StarFunc result for job id Q8N5P1

User Input

>input (291 residues)
MDFENLFSKPPNPALGKTATDSDERIDDEIDTEVEETQEEKIKLECEQIPKKFRHSAISP
KSSLHRKSRSKDYDVYSDNDICSQESEDNFAKELQQYIQAREMANAAQPEESTKKEGVKD
TPQAAKQKNKNLKAGHKNGKQKKMKRKWPGPGNKGSNALLRNSGSQEEDGKPKEKQQHLS
QAFINQHTVERKGKQICKYFLERKCIKGDQCKFDHDAEIEKKKEMCKFYVQGYCTRGENC
LYLHNEYPCKFYHTGTKCYQGEYCKFSHAPLTPETQELLAKVLDTEKKSCK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8N5P1	1.000	1.000	3.447E-46	291	1.000	1.000	Q8N5P1.pdb.gz	ZC3H8_HUMAN Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2
2	AFDB:Q9JJ48	0.427	0.409	3.343E-34	305	0.794	0.757	Q9JJ48.pdb.gz	ZC3H8_MOUSE Zinc finger CCCH domain-containing protein 8 OS=Mus musculus OX=10090 GN=Zc3h8 PE=1 SV=2
3	AFDB:Q6ZPZ3	0.328	0.083	1.680E-12	1304	0.309	0.069	Q6ZPZ3.pdb.gz	ZC3H4_MOUSE Zinc finger CCCH domain-containing protein 4 OS=Mus musculus OX=10090 GN=Zc3h4 PE=1 SV=2
4	PDB:6dnhC	0.138	0.273	2.672E-3	117	0.096	0.239	6dnhC.pdb.gz	Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
5	AFDB:Q8CHP0	0.133	0.059	1.045E-1	950	0.186	0.057	Q8CHP0.pdb.gz	ZC3H3_MOUSE Zinc finger CCCH domain-containing protein 3 OS=Mus musculus OX=10090 GN=Zc3h3 PE=1 SV=1
6	AFDB:Q8IXZ2	0.127	0.047	2.290E-1	948	0.172	0.053	Q8IXZ2.pdb.gz	ZC3H3_HUMAN Zinc finger CCCH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZC3H3 PE=1 SV=3
7	PDB:6id0O	0.085	0.085	2.777E-1	290	0.055	0.055	6id0O.pdb.gz	Structures of the human spliceosomes before and after release of the ligated exon.
8	AFDB:Q6PJT7	0.103	0.052	7.934E-1	736	0.182	0.072	Q6PJT7.pdb.gz	ZC3HE_HUMAN Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1
9	AFDB:Q13064	0.131	0.085	1.339	507	0.151	0.087	Q13064.pdb.gz	MKRN3_HUMAN Probable E3 ubiquitin-protein ligase makorin-3 OS=Homo sapiens OX=9606 GN=MKRN3 PE=1 SV=1
10	AFDB:Q5VTB9	0.089	0.056	2.935	566	0.189	0.097	Q5VTB9.pdb.gz	RN220_HUMAN E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens OX=9606 GN=RNF220 PE=1 SV=1
11	AFDB:Q91765	0.112	0.080	4.639	434	0.086	0.058	Q91765.pdb.gz	FXA2A_XENLA Forkhead box protein A2-A OS=Xenopus laevis OX=8355 GN=foxa2-a PE=1 SV=1
12	AFDB:P20483	0.099	0.067	5.287	479	0.110	0.067	P20483.pdb.gz	MPIP_DROME M-phase inducer phosphatase OS=Drosophila melanogaster OX=7227 GN=stg PE=1 SV=2
13	PDB:7r5jC0	0.055	0.013	7.801	2011	0.027	0.004	7r5jC0.pdb.gz	AI-based structure prediction empowers integrative structural analysis of human nuclear pores

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8N5P1	0.0	601	291	1.000	1.000	ZC3H8_HUMAN Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2
2	Q9JJ48	1.19e-153	433	305	0.794	0.757	ZC3H8_MOUSE Zinc finger CCCH domain-containing protein 8 OS=Mus musculus OX=10090 GN=Zc3h8 PE=1 SV=2
3	Q9UPT8	2.26e-35	137	1303	0.186	0.041	ZC3H4_HUMAN Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3
4	Q6ZPZ3	2.54e-35	137	1304	0.186	0.041	ZC3H4_MOUSE Zinc finger CCCH domain-containing protein 4 OS=Mus musculus OX=10090 GN=Zc3h4 PE=1 SV=2
5	Q22805	1.15e-18	88.2	574	0.137	0.070	Q22805_CAEEL C3H1-type domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=CELE_T26A8.4 PE=1 SV=1
6	P22293	2.45e-12	69.3	1325	0.096	0.021	SUS_DROME Protein suppressor of sable OS=Drosophila melanogaster OX=7227 GN=su(sable) PE=1 SV=2
7	Q9UTD1	5.26e-09	56.6	170	0.141	0.241	YTH1_SCHPO mRNA 3'-end-processing protein yth1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=yth1 PE=3 SV=1
8	Q9H000	3.32e-07	53.5	416	0.082	0.058	MKRN2_HUMAN E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens OX=9606 GN=MKRN2 PE=1 SV=2
9	Q9ERV1	5.46e-07	52.8	416	0.079	0.055	MKRN2_MOUSE E3 ubiquitin-protein ligase makorin-2 OS=Mus musculus OX=10090 GN=Mkrn2 PE=1 SV=2
10	Q98881	7.09e-07	52.0	271	0.103	0.111	Q98881_DANRE Cleavage and polyadenylation specificity factor subunit 4 OS=Danio rerio OX=7955 GN=nar PE=1 SV=1
11	B0F0H3	2.83e-06	50.4	409	0.079	0.056	MKRN2_XENLA E3 ubiquitin-protein ligase makorin-2 OS=Xenopus laevis OX=8355 GN=mkrn2 PE=2 SV=2
12	O95639	3.42e-06	49.7	269	0.103	0.112	CPSF4_HUMAN Cleavage and polyadenylation specificity factor subunit 4 OS=Homo sapiens OX=9606 GN=CPSF4 PE=1 SV=1
13	Q9UHC7	5.71e-06	49.7	482	0.069	0.041	MKRN1_HUMAN E3 ubiquitin-protein ligase makorin-1 OS=Homo sapiens OX=9606 GN=MKRN1 PE=1 SV=3
14	Q9QXP6	5.76e-06	49.7	481	0.069	0.042	MKRN1_MOUSE E3 ubiquitin-protein ligase makorin-1 OS=Mus musculus OX=10090 GN=Mkrn1 PE=1 SV=1
15	P41000	8.54e-06	49.3	583	0.062	0.031	CPS3_SCHPO Protein cps3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cps3 PE=1 SV=3
16	O19137	8.98e-06	48.1	243	0.103	0.123	CPSF4_BOVIN Cleavage and polyadenylation specificity factor subunit 4 OS=Bos taurus OX=9913 GN=CPSF4 PE=1 SV=1
17	Q382Q6	2.29e-05	47.4	277	0.131	0.137	Q382Q6_TRYB2 Cleavage and polyadenylation specificity factor 30 kDa subunit OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.4600 PE=4 SV=1
18	Q86G58	2.29e-05	47.4	277	0.131	0.137	Q86G58_TRYBR Cleavage and polyadenylation specificity factor 30 kDa subunit OS=Trypanosoma brucei rhodesiense OX=31286 PE=4 SV=1
19	A9LNK9	5.63e-05	46.6	631	0.103	0.048	CPSF_ARATH 30-kDa cleavage and polyadenylation specificity factor 30 OS=Arabidopsis thaliana OX=3702 GN=CPSF30 PE=1 SV=1
20	O22243	6.28e-05	46.6	1015	0.065	0.019	C3H31_ARATH DExH-box ATP-dependent RNA helicase DExH8 OS=Arabidopsis thaliana OX=3702 GN=At2g47680 PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16131 Torus	0.053	25.6	Torus domain
2	PF00642 zf-CCCH	1.6e-08	45.5	Zinc finger C-x8-C-x5-C-x3-H type (and similar)
3	PF14608 zf-CCCH_2	1.6e-06	39.6	RNA-binding, Nab2-type zinc finger
4	PF15663 zf-CCCH_3	40	15.8	Zinc-finger containing family
5	PF18044 zf-CCCH_4	7.8e-08	43.2	CCCH-type zinc finger
6	PF18345 zf_CCCH_4	1.7e-10	51.8	Zinc finger domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000386488

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000261520	0.950	Little elongation complex subunit 2
2	9606.ENSP00000296564	0.948	Little elongation complex subunit 1
3	9606.ENSP00000422626	0.911	La-related protein 7
4	9606.ENSP00000262809	0.882	RNA polymerase II elongation factor ELL
5	9606.ENSP00000217109	0.815	Cleavage stimulation factor subunit 1
6	9606.ENSP00000245934	0.808	Symplekin
7	9606.ENSP00000315791	0.806	Cleavage stimulation factor subunit 3
8	9606.ENSP00000429065	0.800	Integrator complex subunit 9
9	9606.ENSP00000445001	0.798	Integrator complex subunit 11
10	9606.ENSP00000298875	0.796	Cleavage and polyadenylation specificity factor subunit 2
11	9606.ENSP00000317872	0.791	E3 ubiquitin-protein ligase RBBP6
12	9606.ENSP00000291386	0.778	RNA polymerase II subunit A C-terminal domain phosphatase SSU72
13	9606.ENSP00000484669	0.778	Cleavage and polyadenylation specificity factor subunit 1
14	9606.ENSP00000296490	0.769	WD repeat-containing protein 82
15	9606.ENSP00000434466	0.753	Integrator complex subunit 4
16	9606.ENSP00000381064	0.752	Integrator complex subunit 10
17	9606.ENSP00000336752	0.748	Pre-mRNA 3'-end-processing factor FIP1
18	9606.ENSP00000238112	0.733	Cleavage and polyadenylation specificity factor subunit 3
19	9606.ENSP00000362063	0.715	Cleavage stimulation factor subunit 2
20	9606.ENSP00000333326	0.695	Tubulin alpha-8 chain

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003723	0.999	RNA binding
GO:0001067	0.320	transcription regulatory region nucleic acid binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0060255	0.989	regulation of macromolecule metabolic process
GO:0019219	0.987	regulation of nucleobase-containing compound metabolic process
GO:0071704	0.980	organic substance metabolic process
GO:0044238	0.980	primary metabolic process
GO:0044237	0.979	cellular metabolic process
GO:0006807	0.976	nitrogen compound metabolic process
GO:0010468	0.968	regulation of gene expression
GO:0048519	0.966	negative regulation of biological process
GO:0010467	0.965	gene expression
GO:0090304	0.965	nucleic acid metabolic process
GO:0016070	0.964	RNA metabolic process
GO:0051252	0.951	regulation of RNA metabolic process
GO:0010556	0.940	regulation of macromolecule biosynthetic process
GO:0031326	0.940	regulation of cellular biosynthetic process
GO:0006355	0.916	regulation of DNA-templated transcription
GO:0048523	0.910	negative regulation of cellular process
GO:0009892	0.885	negative regulation of metabolic process
GO:0045892	0.881	negative regulation of DNA-templated transcription
GO:0034660	0.750	ncRNA metabolic process
GO:0006351	0.716	DNA-templated transcription
GO:0048522	0.518	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.999	nucleoplasm
GO:0043232	0.991	intracellular non-membrane-bounded organelle
GO:0032991	0.988	protein-containing complex
GO:0140513	0.928	nuclear protein-containing complex
GO:0016604	0.699	nuclear body
GO:0005694	0.660	chromosome
GO:0000785	0.553	chromatin
GO:0015030	0.472	Cajal body
GO:0008023	0.470	transcription elongation factor complex
GO:0035363	0.387	histone locus body
GO:0000791	0.359	euchromatin
GO:0005737	0.337	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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