StarFunc result for job id Q8NEV1

User Input

>input (391 residues)
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYD
QLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAATGAQQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P19139	0.877	0.877	1.258E-66	391	0.969	0.969	P19139.pdb.gz	CSK21_RAT Casein kinase II subunit alpha OS=Rattus norvegicus OX=10116 GN=Csnk2a1 PE=1 SV=2
2	PDB:5oniA	0.850	0.994	3.876E-60	334	0.844	0.988	5oniA.pdb.gz	Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '.
3	AFDB:A0A2R8YF43	0.813	0.875	5.668E-58	363	0.913	0.983	A0A2R8YF43.pdb.gz	A0A2R8YF43_HUMAN Casein kinase 2 alpha 1 OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1
4	AFDB:P18334	0.861	0.933	2.956E-57	360	0.703	0.764	P18334.pdb.gz	CSK2A_CAEEL Casein kinase II subunit alpha OS=Caenorhabditis elegans OX=6239 GN=kin-3 PE=1 SV=1
5	AFDB:P08181	0.845	0.983	5.311E-57	336	0.734	0.854	P08181.pdb.gz	CSK2A_DROME Casein kinase II subunit alpha OS=Drosophila melanogaster OX=7227 GN=CkIIalpha PE=1 SV=2
6	AFDB:B4F7A9	0.843	0.942	1.246E-56	350	0.739	0.826	B4F7A9.pdb.gz	B4F7A9_RAT Casein kinase 2, alpha prime polypeptide OS=Rattus norvegicus OX=10116 GN=Csnk2a2 PE=2 SV=1
7	AFDB:Q08467	0.837	0.800	9.609E-53	409	0.616	0.589	Q08467.pdb.gz	CSK21_ARATH Casein kinase II subunit alpha-1 OS=Arabidopsis thaliana OX=3702 GN=CKA1 PE=1 SV=3
8	AFDB:Q08466	0.841	0.816	6.541E-52	403	0.619	0.600	Q08466.pdb.gz	CSK22_ARATH Casein kinase II subunit alpha-2 OS=Arabidopsis thaliana OX=3702 GN=CKA2 PE=1 SV=3
9	AFDB:O64816	0.840	0.760	6.899E-52	432	0.624	0.565	O64816.pdb.gz	CSK2P_ARATH Casein kinase II subunit alpha-4, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=CKA4 PE=2 SV=1
10	AFDB:Q8IIR9	0.827	0.965	1.759E-49	335	0.527	0.615	Q8IIR9.pdb.gz	Q8IIR9_PLAF7 Casein kinase 2, alpha subunit OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1108400 PE=1 SV=1
11	AFDB:Q02720	0.824	0.956	3.333E-49	337	0.563	0.653	Q02720.pdb.gz	CSK2A_DICDI Casein kinase II subunit alpha OS=Dictyostelium discoideum OX=44689 GN=casK PE=2 SV=1
12	PDB:3e3bX	0.828	0.967	1.044E-48	334	0.719	0.841	3e3bX.pdb.gz	Structure of human protein kinase CK2alpha2 with a potent indazole-derivative inhibitor
13	PDB:5xvuA	0.802	0.976	2.268E-46	321	0.524	0.639	5xvuA.pdb.gz	The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.
14	PDB:4fi1A	0.816	0.859	4.200E-44	371	0.537	0.566	4fi1A.pdb.gz	Crystal structure of scCK2 alpha in complex with ATP
15	PDB:1unlA	0.638	0.842	2.957E-23	292	0.217	0.291	1unlA.pdb.gz	Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
16	PDB:4krcA	0.670	0.871	2.462E-21	297	0.217	0.286	4krcA.pdb.gz	New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition.
17	PDB:3mi9A	0.643	0.757	3.977E-21	329	0.228	0.271	3mi9A.pdb.gz	Crystal structure of HIV-1 Tat complexed with human P-TEFb.
18	PDB:1j1bB	0.646	0.691	4.666E-21	364	0.225	0.242	1j1bB.pdb.gz	Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta.
19	PDB:4yc3A	0.639	0.833	6.775E-21	295	0.220	0.292	4yc3A.pdb.gz
20	PDB:2b9iA	0.642	0.736	1.094E-20	338	0.235	0.272	2b9iA.pdb.gz	The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A2R8Y5A0	0.0	660	354	0.890	0.983	A0A2R8Y5A0_HUMAN Casein kinase 2 alpha 1 OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1
2	A0A2R8YDP2	0.0	707	354	0.890	0.983	A0A2R8YDP2_HUMAN Casein kinase 2 alpha 1 OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1
3	A0A2R8YF43	0.0	726	363	0.913	0.983	A0A2R8YF43_HUMAN Casein kinase 2 alpha 1 OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1
4	A0A2R8YFU2	0.0	756	374	0.941	0.984	A0A2R8YFU2_HUMAN Casein kinase 2 alpha 1 OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1
5	B4F7A9	0.0	563	350	0.739	0.826	B4F7A9_RAT Casein kinase 2, alpha prime polypeptide OS=Rattus norvegicus OX=10116 GN=Csnk2a2 PE=2 SV=1
6	F7FH41	0.0	516	462	0.670	0.567	F7FH41_RAT Casein kinase 2 alpha 2 OS=Rattus norvegicus OX=10116 GN=Csnk2a2 PE=1 SV=1
7	O54833	0.0	562	350	0.737	0.823	CSK22_MOUSE Casein kinase II subunit alpha' OS=Mus musculus OX=10090 GN=Csnk2a2 PE=1 SV=1
8	P08181	0.0	567	336	0.734	0.854	CSK2A_DROME Casein kinase II subunit alpha OS=Drosophila melanogaster OX=7227 GN=CkIIalpha PE=1 SV=2
9	P18334	0.0	538	360	0.698	0.758	CSK2A_CAEEL Casein kinase II subunit alpha OS=Caenorhabditis elegans OX=6239 GN=kin-3 PE=1 SV=1
10	P19139	0.0	791	391	0.969	0.969	CSK21_RAT Casein kinase II subunit alpha OS=Rattus norvegicus OX=10116 GN=Csnk2a1 PE=1 SV=2
11	P19784	0.0	562	350	0.737	0.823	CSK22_HUMAN Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1
12	P68400	0.0	803	391	0.985	0.985	CSK21_HUMAN Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1
13	Q60737	0.0	793	391	0.972	0.972	CSK21_MOUSE Casein kinase II subunit alpha OS=Mus musculus OX=10090 GN=Csnk2a1 PE=1 SV=2
14	Q61177	0.0	791	391	0.969	0.969	Q61177_MOUSE Casein kinase II alpha subunit OS=Mus musculus OX=10090 GN=Csnk2a1 PE=1 SV=1
15	Q8NEV1	0.0	816	391	1.000	1.000	CSK23_HUMAN Casein kinase II subunit alpha 3 OS=Homo sapiens OX=9606 GN=CSNK2A3 PE=1 SV=2
16	Q9AR27	1.01e-175	494	333	0.634	0.745	HD6_ORYSI Casein kinase II subunit alpha-2 OS=Oryza sativa subsp. indica OX=39946 GN=HD6 PE=2 SV=1
17	O64816	1.13e-172	490	432	0.616	0.558	CSK2P_ARATH Casein kinase II subunit alpha-4, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=CKA4 PE=2 SV=1
18	Q08467	2.64e-171	486	409	0.616	0.589	CSK21_ARATH Casein kinase II subunit alpha-1 OS=Arabidopsis thaliana OX=3702 GN=CKA1 PE=1 SV=3
19	Q08466	1.34e-170	484	403	0.619	0.600	CSK22_ARATH Casein kinase II subunit alpha-2 OS=Arabidopsis thaliana OX=3702 GN=CKA2 PE=1 SV=3
20	O64817	1.72e-168	476	333	0.614	0.721	CSK23_ARATH Casein kinase II subunit alpha-3 OS=Arabidopsis thaliana OX=3702 GN=CKA3 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	0.11	23.1	ABC1 atypical kinase-like domain
2	PF01636 APH	0.00048	31.6	Phosphotransferase enzyme family
3	PF01633 Choline_kinase	19	16.3	Choline/ethanolamine kinase
4	PF19250 DUF5898	47	15.4	Family of unknown function (DUF5898)
5	PF13095 FTA2	2.7e+02	12.6	Kinetochore Sim4 complex subunit FTA2
6	PF06293 Kdo	2.5	19.0	Lipopolysaccharide kinase (Kdo/WaaP) family
7	PF00069 Pkinase	8.4e-67	236.9	Protein kinase domain
8	PF17667 Pkinase_fungal	1.5	19.2	Fungal protein kinase
9	PF07714 PK_Tyr_Ser-Thr	7.7e-16	69.7	Protein tyrosine and serine/threonine kinase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000473553

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000365042	0.992	Casein kinase II subunit beta
2	9606.ENSP00000311677	0.946	Nuclear inhibitor of protein phosphatase 1
3	9606.ENSP00000216797	0.833	NF-kappa-B inhibitor alpha
4	9606.ENSP00000361021	0.823	Phosphatase and tensin homolog
5	9606.ENSP00000344456	0.817	Catenin beta-1
6	9606.ENSP00000367284	0.805	FUN14 domain-containing protein 1
7	9606.ENSP00000262506	0.802	Casein kinase II subunit alpha
8	9606.ENSP00000217244	0.801	Casein kinase II subunit alpha
9	9606.ENSP00000368752	0.801	Major prion protein
10	9606.ENSP00000384302	0.735	WD repeat-containing protein 43
11	9606.ENSP00000278412	0.728	FACT complex subunit SSRP1
12	9606.ENSP00000005340	0.723	Segment polarity protein dishevelled homolog DVL-2
13	9606.ENSP00000225298	0.719	U3 small nucleolar RNA-associated protein 18 homolog
14	9606.ENSP00000297990	0.711	Nucleolar protein 6
15	9606.ENSP00000478610	0.706	Chimera CSNK2B-LY6G5B splicing isoform 991
16	9606.ENSP00000216297	0.697	FACT complex subunit SPT16
17	9606.ENSP00000321449	0.694	Ribosomal RNA processing 7 homolog A
18	9606.ENSP00000307078	0.678	Kinesin-1 heavy chain
19	9606.ENSP00000368927	0.677	Eukaryotic translation initiation factor 1A, X-chromosomal
20	9606.ENSP00000202816	0.673	ESF1 homolog

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0004674	1.000	protein serine/threonine kinase activity
GO:1901363	0.415	heterocyclic compound binding
GO:0097159	0.415	organic cyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.987	cellular process
GO:0044237	0.983	cellular metabolic process
GO:0044238	0.982	primary metabolic process
GO:0006807	0.981	nitrogen compound metabolic process
GO:0043170	0.981	macromolecule metabolic process
GO:0050794	0.978	regulation of cellular process
GO:0019222	0.970	regulation of metabolic process
GO:1901564	0.956	organonitrogen compound metabolic process
GO:0060255	0.949	regulation of macromolecule metabolic process
GO:0043412	0.941	macromolecule modification
GO:0080090	0.939	regulation of primary metabolic process
GO:0051171	0.939	regulation of nitrogen compound metabolic process
GO:0006468	0.929	protein phosphorylation
GO:0051247	0.887	positive regulation of protein metabolic process
GO:0009894	0.882	regulation of catabolic process
GO:0050896	0.845	response to stimulus
GO:0018105	0.827	peptidyl-serine phosphorylation
GO:0048522	0.816	positive regulation of cellular process
GO:2000058	0.780	regulation of ubiquitin-dependent protein catabolic process
GO:0048583	0.755	regulation of response to stimulus
GO:0051248	0.751	negative regulation of protein metabolic process
GO:0032502	0.729	developmental process
GO:0045861	0.727	negative regulation of proteolysis
GO:0048856	0.715	anatomical structure development
GO:1903051	0.695	negative regulation of proteolysis involved in protein catabolic process
GO:0042176	0.652	regulation of protein catabolic process
GO:0051128	0.621	regulation of cellular component organization
GO:0048523	0.573	negative regulation of cellular process
GO:0032501	0.527	multicellular organismal process
GO:0040008	0.483	regulation of growth
GO:0031099	0.441	regeneration
GO:0010468	0.399	regulation of gene expression
GO:0019219	0.352	regulation of nucleobase-containing compound metabolic process
GO:0031325	0.351	positive regulation of cellular metabolic process
GO:0048513	0.343	animal organ development
GO:0051716	0.341	cellular response to stimulus
GO:0007275	0.337	multicellular organism development
GO:1905475	0.319	regulation of protein localization to membrane
GO:1904375	0.319	regulation of protein localization to cell periphery
GO:1901654	0.315	response to ketone
GO:0010556	0.315	regulation of macromolecule biosynthetic process
GO:0031326	0.314	regulation of cellular biosynthetic process
GO:0023052	0.306	signaling
GO:0007154	0.305	cell communication

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.997	nucleoplasm
GO:0005829	0.984	cytosol
GO:0032991	0.976	protein-containing complex
GO:0043232	0.969	intracellular non-membrane-bounded organelle
GO:0016020	0.959	membrane
GO:0005694	0.696	chromosome
GO:0071944	0.560	cell periphery
GO:0005886	0.530	plasma membrane
GO:0140513	0.498	nuclear protein-containing complex
GO:0000785	0.443	chromatin
GO:0140535	0.405	intracellular protein-containing complex
GO:1902494	0.384	catalytic complex
GO:0005730	0.377	nucleolus
GO:0005956	0.349	protein kinase CK2 complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.1.-	1.000	Phosphotransferases with an alcohol group as acceptor.

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