StarFunc result for job id Q96IV0

User Input

>input (654 residues)
MAAAALGSSSGSASPAVAELCQNTPETFLEASKLLLTYADNILRNPNDEKYRSIRIGNTA
FSTRLLPVRGAVECLFEMGFEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSNKSH
KVKSSQQPAASTQLPTTPSSNPSGLNQHTRNRQGQSSDPPSASTVAADSAILEVLQSNIQ
HVLVYENPALQEKALACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEE
FFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHYCDACQFSNRFPRYNNPEK
LLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCD
KPLLYEIGWGKKLSYVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQ
RQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGEMGLQRKETL
FIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYL
ARKEGSSFAYISWKFECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSL
HSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKFSDL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q5XI55	0.776	0.780	0.000	651	0.844	0.848	Q5XI55.pdb.gz	NGLY1_RAT Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Rattus norvegicus OX=10116 GN=Ngly1 PE=2 SV=2
2	AFDB:Q96IV0	1.000	1.000	0.000	654	1.000	1.000	Q96IV0.pdb.gz	NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1
3	AFDB:Q7KRR5	0.478	0.494	3.288E-56	631	0.323	0.334	Q7KRR5.pdb.gz	NGLY1_DROME Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Drosophila melanogaster OX=7227 GN=Pngl PE=1 SV=1
4	AFDB:Q9TW67	0.461	0.495	6.986E-44	606	0.263	0.284	Q9TW67.pdb.gz	NGLY1_CAEEL Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Caenorhabditis elegans OX=6239 GN=png-1 PE=1 SV=1
5	AFDB:Q9FGY9	0.425	0.390	1.201E-31	721	0.245	0.222	Q9FGY9.pdb.gz	PNG1_ARATH Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Arabidopsis thaliana OX=3702 GN=PNG1 PE=2 SV=1
6	AFDB:Q55FC8	0.390	0.411	2.400E-27	618	0.222	0.235	Q55FC8.pdb.gz	Q55FC8_DICDI Transglutaminase-like domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0268168 PE=4 SV=1
7	AFDB:O74739	0.415	0.800	6.564E-27	333	0.187	0.366	O74739.pdb.gz	PNG1_SCHPO Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=png1 PE=2 SV=2
8	AFDB:Q02890	0.407	0.718	1.950E-23	363	0.174	0.314	Q02890.pdb.gz	PNG1_YEAST Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PNG1 PE=1 SV=1
9	PDB:3eswA	0.399	0.768	1.448E-21	333	0.164	0.321	3eswA.pdb.gz	Structural and mutational studies on the importance of oligosaccharide binding for the activity of yeast PNGase.
10	PDB:7k04A	0.295	0.361	6.823E-7	524	0.072	0.090	7k04A.pdb.gz	Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair.
11	PDB:2e31A	0.110	0.226	8.685E-4	246	0.047	0.126	2e31A.pdb.gz
12	AFDB:Q38FI8	0.158	0.101	8.990E-4	1051	0.141	0.088	Q38FI8.pdb.gz	Q38FI8_TRYB2 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.160.2050 PE=3 SV=1
13	AFDB:Q38BF0	0.136	0.243	1.302E-3	358	0.038	0.070	Q38BF0.pdb.gz	Q38BF0_TRYB2 PUB domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.2710 PE=4 SV=1
14	PDB:6xwuA	0.076	0.229	6.162E-3	138	0.021	0.101	6xwuA.pdb.gz
15	PDB:7eyjA	0.064	0.293	7.223E-3	95	0.012	0.084	7eyjA.pdb.gz
16	PDB:3wsoA	0.131	0.295	8.467E-3	252	0.018	0.048	3wsoA.pdb.gz
17	PDB:5lkiA	0.134	0.071	8.927E-3	1427	0.050	0.023	5lkiA.pdb.gz
18	PDB:2waaA	0.109	0.184	9.924E-3	335	0.014	0.027	2waaA.pdb.gz
19	PDB:6kzbC	0.114	0.115	1.103E-2	649	0.083	0.083	6kzbC.pdb.gz	Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2.
20	PDB:1j3pA	0.075	0.189	1.516E-2	187	0.021	0.075	1j3pA.pdb.gz	Characterization of the cupin-type phosphoglucose isomerase from the hyperthermophilic archaeon Thermococcus litoralis(1).

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q5XI55	0.0	1105	651	0.821	0.825	NGLY1_RAT Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Rattus norvegicus OX=10116 GN=Ngly1 PE=2 SV=2
2	Q96IV0	0.0	1357	654	1.000	1.000	NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1
3	Q9JI78	0.0	1113	651	0.823	0.826	NGLY1_MOUSE Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Mus musculus OX=10090 GN=Ngly1 PE=1 SV=2
4	Q7KRR5	1.37e-109	345	631	0.335	0.347	NGLY1_DROME Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Drosophila melanogaster OX=7227 GN=Pngl PE=1 SV=1
5	Q9TW67	8.03e-90	293	606	0.248	0.267	NGLY1_CAEEL Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Caenorhabditis elegans OX=6239 GN=png-1 PE=1 SV=1
6	O74739	1.60e-70	234	333	0.196	0.384	PNG1_SCHPO Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=png1 PE=2 SV=2
7	Q9FGY9	4.92e-68	238	721	0.203	0.184	PNG1_ARATH Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Arabidopsis thaliana OX=3702 GN=PNG1 PE=2 SV=1
8	Q02890	2.55e-56	197	363	0.180	0.325	PNG1_YEAST Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PNG1 PE=1 SV=1
9	Q55FC8	1.38e-55	201	618	0.190	0.201	Q55FC8_DICDI Transglutaminase-like domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0268168 PE=4 SV=1
10	Q9MAT3	1.86e-06	53.1	413	0.040	0.063	Q9MAT3_ARATH F13M7.16 protein OS=Arabidopsis thaliana OX=3702 GN=At1g04850 PE=1 SV=1
11	Q8WTJ4	8.38e-06	51.2	437	0.061	0.092	UBXN6_CAEEL UBX domain-containing protein 6 OS=Caenorhabditis elegans OX=6239 GN=ubxn-6 PE=1 SV=2
12	Q7K0S5	2.12e-04	46.6	441	0.047	0.070	Q7K0S5_DROME GDI interacting protein 3, isoform B OS=Drosophila melanogaster OX=7227 GN=Gint3 PE=1 SV=1
13	Q38BF0	0.019	40.0	358	0.047	0.087	Q38BF0_TRYB2 PUB domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.2710 PE=4 SV=1
14	Q9N4C3	0.12	38.1	1119	0.034	0.020	Q9N4C3_CAEEL XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog OS=Caenorhabditis elegans OX=6239 GN=xpc-1 PE=1 SV=2
15	Q9BZV1	0.17	37.4	441	0.026	0.039	UBXN6_HUMAN UBX domain-containing protein 6 OS=Homo sapiens OX=9606 GN=UBXN6 PE=1 SV=1
16	Q9HZX3	0.18	37.4	668	0.034	0.033	TGPA_PSEAE Protein-glutamine gamma-glutamyltransferase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=tgpA PE=1 SV=1
17	Q9Y2D8	0.45	36.2	614	0.034	0.036	ADIP_HUMAN Afadin- and alpha-actinin-binding protein OS=Homo sapiens OX=9606 GN=SSX2IP PE=1 SV=3
18	Q9ZU93	0.54	35.8	458	0.026	0.037	PUX2_ARATH Plant UBX domain-containing protein 2 OS=Arabidopsis thaliana OX=3702 GN=PUX2 PE=1 SV=2
19	P53890	0.65	35.4	448	0.031	0.045	BNI5_YEAST Bud neck protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=BNI5 PE=1 SV=1
20	Q8VC66	1.1	34.7	615	0.034	0.036	ADIP_MOUSE Afadin- and alpha-actinin-binding protein OS=Mus musculus OX=10090 GN=Ssx2ip PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF04721 PAW	9.5e-74	259.0	PNGase C-terminal domain, mannose-binding module PAW
2	PF09409 PUB	1e-20	84.8	PUB domain
3	PF03835 Rad4	6.8e-07	40.6	Rad4 transglutaminase-like domain
4	PF01841 Transglut_core	1.8e-12	59.1	Transglutaminase-like superfamily

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000280700

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000350708	0.998	UV excision repair protein RAD23 homolog B
2	9606.ENSP00000351777	0.988	Transitional endoplasmic reticulum ATPase
3	9606.ENSP00000467024	0.979	UV excision repair protein RAD23 homolog A
4	9606.ENSP00000290649	0.954	E3 ubiquitin-protein ligase AMFR
5	9606.ENSP00000261303	0.948	26S proteasome regulatory subunit 4
6	9606.ENSP00000304697	0.935	Polyubiquitin-B
7	9606.ENSP00000441543	0.932	Polyubiquitin-C
8	9606.ENSP00000272317	0.931	Ubiquitin-40S ribosomal protein S27a
9	9606.ENSP00000259512	0.917	Derlin-1
10	9606.ENSP00000388107	0.900	Ubiquitin-60S ribosomal protein L40
11	9606.ENSP00000294119	0.846	UBX domain-containing protein 1
12	9606.ENSP00000285021	0.844	DNA repair protein complementing XP-C cells
13	9606.ENSP00000417748	0.775	DNA damage inducible 1 homolog 2
14	9606.ENSP00000387362	0.717	Ubiquitin conjugation factor E4 A
15	9606.ENSP00000462333	0.713	Cytosolic endo-beta-N-acetylglucosaminidase
16	9606.ENSP00000382507	0.711	UBX domain-containing protein 2B
17	9606.ENSP00000365576	0.708	Ubiquilin-1
18	9606.ENSP00000457788	0.703	Alpha-mannosidase 2C1
19	9606.ENSP00000263202	0.700	Ubiquitin recognition factor in ER-associated degradation protein 1
20	9606.ENSP00000366395	0.697	E3 ubiquitin-protein ligase synoviolin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0000224	1.000	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044237	0.998	cellular metabolic process
GO:0071704	0.997	organic substance metabolic process
GO:0044238	0.997	primary metabolic process
GO:0009057	0.993	macromolecule catabolic process
GO:1901565	0.993	organonitrogen compound catabolic process
GO:0019538	0.990	protein metabolic process
GO:0030163	0.973	protein catabolic process
GO:0044260	0.962	cellular macromolecule metabolic process
GO:1901135	0.952	carbohydrate derivative metabolic process
GO:0044265	0.951	cellular macromolecule catabolic process
GO:1901136	0.935	carbohydrate derivative catabolic process
GO:0006516	0.928	glycoprotein catabolic process
GO:0036211	0.635	protein modification process
GO:0050896	0.511	response to stimulus
GO:0006950	0.422	response to stress
GO:0051716	0.422	cellular response to stimulus
GO:0051603	0.365	proteolysis involved in protein catabolic process
GO:0033554	0.316	cellular response to stress

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.998	cytoplasm
GO:0005829	0.990	cytosol
GO:0032991	0.531	protein-containing complex
GO:0016020	0.470	membrane
GO:0070013	0.456	intracellular organelle lumen
GO:0071944	0.434	cell periphery
GO:0012505	0.388	endomembrane system
GO:0043231	0.326	intracellular membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.5.1.52	1.000	peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase.

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