StarFunc result for job id Q8TDZ2

User Input

>input (1067 residues)
MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGGLPQYHKIKDQLNYWSA
KSLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRTKFS
RHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVT
FTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPEGFKVREMRGKLAIGI
TANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKK
QCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFTRAAADFATHGKLGKLEFAQDAHGQPD
VSAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMV
KRWAEGAESLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVR
DLYDVLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQTAGYPGVHVSDLSSSWADG
LALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQAVVAGSDPLGL
IAYLSHFHSAFKSMAHSPGPVSQASPGTSSAVLFLSKLQRTLQRSRAKENAEDAGGKKLR
LEMEAETPSTEVPPDPEPGVPLTPPSQHQEAGAGDLCALCGEHLYVLERLCVNGHFFHRS
CFRCHTCEATLWPGGYEQHPGDGHFYCLQHLPQTDHKAEGSDRGPESPELPTPSENSMPP
GLSTPTASQEGAGPVPDPSQPTRRQIRLSSPERQRLSSLNLTPDPEMEPPPKPPRSCSAL
ARHALESSFVGWGLPVQSPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTS
GTMNNYPTWRRTLLRRAKEEEMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQS
SSPEQQKKLWVGQLLQLVDKKNSLVAEEAELMITVQELNLEEKQWQLDQELRGYMNREEN
LKTAADRQAEDQVLRKLVDLVNQRDALIRFQEERRLSELALGTGAQG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8TDZ2	1.000	1.000	0.000	1067	1.000	1.000	Q8TDZ2.pdb.gz	MICA1_HUMAN [F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2
2	AFDB:Q8VDP3	0.669	0.681	0.000	1048	0.800	0.815	Q8VDP3.pdb.gz	MICA1_MOUSE [F-actin]-monooxygenase MICAL1 OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1
3	AFDB:F1RA39	0.559	0.437	2.403E-89	1413	0.432	0.326	F1RA39.pdb.gz	MCA2B_DANRE [F-actin]-monooxygenase mical2b OS=Danio rerio OX=7955 GN=mical2b PE=2 SV=3
4	AFDB:Q7RTP6	0.452	0.243	1.726E-83	2002	0.386	0.206	Q7RTP6.pdb.gz	MICA3_HUMAN [F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2
5	AFDB:Q8BML1	0.449	0.498	1.514E-82	960	0.371	0.412	Q8BML1.pdb.gz	MICA2_MOUSE [F-actin]-monooxygenase MICAL2 OS=Mus musculus OX=10090 GN=Mical2 PE=1 SV=2
6	AFDB:O94851	0.448	0.426	1.228E-75	1124	0.346	0.328	O94851.pdb.gz	MICA2_HUMAN [F-actin]-monooxygenase MICAL2 OS=Homo sapiens OX=9606 GN=MICAL2 PE=1 SV=2
7	AFDB:Q8N3D4	0.137	0.097	4.311E-14	1523	0.112	0.079	Q8N3D4.pdb.gz	EH1L1_HUMAN EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2
8	PDB:3ihgA	0.248	0.466	1.013E-10	535	0.074	0.148	3ihgA.pdb.gz	Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.
9	PDB:7on9A	0.229	0.557	1.400E-9	393	0.055	0.150	7on9A.pdb.gz	Debottlenecking 4-hydroxybenzoate hydroxylation in Pseudomonas putida KT2440 improves muconate productivity from p-coumarate.
10	PDB:2dkiA	0.217	0.354	1.895E-9	615	0.048	0.083	2dkiA.pdb.gz	Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni has a large tunnel for substrate and oxygen access to the active site
11	PDB:1d7lA	0.201	0.487	7.794E-9	394	0.064	0.173	1d7lA.pdb.gz	Structure-function correlations of the reaction of reduced nicotinamide analogues with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins.
12	PDB:6lkeA	0.203	0.446	7.794E-9	428	0.048	0.119	6lkeA.pdb.gz	Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.
13	PDB:5fn0A	0.193	0.407	8.623E-9	455	0.058	0.136	5fn0A.pdb.gz	Kynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis.
14	PDB:4k22A	0.211	0.564	4.565E-8	354	0.054	0.164	4k22A.pdb.gz
15	PDB:3rp6A	0.206	0.501	1.077E-7	392	0.056	0.153	3rp6A.pdb.gz	Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae.
16	PDB:3c96A	0.220	0.527	1.192E-7	381	0.059	0.165	3c96A.pdb.gz	Crystal structure of the flavin-containing monooxygenase phzS from Pseudomonas aeruginosa.
17	PDB:5wgrA	0.207	0.311	1.318E-7	664	0.077	0.123	5wgrA.pdb.gz	Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.
18	AFDB:Q9UHB6	0.063	0.087	4.647E-3	759	0.062	0.087	Q9UHB6.pdb.gz	LIMA1_HUMAN LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1
19	AFDB:Q17595	0.094	0.156	6.292E-3	535	0.081	0.161	Q17595.pdb.gz	Q17595_CAEEL TRAF3-interacting protein 1 OS=Caenorhabditis elegans OX=6239 GN=dyf-11 PE=4 SV=1
20	AFDB:A2A891	0.060	0.044	7.321E-3	1682	0.110	0.070	A2A891.pdb.gz	CMTA1_MOUSE Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	F1RA39	0.0	663	1679	0.307	0.195	MCA2B_DANRE [F-actin]-monooxygenase mical2b OS=Danio rerio OX=7955 GN=mical2b PE=2 SV=3
2	O94851	0.0	662	1957	0.306	0.167	MICA2_HUMAN [F-actin]-monooxygenase MICAL2 OS=Homo sapiens OX=9606 GN=MICAL2 PE=1 SV=2
3	Q7RTP6	0.0	761	2002	0.365	0.194	MICA3_HUMAN [F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2
4	Q8BML1	0.0	666	1951	0.307	0.168	MICA2_MOUSE [F-actin]-monooxygenase MICAL2 OS=Mus musculus OX=10090 GN=Mical2 PE=1 SV=2
5	Q8TDZ2	0.0	2194	1067	1.000	1.000	MICA1_HUMAN [F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2
6	Q8VDP3	0.0	1656	1048	0.799	0.814	MICA1_MOUSE [F-actin]-monooxygenase MICAL1 OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1
7	Q86BA1	6.35e-169	554	4723	0.267	0.060	MICAL_DROME [F-actin]-monooxygenase Mical OS=Drosophila melanogaster OX=7227 GN=Mical PE=1 SV=1
8	Q8N3F8	1.94e-30	132	863	0.073	0.090	MILK1_HUMAN MICAL-like protein 1 OS=Homo sapiens OX=9606 GN=MICALL1 PE=1 SV=2
9	Q8BGT6	2.85e-30	131	870	0.074	0.091	MILK1_MOUSE MICAL-like protein 1 OS=Mus musculus OX=10090 GN=Micall1 PE=1 SV=3
10	D3ZQL6	4.68e-30	130	855	0.076	0.095	MILK1_RAT MICAL-like protein 1 OS=Rattus norvegicus OX=10116 GN=Micall1 PE=1 SV=1
11	E1BBG2	5.54e-30	130	853	0.071	0.089	MILK1_BOVIN MICAL-like protein 1 OS=Bos taurus OX=9913 GN=MICALL1 PE=1 SV=2
12	Q8IY33	7.83e-29	127	904	0.075	0.088	MILK2_HUMAN MICAL-like protein 2 OS=Homo sapiens OX=9606 GN=MICALL2 PE=1 SV=1
13	Q3TN34	5.27e-26	118	1009	0.071	0.075	MILK2_MOUSE MICAL-like protein 2 OS=Mus musculus OX=10090 GN=Micall2 PE=1 SV=1
14	D3ZEN0	9.56e-26	117	1014	0.066	0.069	MILK2_RAT MICAL-like protein 2 OS=Rattus norvegicus OX=10116 GN=Micall2 PE=1 SV=2
15	F1QAZ3	9.73e-25	113	783	0.065	0.088	F1QAZ3_DANRE Mical-like 2b OS=Danio rerio OX=7955 GN=MICAL-2 PE=1 SV=2
16	Q9U9J8	2.07e-15	84.3	2302	0.042	0.020	Q9U9J8_CAEEL Spectrin beta chain OS=Caenorhabditis elegans OX=6239 GN=unc-70 PE=1 SV=1
17	G5EG85	2.08e-15	84.3	2257	0.042	0.020	G5EG85_CAEEL Spectrin beta chain OS=Caenorhabditis elegans OX=6239 GN=unc-70 PE=1 SV=1
18	E0AHA7	2.33e-15	84.0	2326	0.042	0.019	E0AHA7_CAEEL Spectrin beta chain OS=Caenorhabditis elegans OX=6239 GN=unc-70 PE=1 SV=1
19	P11277	4.36e-15	83.2	2137	0.037	0.019	SPTB1_HUMAN Spectrin beta chain, erythrocytic OS=Homo sapiens OX=9606 GN=SPTB PE=1 SV=5
20	H2L2C9	4.39e-15	82.8	849	0.037	0.046	H2L2C9_CAEEL Alpha-actinin, sarcomeric OS=Caenorhabditis elegans OX=6239 GN=atn-1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF12130 bMERB_dom	1.2e-29	114.5	Bivalent Mical/EHBP Rab binding domain
2	PF11971 CAMSAP_CH	12	17.2	CAMSAP CH domain
3	PF00307 CH	2.2e-15	68.1	Calponin homology (CH) domain
4	PF01266 DAO	0.064	24.4	FAD dependent oxidoreductase
5	PF00890 FAD_binding_2	1	20.0	FAD binding domain
6	PF01494 FAD_binding_3	0.006	27.5	FAD binding domain
7	PF12831 FAD_oxidored	1.8e+02	12.9	FAD dependent oxidoreductase
8	PF05280 FlhC	1.3e+02	13.7	Flagellar transcriptional activator (FlhC)
9	PF01134 GIDA	1.8e+02	12.6	Glucose inhibited division protein A
10	PF03486 HI0933_like	7	16.9	HI0933-like protein
11	PF00412 LIM	0.016	26.7	LIM domain
12	PF05834 Lycopene_cycl	26	15.3	Lycopene cyclase protein
13	PF13241 NAD_binding_7	16	17.4	Putative NAD(P)-binding
14	PF13450 NAD_binding_8	17	17.0	NAD(P)-binding Rossmann-like domain
15	PF00070 Pyr_redox	13	17.7	Pyridine nucleotide-disulphide oxidoreductase
16	PF07992 Pyr_redox_2	0.073	23.9	Pyridine nucleotide-disulphide oxidoreductase
17	PF13738 Pyr_redox_3	3.7	18.3	Pyridine nucleotide-disulphide oxidoreductase
18	PF01946 Thi4	6.7e+02	10.9	Thi4 family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000351664

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000368759	0.988	Enhancer of filamentation 1
2	9606.ENSP00000264710	0.951	Ras-related protein Rab-10
3	9606.ENSP00000300935	0.849	Ras-related protein Rab-8A
4	9606.ENSP00000229340	0.836	Ras-related protein Rab-35
5	9606.ENSP00000377061	0.757	Plexin-A1
6	9606.ENSP00000321606	0.737	Dihydropyrimidinase-related protein 1
7	9606.ENSP00000432660	0.728	Cofilin-1
8	9606.ENSP00000355084	0.716	Methionine-R-sulfoxide reductase B1
9	9606.ENSP00000258526	0.661	Plexin-C1
10	9606.ENSP00000379441	0.660	Junction-mediating and -regulatory protein
11	9606.ENSP00000324287	0.635	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
12	9606.ENSP00000263116	0.624	Ras-related protein Rab-36
13	9606.ENSP00000357564	0.624	Ras-related protein Rab-13
14	9606.ENSP00000229812	0.592	Serine/threonine-protein kinase 38
15	9606.ENSP00000281419	0.591	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
16	9606.ENSP00000291906	0.589	Serine/threonine-protein kinase N3
17	9606.ENSP00000353518	0.584	Ankyrin repeat and SAM domain-containing protein 1A
18	9606.ENSP00000479153	0.574	EH domain-containing protein 1
19	9606.ENSP00000011619	0.569	Ran-binding protein 9
20	9606.ENSP00000393922	0.563	Iporin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003779	0.999	actin binding
GO:0016709	0.999	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0071949	0.999	FAD binding
GO:0019904	0.994	protein domain specific binding
GO:0050664	0.992	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
GO:0017124	0.866	SH3 domain binding
GO:0019899	0.733	enzyme binding
GO:0016174	0.601	NAD(P)H oxidase H2O2-forming activity
GO:0019901	0.331	protein kinase binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.999	cellular process
GO:0030029	0.986	actin filament-based process
GO:0008154	0.977	actin polymerization or depolymerization
GO:0030042	0.969	actin filament depolymerization
GO:0065007	0.774	biological regulation
GO:0050789	0.731	regulation of biological process
GO:0050794	0.723	regulation of cellular process
GO:0050896	0.306	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005622	0.997	intracellular anatomical structure
GO:0005737	0.983	cytoplasm
GO:0005829	0.955	cytosol
GO:0016020	0.889	membrane
GO:0043229	0.815	intracellular organelle
GO:0120025	0.780	plasma membrane bounded cell projection
GO:0043231	0.777	intracellular membrane-bounded organelle
GO:0030496	0.767	midbody
GO:0030054	0.698	cell junction
GO:0045171	0.542	intercellular bridge

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.14.13.-	0.999	With NADH or NADPH as one donor, and incorporation of one atom of oxygen.
EC:1.6.3.-	0.992	With oxygen as acceptor.
EC:1.6.3.1	0.601	NAD(P)H oxidase (H2O2-forming).

[back to server]