StarFunc result for job id Q96A65

User Input

>input (974 residues)
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDE
LIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIE
HKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE
LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRK
FLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAII
ERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYAS
TGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQGGPDDNLI
EGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQV
LAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAY
SDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQ
PKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWL
ASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHL
EVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYI
FEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYE
MLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQA
AIKQATKDKKITTV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O35382	0.966	0.965	0.000	975	0.958	0.957	O35382.pdb.gz	EXOC4_MOUSE Exocyst complex component 4 OS=Mus musculus OX=10090 GN=Exoc4 PE=1 SV=2
2	AFDB:Q9VNH6	0.696	0.689	8.944E-48	985	0.339	0.335	Q9VNH6.pdb.gz	EXOC4_DROME Exocyst complex component 4 OS=Drosophila melanogaster OX=7227 GN=Sec8 PE=1 SV=3
3	AFDB:Q9XWS2	0.635	0.688	2.960E-38	893	0.246	0.269	Q9XWS2.pdb.gz	EXOC4_CAEEL Exocyst complex component 4 OS=Caenorhabditis elegans OX=6239 GN=sec-8 PE=2 SV=2
4	AFDB:Q54P76	0.593	0.499	4.694E-31	1182	0.232	0.191	Q54P76.pdb.gz	EXOC4_DICDI Exocyst complex component 4 OS=Dictyostelium discoideum OX=44689 GN=exoc4 PE=3 SV=1
5	AFDB:Q93YU5	0.571	0.533	1.159E-27	1053	0.209	0.194	Q93YU5.pdb.gz	SEC8_ARATH Exocyst complex component SEC8 OS=Arabidopsis thaliana OX=3702 GN=SEC8 PE=1 SV=1
6	AFDB:A0A1D8PPF9	0.523	0.469	1.109E-23	1107	0.198	0.174	A0A1D8PPF9.pdb.gz	A0A1D8PPF9_CANAL Exocyst complex component Sec8 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=SEC8 PE=3 SV=1
7	AFDB:P32855	0.500	0.466	1.354E-23	1065	0.166	0.152	P32855.pdb.gz	SEC8_YEAST Exocyst complex component SEC8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SEC8 PE=1 SV=1
8	AFDB:O74562	0.542	0.501	4.475E-23	1073	0.150	0.136	O74562.pdb.gz	SEC8_SCHPO Exocyst complex component sec8 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sec8 PE=1 SV=2
9	AFDB:Q38CI3	0.465	0.292	5.538E-17	1685	0.179	0.103	Q38CI3.pdb.gz	Q38CI3_TRYB2 Exocyst complex component Sec8 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.7690 PE=3 SV=1
10	AFDB:Q0WQF4	0.289	0.331	2.010E-10	828	0.118	0.139	Q0WQF4.pdb.gz	VP53A_ARATH Vacuolar protein sorting-associated protein 53 A OS=Arabidopsis thaliana OX=3702 GN=VPS53 PE=1 SV=1
11	PDB:5yfpD	0.485	0.493	1.880E-8	954	0.145	0.148	5yfpD.pdb.gz
12	PDB:5yfpC	0.202	0.237	1.534E-4	794	0.113	0.139	5yfpC.pdb.gz
13	PDB:3fhnA	0.185	0.244	2.378E-4	673	0.090	0.131	3fhnA.pdb.gz
14	PDB:7ajuUT	0.085	0.048	1.171E-3	2313	0.120	0.051	7ajuUT.pdb.gz	Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
15	PDB:7useB	0.122	0.115	1.320E-3	1099	0.117	0.104	7useB.pdb.gz	Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase.
16	PDB:6vaeA	0.078	0.069	2.928E-3	1198	0.111	0.090	6vaeA.pdb.gz	DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.
17	PDB:2x1gF	0.080	0.085	4.724E-3	896	0.111	0.121	2x1gF.pdb.gz
18	PDB:7sqcR1	0.080	0.052	4.724E-3	2080	0.100	0.047	7sqcR1.pdb.gz	Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
19	PDB:5yfpE	0.176	0.209	5.765E-3	776	0.076	0.095	5yfpE.pdb.gz
20	PDB:7dkhI	0.091	0.094	7.621E-3	914	0.115	0.123	7dkhI.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A8C0N5P9	0.0	1952	975	0.970	0.969	A0A8C0N5P9_CANLF Exocyst complex component Sec8 OS=Canis lupus familiaris OX=9615 GN=EXOC4 PE=1 SV=1
2	O35382	0.0	1910	975	0.959	0.958	EXOC4_MOUSE Exocyst complex component 4 OS=Mus musculus OX=10090 GN=Exoc4 PE=1 SV=2
3	Q62824	0.0	1899	975	0.954	0.953	EXOC4_RAT Exocyst complex component 4 OS=Rattus norvegicus OX=10116 GN=Exoc4 PE=1 SV=1
4	Q96A65	0.0	2009	974	1.000	1.000	EXOC4_HUMAN Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1
5	Q9VNH6	2.54e-178	546	985	0.353	0.349	EXOC4_DROME Exocyst complex component 4 OS=Drosophila melanogaster OX=7227 GN=Sec8 PE=1 SV=3
6	Q9XWS2	2.36e-66	242	893	0.165	0.180	EXOC4_CAEEL Exocyst complex component 4 OS=Caenorhabditis elegans OX=6239 GN=sec-8 PE=2 SV=2
7	Q54P76	2.38e-32	138	1182	0.121	0.100	EXOC4_DICDI Exocyst complex component 4 OS=Dictyostelium discoideum OX=44689 GN=exoc4 PE=3 SV=1
8	Q93YU5	6.95e-16	85.1	1053	0.114	0.105	SEC8_ARATH Exocyst complex component SEC8 OS=Arabidopsis thaliana OX=3702 GN=SEC8 PE=1 SV=1
9	A0A1D8PPF9	2.52e-11	70.5	1107	0.053	0.047	A0A1D8PPF9_CANAL Exocyst complex component Sec8 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=SEC8 PE=3 SV=1
10	O74562	0.002	44.7	1073	0.042	0.038	SEC8_SCHPO Exocyst complex component sec8 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sec8 PE=1 SV=2
11	P32855	0.029	40.8	1065	0.095	0.087	SEC8_YEAST Exocyst complex component SEC8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SEC8 PE=1 SV=1
12	Q0WQ75	0.031	40.8	780	0.032	0.040	VPS51_ARATH Vacuolar protein sorting-associated protein 51 homolog OS=Arabidopsis thaliana OX=3702 GN=VPS51 PE=1 SV=1
13	Q9SIM9	2.6	34.3	693	0.020	0.027	MAX2_ARATH F-box protein MAX2 OS=Arabidopsis thaliana OX=3702 GN=MAX2 PE=1 SV=2
14	Q9HWW1	3.7	33.1	232	0.033	0.138	Q9HWW1_PSEAE Outer membrane protein OprG OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=oprG PE=1 SV=1
15	P41004	6.0	33.1	1324	0.033	0.024	SMC4_SCHPO Structural maintenance of chromosomes protein 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cut3 PE=1 SV=2
16	Q8IJ45	9.4	32.7	762	0.020	0.025	Q8IJ45_PLAF7 Duffy binding-like merozoite surface protein 2 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1036300 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF10392 COG5	9e+02	11.4	Golgi transport complex subunit 5
2	PF04124 Dor1	74	13.7	Dor1-like family
3	PF06103 DUF948	5.4e+02	12.3	Bacterial protein of unknown function (DUF948)
4	PF05524 PEP-utilisers_N	3.4e+02	12.9	PEP-utilising enzyme, N-terminal
5	PF04048 Sec8_exocyst	1.1e-14	66.0	Sec8 exocyst complex component specific domain
6	PF10475 Vps54_N	9.3	17.0	Vacuolar-sorting protein 54, of GARP complex

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000253861

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000230449	0.999	Exocyst complex component 2
2	9606.ENSP00000260762	0.999	Exocyst complex component 6
3	9606.ENSP00000334100	0.999	Exocyst complex component 7
4	9606.ENSP00000355605	0.999	Exocyst complex component 8
5	9606.ENSP00000370695	0.999	Exocyst complex component 1
6	9606.ENSP00000425587	0.999	Exocyst complex component 3
7	9606.ENSP00000484855	0.999	Exocyst complex component 5
8	9606.ENSP00000264710	0.996	Ras-related protein Rab-10
9	9606.ENSP00000382177	0.984	Unconventional myosin-Va
10	9606.ENSP00000005257	0.977	Ras-related protein Ral-A
11	9606.ENSP00000238738	0.973	Rho-related GTP-binding protein RhoQ
12	9606.ENSP00000272427	0.971	Exocyst complex component 6B
13	9606.ENSP00000298316	0.962	ADP-ribosylation factor 6
14	9606.ENSP00000357564	0.959	Ras-related protein Rab-13
15	9606.ENSP00000348461	0.957	Ras-related C3 botulinum toxin substrate 1
16	9606.ENSP00000300935	0.948	Ras-related protein Rab-8A
17	9606.ENSP00000249647	0.938	Synaptosomal-associated protein 23
18	9606.ENSP00000261769	0.938	Cadherin-1
19	9606.ENSP00000400713	0.928	Exocyst complex component 3-like protein 2
20	9606.ENSP00000216181	0.927	Myosin-9

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0030165	0.986	PDZ domain binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0065007	0.985	biological regulation
GO:0050794	0.984	regulation of cellular process
GO:0032502	0.944	developmental process
GO:0048856	0.934	anatomical structure development
GO:0009987	0.933	cellular process
GO:0032501	0.910	multicellular organismal process
GO:0010506	0.854	regulation of autophagy
GO:0051179	0.787	localization
GO:0051234	0.755	establishment of localization
GO:0006810	0.632	transport
GO:0016241	0.594	regulation of macroautophagy
GO:0016192	0.554	vesicle-mediated transport
GO:0071840	0.553	cellular component organization or biogenesis
GO:0051641	0.515	cellular localization
GO:0048518	0.463	positive regulation of biological process
GO:0007275	0.453	multicellular organism development
GO:0016043	0.422	cellular component organization
GO:0048522	0.419	positive regulation of cellular process
GO:0050896	0.408	response to stimulus
GO:0009653	0.402	anatomical structure morphogenesis
GO:0048513	0.386	animal organ development
GO:0072132	0.377	mesenchyme morphogenesis
GO:0051649	0.324	establishment of localization in cell
GO:0051716	0.311	cellular response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.998	cytoplasm
GO:0005886	0.997	plasma membrane
GO:0043229	0.996	intracellular organelle
GO:0005829	0.993	cytosol
GO:0043232	0.991	intracellular non-membrane-bounded organelle
GO:0043227	0.977	membrane-bounded organelle
GO:0043231	0.965	intracellular membrane-bounded organelle
GO:0032991	0.960	protein-containing complex
GO:0012505	0.958	endomembrane system
GO:0031982	0.920	vesicle
GO:0005856	0.919	cytoskeleton
GO:0042995	0.905	cell projection
GO:0120025	0.903	plasma membrane bounded cell projection
GO:0043005	0.730	neuron projection
GO:0030054	0.706	cell junction
GO:0031410	0.657	cytoplasmic vesicle
GO:0070062	0.649	extracellular exosome
GO:0070013	0.416	intracellular organelle lumen
GO:0005768	0.378	endosome
GO:0030424	0.377	axon
GO:0032584	0.368	growth cone membrane
GO:0035748	0.365	myelin sheath abaxonal region
GO:0015630	0.364	microtubule cytoskeleton
GO:0005938	0.340	cell cortex
GO:0005815	0.338	microtubule organizing center
GO:0005813	0.300	centrosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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