StarFunc result for job id Q8WUD6

User Input

>input (406 residues)
MAAGAGAGSAPRWLRALSEPLSAAQLRRLEEHRYSAAGVSLLEPPLQLYWTWLLQWIPLW
MAPNSITLLGLAVNVVTTLVLISYCPTATEEAPYWTYLLCALGLFIYQSLDAIDGKQARR
TNSCSPLGELFDHGCDSLSTVFMAVGASIAARLGTYPDWFFFCSFIGMFVFYCAHWQTYV
SGMLRFGKVDVTEIQIALVIVFVLSAFGGATMWDYTIPILEIKLKILPVLGFLGGVIFSC
SNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATDVFEKHPCLYILM
FGCVFAKVSQKLVVAHMTKSELYLQDTVFLGPGLLFLDQYFNNFIDEYVVLWMAMVISSF
DMVIYFSALCLQISRHLHLNIFKTACHQAPEQVQVLSSKSHQNNMD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8WUD6	1.000	1.000	4.595E-58	406	1.000	1.000	Q8WUD6.pdb.gz	CHPT1_HUMAN Cholinephosphotransferase 1 OS=Homo sapiens OX=9606 GN=CHPT1 PE=1 SV=1
2	AFDB:Q8C025	0.961	0.980	3.304E-53	398	0.865	0.882	Q8C025.pdb.gz	CHPT1_MOUSE Cholinephosphotransferase 1 OS=Mus musculus OX=10090 GN=Chpt1 PE=1 SV=1
3	AFDB:Q8BGS7	0.902	0.880	1.037E-41	416	0.611	0.596	Q8BGS7.pdb.gz	CEPT1_MOUSE Choline/ethanolaminephosphotransferase 1 OS=Mus musculus OX=10090 GN=Cept1 PE=1 SV=1
4	AFDB:A0A0B4K7Y4	0.905	0.882	7.459E-37	417	0.478	0.465	A0A0B4K7Y4.pdb.gz	A0A0B4K7Y4_DROME Bb in a boxcar, isoform C OS=Drosophila melanogaster OX=7227 GN=bbc PE=1 SV=1
5	AFDB:O82567	0.810	0.843	1.920E-20	389	0.259	0.270	O82567.pdb.gz	AAPT1_ARATH Choline/ethanolaminephosphotransferase 1 OS=Arabidopsis thaliana OX=3702 GN=AAPT1 PE=1 SV=1
6	AFDB:Q9VIU4	0.796	0.759	5.477E-20	427	0.217	0.206	Q9VIU4.pdb.gz	Q9VIU4_DROME FI05338p OS=Drosophila melanogaster OX=7227 GN=Dmel\CG33116 PE=1 SV=2
7	AFDB:Q8T0S3	0.840	0.822	5.722E-20	415	0.214	0.210	Q8T0S3.pdb.gz	Q8T0S3_DROME GH11618p OS=Drosophila melanogaster OX=7227 GN=dCCS3 PE=2 SV=1
8	AFDB:O13901	0.797	0.836	7.209E-19	386	0.261	0.275	O13901.pdb.gz	YF3A_SCHPO Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC22A12.10 PE=3 SV=1
9	AFDB:Q38A84	0.792	0.748	9.788E-19	432	0.236	0.222	Q38A84.pdb.gz	Q38A84_TRYB2 Ethanolaminephosphotransferase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.6k15.1570 PE=3 SV=1
10	AFDB:Q59M00	0.792	0.799	1.749E-17	402	0.219	0.221	Q59M00.pdb.gz	Q59M00_CANAL Bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=EPT1 PE=3 SV=1
11	PDB:3uonA	0.153	0.145	2.459E-2	438	0.101	0.094	3uonA.pdb.gz	Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
12	PDB:8dh6a	0.260	0.220	3.807E-2	534	0.140	0.107	8dh6a.pdb.gz	Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid nanodiscs
13	PDB:3aymA	0.166	0.179	6.717E-2	350	0.091	0.106	3aymA.pdb.gz	Crystallographic Analysis of the Primary Photochemical Reaction of Squid Rhodopsin
14	PDB:1m56A	0.241	0.202	8.000E-2	547	0.121	0.090	1m56A.pdb.gz	The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides.
15	PDB:6kpcA	0.183	0.172	8.000E-2	445	0.116	0.106	6kpcA.pdb.gz	Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
16	PDB:4u14A	0.151	0.145	8.357E-2	436	0.111	0.103	4u14A.pdb.gz	Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.
17	PDB:7td3R	0.201	0.241	9.120E-2	292	0.096	0.134	7td3R.pdb.gz	Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
18	PDB:7o37C	0.161	0.171	1.086E-1	380	0.131	0.139	7o37C.pdb.gz	Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV.
19	PDB:8cs9Q	0.159	0.163	1.086E-1	390	0.103	0.108	8cs9Q.pdb.gz	Architecture of the human erythrocyte ankyrin-1 complex.
20	PDB:6m9tA	0.125	0.118	1.185E-1	444	0.135	0.124	6m9tA.pdb.gz	Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8BGS7	0.0	525	416	0.596	0.582	CEPT1_MOUSE Choline/ethanolaminephosphotransferase 1 OS=Mus musculus OX=10090 GN=Cept1 PE=1 SV=1
2	Q8C025	0.0	726	398	0.840	0.857	CHPT1_MOUSE Cholinephosphotransferase 1 OS=Mus musculus OX=10090 GN=Chpt1 PE=1 SV=1
3	Q8WUD6	0.0	835	406	1.000	1.000	CHPT1_HUMAN Cholinephosphotransferase 1 OS=Homo sapiens OX=9606 GN=CHPT1 PE=1 SV=1
4	Q9Y6K0	0.0	525	416	0.599	0.584	CEPT1_HUMAN Choline/ethanolaminephosphotransferase 1 OS=Homo sapiens OX=9606 GN=CEPT1 PE=1 SV=1
5	A0A0B4K7Y4	6.51e-136	397	417	0.468	0.456	A0A0B4K7Y4_DROME Bb in a boxcar, isoform C OS=Drosophila melanogaster OX=7227 GN=bbc PE=1 SV=1
6	O82567	2.91e-37	141	389	0.246	0.257	AAPT1_ARATH Choline/ethanolaminephosphotransferase 1 OS=Arabidopsis thaliana OX=3702 GN=AAPT1 PE=1 SV=1
7	O13901	4.41e-31	124	386	0.187	0.197	YF3A_SCHPO Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC22A12.10 PE=3 SV=1
8	Q38A84	2.16e-29	120	432	0.227	0.213	Q38A84_TRYB2 Ethanolaminephosphotransferase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.6k15.1570 PE=3 SV=1
9	Q8T0S3	1.04e-28	118	415	0.219	0.214	Q8T0S3_DROME GH11618p OS=Drosophila melanogaster OX=7227 GN=dCCS3 PE=2 SV=1
10	Q9C0D9	2.30e-28	117	397	0.234	0.239	EPT1_HUMAN Ethanolaminephosphotransferase 1 OS=Homo sapiens OX=9606 GN=SELENOI PE=1 SV=3
11	Q59M00	1.91e-26	111	402	0.234	0.236	Q59M00_CANAL Bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=EPT1 PE=3 SV=1
12	Q9VIU4	3.27e-26	111	427	0.212	0.201	Q9VIU4_DROME FI05338p OS=Drosophila melanogaster OX=7227 GN=Dmel\CG33116 PE=1 SV=2
13	P17898	1.43e-25	108	393	0.167	0.173	CPT1_YEAST Cholinephosphotransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CPT1 PE=1 SV=3
14	P22140	1.20e-24	106	391	0.163	0.169	EPT1_YEAST Choline/ethanolaminephosphotransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=EPT1 PE=1 SV=2
15	Q8WU57	1.15e-23	101	258	0.170	0.267	Q8WU57_HUMAN SELI protein OS=Homo sapiens OX=9606 GN=SELI PE=1 SV=1
16	Q388W5	7.52e-08	56.6	506	0.099	0.079	Q388W5_TRYB2 ethanolamine-phosphate cytidylyltransferase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.389.0730 PE=3 SV=1
17	Q388R8	0.023	39.3	412	0.081	0.080	Q388R8_TRYB2 Ethanolamine phosphotransferase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.389.0140 PE=3 SV=1
18	Q4QDW1	0.024	39.3	415	0.069	0.067	Q4QDW1_LEIMA Putative ethanolamine phosphotransferase OS=Leishmania major OX=5664 GN=LMJF_18_0810 PE=3 SV=1
19	P06197	0.15	35.8	220	0.081	0.150	PIS_YEAST CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PIS1 PE=1 SV=1
20	C0H5B7	0.17	35.8	209	0.039	0.077	C0H5B7_PLAF7 CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1315600 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01066 CDP-OH_P_transf	1.4e-09	50.0	CDP-alcohol phosphatidyltransferase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000229266

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000368439	0.987	Choline-phosphate cytidylyltransferase B
2	9606.ENSP00000292823	0.981	Choline-phosphate cytidylyltransferase A
3	9606.ENSP00000320337	0.964	HRAS-like suppressor 3
4	9606.ENSP00000255389	0.962	Phosphatidylethanolamine N-methyltransferase
5	9606.ENSP00000283415	0.959	Lysophosphatidylcholine acyltransferase 1
6	9606.ENSP00000261407	0.953	Lysophospholipid acyltransferase 5
7	9606.ENSP00000262134	0.948	Lysophosphatidylcholine acyltransferase 2
8	9606.ENSP00000317300	0.945	Lysophospholipid acyltransferase LPCAT4
9	9606.ENSP00000430548	0.945	Phosphatidylserine synthase 1
10	9606.ENSP00000263088	0.942	Phospholipase D2
11	9606.ENSP00000342793	0.934	Phospholipase D1
12	9606.ENSP00000264005	0.928	Phosphatidylcholine-sterol acyltransferase
13	9606.ENSP00000260585	0.924	Ethanolaminephosphotransferase 1
14	9606.ENSP00000329697	0.921	Phospholipid phosphatase 2
15	9606.ENSP00000360296	0.914	Phospholipid phosphatase 3
16	9606.ENSP00000381302	0.908	Phospholipid phosphatase 4
17	9606.ENSP00000392553	0.908	Phospholipid phosphatase 5
18	9606.ENSP00000387050	0.907	Phospholipase D3
19	9606.ENSP00000441980	0.904	Choline/ethanolaminephosphotransferase 1
20	9606.ENSP00000311648	0.900	2-hydroxyacylsphingosine 1-beta-galactosyltransferase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016780	1.000	phosphotransferase activity, for other substituted phosphate groups
GO:0005515	0.995	protein binding
GO:0017169	0.991	CDP-alcohol phosphatidyltransferase activity
GO:0004142	0.442	diacylglycerol cholinephosphotransferase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.998	organic substance metabolic process
GO:0044237	0.998	cellular metabolic process
GO:0044238	0.997	primary metabolic process
GO:0006644	0.990	phospholipid metabolic process
GO:0008610	0.988	lipid biosynthetic process
GO:0046470	0.977	phosphatidylcholine metabolic process
GO:0006656	0.972	phosphatidylcholine biosynthetic process
GO:0044281	0.309	small molecule metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	1.000	membrane
GO:0012505	1.000	endomembrane system
GO:0005737	1.000	cytoplasm
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0031090	0.984	organelle membrane
GO:0005794	0.859	Golgi apparatus
GO:0005783	0.750	endoplasmic reticulum
GO:0005789	0.633	endoplasmic reticulum membrane
GO:0098588	0.378	bounding membrane of organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.8.-	1.000	Transferases for other substituted phosphate groups.
RHEA:32939	0.442	a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
EC:2.7.8.2	0.442	diacylglycerol cholinephosphotransferase.

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