StarFunc result for job id Q92990

User Input

>input (594 residues)
MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIEEGHTDQLLEIIQNEKNKVIIKN
MGWNLVGPVVRCLLCKDKEDSKRKVYFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQ
SILLLLQPLQTVIQKLHNKAYSIGLALSTLWNQLSLLPVPYSKEQIQMDDYGLCQCCKAL
IEFTKPFVEEVIDNKENSLENEKLKDELLKFCFKSLKCPLLTAQFFEQSEEGGNDPFRYF
ASEIIGFLSAIGHPFPKMIFNHGRKKRTWNYLEFEEEENKQLADSMASLAYLVFVQGIHI
DQLPMVLSPLYLLQFNMGHIEVFLQRTEESVISKGLELLENSLLRIEDNSLLYQYLEIKS
FLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQGKYTLFRCLLNTSNHSGVEAFI
IQNIKNQIDMSLKRTRNNKWFTGPQLISLLDLVLFLPEGAETDLLQNSDRIMASLNLLRY
LVIKDNENDNQTGLWTELGNIENNFLKPLHIGLNMSKAHYEAEIKNSQEAQKSKDLCSIT
VSGEEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKTKSTSEENIGIK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q92990	1.000	1.000	6.301E-71	594	1.000	1.000	Q92990.pdb.gz	GLMN_HUMAN Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2
2	AFDB:Q8BZM1	0.975	0.972	2.001E-60	596	0.862	0.859	Q8BZM1.pdb.gz	GLMN_MOUSE Glomulin OS=Mus musculus OX=10090 GN=Glmn PE=1 SV=1
3	PDB:4f52E	0.850	0.962	3.577E-48	523	0.875	0.994	4f52E.pdb.gz	Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface.
4	AFDB:Q84VX3	0.553	0.531	2.222E-9	626	0.172	0.163	Q84VX3.pdb.gz	ALF4_ARATH Aberrant root formation protein 4 OS=Arabidopsis thaliana OX=3702 GN=ALF4 PE=1 SV=2
5	AFDB:Q76PC4	0.513	0.538	2.938E-6	562	0.140	0.148	Q76PC4.pdb.gz	YQ72_SCHPO UPF0649 protein C1442.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC1442.02 PE=1 SV=1
6	AFDB:Q387N0	0.379	0.318	4.434E-6	732	0.128	0.104	Q387N0.pdb.gz	Q387N0_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.03.0930 PE=4 SV=1
7	AFDB:P38315	0.486	0.439	2.576E-5	674	0.130	0.114	P38315.pdb.gz	YBP1_YEAST YAP1-binding protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YBP1 PE=1 SV=1
8	AFDB:Q6FMM8	0.443	0.410	1.109E-4	655	0.123	0.111	Q6FMM8.pdb.gz	Q6FMM8_CANGA Candida glabrata strain CBS138 chromosome K complete sequence OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=YBP1 PE=4 SV=1
9	AFDB:P40069	0.203	0.131	1.337E-4	1113	0.131	0.070	P40069.pdb.gz	IMB4_YEAST Importin subunit beta-4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=KAP123 PE=1 SV=1
10	AFDB:P54362	0.170	0.121	2.935E-4	1034	0.121	0.070	P54362.pdb.gz	AP3D_DROME AP-3 complex subunit delta OS=Drosophila melanogaster OX=7227 GN=g PE=1 SV=4
11	AFDB:P53169	0.457	0.431	3.959E-4	641	0.125	0.115	P53169.pdb.gz	YBP2_YEAST YAP1-binding protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YBP2 PE=1 SV=1
12	PDB:2xwuB	0.144	0.111	6.132E-4	910	0.143	0.093	2xwuB.pdb.gz
13	PDB:4c0qA	0.203	0.154	1.397E-3	871	0.143	0.098	4c0qA.pdb.gz	Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3.
14	PDB:7mqaLM	0.248	0.094	1.450E-3	2041	0.130	0.038	7mqaLM.pdb.gz	Nucleolar maturation of the human small subunit processome.
15	PDB:2z6gA	0.220	0.231	1.749E-3	550	0.125	0.135	2z6gA.pdb.gz
16	PDB:3w3zA	0.229	0.164	1.749E-3	1013	0.128	0.075	3w3zA.pdb.gz	Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p.
17	PDB:3w3uA	0.169	0.121	1.957E-3	1030	0.130	0.075	3w3uA.pdb.gz
18	PDB:6xu2A	0.240	0.155	2.189E-3	1091	0.128	0.070	6xu2A.pdb.gz	X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
19	PDB:6x9oA	0.155	0.064	2.273E-3	2425	0.148	0.036	6x9oA.pdb.gz
20	PDB:7unkA	0.168	0.117	2.450E-3	1047	0.141	0.080	7unkA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8BZM1	0.0	972	596	0.864	0.861	GLMN_MOUSE Glomulin OS=Mus musculus OX=10090 GN=Glmn PE=1 SV=1
2	Q92990	0.0	1202	594	1.000	1.000	GLMN_HUMAN Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2
3	Q84VX3	0.068	38.5	626	0.052	0.050	ALF4_ARATH Aberrant root formation protein 4 OS=Arabidopsis thaliana OX=3702 GN=ALF4 PE=1 SV=2
4	Q8NCX0	2.9	33.5	1101	0.045	0.025	CC150_HUMAN Coiled-coil domain-containing protein 150 OS=Homo sapiens OX=9606 GN=CCDC150 PE=1 SV=2
5	Q9U8W8	3.7	32.7	292	0.042	0.086	TL5A_TACTR Techylectin-5A OS=Tachypleus tridentatus OX=6853 PE=1 SV=1
6	Q92353	5.2	32.3	468	0.027	0.034	UBP6_SCHPO Ubiquitin carboxyl-terminal hydrolase 6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ubp6 PE=1 SV=2
7	P27742	9.7	32.0	3770	0.039	0.006	ACVA_EMENI N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=acvA PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08568 Kinetochor_Ybp2	6.5e-102	353.7	Uncharacterised protein family, YAP/Alf4/glomulin

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000359385

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000216225	0.998	E3 ubiquitin-protein ligase RBX1
2	9606.ENSP00000438788	0.988	Cullin-7
3	9606.ENSP00000001008	0.976	Peptidyl-prolyl cis-trans isomerase FKBP4
4	9606.ENSP00000310686	0.966	F-box/WD repeat-containing protein 8
5	9606.ENSP00000326804	0.966	Cullin-1
6	9606.ENSP00000231487	0.941	S-phase kinase-associated protein 1
7	9606.ENSP00000383003	0.906	Peptidyl-prolyl cis-trans isomerase FKBP1A
8	9606.ENSP00000364589	0.884	Cullin-4A
9	9606.ENSP00000444856	0.874	Cullin-2
10	9606.ENSP00000385090	0.847	NLR family CARD domain-containing protein 4
11	9606.ENSP00000337383	0.829	NACHT, LRR and PYD domains-containing protein 3
12	9606.ENSP00000456340	0.825	DET1 homolog
13	9606.ENSP00000264414	0.812	Cullin-3
14	9606.ENSP00000301764	0.812	DNA damage-binding protein 1
15	9606.ENSP00000231948	0.787	Protein cereblon
16	9606.ENSP00000384109	0.782	Cullin-4B
17	9606.ENSP00000355958	0.758	Denticleless protein homolog
18	9606.ENSP00000370671	0.754	Kelch-like protein 42
19	9606.ENSP00000228495	0.753	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
20	9606.ENSP00000351147	0.746	DDB1- and CUL4-associated factor 4

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0019899	0.974	enzyme binding
GO:0031625	0.964	ubiquitin protein ligase binding
GO:0055106	0.962	ubiquitin-protein transferase regulator activity
GO:0004857	0.962	enzyme inhibitor activity
GO:0070851	0.960	growth factor receptor binding
GO:0005171	0.831	hepatocyte growth factor receptor binding
GO:0055105	0.831	ubiquitin-protein transferase inhibitor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.982	cellular process
GO:0050794	0.981	regulation of cellular process
GO:0048519	0.955	negative regulation of biological process
GO:0048523	0.952	negative regulation of cellular process
GO:0060255	0.937	regulation of macromolecule metabolic process
GO:0032501	0.878	multicellular organismal process
GO:0048856	0.878	anatomical structure development
GO:0051171	0.856	regulation of nitrogen compound metabolic process
GO:0080090	0.855	regulation of primary metabolic process
GO:0051246	0.848	regulation of protein metabolic process
GO:0007275	0.831	multicellular organism development
GO:0048518	0.822	positive regulation of biological process
GO:0051239	0.819	regulation of multicellular organismal process
GO:0009893	0.770	positive regulation of metabolic process
GO:0010468	0.708	regulation of gene expression
GO:0023052	0.705	signaling
GO:0051249	0.699	regulation of lymphocyte activation
GO:0050896	0.692	response to stimulus
GO:0070664	0.651	negative regulation of leukocyte proliferation
GO:0051716	0.636	cellular response to stimulus
GO:0048522	0.622	positive regulation of cellular process
GO:1903037	0.608	regulation of leukocyte cell-cell adhesion
GO:0032663	0.600	regulation of interleukin-2 production
GO:1903038	0.600	negative regulation of leukocyte cell-cell adhesion
GO:0032945	0.600	negative regulation of mononuclear cell proliferation
GO:0002695	0.600	negative regulation of leukocyte activation
GO:0050863	0.598	regulation of T cell activation
GO:0051250	0.593	negative regulation of lymphocyte activation
GO:0010604	0.592	positive regulation of macromolecule metabolic process
GO:0042129	0.571	regulation of T cell proliferation
GO:0050868	0.567	negative regulation of T cell activation
GO:0050672	0.567	negative regulation of lymphocyte proliferation
GO:0009653	0.564	anatomical structure morphogenesis
GO:0048731	0.531	system development
GO:0071840	0.528	cellular component organization or biogenesis
GO:0042130	0.526	negative regulation of T cell proliferation
GO:0035239	0.522	tube morphogenesis
GO:0031323	0.513	regulation of cellular metabolic process
GO:0007154	0.511	cell communication
GO:0016043	0.500	cellular component organization
GO:0072359	0.487	circulatory system development
GO:0007165	0.461	signal transduction
GO:0009894	0.445	regulation of catabolic process
GO:0030162	0.338	regulation of proteolysis
GO:0042176	0.336	regulation of protein catabolic process
GO:1903050	0.305	regulation of proteolysis involved in protein catabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0080008	0.999	Cul4-RING E3 ubiquitin ligase complex
GO:0031463	0.999	Cul3-RING ubiquitin ligase complex
GO:0031462	0.998	Cul2-RING ubiquitin ligase complex
GO:0005737	0.967	cytoplasm
GO:0043229	0.964	intracellular organelle
GO:0005829	0.954	cytosol
GO:0043231	0.940	intracellular membrane-bounded organelle
GO:0005634	0.918	nucleus
GO:0070013	0.871	intracellular organelle lumen
GO:0031464	0.723	Cul4A-RING E3 ubiquitin ligase complex
GO:0031981	0.708	nuclear lumen
GO:0005654	0.702	nucleoplasm
GO:0043232	0.572	intracellular non-membrane-bounded organelle
GO:0016020	0.423	membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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