StarFunc result for job id Q8NFW1

User Input

>input (1626 residues)
MAGLRGNAVAGLLWMLLLWSGGGGCQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQW
VANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGSQEEVKAAARRLAYHGGNTNTGDA
LRYITARSFSPHAGGRPRDRAYKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEA
LKEELEEIASEPKSAHVFHVSDFNAIDKIRGKLRRRLCENVLCPSVRVEGDRFKHTNGGT
KEITGFDLMDLFSVKEILGKRENGAQSSYVRMGSFPVVQSTEDVFPQGLPDEYAFVTTFR
FRKTSRKEDWYIWQVIDQYSIPQVSIRLDGENKAVEYNAVGAMKDAVRVVFRGSRVNDLF
DRDWHKMALSIQAQNVSLHIDCALVQTLPIEERENIDIQGKTVIGKRLYDSVPIDFDLQR
IVIYCDSRHAELETCCDIPSGPCQVTVVTEPPPPPPPQRPPTPGSEQIGFLKTINCSCPA
GEKGEMGVAGPMGLPGPKGDIGAIGPVGAPGPKGEKGDVGIGPFGQGEKGEKGSLGLPGP
PGRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAPGLQGERGEKGTRGE
KGERGLDGFPGKPGDTGQQGRPGPSGVAGPQGEKGDVGPAGPPGVPGSVVQQEGLKGEQG
APGPRGHQGAPGPPGARGPIGPEGRDGPPGLQGLRGKKGDMGPPGIPGLLGLQGPPGPPG
VPGPPGPGGSPGLPGEIGFPGKPGPPGPTGPPGKDGPNGPPGPPGTKGEPGERGEDGLPG
KPGLRGEIGEQGLAGRPGEKGEAGLPGAPGFPGVRGEKGDQGEKGELGLPGLKGDRGEKG
EAGPAGPPGLPGTTSLFTPHPRMPGEQGPKGEKGDPGLPGEPGLQGRPGELGPQGPTGPP
GAKGQEGAHGAPGAAGNPGAPGHVGAPGPSGPPGSVGAPGLRGTPGKDGERGEKGAAGEE
GSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRGSPGLPGPLGTKAACGKVRGSENCALGG
QCVKGDRGAPGIPGSPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRGLPGFPGPQGPAGRD
GAPGNPGERGPPGKPGLSSLLSPGDINLLAKDVCNDCPPGPPGLPGLPGFKGDKGVPGKP
GREGTEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGNP
GPPGADGIAGAAGPPGIQGSPGKEGPPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKA
GEPGLPGPEGARGPPGFKGHTGDSGAPGPRGESGAMGLPGQEGLPGKDGDTGPTGPQGPQ
GPRGPPGKNGSPGSPGEPGPSGTPGQKGSKGENGSPGLPGFLGPRGPPGEPGEKGVPGKE
GVPGKPGEPGFKGERGDPGIKGDKGPPGGKGQPGDPGIPGHKGHTGLMGPQGLPGENGPV
GPPGPPGQPGFPGLRGESPSMETLRRLIQEELGKQLETRLAYLLAQMPPAYMKSSQGRPG
PPGPPGKDGLPGRAGPMGEPGRPGQGGLEGPSGPIGPKGERGAKGDPGAPGVGLRGEMGP
PGIPGQPGEPGYAKDGLPGIPGPQGETGPAGHPGLPGPPGPPGQCDPSQCAYFASLAARP
GNVKGP

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:E9Q7P1	0.282	0.285	0.000	1613	0.870	0.877	E9Q7P1.pdb.gz	E9Q7P1_MOUSE Collagen, type XXII, alpha 1 OS=Mus musculus OX=10090 GN=Col22a1 PE=1 SV=1
2	AFDB:Q8NFW1	1.000	1.000	0.000	1626	1.000	1.000	Q8NFW1.pdb.gz	COMA1_HUMAN Collagen alpha-1(XXII) chain OS=Homo sapiens OX=9606 GN=COL22A1 PE=2 SV=2
3	AFDB:A0A0R4IR54	0.265	0.265	4.227E-99	1622	0.586	0.588	A0A0R4IR54.pdb.gz
4	AFDB:Q14993	0.141	0.199	3.141E-36	1142	0.328	0.468	Q14993.pdb.gz	COJA1_HUMAN Collagen alpha-1(XIX) chain OS=Homo sapiens OX=9606 GN=COL19A1 PE=1 SV=3
5	AFDB:Q0VF58	0.132	0.187	1.019E-35	1136	0.328	0.469	Q0VF58.pdb.gz	COJA1_MOUSE Collagen alpha-1(XIX) chain OS=Mus musculus OX=10090 GN=Col19a1 PE=2 SV=2
6	AFDB:Q07092	0.140	0.142	1.938E-35	1604	0.392	0.398	Q07092.pdb.gz	COGA1_HUMAN Collagen alpha-1(XVI) chain OS=Homo sapiens OX=9606 GN=COL16A1 PE=1 SV=2
7	AFDB:Q8BLX7	0.138	0.142	1.330E-34	1580	0.380	0.391	Q8BLX7.pdb.gz	COGA1_MOUSE Collagen alpha-1(XVI) chain OS=Mus musculus OX=10090 GN=Col16a1 PE=1 SV=2
8	AFDB:P20849	0.124	0.214	3.441E-24	921	0.215	0.380	P20849.pdb.gz	CO9A1_HUMAN Collagen alpha-1(IX) chain OS=Homo sapiens OX=9606 GN=COL9A1 PE=1 SV=3
9	AFDB:P12107	0.096	0.088	4.443E-15	1806	0.354	0.319	P12107.pdb.gz	COBA1_HUMAN Collagen alpha-1(XI) chain OS=Homo sapiens OX=9606 GN=COL11A1 PE=1 SV=4
10	AFDB:Q9JLI2	0.108	0.101	1.605E-14	1739	0.344	0.321	Q9JLI2.pdb.gz	Q9JLI2_MOUSE Collagen type V alpha 3 chain OS=Mus musculus OX=10090 GN=Col5a3 PE=1 SV=1
11	PDB:4nenA	0.103	0.154	1.073E-13	1063	0.045	0.069	4nenA.pdb.gz	An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
12	PDB:4nehA	0.102	0.150	5.636E-13	1084	0.050	0.076	4nehA.pdb.gz	An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
13	PDB:2xwbF	0.100	0.213	2.647E-8	714	0.039	0.088	2xwbF.pdb.gz	Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
14	PDB:7zs96	0.103	0.398	3.278E-8	383	0.019	0.081	7zs96.pdb.gz	Structures of transcription preinitiation complex engaged with the +1 nucleosome.
15	PDB:6jp8F	0.104	0.169	5.307E-8	973	0.030	0.050	6jp8F.pdb.gz	Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
16	PDB:6gym6	0.098	0.430	7.316E-8	335	0.017	0.084	6gym6.pdb.gz	Promoter Distortion and Opening in the RNA Polymerase II Cleft.
17	PDB:3v0aB	0.092	0.126	9.063E-8	1150	0.019	0.027	3v0aB.pdb.gz	Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
18	PDB:5n0cA	0.074	0.090	1.318E-7	1293	0.016	0.020	5n0cA.pdb.gz	The structure of the tetanus toxin reveals pH-mediated domain dynamics.
19	PDB:7qfqA	0.094	0.115	5.300E-7	1291	0.015	0.019	7qfqA.pdb.gz
20	PDB:7ad8D	0.093	0.476	9.549E-7	280	0.015	0.086	7ad8D.pdb.gz	The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	E9Q7P1	0.0	1847	1613	0.863	0.870	E9Q7P1_MOUSE Collagen, type XXII, alpha 1 OS=Mus musculus OX=10090 GN=Col22a1 PE=1 SV=1
2	Q8NFW1	0.0	3006	1626	1.000	1.000	COMA1_HUMAN Collagen alpha-1(XXII) chain OS=Homo sapiens OX=9606 GN=COL22A1 PE=2 SV=2
3	M5BFV8	8.39e-147	494	1622	0.343	0.344	M5BFV8_DANRE Collagen alpha-1(XXII) chain precursor OS=Danio rerio OX=7955 GN=prp PE=1 SV=1
4	F5GZK2	4.64e-130	432	956	0.195	0.332	F5GZK2_HUMAN Collagen type XXI alpha 1 chain OS=Homo sapiens OX=9606 GN=COL21A1 PE=1 SV=2
5	A0A158RFW1	1.06e-121	409	957	0.191	0.325	A0A158RFW1_HUMAN Alpha 1 type XXI collagen OS=Homo sapiens OX=9606 GN=COL21A1 PE=4 SV=1
6	Q96P44	1.06e-121	409	957	0.191	0.325	COLA1_HUMAN Collagen alpha-1(XXI) chain OS=Homo sapiens OX=9606 GN=COL21A1 PE=2 SV=1
7	P08120	1.00e-105	376	1779	0.333	0.304	CO4A1_DROME Collagen alpha-1(IV) chain OS=Drosophila melanogaster OX=7227 GN=Col4a1 PE=1 SV=3
8	P17139	5.10e-103	367	1759	0.322	0.297	CO4A1_CAEEL Collagen alpha-1(IV) chain OS=Caenorhabditis elegans OX=6239 GN=emb-9 PE=1 SV=5
9	Q0VF58	4.53e-98	345	1136	0.216	0.309	COJA1_MOUSE Collagen alpha-1(XIX) chain OS=Mus musculus OX=10090 GN=Col19a1 PE=2 SV=2
10	Q9VMV5	6.80e-97	349	1940	0.314	0.263	Q9VMV5_DROME Viking, isoform A OS=Drosophila melanogaster OX=7227 GN=vkg PE=1 SV=1
11	A0MSJ1	7.32e-97	348	1658	0.244	0.239	CRA1B_DANRE Collagen alpha-1(XXVII) chain B OS=Danio rerio OX=7955 GN=col27a1b PE=2 SV=1
12	O18407	2.19e-95	344	1761	0.311	0.287	O18407_DROME Collagen type IV alpha 2 OS=Drosophila melanogaster OX=7227 GN=vkg PE=1 SV=1
13	Q17RW2	6.20e-94	339	1714	0.248	0.236	COOA1_HUMAN Collagen alpha-1(XXIV) chain OS=Homo sapiens OX=9606 GN=COL24A1 PE=1 SV=2
14	Q30D77	6.75e-88	320	1733	0.266	0.249	COOA1_MOUSE Collagen alpha-1(XXIV) chain OS=Mus musculus OX=10090 GN=Col24a1 PE=2 SV=2
15	P02466	2.50e-87	316	1372	0.269	0.319	CO1A2_RAT Collagen alpha-2(I) chain OS=Rattus norvegicus OX=10116 GN=Col1a2 PE=1 SV=3
16	Q9ESQ1	2.87e-87	318	1691	0.301	0.290	Q9ESQ1_MOUSE Type IV collagen alpha 6 chain OS=Mus musculus OX=10090 GN=Col4a6 PE=2 SV=1
17	B1AVK5	5.02e-87	317	1691	0.294	0.283	B1AVK5_MOUSE Collagen, type IV, alpha 6 OS=Mus musculus OX=10090 GN=Col4a6 PE=1 SV=1
18	Q14031	5.14e-86	314	1691	0.332	0.319	CO4A6_HUMAN Collagen alpha-6(IV) chain OS=Homo sapiens OX=9606 GN=COL4A6 PE=1 SV=3
19	Q14993	3.13e-83	301	1142	0.145	0.206	COJA1_HUMAN Collagen alpha-1(XIX) chain OS=Homo sapiens OX=9606 GN=COL19A1 PE=1 SV=3
20	Q01149	7.24e-83	302	1372	0.266	0.315	CO1A2_MOUSE Collagen alpha-2(I) chain OS=Mus musculus OX=10090 GN=Col1a2 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01391 Collagen	8.5e-152	504.4	Collagen triple helix repeat (20 copies)
2	PF17930 LpxI_N	7.2e+02	11.5	LpxI N-terminal domain
3	PF00092 VWA	9e-43	158.1	von Willebrand factor type A domain
4	PF13519 VWA_2	3.8e-11	55.0	von Willebrand factor type A domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000303153

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000401749	0.917	Prolyl 4-hydroxylase subunit alpha-3
2	9606.ENSP00000263556	0.909	Prolyl 4-hydroxylase subunit alpha-1
3	9606.ENSP00000384999	0.908	Prolyl 4-hydroxylase subunit alpha-2
4	9606.ENSP00000282903	0.759	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
5	9606.ENSP00000323696	0.741	Cartilage-associated protein
6	9606.ENSP00000196061	0.712	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
7	9606.ENSP00000236040	0.709	Prolyl 3-hydroxylase 1
8	9606.ENSP00000223127	0.677	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
9	9606.ENSP00000434412	0.674	Serpin H1
10	9606.ENSP00000300026	0.642	Peptidyl-prolyl cis-trans isomerase B
11	9606.ENSP00000316881	0.638	Prolyl 3-hydroxylase 2
12	9606.ENSP00000478600	0.638	Prolyl 3-hydroxylase 3
13	9606.ENSP00000252599	0.637	Procollagen galactosyltransferase 1
14	9606.ENSP00000354960	0.634	Procollagen galactosyltransferase 2
15	9606.ENSP00000327801	0.608	Protein disulfide-isomerase
16	9606.ENSP00000325146	0.533	Collagen alpha-1(XII) chain
17	9606.ENSP00000359114	0.525	Collagen alpha-1(XI) chain
18	9606.ENSP00000298282	0.523	Homeobox protein PKNOX2
19	9606.ENSP00000274341	0.521	Hyaluronan and proteoglycan link protein 1
20	9606.ENSP00000373979	0.517	Trafficking protein particle complex subunit 9

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0030020	0.967	extracellular matrix structural constituent conferring tensile strength

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0048856	0.990	anatomical structure development
GO:0032501	0.983	multicellular organismal process
GO:0009987	0.982	cellular process
GO:0007275	0.799	multicellular organism development
GO:0048731	0.503	system development
GO:0050789	0.416	regulation of biological process
GO:0048513	0.376	animal organ development
GO:0050794	0.343	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071944	0.999	cell periphery
GO:0012505	0.999	endomembrane system
GO:0005737	0.997	cytoplasm
GO:0070013	0.997	intracellular organelle lumen
GO:0043231	0.996	intracellular membrane-bounded organelle
GO:0005576	0.988	extracellular region
GO:0030312	0.985	external encapsulating structure
GO:0031012	0.982	extracellular matrix
GO:0005783	0.971	endoplasmic reticulum
GO:0062023	0.949	collagen-containing extracellular matrix
GO:0005788	0.928	endoplasmic reticulum lumen
GO:0032991	0.638	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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