StarFunc result for job id Q8TCG1

User Input

>input (905 residues)
MDSTACLKSLLLTVSQYKAVKSEANATQLLRHLEVISGQKLTRLFTSNQILTSECLSCLV
ELLEDPNISASLILSIIGLLSQLAVDIETRDCLQNTYNLNSVLAGVVCRSSHTDSVFLQC
IQLLQKLTYNVKIFYSGANIDELITFLIDHIQSSEDELKMPCLGLLANLCRHNLSVQTHI
KTLSNVKSFYRTLITLLAHSSLTVVVFALSILSSLTLNEEVGEKLFHARNIHQTFQLIFN
ILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLHQVLGLLNGKDPDSSSKVL
ELLLAFCSVTQLRHMLTQMMFEQSPPGSATLGSHTKCLEPTVALLRWLSQPLDGSENCSV
LALELFKEIFEDVIDAANCSSADRFVTLLLPTILDQLQFTEQNLDEALTRKKCERIAKAI
EVLLTLCGDDTLKMHIAKILTTVKCTTLIEQQFTYGKIDLGFGTKVADSELCKLAADVIL
KTLDLINKLKPLVPGMEVSFYKILQDPRLITPLAFALTSDNREQVQSGLRILLEAAPLPD
FPALVLGESIAANNAYRQQETEHIPRKMPWQSSNHSFPTSIKCLTPHLKDGVPGLNIEEL
IEKLQSGMVVKDQICDVRISDIMDVYEMKLSTLASKESRLQDLLETKALALAQADRLIAQ
HRCQRTQAETEARTLASMLREVERKNEELSVLLKAQQVESERAQSDIEHLFQHNRKLESV
AEEHEILTKSYMELLQRNESTEKKNKDLQITCDSLNKQIETVKKLNESLKEQNEKSIAQL
IEKEEQRKEVQNQLVDREHKLANLHQKTKVQEEKIKTLQKEREDKEETIDILRKELSRTE
QIRKELSIKASSLEVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIHSLSGGKINPET
VNLSI

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8TCG1	1.000	1.000	4.890E-103	905	1.000	1.000	Q8TCG1.pdb.gz	CIP2A_HUMAN Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2
2	AFDB:Q8BWY9	0.621	0.620	4.362E-85	907	0.875	0.873	Q8BWY9.pdb.gz	CIP2A_MOUSE Protein CIP2A OS=Mus musculus OX=10090 GN=Cip2a PE=1 SV=3
3	AFDB:Q54P24	0.201	0.160	1.429E-10	1215	0.156	0.116	Q54P24.pdb.gz	Q54P24_DICDI DH domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=gxcC PE=4 SV=1
4	AFDB:Q09857	0.225	0.200	2.684E-8	1067	0.145	0.123	Q09857.pdb.gz	USO1_SCHPO Intracellular protein transport protein uso1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=uso1 PE=3 SV=3
5	PDB:7rroH7	0.247	0.348	6.479E-8	580	0.085	0.133	7rroH7.pdb.gz	De novo identification of mammalian ciliary motility proteins using cryo-EM.
6	PDB:2z6gA	0.235	0.338	1.942E-7	550	0.078	0.129	2z6gA.pdb.gz
7	PDB:7q2xD	0.183	0.170	2.113E-7	994	0.099	0.091	7q2xD.pdb.gz	Clamping of DNA shuts the condensin neck gate.
8	PDB:3w3uA	0.339	0.306	2.722E-7	1030	0.082	0.072	3w3uA.pdb.gz
9	AFDB:P25386	0.230	0.146	3.379E-7	1790	0.176	0.089	P25386.pdb.gz	USO1_YEAST Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=USO1 PE=1 SV=2
10	PDB:6kbnC	0.256	0.408	4.152E-7	504	0.080	0.143	6kbnC.pdb.gz	Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
11	AFDB:O93614	0.229	0.320	5.377E-7	607	0.098	0.147	O93614.pdb.gz	GDS1A_XENLA Rap1 GTPase-GDP dissociation stimulator 1-A OS=Xenopus laevis OX=8355 GN=rap1gds1-a PE=1 SV=1
12	PDB:6xu2A	0.233	0.203	1.051E-6	1091	0.090	0.074	6xu2A.pdb.gz	X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
13	PDB:7qenD	0.171	0.154	1.051E-6	1050	0.093	0.080	7qenD.pdb.gz	A hold-and-feed mechanism drives directional DNA loop extrusion by condensin.
14	PDB:1b3uA	0.193	0.263	1.354E-6	588	0.066	0.102	1b3uA.pdb.gz
15	PDB:5tbkA	0.191	0.347	1.354E-6	417	0.071	0.153	5tbkA.pdb.gz
16	PDB:4jlqA	0.290	0.306	1.413E-6	840	0.103	0.111	4jlqA.pdb.gz	Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
17	AFDB:P38249	0.138	0.132	2.076E-6	964	0.140	0.132	P38249.pdb.gz	EIF3A_YEAST Eukaryotic translation initiation factor 3 subunit A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPG1 PE=1 SV=1
18	AFDB:Q9LD55	0.111	0.104	1.033E-5	987	0.151	0.139	Q9LD55.pdb.gz	EIF3A_ARATH Eukaryotic translation initiation factor 3 subunit A OS=Arabidopsis thaliana OX=3702 GN=TIF3A1 PE=1 SV=1
19	AFDB:A0A0G2K1D2	0.243	0.369	2.968E-5	527	0.077	0.133	A0A0G2K1D2.pdb.gz	A0A0G2K1D2_RAT Rap1 GTPase-GDP dissociation stimulator 1 OS=Rattus norvegicus OX=10116 GN=Rap1gds1 PE=4 SV=2
20	AFDB:O74760	0.109	0.107	4.339E-5	932	0.159	0.155	O74760.pdb.gz	EIF3A_SCHPO Eukaryotic translation initiation factor 3 subunit A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=tif32 PE=1 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8BWY9	0.0	1543	907	0.875	0.873	CIP2A_MOUSE Protein CIP2A OS=Mus musculus OX=10090 GN=Cip2a PE=1 SV=3
2	Q8TCG1	0.0	1831	905	1.000	1.000	CIP2A_HUMAN Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2
3	P25386	0.038	40.4	1790	0.082	0.041	USO1_YEAST Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=USO1 PE=1 SV=2
4	Q5VT25	0.13	38.5	1732	0.052	0.027	MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1
5	B5DFK5	0.23	37.7	1068	0.050	0.042	B5DFK5_RAT Hip1r protein OS=Rattus norvegicus OX=10116 GN=Hip1r PE=2 SV=1
6	F1LML7	0.23	37.7	1069	0.050	0.042	F1LML7_RAT Huntingtin interacting protein 1 related OS=Rattus norvegicus OX=10116 GN=Hip1r PE=1 SV=1
7	Q99PW9	0.23	37.7	1079	0.050	0.042	Q99PW9_RAT Huntingtin interacting protein 1 related (Fragment) OS=Rattus norvegicus OX=10116 GN=Hip1r PE=2 SV=1
8	Q9JKY5	0.26	37.7	1068	0.050	0.042	HIP1R_MOUSE Huntingtin-interacting protein 1-related protein OS=Mus musculus OX=10090 GN=Hip1r PE=1 SV=2
9	O75146	0.29	37.4	1068	0.071	0.060	HIP1R_HUMAN Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2
10	Q3UU96	0.31	37.4	1719	0.059	0.031	MRCKA_MOUSE Serine/threonine-protein kinase MRCK alpha OS=Mus musculus OX=10090 GN=Cdc42bpa PE=1 SV=2
11	Q02440	0.49	36.6	1829	0.054	0.027	MYO5A_CHICK Unconventional myosin-Va OS=Gallus gallus OX=9031 GN=MYO5A PE=1 SV=1
12	Q86UP2	0.56	36.6	1357	0.043	0.029	KTN1_HUMAN Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1
13	O54874	0.88	35.8	1732	0.056	0.029	MRCKA_RAT Serine/threonine-protein kinase MRCK alpha OS=Rattus norvegicus OX=10116 GN=Cdc42bpa PE=1 SV=1
14	Q9JIR0	0.89	35.8	1847	0.049	0.024	RIMB1_RAT Peripheral-type benzodiazepine receptor-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Tspoap1 PE=1 SV=2
15	Q9LSB4	1.0	35.4	772	0.045	0.053	NAI2_ARATH TSA1-like protein OS=Arabidopsis thaliana OX=3702 GN=NAI2 PE=1 SV=1
16	Q9Y5S2	1.5	35.0	1711	0.050	0.026	MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta OS=Homo sapiens OX=9606 GN=CDC42BPB PE=1 SV=2
17	Q13137	2.2	34.3	446	0.042	0.085	CACO2_HUMAN Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1
18	Q20641	2.7	34.3	1963	0.042	0.019	Q20641_CAEEL Myosin-11 OS=Caenorhabditis elegans OX=6239 GN=nmy-1 PE=1 SV=2
19	Q5AMN3	3.3	33.9	1165	0.045	0.035	ATG11_CANAL Autophagy-related protein 11 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ATG11 PE=2 SV=1
20	F4IVR7	4.2	33.5	1770	0.051	0.026	MYO10_ARATH Myosin-10 OS=Arabidopsis thaliana OX=3702 GN=XI-D PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000295746

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000479618	0.974	Myc proto-oncogene protein
2	9606.ENSP00000377036	0.934	Serine/threonine-protein phosphatase 2A activator
3	9606.ENSP00000219548	0.929	E3 ubiquitin-protein ligase CHIP
4	9606.ENSP00000324804	0.837	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
5	9606.ENSP00000355966	0.830	Serine/threonine-protein kinase Nek2
6	9606.ENSP00000407586	0.817	GTPase HRas
7	9606.ENSP00000245812	0.788	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
8	9606.ENSP00000357076	0.788	Transgelin-2
9	9606.ENSP00000361777	0.716	Protein SET
10	9606.ENSP00000331720	0.712	UPF0472 protein C16orf72
11	9606.ENSP00000225972	0.692	Leucine-rich repeat-containing protein 59
12	9606.ENSP00000261461	0.685	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
13	9606.ENSP00000377492	0.685	Hyaluronan mediated motility receptor
14	9606.ENSP00000320184	0.680	Mitochondrial ribosomal protein S23
15	9606.ENSP00000251496	0.679	Condensin complex subunit 3
16	9606.ENSP00000232603	0.674	MORC family CW-type zinc finger protein 1
17	9606.ENSP00000240423	0.671	Condensin complex subunit 2
18	9606.ENSP00000324020	0.668	Kinesin-like protein KIF15
19	9606.ENSP00000300093	0.655	Serine/threonine-protein kinase PLK1
20	9606.ENSP00000420176	0.654	DNA polymerase epsilon subunit 4

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0045296	1.000	cadherin binding
GO:0042803	1.000	protein homodimerization activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.989	cellular process
GO:0048522	0.989	positive regulation of cellular process
GO:0042127	0.955	regulation of cell population proliferation
GO:0008284	0.911	positive regulation of cell population proliferation
GO:2000177	0.897	regulation of neural precursor cell proliferation
GO:0032502	0.891	developmental process
GO:0051239	0.870	regulation of multicellular organismal process
GO:0050793	0.849	regulation of developmental process
GO:0048856	0.846	anatomical structure development
GO:0008283	0.844	cell population proliferation
GO:0030154	0.839	cell differentiation
GO:0032501	0.827	multicellular organismal process
GO:0051960	0.826	regulation of nervous system development
GO:0061351	0.822	neural precursor cell proliferation
GO:0045595	0.822	regulation of cell differentiation
GO:0051240	0.796	positive regulation of multicellular organismal process
GO:0048609	0.793	multicellular organismal reproductive process
GO:0060284	0.792	regulation of cell development
GO:2000179	0.790	positive regulation of neural precursor cell proliferation
GO:0045597	0.790	positive regulation of cell differentiation
GO:1902692	0.788	regulation of neuroblast proliferation
GO:0048731	0.786	system development
GO:0007399	0.777	nervous system development
GO:0022008	0.768	neurogenesis
GO:0050767	0.766	regulation of neurogenesis
GO:0010720	0.766	positive regulation of cell development
GO:0007405	0.759	neuroblast proliferation
GO:0051962	0.758	positive regulation of nervous system development
GO:0050769	0.698	positive regulation of neurogenesis
GO:0007276	0.357	gamete generation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0005886	0.998	plasma membrane
GO:0043231	0.948	intracellular membrane-bounded organelle
GO:0043232	0.900	intracellular non-membrane-bounded organelle
GO:0032991	0.703	protein-containing complex
GO:0031981	0.524	nuclear lumen
GO:0005654	0.501	nucleoplasm
GO:0015630	0.383	microtubule cytoskeleton
GO:0012505	0.364	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]