StarFunc result for job id Q92604

User Input

>input (370 residues)
MAITLEEAPWLGWLLVKALMRFAFMVVNNLVAIPSYICYVIILQPLRVLDSKRFWYIEGI
MYKWLLGMVASWGWYAGYTVMEWGEDIKAVSKDEAVMLVNHQATGDVCTLMMCLQDKGLV
VAQMMWLMDHIFKYTNFGIVSLVHGDFFIRQGRSYRDQQLLLLKKHLENNYRSRDRKWIV
LFPEGGFLRKRRETSQAFAKKNNLPFLTNVTLPRSGATKIILNALVAQQKNGSPAGGDAK
ELDSKSKGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIKDVPLETDDLT
TWLYQRFVEKEDLLSHFYETGAFPPSKGHKEAVSREMTLSNLWIFLIQSFAFLSGYMWYN
IIQYFYHCLF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q92604	1.000	1.000	2.052E-68	370	1.000	1.000	Q92604.pdb.gz	LGAT1_HUMAN Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPGAT1 PE=1 SV=1
2	AFDB:Q91YX5	0.967	0.967	2.233E-61	370	0.900	0.900	Q91YX5.pdb.gz	LGAT1_MOUSE Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Mus musculus OX=10090 GN=Lpgat1 PE=1 SV=1
3	AFDB:Q20800	0.742	0.706	4.577E-19	391	0.208	0.197	Q20800.pdb.gz	LPIAT_CAEEL Lysophosphatidylinositol acyltransferase 10 OS=Caenorhabditis elegans OX=6239 GN=bus-18 PE=1 SV=2
4	AFDB:Q9D1E8	0.731	0.740	1.010E-18	365	0.208	0.211	Q9D1E8.pdb.gz	PLCE_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon OS=Mus musculus OX=10090 GN=Agpat5 PE=1 SV=2
5	AFDB:A0A024R640	0.688	0.698	4.668E-18	364	0.216	0.220	A0A024R640.pdb.gz	A0A024R640_HUMAN 1-acylglycerol-3-phosphate O-acyltransferase 5 (Lysophosphatidic acid acyltransferase, epsilon), isoform CRA_a OS=Homo sapiens OX=9606 GN=AGPAT5 PE=2 SV=1
6	AFDB:Q6UWP7	0.671	0.605	6.078E-18	414	0.192	0.171	Q6UWP7.pdb.gz	LCLT1_HUMAN Lysocardiolipin acyltransferase 1 OS=Homo sapiens OX=9606 GN=LCLAT1 PE=1 SV=1
7	AFDB:Q9NRZ5	0.716	0.702	7.913E-18	378	0.173	0.169	Q9NRZ5.pdb.gz	PLCD_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Homo sapiens OX=9606 GN=AGPAT4 PE=1 SV=1
8	AFDB:Q8K4X7	0.720	0.706	8.794E-18	378	0.170	0.167	Q8K4X7.pdb.gz	PLCD_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Mus musculus OX=10090 GN=Agpat4 PE=1 SV=1
9	AFDB:O94361	0.731	0.769	1.571E-17	350	0.178	0.189	O94361.pdb.gz	YHOE_SCHPO Uncharacterized acyltransferase C428.14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC428.14 PE=3 SV=1
10	AFDB:Q8LG50	0.706	0.675	2.046E-17	389	0.197	0.188	Q8LG50.pdb.gz	LPAT2_ARATH 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 OS=Arabidopsis thaliana OX=3702 GN=LPAT2 PE=1 SV=2
11	PDB:6xlpA	0.214	0.155	8.016E-2	586	0.130	0.082	6xlpA.pdb.gz	Structure of the essential inner membrane lipopolysaccharide-PbgA complex.
12	PDB:1ko5A	0.165	0.296	1.510E-1	172	0.059	0.128	1ko5A.pdb.gz	Conformational changes during the catalytic cycle of gluconate kinase as revealed by X-ray crystallography.
13	PDB:7z6hK	0.153	0.134	3.333E-1	439	0.062	0.052	7z6hK.pdb.gz	Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction.
14	PDB:4yp9B	0.123	0.130	4.575E-1	342	0.084	0.091	4yp9B.pdb.gz	Discovery of Glycomimetic Agonists from a Protocell Metabolism, Proto-natural Product Libraries
15	PDB:2vk2A	0.130	0.150	5.650E-1	296	0.073	0.091	2vk2A.pdb.gz	Furanose-Specific Sugar Transport: Characterization of a Bacterial Galactofuranose-Binding Protein.
16	PDB:2d1fA	0.128	0.134	5.956E-1	349	0.041	0.043	2d1fA.pdb.gz	Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis.
17	PDB:3ma0A	0.109	0.119	6.279E-1	313	0.073	0.086	3ma0A.pdb.gz	Conformational changes and ligand recognition of Escherichia coli D-xylose binding protein revealed
18	PDB:2dekA	0.138	0.171	6.619E-1	265	0.073	0.102	2dekA.pdb.gz	Crystal structure of project ID PH0725 from Pyrococcus horikoshii OT3 at 1.65 A resolution
19	PDB:7obqx	0.218	0.208	6.619E-1	393	0.105	0.099	7obqx.pdb.gz	Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
20	PDB:3tlxB	0.143	0.204	6.978E-1	240	0.046	0.071	3tlxB.pdb.gz	Crystal Structure of PF10_0086, adenylate kinase from plasmodium falciparum

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q91YX5	0.0	713	370	0.900	0.900	LGAT1_MOUSE Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Mus musculus OX=10090 GN=Lpgat1 PE=1 SV=1
2	Q92604	0.0	771	370	1.000	1.000	LGAT1_HUMAN Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPGAT1 PE=1 SV=1
3	Q6NYV8	3.82e-13	72.4	388	0.197	0.188	LCLT1_DANRE Lysocardiolipin acyltransferase 1 OS=Danio rerio OX=7955 GN=lclat1 PE=1 SV=1
4	Q9D1E8	9.89e-13	70.9	365	0.192	0.195	PLCE_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon OS=Mus musculus OX=10090 GN=Agpat5 PE=1 SV=2
5	Q8LG50	1.31e-11	67.8	389	0.192	0.183	LPAT2_ARATH 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 OS=Arabidopsis thaliana OX=3702 GN=LPAT2 PE=1 SV=2
6	Q3UN02	1.37e-11	67.4	376	0.222	0.218	LCLT1_MOUSE Lysocardiolipin acyltransferase 1 OS=Mus musculus OX=10090 GN=Lclat1 PE=1 SV=2
7	A0A024R640	6.42e-11	65.5	364	0.184	0.187	A0A024R640_HUMAN 1-acylglycerol-3-phosphate O-acyltransferase 5 (Lysophosphatidic acid acyltransferase, epsilon), isoform CRA_a OS=Homo sapiens OX=9606 GN=AGPAT5 PE=2 SV=1
8	Q9NUQ2	6.42e-11	65.5	364	0.184	0.187	PLCE_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon OS=Homo sapiens OX=9606 GN=AGPAT5 PE=1 SV=3
9	Q20800	1.12e-10	64.7	391	0.149	0.141	LPIAT_CAEEL Lysophosphatidylinositol acyltransferase 10 OS=Caenorhabditis elegans OX=6239 GN=bus-18 PE=1 SV=2
10	Q6UWP7	1.15e-10	64.7	414	0.178	0.159	LCLT1_HUMAN Lysocardiolipin acyltransferase 1 OS=Homo sapiens OX=9606 GN=LCLAT1 PE=1 SV=1
11	O94361	1.86e-10	63.9	350	0.143	0.151	YHOE_SCHPO Uncharacterized acyltransferase C428.14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC428.14 PE=3 SV=1
12	Q9VV51	1.53e-09	61.2	386	0.195	0.187	Q9VV51_DROME 1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform A OS=Drosophila melanogaster OX=7227 GN=Agpat3 PE=1 SV=1
13	D5AEK7	1.55e-09	61.2	397	0.195	0.181	D5AEK7_DROME 1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform E OS=Drosophila melanogaster OX=7227 GN=Agpat3 PE=1 SV=1
14	P38226	1.22e-08	58.5	397	0.122	0.113	CST26_YEAST 2-acyl-1-lysophosphatidylinositol acyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CST26 PE=1 SV=1
15	Q9NRZ5	2.01e-05	48.5	378	0.092	0.090	PLCD_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Homo sapiens OX=9606 GN=AGPAT4 PE=1 SV=1
16	Q8K4X7	3.94e-05	47.8	378	0.100	0.098	PLCD_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Mus musculus OX=10090 GN=Agpat4 PE=1 SV=1
17	Q12185	7.86e-05	46.6	396	0.119	0.111	YD018_YEAST Uncharacterized acyltransferase YDR018C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YDR018C PE=3 SV=1
18	Q961F9	9.80e-05	44.3	143	0.057	0.147	Q961F9_DROME 1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform D OS=Drosophila melanogaster OX=7227 GN=Agpat3 PE=1 SV=1
19	Q582D7	1.83e-04	45.4	434	0.165	0.141	Q582D7_TRYB2 Acetyltransferase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb05.3C6.270 PE=4 SV=1
20	Q9SYC8	0.002	42.0	376	0.143	0.141	LPAT3_ARATH 1-acyl-sn-glycerol-3-phosphate acyltransferase 3 OS=Arabidopsis thaliana OX=3702 GN=LPAT3 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01553 Acyltransferase	0.00029	31.9	Acyltransferase
2	PF16076 Acyltransf_C	3.4e-16	70.3	Acyltransferase C-terminus

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000355964

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000368140	0.933	Cardiolipin synthase (CMP-forming)
2	9606.ENSP00000283415	0.905	Lysophosphatidylcholine acyltransferase 1
3	9606.ENSP00000317300	0.897	Lysophospholipid acyltransferase LPCAT4
4	9606.ENSP00000324944	0.854	Lysophospholipid acyltransferase 1
5	9606.ENSP00000262134	0.852	Lysophosphatidylcholine acyltransferase 2
6	9606.ENSP00000265276	0.835	Glycerol-3-phosphate acyltransferase 1, mitochondrial
7	9606.ENSP00000310551	0.829	Lysocardiolipin acyltransferase 1
8	9606.ENSP00000261461	0.815	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
9	9606.ENSP00000271751	0.812	Potassium voltage-gated channel subfamily H member 1
10	9606.ENSP00000375778	0.720	Laminin subunit beta-3
11	9606.ENSP00000337446	0.691	StAR-related lipid transfer protein 3
12	9606.ENSP00000385968	0.680	Potassium voltage-gated channel subfamily S member 3
13	9606.ENSP00000357835	0.671	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
14	9606.ENSP00000356584	0.666	Torsin-1A-interacting protein 2
15	9606.ENSP00000355966	0.642	Serine/threonine-protein kinase Nek2
16	9606.ENSP00000435289	0.622	Platelet-activating factor acetylhydrolase IB subunit beta
17	9606.ENSP00000355969	0.592	Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:29515371, PubMed:21928830, PubMed:21078983, PubMed:27471269, PubMed:30559291). Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291). Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment . Up-regulates the activity of GUK1, a kinase that plays [...]
18	9606.ENSP00000360184	0.587	Transmembrane 9 superfamily member 3
19	9606.ENSP00000382342	0.584	Multidrug resistance-associated protein 1
20	9606.ENSP00000302177	0.578	Lysophospholipid acyltransferase 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0047190	1.000	2-acylglycerophosphocholine O-acyltransferase activity
GO:0003841	0.998	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0005515	0.527	protein binding
GO:0047144	0.403	2-acylglycerol-3-phosphate O-acyltransferase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044238	0.995	primary metabolic process
GO:0044237	0.995	cellular metabolic process
GO:0006644	0.985	phospholipid metabolic process
GO:0006650	0.984	glycerophospholipid metabolic process
GO:0065007	0.937	biological regulation
GO:0050789	0.930	regulation of biological process
GO:0019222	0.797	regulation of metabolic process
GO:0050794	0.756	regulation of cellular process
GO:0019216	0.734	regulation of lipid metabolic process
GO:0062012	0.592	regulation of small molecule metabolic process
GO:0045017	0.549	glycerolipid biosynthetic process
GO:0046471	0.537	phosphatidylglycerol metabolic process
GO:0006807	0.515	nitrogen compound metabolic process
GO:0048518	0.473	positive regulation of biological process
GO:0048522	0.426	positive regulation of cellular process
GO:1901564	0.425	organonitrogen compound metabolic process
GO:0009893	0.413	positive regulation of metabolic process
GO:0031323	0.374	regulation of cellular metabolic process
GO:0009891	0.312	positive regulation of biosynthetic process
GO:0031325	0.306	positive regulation of cellular metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005789	0.996	endoplasmic reticulum membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:10332	1.000	a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
EC:2.3.1.62	1.000	2-acylglycerophosphocholine O-acyltransferase.
RHEA:19709	0.998	a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
EC:2.3.1.51	0.998	1-acylglycerol-3-phosphate O-acyltransferase.
RHEA:14233	0.403	a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
EC:2.3.1.52	0.403	2-acylglycerol-3-phosphate O-acyltransferase.

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