StarFunc result for job id Q92833

User Input

>input (1246 residues)
MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQKRQHAEGIAGSLKTVN
GLLGNDQSKGLGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQS
QPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQ
DEEEVEEEDDETEDVKTATNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSTREKEPVQK
HKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLR
KQVSKVNGVTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDT
KPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTK
EVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGL
LNGHVKKEVPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSG
KAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVRAQVEKFGMCRVIPPPDWRPECK
LNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFR
LINEMGGMQQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLE
KEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKNGLIHGVAPRNGFRSKLKEVGQA
QLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKE
PAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTG
SILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKL
EDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVC
CGYSVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLST
ISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQ
ICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKV
SGKNGSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q92833	0.999	0.999	0.000	1246	1.000	1.000	Q92833.pdb.gz	JARD2_HUMAN Protein Jumonji OS=Homo sapiens OX=9606 GN=JARID2 PE=1 SV=2
2	AFDB:G3V9U4	0.242	0.224	1.898E-13	1356	0.139	0.128	G3V9U4.pdb.gz	G3V9U4_RAT [histone H3]-trimethyl-L-lysine(27) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm6b PE=3 SV=4
3	AFDB:Q61645	0.130	0.137	9.118E-9	1182	0.134	0.141	Q61645.pdb.gz	HAIR_MOUSE Lysine-specific demethylase hairless OS=Mus musculus OX=10090 GN=Hr PE=2 SV=2
4	AFDB:Q69ZK6	0.141	0.078	5.176E-5	2350	0.150	0.080	Q69ZK6.pdb.gz	JHD2C_MOUSE Probable JmjC domain-containing histone demethylation protein 2C OS=Mus musculus OX=10090 GN=Jmjd1c PE=1 SV=3
5	PDB:4b7eA	0.106	0.327	6.601E-5	349	0.015	0.054	4b7eA.pdb.gz	Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
6	PDB:3al5B	0.103	0.367	1.098E-4	311	0.016	0.064	3al5B.pdb.gz	Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
7	AFDB:F1QPD2	0.205	0.175	2.634E-4	1482	0.077	0.065	F1QPD2.pdb.gz
8	PDB:3al5C	0.098	0.373	7.202E-4	284	0.018	0.077	3al5C.pdb.gz	Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
9	AFDB:A0A0R4IYD2	0.132	0.066	9.880E-4	2557	0.146	0.071	A0A0R4IYD2.pdb.gz
10	AFDB:Q940Y3	0.075	0.114	1.040E-3	786	0.097	0.154	Q940Y3.pdb.gz	ARID3_ARATH AT-rich interactive domain-containing protein 3 OS=Arabidopsis thaliana OX=3702 GN=ARID3 PE=1 SV=1
11	PDB:4cclB	0.080	0.236	1.625E-3	372	0.016	0.054	4cclB.pdb.gz	Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
12	PDB:7yxgA	0.102	0.350	2.319E-3	313	0.019	0.077	7yxgA.pdb.gz	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans.
13	PDB:4qszA	0.102	0.174	4.973E-3	686	0.018	0.032	4qszA.pdb.gz	Crystal structure of mouse JMJd7 fused with maltose-binding protein
14	PDB:5zmdG	0.065	0.177	4.973E-3	403	0.022	0.067	5zmdG.pdb.gz	Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.
15	AFDB:Q8NFD5	0.068	0.039	5.291E-3	2236	0.095	0.053	Q8NFD5.pdb.gz	ARI1B_HUMAN AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3
16	PDB:5nfnB	0.097	0.316	5.505E-3	318	0.018	0.072	5nfnB.pdb.gz	(3S)-Lysyl hydroxylation of TRAFAC GTPases is catalyzed by the human Jumonji-C oxygenase JMJD7.
17	PDB:6xwvD	0.058	0.542	1.066E-2	123	0.008	0.081	6xwvD.pdb.gz	Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
18	PDB:2vqaA	0.057	0.191	1.307E-2	356	0.009	0.031	2vqaA.pdb.gz	Protein-Folding Location Can Regulate Manganese-Binding Versus Copper- or Zinc-Binding.
19	AFDB:O14497	0.059	0.032	1.539E-2	2285	0.092	0.050	O14497.pdb.gz	ARI1A_HUMAN AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3
20	AFDB:Q7LBC6	0.120	0.087	1.704E-2	1761	0.115	0.081	Q7LBC6.pdb.gz	KDM3B_HUMAN Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	M0RBV7	0.0	2291	1234	0.917	0.926	M0RBV7_RAT Jumonji and AT-rich interaction domain containing 2 OS=Rattus norvegicus OX=10116 GN=Jarid2 PE=4 SV=1
2	Q62315	0.0	2284	1234	0.921	0.929	JARD2_MOUSE Protein Jumonji OS=Mus musculus OX=10090 GN=Jarid2 PE=1 SV=1
3	Q92833	0.0	2585	1246	1.000	1.000	JARD2_HUMAN Protein Jumonji OS=Homo sapiens OX=9606 GN=JARID2 PE=1 SV=2
4	Q9VT00	2.25e-72	269	2351	0.116	0.061	Q9VT00_DROME Jumonji, AT rich interactive domain 2 OS=Drosophila melanogaster OX=7227 GN=Jarid2 PE=1 SV=3
5	Q8SXP6	2.33e-71	256	738	0.115	0.194	Q8SXP6_DROME GH09982p OS=Drosophila melanogaster OX=7227 GN=Jarid2 PE=2 SV=1
6	Q9US53	3.17e-48	187	715	0.132	0.231	JMJ2_SCHPO Jumonji/ARID domain-containing protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=jmj2 PE=4 SV=1
7	Q9VMJ7	1.69e-38	159	1838	0.101	0.069	KDM5_DROME Lysine-specific demethylase 5 OS=Drosophila melanogaster OX=7227 GN=Kdm5 PE=1 SV=1
8	B0S6L0	2.05e-38	159	1578	0.096	0.075	B0S6L0_DANRE [histone H3]-trimethyl-L-lysine(4) demethylase OS=Danio rerio OX=7955 GN=im:7158173 PE=1 SV=1
9	Q53WJ1	2.07e-37	155	1238	0.100	0.100	JM703_ORYSJ Lysine-specific demethylase JMJ703 OS=Oryza sativa subsp. japonica OX=39947 GN=JMJ703 PE=1 SV=1
10	P29375	2.05e-36	153	1690	0.096	0.070	KDM5A_HUMAN Lysine-specific demethylase 5A OS=Homo sapiens OX=9606 GN=KDM5A PE=1 SV=3
11	P41229	3.22e-36	152	1560	0.093	0.074	KDM5C_HUMAN Lysine-specific demethylase 5C OS=Homo sapiens OX=9606 GN=KDM5C PE=1 SV=2
12	A0A096MJZ8	3.88e-36	152	1635	0.094	0.072	A0A096MJZ8_RAT [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5a PE=1 SV=1
13	A0A0G2K454	3.92e-36	152	1634	0.094	0.072	A0A0G2K454_RAT [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5a PE=1 SV=1
14	A0A8I5ZPK6	4.02e-36	152	1636	0.094	0.072	A0A8I5ZPK6_RAT [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5a PE=3 SV=1
15	A0A0G2K897	5.19e-36	151	1510	0.093	0.077	A0A0G2K897_RAT [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5c PE=1 SV=2
16	A0A0G2K1H0	5.68e-36	151	1554	0.093	0.075	A0A0G2K1H0_RAT [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5c PE=1 SV=1
17	V9GW19	6.07e-36	151	1551	0.093	0.075	V9GW19_RAT [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5c PE=2 SV=1
18	P41230	6.97e-36	151	1554	0.093	0.075	KDM5C_MOUSE Lysine-specific demethylase 5C OS=Mus musculus OX=10090 GN=Kdm5c PE=1 SV=4
19	A0A0G2JTU9	8.69e-36	150	1553	0.094	0.075	A0A0G2JTU9_RAT [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5a PE=1 SV=2
20	A6N6J7	8.98e-36	150	1440	0.093	0.081	A6N6J7_HUMAN [histone H3]-trimethyl-L-lysine(4) demethylase OS=Homo sapiens OX=9606 GN=JARID1C PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01388 ARID	7e-10	50.8	ARID/BRIGHT DNA binding domain
2	PF02373 JmjC	1.9e-30	117.0	JmjC domain, hydroxylase
3	PF02375 JmjN	2e-09	48.4	jmjN domain
4	PF02928 zf-C5HC2	3.9e-05	35.2	C5HC2 zinc finger

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000341280

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000316578	0.999	Polycomb protein SUZ12
2	9606.ENSP00000320147	0.999	Histone-lysine N-methyltransferase EZH2
3	9606.ENSP00000381840	0.999	Zinc finger protein AEBP2
4	9606.ENSP00000263360	0.998	Polycomb protein EED
5	9606.ENSP00000359321	0.993	Metal-response element-binding transcription factor 2
6	9606.ENSP00000362592	0.992	Histone-binding protein RBBP4
7	9606.ENSP00000483946	0.980	PHD finger protein 19
8	9606.ENSP00000404658	0.970	Histone-lysine N-methyltransferase EZH1
9	9606.ENSP00000369424	0.937	Histone-binding protein RBBP7
10	9606.ENSP00000271640	0.936	Histone-lysine N-methyltransferase SETDB1
11	9606.ENSP00000364678	0.902	Histone-lysine N-methyltransferase EHMT2
12	9606.ENSP00000363640	0.881	PHD finger protein 1
13	9606.ENSP00000264709	0.834	DNA (cytosine-5)-methyltransferase 3A
14	9606.ENSP00000484710	0.827	Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine- tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter si [...]
15	9606.ENSP00000262238	0.818	Transcriptional repressor protein YY1
16	9606.ENSP00000327758	0.805	Homeobox protein Nkx-2.5
17	9606.ENSP00000332194	0.799	Histone H2A type 2-C
18	9606.ENSP00000352516	0.797	DNA (cytosine-5)-methyltransferase 1
19	9606.ENSP00000328547	0.786	DNA (cytosine-5)-methyltransferase 3B
20	9606.ENSP00000296417	0.772	Histone H2A.Z

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0140096	0.990	catalytic activity, acting on a protein
GO:0003676	0.795	nucleic acid binding
GO:0003677	0.718	DNA binding
GO:0032451	0.606	demethylase activity
GO:0032452	0.586	histone demethylase activity
GO:0043565	0.393	sequence-specific DNA binding
GO:0008134	0.347	transcription factor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0048519	0.987	negative regulation of biological process
GO:0050794	0.982	regulation of cellular process
GO:0048523	0.956	negative regulation of cellular process
GO:0032502	0.935	developmental process
GO:0032501	0.935	multicellular organismal process
GO:0009987	0.919	cellular process
GO:0048856	0.916	anatomical structure development
GO:0019222	0.866	regulation of metabolic process
GO:0007275	0.860	multicellular organism development
GO:0060255	0.858	regulation of macromolecule metabolic process
GO:0051239	0.832	regulation of multicellular organismal process
GO:0048731	0.779	system development
GO:0010468	0.762	regulation of gene expression
GO:0048513	0.670	animal organ development
GO:0080090	0.641	regulation of primary metabolic process
GO:0051171	0.641	regulation of nitrogen compound metabolic process
GO:0031323	0.640	regulation of cellular metabolic process
GO:0040008	0.580	regulation of growth
GO:0071840	0.573	cellular component organization or biogenesis
GO:0019219	0.570	regulation of nucleobase-containing compound metabolic process
GO:0031326	0.564	regulation of cellular biosynthetic process
GO:0010556	0.563	regulation of macromolecule biosynthetic process
GO:0051252	0.541	regulation of RNA metabolic process
GO:0016043	0.514	cellular component organization
GO:0006355	0.493	regulation of DNA-templated transcription
GO:0050793	0.461	regulation of developmental process
GO:0009892	0.407	negative regulation of metabolic process
GO:0010605	0.404	negative regulation of macromolecule metabolic process
GO:0048518	0.394	positive regulation of biological process
GO:0046620	0.382	regulation of organ growth
GO:0051093	0.381	negative regulation of developmental process
GO:0045926	0.379	negative regulation of growth
GO:0042127	0.375	regulation of cell population proliferation
GO:0007399	0.372	nervous system development
GO:0048640	0.365	negative regulation of developmental growth
GO:0008285	0.363	negative regulation of cell population proliferation
GO:0050896	0.354	response to stimulus
GO:0051241	0.352	negative regulation of multicellular organismal process
GO:0031324	0.345	negative regulation of cellular metabolic process
GO:0008152	0.338	metabolic process
GO:0071704	0.329	organic substance metabolic process
GO:0051172	0.319	negative regulation of nitrogen compound metabolic process
GO:0006357	0.315	regulation of transcription by RNA polymerase II
GO:0006325	0.305	chromatin organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0032991	0.989	protein-containing complex
GO:0005737	0.985	cytoplasm
GO:1902494	0.959	catalytic complex
GO:0140513	0.955	nuclear protein-containing complex
GO:0005739	0.901	mitochondrion
GO:1990234	0.857	transferase complex
GO:0035097	0.502	histone methyltransferase complex
GO:0031519	0.437	PcG protein complex
GO:0035098	0.330	ESC/E(Z) complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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