SV=1
9	P02792	6.50e-65	201	175	0.388	0.537	FRIL_HUMAN Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2
10	Q8TD27	3.86e-64	199	165	0.397	0.582	Q8TD27_HUMAN Ferritin OS=Homo sapiens OX=9606 PE=2 SV=1
11	Q9TYS3	6.43e-64	198	170	0.401	0.571	Q9TYS3_CAEEL Ferritin OS=Caenorhabditis elegans OX=6239 GN=ftn-2 PE=1 SV=1
12	P02793	2.61e-61	192	183	0.376	0.497	FRIL1_RAT Ferritin light chain 1 OS=Rattus norvegicus OX=10116 GN=Ftl1 PE=1 SV=3
13	P29391	4.68e-60	189	183	0.372	0.492	FRIL1_MOUSE Ferritin light chain 1 OS=Mus musculus OX=10090 GN=Ftl1 PE=1 SV=2
14	O16453	1.72e-56	179	170	0.355	0.506	O16453_CAEEL Ferritin OS=Caenorhabditis elegans OX=6239 GN=ftn-1 PE=1 SV=2
15	Q7TP54	2.71e-45	164	1310	0.347	0.064	RIPR2_RAT Rho family-interacting cell polarization regulator 2 OS=Rattus norvegicus OX=10116 GN=Ripor2 PE=1 SV=1
16	Q9S756	1.12e-43	149	259	0.360	0.336	FRI4_ARATH Ferritin-4, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=FER4 PE=2 SV=1
17	Q9LYN2	8.25e-42	145	259	0.339	0.317	FRI3_ARATH Ferritin-3, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=FER3 PE=1 SV=1
18	Q39101	9.81e-42	144	255	0.314	0.298	FRI1_ARATH Ferritin-1, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=FER1 PE=1 SV=1
19	Q9SRL5	9.38e-40	139	253	0.339	0.324	FRI2_ARATH Ferritin-2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=FER2 PE=2 SV=1
20	Q9VYH1	1.08e-38	134	186	0.310	0.403	Q9VYH1_DROME Ferritin OS=Drosophila melanogaster OX=7227 GN=Fer3HCH PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00210 Ferritin	1.1e-32	124.4	Ferritin-like domain
2	PF02915 Rubrerythrin	2.4e+02	13.5	Rubrerythrin

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000313691

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000366482	0.795	Frataxin, mitochondrial
2	9606.ENSP00000482552	0.732	Protein FAM170A
3	9606.ENSP00000306100	0.681	Peptidyl-glycine alpha-amidating monooxygenase
4	9606.ENSP00000237853	0.672	RNA polymerase II elongation factor ELL2
5	9606.ENSP00000334300	0.662	Actin-like protein 7A
6	9606.ENSP00000309477	0.645	Cytoplasmic aconitate hydratase
7	9606.ENSP00000360320	0.631	Lymphocyte expansion molecule
8	9606.ENSP00000351727	0.620	Coiled-coil glutamate rich protein 1
9	9606.ENSP00000258886	0.605	Iron-responsive element-binding protein 2
10	9606.ENSP00000300688	0.605	ATP synthase subunit g, mitochondrial
11	9606.ENSP00000269143	0.602	AFG3-like protein 2
12	9606.ENSP00000378364	0.598	Natural resistance-associated macrophage protein 2
13	9606.ENSP00000297185	0.591	Stress-70 protein, mitochondrial
14	9606.ENSP00000442129	0.586	Hepatoma-derived growth factor-like protein 1
15	9606.ENSP00000367658	0.583	Actin related protein T2
16	9606.ENSP00000368030	0.577	ATPase family AAA domain-containing protein 3A
17	9606.ENSP00000420026	0.575	LYR motif-containing protein 4
18	9606.ENSP00000296350	0.572	Melanotransferrin
19	9606.ENSP00000353224	0.570	Transferrin receptor protein 1
20	9606.ENSP00000369531	0.559	Ubiquilin-like protein

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005506	1.000	iron ion binding
GO:0005515	0.999	protein binding
GO:0004322	0.999	ferroxidase activity
GO:0042802	0.786	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0098771	0.990	inorganic ion homeostasis
GO:0055080	0.990	monoatomic cation homeostasis
GO:0019725	0.975	cellular homeostasis
GO:0030003	0.968	intracellular monoatomic cation homeostasis
GO:0055072	0.962	iron ion homeostasis
GO:0006879	0.948	intracellular iron ion homeostasis
GO:0065007	0.909	biological regulation
GO:0044093	0.745	positive regulation of molecular function
GO:0050789	0.716	regulation of biological process
GO:0050794	0.691	regulation of cellular process
GO:0051339	0.650	regulation of lyase activity
GO:0009987	0.630	cellular process
GO:0051341	0.546	regulation of oxidoreductase activity
GO:0048518	0.505	positive regulation of biological process
GO:0048522	0.475	positive regulation of cellular process
GO:0043085	0.451	positive regulation of catalytic activity
GO:0051353	0.330	positive regulation of oxidoreductase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	1.000	mitochondrion
GO:0070013	0.999	intracellular organelle lumen
GO:0005634	0.990	nucleus
GO:0005759	0.820	mitochondrial matrix
GO:0031981	0.598	nuclear lumen
GO:0005654	0.478	nucleoplasm
GO:0012505	0.313	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:11148	0.999	4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O
EC:1.16.3.1	0.999	ferroxidase.

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