StarFunc result for job id Q8NER1

User Input

>input (839 residues)
MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8NER1	1.000	1.000	0.000	839	1.000	1.000	Q8NER1.pdb.gz	TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 OS=Homo sapiens OX=9606 GN=TRPV1 PE=1 SV=2
2	AFDB:Q704Y3	0.809	0.809	3.991E-102	839	0.867	0.867	Q704Y3.pdb.gz	TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 OS=Mus musculus OX=10090 GN=Trpv1 PE=1 SV=1
3	PDB:7lp9A	0.726	0.953	6.883E-72	634	0.696	0.921	7lp9A.pdb.gz	Heat-dependent opening of TRPV1 in the presence of capsaicin.
4	AFDB:B2KN54	0.743	0.716	7.200E-62	871	0.443	0.427	B2KN54.pdb.gz	B2KN54_CANLF TRPV4 OS=Canis lupus familiaris OX=9615 GN=LOC100856786 PE=2 SV=1
5	AFDB:A0A6I8RQZ3	0.742	0.718	3.688E-60	868	0.439	0.424	A0A6I8RQZ3.pdb.gz	A0A6I8RQZ3_XENTR Transient receptor potential cation channel subfamily V member 4 OS=Xenopus tropicalis OX=8364 GN=trpv4 PE=1 SV=1
6	AFDB:A2BG42	0.739	0.725	6.026E-59	856	0.437	0.429	A2BG42.pdb.gz
7	AFDB:A0A1J0M1I2	0.726	0.743	7.968E-58	819	0.428	0.438	A0A1J0M1I2.pdb.gz
8	AFDB:G1SNM3	0.717	0.735	2.498E-57	817	0.434	0.446	G1SNM3.pdb.gz	G1SNM3_RABIT Transient receptor potential cation channel subfamily V member 2 OS=Oryctolagus cuniculus OX=9986 GN=TRPV2 PE=1 SV=2
9	AFDB:Q9WUD2	0.722	0.792	3.980E-57	761	0.429	0.473	Q9WUD2.pdb.gz	TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 OS=Rattus norvegicus OX=10116 GN=Trpv2 PE=1 SV=2
10	AFDB:Q9Y5S1	0.726	0.794	6.392E-55	764	0.409	0.449	Q9Y5S1.pdb.gz	TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1
11	AFDB:Q5EA32	0.706	0.783	1.062E-54	753	0.404	0.450	Q5EA32.pdb.gz	Q5EA32_BOVIN Transient receptor potential cation channel subfamily V member 2 OS=Bos taurus OX=9913 GN=TRPV2 PE=1 SV=1
12	PDB:6u84A	0.659	0.864	1.067E-47	630	0.393	0.524	6u84A.pdb.gz
13	PDB:6bwjB	0.683	0.916	1.191E-46	617	0.398	0.541	6bwjB.pdb.gz	Conformational plasticity in the selectivity filter of the TRPV2 ion channel.
14	PDB:7aa5A	0.643	0.864	1.699E-42	612	0.383	0.525	7aa5A.pdb.gz
15	PDB:6mhvA	0.657	0.884	2.661E-41	613	0.343	0.470	6mhvA.pdb.gz
16	PDB:6pvpA	0.665	0.831	7.411E-39	661	0.340	0.431	6pvpA.pdb.gz
17	PDB:6uw9A	0.613	0.863	2.117E-35	582	0.330	0.476	6uw9A.pdb.gz
18	PDB:6pvqA	0.562	0.820	4.095E-29	562	0.273	0.407	6pvqA.pdb.gz
19	PDB:6e2fC	0.585	0.745	1.385E-25	647	0.225	0.292	6e2fC.pdb.gz	Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6.
20	PDB:6dmwA	0.577	0.749	4.532E-25	631	0.213	0.284	6dmwA.pdb.gz	Structural insights on TRPV5 gating by endogenous modulators.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A6I8RQZ3	709	868	0.421	0.407	A0A6I8RQZ3_XENTR Transient receptor potential cation channel subfamily V member 4 OS=Xenopus tropicalis OX=8364 GN=trpv4 PE=1 SV=1
2	B0S711	684	813	0.428	0.442	B0S711_DANRE Transient receptor potential cation channel subfamily V member 1 OS=Danio rerio OX=7955 GN=si:dkey-9e15.2 PE=4 SV=1
3	B2KN54	708	871	0.423	0.408	B2KN54_CANLF TRPV4 OS=Canis lupus familiaris OX=9615 GN=LOC100856786 PE=2 SV=1
4	B3VP30	706	871	0.422	0.406	B3VP30_PIG Transient receptor potential cation channel subfamily V member 4 OS=Sus scrofa OX=9823 GN=TRPV4 PE=2 SV=1
5	B6RTA2	682	819	0.428	0.438	B6RTA2_DANRE Transient receptor potential cation channel subfamily V member 1 OS=Danio rerio OX=7955 GN=TRPV1 PE=2 SV=1
6	E9PU00	543	791	0.350	0.372	E9PU00_RAT Transient receptor potential cation channel, subfamily V, member 3 OS=Rattus norvegicus OX=10116 GN=Trpv3 PE=4 SV=1
7	F1RIT1	627	823	0.386	0.394	F1RIT1_PIG Transient receptor potential cation channel subfamily V member 4 OS=Sus scrofa OX=9823 GN=TRPV4 PE=4 SV=4
8	G1SNM3	615	817	0.408	0.419	G1SNM3_RABIT Transient receptor potential cation channel subfamily V member 2 OS=Oryctolagus cuniculus OX=9986 GN=TRPV2 PE=1 SV=2
9	O35433	1496	838	0.859	0.860	TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 OS=Rattus norvegicus OX=10116 GN=Trpv1 PE=1 SV=1
10	Q0PEH1	684	841	0.402	0.401	Q0PEH1_DANRE Transient receptor potential cation channel subfamily V member 4 OS=Danio rerio OX=7955 GN=wu:fp52e02 PE=2 SV=1
11	Q5EA32	593	753	0.418	0.466	Q5EA32_BOVIN Transient receptor potential cation channel subfamily V member 2 OS=Bos taurus OX=9913 GN=TRPV2 PE=1 SV=1
12	Q704Y3	1517	839	0.869	0.869	TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 OS=Mus musculus OX=10090 GN=Trpv1 PE=1 SV=1
13	Q8K424	542	791	0.350	0.372	TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 OS=Mus musculus OX=10090 GN=Trpv3 PE=1 SV=2
14	Q8NER1	1748	839	1.000	1.000	TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 OS=Homo sapiens OX=9606 GN=TRPV1 PE=1 SV=2
15	Q9EPK8	702	871	0.420	0.404	TRPV4_MOUSE Transient receptor potential cation channel subfamily V member 4 OS=Mus musculus OX=10090 GN=Trpv4 PE=1 SV=1
16	Q9ERZ8	706	871	0.422	0.406	TRPV4_RAT Transient receptor potential cation channel subfamily V member 4 OS=Rattus norvegicus OX=10116 GN=Trpv4 PE=1 SV=1
17	Q9HBA0	704	871	0.422	0.406	TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 OS=Homo sapiens OX=9606 GN=TRPV4 PE=1 SV=2
18	Q9WTR1	597	756	0.416	0.462	TRPV2_MOUSE Transient receptor potential cation channel subfamily V member 2 OS=Mus musculus OX=10090 GN=Trpv2 PE=1 SV=2
19	Q9WUD2	602	761	0.422	0.465	TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 OS=Rattus norvegicus OX=10116 GN=Trpv2 PE=1 SV=2
20	Q9Y5S1	615	764	0.402	0.441	TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00023 Ank	4.2e-07	41.3	Ankyrin repeat
2	PF12796 Ank_2	7.5e-11	53.8	Ankyrin repeats (3 copies)
3	PF13606 Ank_3	2e-05	35.4	Ankyrin repeat
4	PF13637 Ank_4	0.002	29.9	Ankyrin repeats (many copies)
5	PF13857 Ank_5	0.00011	33.7	Ankyrin repeats (many copies)
6	PF12085 DUF3562	4.8e+02	11.7	Protein of unknown function (DUF3562)
7	PF00520 Ion_trans	2.4e-11	54.9	Ion transport protein

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000461007

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000262209	0.992	Transient receptor potential cation channel subfamily A member 1
2	9606.ENSP00000347454	0.978	Anoctamin-1
3	9606.ENSP00000358513	0.961	Cannabinoid receptor 1
4	9606.ENSP00000323926	0.960	Transient receptor potential cation channel subfamily M member 8
5	9606.ENSP00000378207	0.956	A-kinase anchor protein 5
6	9606.ENSP00000375894	0.918	G-protein coupled receptor 55
7	9606.ENSP00000331746	0.915	Calcitonin
8	9606.ENSP00000243167	0.893	Fatty-acid amide hydrolase 1
9	9606.ENSP00000321106	0.889	Protachykinin-1
10	9606.ENSP00000265709	0.878	Ankyrin-1
11	9606.ENSP00000263314	0.875	P2X purinoceptor 3
12	9606.ENSP00000419313	0.870	Short transient receptor potential channel 1
13	9606.ENSP00000358525	0.868	Beta-nerve growth factor
14	9606.ENSP00000297512	0.860	Acid-sensing ion channel 3
15	9606.ENSP00000390600	0.852	Sodium channel protein type 10 subunit alpha
16	9606.ENSP00000451828	0.851	RAC-alpha serine/threonine-protein kinase
17	9606.ENSP00000462046	0.843	Phosphoinositide-interacting protein
18	9606.ENSP00000366314	0.829	Transient receptor potential cation channel subfamily M member 3
19	9606.ENSP00000357674	0.826	SNARE-associated protein Snapin
20	9606.ENSP00000155858	0.824	Transient receptor potential cation channel subfamily M member 5

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005262	1.000	calcium channel activity
GO:0022839	0.911	monoatomic ion gated channel activity
GO:0042802	0.869	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.998	cellular process
GO:0050896	0.996	response to stimulus
GO:0065007	0.985	biological regulation
GO:0032501	0.981	multicellular organismal process
GO:0050789	0.980	regulation of biological process
GO:0009266	0.972	response to temperature stimulus
GO:0050794	0.970	regulation of cellular process
GO:0006811	0.952	monoatomic ion transport
GO:0055085	0.946	transmembrane transport
GO:0034220	0.924	monoatomic ion transmembrane transport
GO:0098662	0.912	inorganic cation transmembrane transport
GO:0006812	0.908	monoatomic cation transport
GO:0003008	0.900	system process
GO:0098655	0.887	monoatomic cation transmembrane transport
GO:0006950	0.886	response to stress
GO:0006816	0.885	calcium ion transport
GO:0042221	0.883	response to chemical
GO:0051716	0.876	cellular response to stimulus
GO:0009408	0.850	response to heat
GO:0070588	0.822	calcium ion transmembrane transport
GO:0023052	0.681	signaling
GO:0007154	0.651	cell communication
GO:0099587	0.544	inorganic ion import across plasma membrane
GO:0007600	0.518	sensory perception
GO:0009268	0.504	response to pH
GO:0007165	0.502	signal transduction
GO:0098659	0.463	inorganic cation import across plasma membrane
GO:0010033	0.452	response to organic substance
GO:0050951	0.416	sensory perception of temperature stimulus
GO:0048518	0.409	positive regulation of biological process
GO:0007610	0.364	behavior
GO:0048522	0.350	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0043226	0.700	organelle
GO:0043227	0.666	membrane-bounded organelle
GO:0005622	0.655	intracellular anatomical structure
GO:0120025	0.579	plasma membrane bounded cell projection
GO:0005737	0.504	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:29671	1.000	Ca(2+)(in) = Ca(2+)(out)

[back to server]