StarFunc result for job id Q96EF6

User Input

>input (278 residues)
MGARLSRRRLPADPSLALDALPPELLVQVLSHVPPRSLVTRCRPVCRAWRDIVDGPTVWL
LQLARDRSAEGRALYAVAQRCLPSNEDKEEFPLCALARYCLRAPFGRNLIFNSCGEQGFR
GWEVEHGGNGWAIEKNLTPVPGAPSQTCFVTSFEWCSKRQLVDLVMEGVWQELLDSAQIE
ICVADWWGARENCGCVYQLRVRLLDVYEKEVVKFSASPDPVLQWTERGCRQVSHVFTNFG
KGIRYVSFEQYGRDVSSWVGHYGALVTHSSVRVRIRLS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q96EF6	1.000	1.000	1.026E-62	278	1.000	1.000	Q96EF6.pdb.gz	FBX17_HUMAN F-box only protein 17 OS=Homo sapiens OX=9606 GN=FBXO17 PE=1 SV=1
2	AFDB:Q8NI29	0.905	0.889	1.127E-44	283	0.590	0.580	Q8NI29.pdb.gz	FBX27_HUMAN F-box only protein 27 OS=Homo sapiens OX=9606 GN=FBXO27 PE=1 SV=2
3	AFDB:Q9UK22	0.622	0.588	8.700E-29	296	0.371	0.348	Q9UK22.pdb.gz	FBX2_HUMAN F-box only protein 2 OS=Homo sapiens OX=9606 GN=FBXO2 PE=1 SV=2
4	AFDB:Q8VD40	0.620	0.579	1.909E-28	300	0.371	0.343	Q8VD40.pdb.gz	Q8VD40_CAVPO F-box protein 2 OS=Cavia porcellus OX=10141 GN=OCP1 PE=2 SV=1
5	AFDB:Q80UW2	0.625	0.589	3.945E-28	297	0.349	0.327	Q80UW2.pdb.gz	FBX2_MOUSE F-box only protein 2 OS=Mus musculus OX=10090 GN=Fbxo2 PE=1 SV=1
6	AFDB:Q9NRD1	0.622	0.593	1.485E-26	293	0.335	0.317	Q9NRD1.pdb.gz	FBX6_HUMAN F-box only protein 6 OS=Homo sapiens OX=9606 GN=FBXO6 PE=1 SV=1
7	PDB:2e31A	0.629	0.702	1.896E-26	246	0.338	0.382	2e31A.pdb.gz
8	AFDB:Q8BK26	0.625	0.676	2.408E-26	255	0.335	0.365	Q8BK26.pdb.gz	FBX44_MOUSE F-box only protein 44 OS=Mus musculus OX=10090 GN=Fbxo44 PE=1 SV=1
9	AFDB:Q9QZN4	0.651	0.618	5.965E-26	295	0.299	0.281	Q9QZN4.pdb.gz	FBX6_MOUSE F-box only protein 6 OS=Mus musculus OX=10090 GN=Fbxo6 PE=1 SV=1
10	PDB:3wsoA	0.571	0.623	4.629E-23	252	0.331	0.365	3wsoA.pdb.gz
11	AFDB:Q17962	0.687	0.515	6.914E-19	384	0.198	0.143	Q17962.pdb.gz	Q17962_CAEEL F-box domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=C14B1.3 PE=1 SV=1
12	AFDB:Q6ZVX7	0.465	0.469	2.724E-14	275	0.255	0.258	Q6ZVX7.pdb.gz	FBX50_HUMAN F-box only protein 50 OS=Homo sapiens OX=9606 GN=NCCRP1 PE=1 SV=1
13	PDB:7ungXA	0.295	0.403	1.597E-3	186	0.058	0.086	7ungXA.pdb.gz	SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
14	PDB:7rslA	0.233	0.262	7.240E-3	235	0.068	0.081	7rslA.pdb.gz
15	PDB:6ve73	0.293	0.395	8.171E-3	187	0.061	0.091	6ve73.pdb.gz	The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications.
16	PDB:5eiyB	0.261	0.129	8.680E-3	658	0.083	0.035	5eiyB.pdb.gz	Observing cellulose biosynthesis and membrane translocation in crystallo.
17	PDB:6vlsD	0.330	0.113	8.680E-3	963	0.058	0.017	6vlsD.pdb.gz
18	PDB:5vaeB	0.229	0.416	1.041E-2	134	0.072	0.149	5vaeB.pdb.gz
19	PDB:7l2zF	0.199	0.102	1.041E-2	664	0.047	0.020	7l2zF.pdb.gz
20	PDB:4bxsV	0.251	0.077	1.408E-2	1262	0.065	0.014	4bxsV.pdb.gz	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q96EF6	0.0	568	278	1.000	1.000	FBX17_HUMAN F-box only protein 17 OS=Homo sapiens OX=9606 GN=FBXO17 PE=1 SV=1
2	Q8NI29	9.58e-104	305	283	0.518	0.509	FBX27_HUMAN F-box only protein 27 OS=Homo sapiens OX=9606 GN=FBXO27 PE=1 SV=2
3	Q9NRD1	6.63e-52	173	293	0.327	0.311	FBX6_HUMAN F-box only protein 6 OS=Homo sapiens OX=9606 GN=FBXO6 PE=1 SV=1
4	Q8VD40	1.37e-49	167	300	0.353	0.327	Q8VD40_CAVPO F-box protein 2 OS=Cavia porcellus OX=10141 GN=OCP1 PE=2 SV=1
5	Q8BK26	2.71e-48	162	255	0.320	0.349	FBX44_MOUSE F-box only protein 44 OS=Mus musculus OX=10090 GN=Fbxo44 PE=1 SV=1
6	Q9UK22	3.31e-48	164	296	0.349	0.328	FBX2_HUMAN F-box only protein 2 OS=Homo sapiens OX=9606 GN=FBXO2 PE=1 SV=2
7	Q9QZN4	6.01e-48	163	295	0.327	0.308	FBX6_MOUSE F-box only protein 6 OS=Mus musculus OX=10090 GN=Fbxo6 PE=1 SV=1
8	Q9H4M3	7.20e-48	161	255	0.320	0.349	FBX44_HUMAN F-box only protein 44 OS=Homo sapiens OX=9606 GN=FBXO44 PE=1 SV=3
9	G3V774	1.45e-46	159	296	0.338	0.318	G3V774_RAT F-box protein 2 OS=Rattus norvegicus OX=10116 GN=Fbxo2 PE=4 SV=1
10	Q9Z1X8	1.50e-46	159	296	0.338	0.318	Q9Z1X8_RAT Neural F box protein NFB42 OS=Rattus norvegicus OX=10116 GN=Fbxo2 PE=2 SV=1
11	A0A8I6AAF5	1.69e-46	159	297	0.338	0.316	A0A8I6AAF5_RAT F-box protein 2 OS=Rattus norvegicus OX=10116 GN=Fbxo2 PE=4 SV=1
12	A0A8I6A9Y7	2.05e-46	159	309	0.338	0.304	A0A8I6A9Y7_RAT F-box protein 2 OS=Rattus norvegicus OX=10116 GN=Fbxo2 PE=4 SV=1
13	A0A8I5ZK45	2.29e-46	159	305	0.338	0.308	A0A8I5ZK45_RAT F-box protein 2 OS=Rattus norvegicus OX=10116 GN=Fbxo2 PE=4 SV=1
14	Q80UW2	4.23e-45	155	297	0.335	0.313	FBX2_MOUSE F-box only protein 2 OS=Mus musculus OX=10090 GN=Fbxo2 PE=1 SV=1
15	W5UTZ0	1.90e-21	92.0	235	0.180	0.213	W5UTZ0_ICTPU F-box only protein 50 OS=Ictalurus punctatus OX=7998 GN=nccrp1 PE=2 SV=1
16	Q9PTD4	5.64e-19	85.5	235	0.173	0.204	Q9PTD4_ICTPU F-box only protein 50 OS=Ictalurus punctatus OX=7998 GN=NCCRP-1 PE=2 SV=1
17	Q6ZVX7	3.52e-15	75.9	275	0.165	0.167	FBX50_HUMAN F-box only protein 50 OS=Homo sapiens OX=9606 GN=NCCRP1 PE=1 SV=1
18	Q17962	0.003	41.2	384	0.223	0.161	Q17962_CAEEL F-box domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=C14B1.3 PE=1 SV=1
19	Q5A9A6	0.011	39.7	768	0.058	0.021	Q5A9A6_CANAL SCF ubiquitin ligase complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CDC4 PE=4 SV=1
20	Q0V7S0	0.029	38.1	459	0.072	0.044	FB39_ARATH F-box protein At1g47340 OS=Arabidopsis thaliana OX=3702 GN=At1g47340 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00646 F-box	2.8e-06	38.3	F-box domain
2	PF12937 F-box-like	6.4e-07	40.5	F-box-like
3	PF04300 FBA	4.4e-64	226.9	F-box associated region

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000292852

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000231487	0.980	S-phase kinase-associated protein 1
2	9606.ENSP00000326804	0.890	Cullin-1
3	9606.ENSP00000264389	0.875	COP9 signalosome complex subunit 4
4	9606.ENSP00000362710	0.812	COP9 signalosome complex subunit 7b
5	9606.ENSP00000350512	0.799	COP9 signalosome complex subunit 5
6	9606.ENSP00000216225	0.746	E3 ubiquitin-protein ligase RBX1
7	9606.ENSP00000304102	0.738	COP9 signalosome complex subunit 6
8	9606.ENSP00000299259	0.678	COP9 signalosome complex subunit 2
9	9606.ENSP00000250495	0.641	NEDD8
10	9606.ENSP00000353794	0.553	F-box and leucine-rich protein 22
11	9606.ENSP00000471896	0.533	Interferon regulatory factor 3
12	9606.ENSP00000476369	0.533	F-box/WD repeat-containing protein 2
13	9606.ENSP00000244426	0.508	F-box only protein 9

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003824	0.364	catalytic activity
GO:0140096	0.318	catalytic activity, acting on a protein
GO:0016740	0.308	transferase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0071704	0.992	organic substance metabolic process
GO:0044238	0.990	primary metabolic process
GO:0006807	0.982	nitrogen compound metabolic process
GO:0050789	0.972	regulation of biological process
GO:0019538	0.966	protein metabolic process
GO:0009987	0.908	cellular process
GO:0044237	0.897	cellular metabolic process
GO:0006508	0.890	proteolysis
GO:0050794	0.836	regulation of cellular process
GO:1901565	0.829	organonitrogen compound catabolic process
GO:0009057	0.669	macromolecule catabolic process
GO:0044260	0.664	cellular macromolecule metabolic process
GO:0030163	0.662	protein catabolic process
GO:0051603	0.618	proteolysis involved in protein catabolic process
GO:0010498	0.600	proteasomal protein catabolic process
GO:0006511	0.551	ubiquitin-dependent protein catabolic process
GO:0043161	0.501	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0036211	0.479	protein modification process
GO:0031146	0.329	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032991	0.995	protein-containing complex
GO:0005829	0.995	cytosol
GO:0019005	0.994	SCF ubiquitin ligase complex
GO:0070013	0.467	intracellular organelle lumen
GO:0031981	0.433	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	0.308	Transferases.

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